ライフサイエンスコーパス: cytochrome P450

1 equired for electron transport from NADPH to cytochrome P450.

2 y transgenic expression of a gene encoding a cytochrome P450.

3 in the metabolism of various xenobiotics by cytochrome P450.

4 ut have only been observed in Compound II of cytochrome P450s.

5 dimers of some microsomal drug-metabolizing cytochromes P450.

6 The enzyme cytochrome P450 11A1 cleaves the C20-C22 carbon-carbon b

7 Aldosterone synthase (AS, cytochrome P450 11B2, cyp11B2) is the sole enzyme respon

8 The clinical utility of inhibiting cytochrome P450 17A1 (CYP17), a cytochrome p450 enzyme t

9 The multifunctional cytochrome P450 17A1 (CYP17A1) first catalyzes the typic

10 Cytochrome P450 17A1 (CYP17A1) is an important target in

11 The activities of cytochrome P450 17A1, 19A1, and 21A2, critical in steroi

12 describes the linkage between inhibition of cytochrome P450 19A aromatase (the MIE) and population-l

13 tial upregulation of mRNA and enzymes of the cytochrome P450 1A family during a lead optimization cam

14 ure does not induce the canonical AhR target cytochrome P450 1a1 (Cyp1a1).

15 by the indole-3-carbinol (I3C)-inducible rat cytochrome P450 1A1 promoter.

16 n growth was impaired in mice lacking either cytochrome P450 26B1 (Cyp26b1), which results in excess

17 Cytochrome P450 27A1 (CYP27A1 or sterol 27-hydroxylase)

18 Cytochrome P450 27A1 (CYP27A1) is a ubiquitous enzyme th

19 d full-length substrate-free/substrate-bound cytochrome P450 2B4 (CYP2B4) are investigated using NMR

20 al incubations of each PBDE with recombinant cytochrome P450 2B6.

21 f on-treatment platelet reactivity including cytochrome P450 2C19 (CYP2C19) polymorphisms, age, body

22 cking study of fluorescently labeled CPR and cytochrome P450 2C9 (CYP2C9) molecules in which stochast

23 MED25 in the epigenetic regulation of human cytochrome P450 2C9 (CYP2C9).

24 ed that SHP represses the transactivation of cytochrome P450 2D6 (CYP2D6) promoter by hepatocyte nucl

25 Cytochrome P450-2E1 (CYP2E1) increases oxidative stress.

26 resent the detection of substrate binding to cytochrome P450-2J2 (CYP2J2), the predominant P450 in th

27 Cytochrome P450 3A (CYP3A) is the most abundant CYP450 e

28 anscriptional induction of the gene encoding cytochrome P450 3A oxygenase (CYP3A) causes a prominent

29 arbazepine, and topiramate, enhances hepatic cytochrome P450 3A4 (CYP3A4) activity, and can decrease

30 loring the conformational landscape of human cytochrome P450 3A4 (CYP3A4) by electron paramagnetic re

31 ed prostate cancer drug, in interaction with cytochrome P450 3A4 (CYP3A4) enzyme and multiwalled carb

32 priate substituent alleviated time-dependent cytochrome P450 3A4 (CYP3A4) inhibition.

33 Human cytochrome P450 3A4 (CYP3A4) is a key xenobiotic-metabol

34 Human cytochrome P450 3A4 (CYP3A4) is a major hepatic and inte

35 Cytochrome P450 3A4 (CYP3A4) is the dominant P450 enzyme

36 Inhibition of cytochrome P450 3A4 (CYP3A4), the major drug metabolizin

37 ine medications and the presence of combined cytochrome P450 3A4 and P-glycoprotein inhibitors in the

38 utcomes in those treated with >/= 1 combined cytochrome P450 3A4 and P-glycoprotein inhibitors.

39 potential drug-drug interactions due to its cytochrome P450 3A4 profile.

40 The contributions of cytochrome P450 3A5 to the metabolic clearance of market

41 Cytochrome P450 46A1 (CYP46A1) is a microsomal enzyme an

42 Cytochrome P450 46A1 (CYP46A1, cholesterol 24-hydroxylas

43 29/Sv mice carrying four copies of the human cytochrome P450 4A11 gene (CYP4A11) under control of its

44 Cytochrome P450 71A13 (CYP71A13) is a key enzyme for cam

45 By the time cytochrome P450 7A1 expression is reduced these drugs ma

46 C57Bl/6 or cytochrome p450 7A1 knockout (Cyp7A1(-/-)) mice were fed

47 or hepatocellular bile salt transporters and cytochrome P450 7a1, the key regulator of bile salt synt

48 brinogen, metabolized ammonia, and displayed cytochrome P450 activities and functional activities typ

49 explained by the effect of the two azoles on cytochrome P450 activity, measured on D. magna in vivo.

50 inal chemists to stabilize candidates toward cytochrome P450 activity, which increases the risk for n

51 Surprisingly, this cytochrome P450 also catalyzes the non-oxidative isomeri

52 synthesis, which involves a uniquely adapted cytochrome P450-amidotransferase enzyme pair and highlig

53 sented pathways Metabolism of Xenobiotics by Cytochrome P450 and Butanoate and Tryptophan Metabolism.

54 otein had moderately decreased activity with cytochrome P450 and cytochrome c It formed a flexible lo

55 ne heterogeneity affects the organization of cytochrome P450s and their cognate redox partner, the cy

56 Here, we report the discovery of five cytochrome P450s and two acetyltransferases which cataly

57 s ago to help explain reactivity patterns in cytochrome P450, and subsequently has been used to provi

58 triterpenoid synthases, epoxide hydrolases, cytochrome P450s, and UDP-glucosyltransferases.

59 Cytochrome P450s are the primary enzymes involved in pha

60 Here we provide evidence that cytochrome P450 aromatase (AROM), the enzyme converting

61 which reportedly regulates the expression of cytochrome P450 aromatase (P450arom).

62 in mood disorders and of the side effects of cytochrome P450 aromatase inhibitors, which are frequent

63 They are antitumor prodrugs that require cytochrome P450 bioactivation leading to 4-hydroxy deriv

64 able than those of the corresponding loop in cytochrome P450 BM3 and the neuronal NOS mutant (DeltaGl

65 As reference enzyme, we chose cytochrome P450 BM3 that is restricted by NADPH dependen

66 A "P411" serine-ligated variant of cytochrome P450(BM3) has been engineered to initiate a s

67 d DeltaG141/E142N mutants were inactive with cytochrome P450 but fully active in reducing cytochrome

68 genously in the course of cell metabolism by cytochrome P450, by oxidative stress or by a deviating n

69 verage structures of the camphor hydroxylase cytochrome P450(cam) (CYP101) obtained from residual dip

70 an facilitate, inhibit, or have no effect on cytochrome P450 catalysis, often in a P450-dependent and

71 ctivation pathways that are operative during cytochrome P450-catalyzed cyclopropanation.

72 Biosynthetic pathways involving cytochrome P450-catalyzed oxidation of fatty acids in ye

73 c pentalenolactone (1) is the highly unusual cytochrome P450-catalyzed, oxidative rearrangement of pe

74 We show that the predicted cytochrome P450 ClaM catalyzes the dimerization of natal

75 Differential expression patterns of cytochrome P450 complement (CYPome) were analyzed betwee

76 ction, we have prepared a selenolate-ligated cytochrome P450 compound I intermediate.

77 that ligands selectively stabilize discrete cytochrome P450 conformational states.

78 Direct electrochemistry of cytochrome P450 containing systems has primarily focused

79 Knockdown of the cytochrome P450s cyp-35A3 and cyp-35A4 increased the tox

80 Prodrug-mediated utilization of the cytochrome P450 (CYP) 1A1 to obtain the selective releas

81 Cytochrome P450 (CYP) 1B1 is implicated in vascular smoo

82 nhibition ofatRA metabolism by talarozole, a cytochrome P450 (CYP) 26 specific inhibitor, increased t

83 Human cytochrome P450 (CYP) 2C enzymes metabolize approximatel

84 in vitro assessment confirmed inhibition of cytochrome P450 (CYP) 2C19 and CYP3A4 by meropenem, sugg

85 Cytochrome P450 (CYP) 3A accounts for nearly 30% of the

86 study demonstrated that dronedarone inhibits cytochrome P450 (CYP) 3A4 and 3A5 in a time-dependent ma

87 Here we have begun to uncover the effects of cytochrome P450 (CYP) 4A in TAMs on lung pre-metastatic

88 th factor 15- and Fxr-mediated inhibition of cytochrome p450 (Cyp) 7a1 and Cyp27a1, along with increa

89 The virulent Mtb H37Rv strain encodes 20 cytochrome P450 (CYP) enzymes, many of which are implica

90 sEH limits tissue levels of cytochrome P450 (CYP) epoxides derived from omega-6 and

91 om the crosstalk between endocannabinoid and cytochrome P450 (CYP) epoxygenase metabolic pathways.

92 Cytochrome P450 (CYP) family members are known to be pre

93 carbamoyl-phosphate synthetase1 and several cytochrome P450 (CYP) genes in this culture system.

94 In addition, the expression of several cytochrome P450 (CYP) genes were also modified in both f

95 synthesis and transport in humans, including cytochrome P450 (CYP) isoform 7A1 (CYP7A1), CYP27A1, CYP

96 polyunsaturated fatty acids derived from the cytochrome P450 (CYP) monooxygenase pathway serve as vit

97 tested the hypothesis that enzymes from the cytochrome P450 (CYP) superfamily can participate in the

98 Almost all known members of the cytochrome P450 (CYP) superfamily conserve a key cystein

99 Here we investigated the roles of cytochrome P450 (CYP)-derived epoxy-oxylipins in a well-

100 y biphenyl synthase (BIS), is catalyzed by a cytochrome P450 (CYP).

101 Cytochrome P450 (CYP)1A enzymes are protective against h

102 dibenzo-p-dioxin (TCDD) on the expression of cytochrome P450 (CYP)1A1 and cytokines in various tissue

103 The most up-regulated genes include cytochrome P450s (CYP) CYP6P9a, CYP6P9b and CYP6M7.

104 these genes, as well as that for one of the cytochromes P450 (CYP112) found in the operon.

105 al that inhibits a key steroidogenic enzyme [cytochrome P450(CYP19) aromatase] required for estrogen

106 Multiple cytochrome P450 (CYP1A1, CYP2A19 and CYP2C36) genes disp

107 Cytochrome P450 CYP26 enzymes are responsible for all-tr

108 Cytochrome P450 CYP27A1 is the only enzyme in humans con

109 Although the cytochrome P450 CYP27B1 plays a critical role in vitamin

110 n (CHIP) E3 ubiquitin-ligase impairs hepatic cytochrome P450 CYP2E1 degradation.

111 larity, secretion of albumin and urea, basal cytochrome P450 (CYP450) activities, phase II conjugatio

112 Additionally, inhibition of human cytochrome P450 (CYP450) by NSC23925b was examined in vi

113 f most xenobiotics owing to its abundance in cytochrome P450 (CYP450) enzymes.

114 d pheromones in the MG, including members of cytochrome P450 (CYP450) family and genes involved in fa

115 yclooxygenase (COX), lipoxygenase (LOX), and cytochrome P450 (CYP450) pathways.

116 Intracellular enzymes, such as cytochrome P450 (CYP450), have also been suggested to co

117 Malassezia globosa cytochromes P450 CYP51 and CYP5218 are sterol 14alpha-de

118 -induced gene silencing (VIGS) to identify a cytochrome P450 [CYP71D1V2; tabersonine 3-oxygenase (T3O

119 maize PLASTOCHRON1 (ZmPLA1) gene, encoding a cytochrome P450 (CYP78A1), results in increased organ gr

120 luated whether tyrosine hydroxylase (TH) and cytochrome P450s (CYPs) catalyzed this process.

121 Characterization of the cytochrome P450s (CYPs) identified from these loci enabl

122 Cytochromes P450 (CYPs) play a key role in generating th

123 nteractions of full-length mammalian 72-kDa cytochrome P450-cytochrome b5 complex in lipid bilayers.

124 membrane protein vital for the regulation of cytochrome P450 (cytP450) metabolism and is capable of e

125 The cytochrome P450-dependent mono-oxygenase system is respo

126 s, more commonly, oxygenation is achieved by cytochrome P450-dependent mono-oxygenases.

127 The role of cytochrome P450 drug metabolizing enzymes in the efficac

128 ls suggest that changes in the production of cytochrome P450 eicosanoids alter BP.

129 review summarizes the emerging evidence that cytochrome P450 eicosanoids have a role in the pathogene

130 raenoic acid (20-HETE), one of the principle cytochrome P450 eicosanoids, is a potent vasoactive lipi

131 cross-talk, the catalytic properties of the cytochrome P450 ensemble cannot be predicted by simple s

132 he activity and substrate specificity of the cytochrome P450 ensemble through interactions between mu

133 icular, for studies of the multiply reactive cytochrome P450, ent-kaurene oxidase (KO), which is invo

134 orometric method was used to compare general cytochrome P450 enzyme activity by monitoring the transf

135 arvae relative to adults may be due to lower cytochrome P450 enzyme activity in fat bodies.

136 Here we report the engineering of a cytochrome P450 enzyme by directed evolution to catalyze

137 tabolism by transcriptionally regulating the cytochrome P450 enzyme Cyp1b1 Furthermore, expression of

138 metrix expression analysis, we show that the cytochrome P450 enzyme Cyp1b1 was significantly decrease

139 (1,25(OH)2D3), occurs in the kidney via the cytochrome P450 enzyme CYP27B1.

140 CYP121 is a cytochrome P450 enzyme from Mycobacterium tuberculosis t

141 CYP121, the cytochrome P450 enzyme in Mycobacterium tuberculosis tha

142 The cytochrome P450 enzyme KtnC from the kotanin biosyntheti

143 Sterol 14alpha-demethylase (CYP51) is a cytochrome P450 enzyme required for biosynthesis of ster

144 fungi using azole compounds that inhibit the cytochrome P450 enzyme sterol 14alpha-demethylase.

145 characterization of vinorine hydroxylase, a cytochrome P450 enzyme that hydroxylates vinorine to for

146 f inhibiting cytochrome P450 17A1 (CYP17), a cytochrome p450 enzyme that is required for the producti

147 o deliver the desired outcome, an engineered cytochrome P450 enzyme was employed to effect a chemo- a

148 of these regions contains a gene encoding a cytochrome P450 enzyme, CYP2J19.

149 anotubes (SWCNTs) with the drug-metabolizing cytochrome P450 enzyme, CYP3A4.

150 via pomifera and Rosmarinus officinalis.Four cytochrome P450 enzymes are identified (CYP76AH24, CYP71

151 Exquisitely engineered myoglobin and cytochrome P450 enzymes can generate these complexes and

152 ay for the metabolism of arachidonic acid by cytochrome P450 enzymes emerged.

153 results show that fungi use highly specific cytochrome P450 enzymes for regio- and stereoselective p

154 Cytochrome P450 enzymes have been engineered to catalyze

155 Since cytochrome P450 enzymes include key detoxification enzym

156 ucturally similar to the substrates of other cytochrome P450 enzymes involved in steroidogenesis, and

157 Cytochrome P450 enzymes of the CYP720B subfamily play a

158 abolism to steroidogenesis, human microsomal cytochrome P450 enzymes require the sequential input of

159 the identification and expression of fungal cytochrome P450 enzymes that catalyze regio- and stereos

160 tuberculosiswhen CYP125A1 and CYP142A1, the cytochrome P450 enzymes that initiate degradation of the

161 icacy and aromatase selectivity versus other cytochrome P450 enzymes, a series of structurally relate

162 in biosynthesis, including ABC transporters, cytochrome P450 enzymes, and an acyltransferase.

163 ately, the compound is a potent inhibitor of cytochrome P450 enzymes, probably due to a 4-pyridyl sub

164 se (CPR) is the redox partner for most human cytochrome P450 enzymes.

165 e chain even in the presence of the relevant cytochrome P450 enzymes.

166 Here, we report increased expression of the cytochrome-P450-epoxygenase CYP2J6 and increased concent

167 In contrast, pharmacological inhibition of cytochrome P450 epoxygenases opened the myocardial mPTP

168 0 family 2 subfamily E member 1 (CYP2E1) and cytochrome P450 family 1 subfamily A member 2 (CYP1A2) t

169 ify novel phenotypic associations related to Cytochrome P450 Family 2 Subfamily A Member 6 (CYP2A6),

170 livers exhibited higher basal expression of cytochrome P450 family 2 subfamily E member 1 (CYP2E1) a

171 D responsive genes, 25(OH)D3-24-hydroxylase (cytochrome P450 family 24 subfamily A member 1) mRNA exp

172 ry low level of 25(OH)D3-1alpha-hydroxylase (cytochrome P450 family 27 subfamily B member 1), and the

173 Enzymes belonging to the cytochrome P450 family have an essential role in creatin

174 Here, we show that a cytochrome P450 family member, Cyp27c1, mediates this sw

175 Epoxygenases belong to the cytochrome P450 family.

176 process is dependent on hepatic induction of cytochrome P450, family 7, subfamily b, polypeptide 1 (C

177 water potential were found to be alleles of Cytochrome P450, Family 86, Subfamily A, Polypeptide2 (C

178 ither pitavastatin nor pravastatin depend on cytochrome P450 for primary metabolism.

179 ragments minimized undesirable inhibition of cytochrome P450s from human liver microsomes.

180 These enzymes include two cytochromes P450 from the CYP71 clan and an alcohol dehy

181 from e-vapor alone including alterations of cytochrome P450 function, retinoid metabolism, and nicot

182 Expansion of the cytochrome P450 gene family is often proposed to have a

183 ed the function of the low-duplicated CYP715 cytochrome P450 gene family that appeared early in seed

184 ts, we have investigated the function of the cytochrome P450 gene LmCYP4G102 in the migratory locust

185 iption analysis identified overexpression of cytochrome P450 genes as the main mechanism driving this

186 , functions similarly to regulate cycling of cytochrome P450 genes in the mouse liver.

187 and insecticides, such as carboxylesterases, cytochrome P450, gluthathione S-transferases, ATP-bindin

188 n-donation from the axial thiolate ligand of cytochrome P450 has been proposed to increase the reacti

189 roperoxide substrate, is known only in plant cytochrome P450 hydroperoxide lyases.

190 lecule-its metabolized sites-are oxidized by Cytochrome P450s in order to modify their metabolism.

191 Subsequently, deletion of two cytochromes P450 in the dynemicin cluster suggested that

192 cterium tuberculosis H37Rv genome encodes 20 cytochromes P450, including P450s crucial to infection a

193 ere those of several xenobiotic-metabolizing cytochromes P450, indicating that the A287P protein is f

194 ed metabolic product secretion, and enhanced cytochrome P450 induction.

195 , improving metabolic stability and reducing cytochrome P450 inhibition driven drug-drug interaction

196 olic stability in human liver microsomes and cytochrome P450 inhibition potential.

197 the compound was coadministered with the pan-cytochrome P450 inhibitor 1-aminobenzotriazole.

198 ed Nrf2-luc response were ameliorated by the cytochrome P450 inhibitor aminobenzotriazole.

199 e (CBR-096-4) devoid of antifungal and human cytochrome P450 inhibitory activity with excellent pharm

200 ectivity for MPO over thyroid peroxidase and cytochrome P450 isoforms.

201 Cytochrome P450 isozymes are also increased in immune ce

202 Oxidative enzymes such as cytochrome P450 isozymes are rapidly upregulated in TG n

203 0 000 un-metabolized sites and covering nine Cytochrome P450 isozymes.

204 apped to chromosome 8, close to a cluster of cytochrome P450 loci (CYP2J2-like) that are candidates f

205 ther taxa, NMP is primarily detoxified via a cytochrome P450 mediated pathway.

206 hesis of the TMC-86A warhead is completed by cytochrome P450-mediated hydroxylation of the alpha-meth

207 emurafenib disposition, particularly through cytochrome P450-mediated oxidation pathways, could poten

208 of in vivo glycosylation, selective in vitro cytochrome P450-mediated oxidation, and chemical oxidati

209 NSII enzymes are oxygen- and NADPH-dependent cytochrome P450 membrane-bound monooxygenases.

210 ntial for drug interactions due to competing cytochrome P450 metabolism between statins and commonly

211 Using a LC-MS method, putative cytochrome P450 metabolites of NMP were identified and q

212 ncorporation of the historically problematic cytochrome P450 mono-oxygenases.

213 vestigated whether stromal expression of the cytochrome P450 monooxygenase CYP26 modulates BTZ sensit

214 on is catalyzed by the Brassicaceae-specific cytochrome P450 monooxygenase CYP705A1 and is transientl

215 PEN2 substrate production by the cytochrome P450 monooxygenase CYP81F2 is localized to th

216 Cytochrome P450 monooxygenase was involved in the produc

217 PtmO5, a cytochrome P450 monooxygenase, is proposed to catalyze t

218 ron-containing enzymatic catalyst-based on a cytochrome P450 monooxygenase-for the highly enantiosele

219 own inhibitors of the important enzyme class cytochrome P450 monooxygenases (CYPs), thereby influenci

220 Since the initial identification of cytochrome P450 monooxygenases (CYPs/P450s), great progr

221 Cytochrome P450 monooxygenases (P450) in the honey bee,

222 Cytochrome P450 monooxygenases (P450s) are heme-thiolate

223 Cytochrome P450 monooxygenases (P450s) are involved in m

224 howed that more than half (51.2%) of the CBP cytochrome P450 monooxygenases (P450s) that are up-regul

225 extremely large repertoire of genes encoding cytochrome P450 monooxygenases and glutathione S-transfe

226 While CYP81Fs encoding cytochrome P450 monooxygenases and IGMTs encoding indole

227 erentially expressed genes (DEGs), including cytochrome P450 monooxygenases and UDP-glycosyltransfera

228 Cytochrome P450 monooxygenases CYP101A1 and MycG catalyz

229 Cytochrome P450 monooxygenases play a critical role in i

230 M on large Arabidopsis gene families such as cytochrome P450 monooxygenases to group the members func

231 Cytochrome P450 monooxygenases typically catalyze the in

232 cloning, and functional characterization of cytochrome P450 monooxygenases, we established that tran

233 The heme iron of cytochromes P450 must be reduced to bind and activate mo

234 The Jeotgalicoccus sp. peroxygenase cytochrome P450 OleTJE (CYP152L1) is a hydrogen peroxide

235 s associated with resistance, most affecting cytochrome P450s overtranscribed in resistant population

236 he omega-3 and the omega-6 lipid products of cytochrome P450 oxidase 2C promote neovascularization in

237 l functional replicas of the peroxidases and cytochrome P450 oxidizing enzymes.

238 bolism due to the liver-specific deletion of cytochrome P450 oxidoreductase (KO mice).

239 Human NADPH-cytochrome P450 oxidoreductase (POR) gene mutations are

240 ults indicate that the catalytic activity of cytochrome P450 oxidoreductase is a function of the leng

241 NADPH-cytochrome P450 oxidoreductase transfers electrons from

242 enzyme reduction by the redox partner NADPH-cytochrome P450 oxidoreductase, and the amount of P450 r

243 ncluding a set of detoxifying genes encoding cytochrome P450, oxidoreductase, hydrolase and transfera

244 a two-electron transfer catalyzed by shared cytochrome P450 oxidoreductases (CPRs), making these aux

245 actam-negative P. chrysogenum DS50662, a new cytochrome P450 (P450 or CYP) from Amycolatopsis orienta

246 Cytochrome P450 (P450) 17A1 catalyzes the oxidations of

247 Recently, zebrafish and human cytochrome P450 (P450) 27C1 enzymes have been shown to b

248 Previous studies showed that human cytochrome P450 (P450) 2D6 can catalyze thebaine O(3)-de

249 Cytochrome P450 (P450) activity is regulated transcripti

250 ate that hepatic and, possibly, extrahepatic cytochrome P450 (P450) enzymes play a role in the dispos

251 in) interacting with three to four modifying Cytochrome P450 (P450) enzymes that are responsible for

252 d protein capable of donating an electron to cytochrome P450 (P450) in the P450 catalytic cycle.

253 Mammalian cytochrome P450 (P450) is a membrane-bound monooxygenase

254 dogenous mechanisms that negatively regulate cytochrome P450 (P450) monooxygenases in response to phy

255 Cytochrome P450 (P450) reactions can involve C-C bond cl

256 Cytochrome P450 (P450, CYP) 17A1 plays a critical role i

257 Cytochrome P450 (P450, CYP) 21A2 is the major steroid 21

258 cluding the drug-metabolizing enzymes of the cytochrome P450s (P450).

259 y import heme derivatives, we have evolved a cytochrome P450 (P450BM3) that selectively incorporates

260 Cytochrome P450s (P450s) are a superfamily of enzymes re

261 Cytochrome P450 pathway oxylipins from arachidonic acid,

262 ereas anti-inflammatory metabolites from the cytochrome P450 pathway were reduced in cART/HIV-1-expos

263 s, ribosome biogenesis and activation of the cytochrome P450 pathway.

264 Many family 4 cytochrome P450s play key roles in fatty acid hydroxylat

265 ct metabolism-an alcohol dehydrogenase and a cytochrome P450-produces unexpected rearrangements in st

266 ion of mitogen-activated protein kinases and cytochrome P450 proteins in Arabidopsis and cotton plant

267 It lacks all genes encoding heme-containing cytochrome P450 proteins.

268 nd CYP6AA7 were separately co-expressed with cytochrome P450 reductase (CPR) in insect Spodoptera fru

269 Cytochrome P450 reductase (CPR) is the redox partner for

270 resistance to insecticides and require NADPH cytochrome P450 reductase (CPR) to transfer electrons wh

271 rmational free-energy landscape of the NADPH-cytochrome P450 reductase (CPR), a typical bidomain redo

272 e P450s and their cognate redox partner, the cytochrome P450 reductase (CPR).

273 nctioned as type I nitroreductase (TbNTR) or cytochrome P450 reductase (TbCPR) dependent prodrugs tha

274 ome b5, for human steroidogenic CYP17A1, the cytochrome P450 reductase FMN domain delivers both elect

275 NADPH-cytochrome P450 reductase is a multi-domain redox enzyme

276 one synthetase, glutathione reductase, NADPH-cytochrome P450 reductase, biliverdin reductase, and thi

277 ts redox partners: cytochrome b5 (cytb5) and cytochrome P450 reductase, both of which are membrane pr

278 ectrons delivered by the FMN domain of NADPH-cytochrome P450 reductase.

279 Cytochrome P450-reductase (CPR) is a versatile NADPH-dep

280 pe-III polyketide synthases, hydrolases, and cytochrome P450s related to known fatty acid hydroxylase

281 mitochondrial import of cytochrome P450scc (cytochrome P450 side chain cleavage enzyme) and aldoster

282 d alpha-linolenic acid, respectively) in the cytochrome P450/soluble epoxide hydrolase pathway.

283 Cytochrome P450 superfamily proteins play important role

284 nhibit warfarin deactivation via the hepatic cytochrome P450 system.

285 apsigargin biosynthesis, by showing that the cytochrome P450 TgCYP76AE2, transiently expressed in Nic

286 OleT is a cytochrome P450 that catalyzes the hydrogen peroxide-dep

287 le of CYP46A1, an important brain enzyme and cytochrome P450 that could be activated pharmacologicall

288 ably results from the massive recruitment of cytochrome P450s that catalyze multiple types of convers

289 Similar to cytochromes P450, the buildup of I435 occurs in nitric o

290 ) is metabolized by cyclooxygenase (COX) and cytochrome P450 to produce proangiogenic metabolites.

291 stem, we use nature's favored oxygenase, the cytochrome P450, to perform high-level oxygenation chemi

292 Additionally, 16 cytochrome P450 transcripts related to secondary metabol

293 Interestingly, rhythmic expression of the cytochrome P450 transcripts, sex-specific enzyme 1 (sxe1

294 le mutation in the F/G loop of the nitrating cytochrome P450 TxtE that simultaneously controls loop d

295 alapa) to identify a novel, betalain-related cytochrome P450-type gene, CYP76AD6, and carried out gen

296 inases, transcription factors, transporters, cytochrome P450, ubiquitin and heat shock proteins were

297 e, direct electrochemistry of non-engineered cytochromes P450 under native-like conditions.

298 rofiling revealed that metabolic resistance (cytochrome P450 up-regulation) and possibly a reduced pe

299 oreductase transfers electrons from NADPH to cytochromes P450 via its FAD and FMN.

300 s that the reaction of hemoproteins, notably cytochrome P450, with PN leads to the buildup of an inte