ライフサイエンスコーパス: cytohesin-1

1 mediated signaling of kinase Erk1/2 through cytohesin-1.

2 r an extra 3-base pair (GAG) exon present in cytohesin-1.

3 e critical for the specific interaction with cytohesin-1.

4 o-expressed with GRP1 or the related protein cytohesin-1.

5 139L decreased markedly the interaction with cytohesin-1.

6 guanine nucleotide exchange proteins such as cytohesin-1.

7 re to interact functionally with C-1 Sec7 or cytohesin-1.

8 city of Grsp1 complexes with Grp1, ARNO, and Cytohesin-1.

9 nd by phosphorylation of tandem PKC sites in Cytohesin-1.

10 ns the same structural components present in cytohesin -1, -2, and -3, including an approximately 200

11 were found in brain in different ratios for cytohesin-1, -2, and -3 but not cytohesin-4.

12 Cytohesin-1, a 46-kDa ARF GEP, contains a central Sec7 d

13 sing the yeast two-hybrid system, a cDNA for cytohesin-1, a approximately 50-kDa protein with ARF gua

14 Cybr also binds cytohesin-1, a guanine nucleotide exchange factor for th

15 Cytohesin-1, a protein abundant in cells of the immune s

16 Cytohesin-1 accelerated GTPgammaS (guanosine 5'-3-O-(thi

17 nonspecific ARF N terminus was required for cytohesin-1 action.

18 st that the Grsp1 heterodimers with Grp1 and Cytohesin-1 adopt a largely antiparallel orientation.

19 Cytohesin-1 also has been reported to promote cellular a

20 Cytohesin-1 also increased ARF1 binding to a Golgi fract

21 of single amino acids in the Sec7 domains of cytohesin-1 and -2 showed that residue 30 is critical fo

22 ide exchange factors for ARFs which includes cytohesin-1 and GRP-1 [2] [3-5].

23 tions, Grp1 and ARNO are homodimeric whereas Cytohesin-1 and Grsp1 are monomeric.

24 Cytohesin-1 and its 22-kDa Sec7 domain (C-1 Sec7), synth

25 Cytohesin-1 and its Sec7 domain (C-1Sec7) exhibit guanin

26 GRP1 and cytohesin-1 appear to connect receptor-activated PI 3-ki

27 GRP1 and the related proteins ARNO and cytohesin-1 are ARF exchange factors that contain a plec

28 p1 and Grp1 family proteins (Grp1, ARNO, and Cytohesin-1) as well as the oligomeric state, stoichiome

29 Cytohesin-1 (B2-1) is a guanine nucleotide exchange fact

30 NO (Arf nucleotide binding site opener), and Cytohesin-1 bind phosphatidylinositol (PtdIns) 3,4,5-tri

31 n this system, ARD1-GDP interacted well with cytohesin-1 but very poorly with cytohesin-2.

32 In agreement, cytohesin-1, but not cytohesin-2, markedly accelerated [

33 nse to insulin, as were full-length GRP1 and cytohesin-1, but the PH domain of cytohesin-1 was not.

34 7 protein (ySec7d) and the insensitive human cytohesin-1 (C-1Sec7).

35 Grp1, ARNO, and Cytohesin-1 comprise a family of phosphoinositide-depend

36 sing an RNA interference screen, we identify cytohesin 1 (CYTH1) as a critical mediator of adhesive p

37 in, as opposed to the triglycine in ARNO and cytohesin-1, directs its remarkable PtdIns(3,4,5)P(3) bi

38 Both C-1Sec7 and cytohesin-1 effectively released guanosine 5'-(gamma-thi

39 Cytohesin-1 enhanced binding of 35S-labeled guanosine 5'

40 Structures of the cytohesin-4 and cytohesin-1 genes were remarkably similar, except for an

41 inute-O-(thiotriphosphate) binding to ARF by cytohesin-1 in vitro was enhanced by Cybr.

42 Cytohesin-1, in addition to its role in cell adhesion, i

43 Cytohesin-1 increased [35S]guanosine 5'-(gamma-thio)trip

44 Neither C-1 Sec7 nor cytohesin-1 increased GTPgammaS binding to human ARF-lik

45 Dominant negatives of both JAB-1 and cytohesin-1 inhibited interleukin 2 production and impai

46 s loss of DNA methylation enables HIF-driven cytohesin 1 interacting protein (CYTIP) expression to pr

47 n addition to the Sec7 domain is involved in cytohesin-1 interaction.

48 It was concluded that cytohesin-1 is likely to be involved in ARD1 activation,

49 1 Sec7 was much less substrate-specific than cytohesin-1, it appears that structure outside of the Se

50 When mixed with Grsp1, Grp1 homodimers and Cytohesin-1 monomers spontaneously re-equilibrate to for

51 lished the ability to serve as substrate for cytohesin-1 or C-1Sec7.

52 participate in functional interactions with cytohesin-1 (or its catalytic domain C-1Sec7), which wer

53 onsistent with the previous observation that cytohesin-1 regulates the adhesiveness of alphaLbeta2 in

54 0 are also important in the interaction with cytohesin-1; replacement of Lys-38 with Gln, the corresp

55 , 1.6 and 1.0 micrometer for GRP1, ARNO, and cytohesin-1, respectively.

56 Structure-based mutational analysis of the cytohesin-1 Sec7 domain has been used to identify residu

57 ted, but it was much weaker than that of the cytohesin-1 Sec7 domain with the same ARF protein.

58 RF N terminus is an important determinant of cytohesin-1 specificity.

59 en ARF and Sec7-related proteins, effects of cytohesin-1, synthesized in Escherichia coli, on ARF act

60 Addition of cytohesin-1 to ARF3 with [35S]GTP[gammaS] bound, acceler

61 oth control cells and in response to GRP1 or cytohesin-1 was insensitive to brefeldin A, consistent w

62 on by the guanine nucleotide-exchange factor cytohesin-1 was known.

63 h GRP1 and cytohesin-1, but the PH domain of cytohesin-1 was not.

64 ndent on the coiled-coil domains of Cybr and cytohesin-1, was demonstrated by coimmunoprecipitation o

65 In contrast, another PI3K downstream target, cytohesin-1, was shown to mediate P. gingivalis fimbria-

66 ied activation of ADP ribosylation factor by cytohesin-1, we designate this cytokine-inducible protei

67 Recently, ARNO and its close homologue cytohesin-1 were found to catalyze in vitro nucleotide e

68 nsfected COS-7 cells, overexpressed ARD1 and cytohesin-1 were partially colocalized, as determined by

69 The solution structure of the Sec7 domain of cytohesin-1, which is responsible for both the protein's

70 The PH domain of the closely related protein cytohesin-1, which, through its Sec7 homology domain, re