ライフサイエンスコーパス: cytokeratin-18

1 claudin 3, 4, and 7 and the luminal marker, cytokeratin 18.

2 8, but in the presence of actin, AVP cleaved cytokeratin 18.

3 cells exhibited caspase-specific cleavage of cytokeratin 18.

4 ith a monoclonal antibody specific for human cytokeratin 18.

5 pase-3, and immunohistochemical staining for cytokeratin 18.

6 For AVP to cleave cytokeratin 18, a cellular cofactor was shown to be requ

7 skeletal filaments: vimentin, cytokeratin 8, cytokeratin 18, actin, and hair type II basic keratin.

8 ormal unperturbed RPE are immunoreactive for cytokeratin 18 and negative for cytokeratin 19, vimentin

9 ch as increased expression of E-Cadherin and cytokeratin-18 and decreased expression of Snail.

10 2-derived peptide, alanine aminotransferase, Cytokeratin-18 and homeostasis model of insulin resistan

11 Colonies of cytokeratin-18 and human albumin-expressing cells were p

12 ation of fibrosis-associated markers such as cytokeratins 18 and 19 and annexin 2, as determined both

13 e positive for prostate-specific antigen and cytokeratins 18 and 19 and negative for keratin 15.

14 Type I cytokeratins 18 and 19 present in these cells specifical

15 tested M65 and M30 (circulating fragments of cytokeratin-18) and their respective fraction carried by

16 , hepatocyte nuclear factor 4alpha, albumin, cytokeratin 18, and cytochrome P450 3A.

17 epithelial phenotype, expressing E-cadherin, cytokeratin 18, and desmin.

18 es in HeLa cells revealed AVP localized with cytokeratin 18, and this was followed by destruction of

19 ll as the epithelial markers pancytokeratin, cytokeratin-18, and occludin, but not mesenchymal (CD44,

20 The proteinase alone could not cleave cytokeratin 18, but in the presence of actin, AVP cleave

21 rum transaminases were normal in TASH, total cytokeratin 18, but not the caspase-cleaved fragment, wa

22 ppearance of E1A protein and the cleavage of cytokeratin 18 by AVP.

23 tro, actin was a cofactor in the cleavage of cytokeratin 18 by AVP.

24 Levels of M30, a cleavage product of cytokeratin-18 caspase, are significantly increased in s

25 We have recently demonstrated that plasma cytokeratin 18 (CK-18) fragment levels correlate with th

26 say (ELISA), which detects a caspase-cleaved cytokeratin-18 (CK-18) fragment and thereby apoptotic ce

27 mined by alanine aminotransaminase [ALT] and cytokeratin-18 [CK-18]).

28 necrosis in serum was quantified using serum cytokeratin 18 (CK18) M30 and M65 enzyme-linked immunoso

29 reased expression of HDAC1 target genes Bax, cytokeratin 18 (CK18), and p21(WAF1/CIP1), whereas maspi

30 Apoptosis was monitored by determining cytokeratin 18 cleavage and caspase-3 activation.

31 vities, and immunohistochemical staining for cytokeratin 18 cleavage products indicated no activation

32 ated with increased apoptosis (caspase 3 and cytokeratin 18 cleavage) in excised tumors.

33 ropeptide Y receptor Y1, p21 WAF-1, p55 PIK, cytokeratin 18 (cloned twice), fructose-1,6-biphosphatas

34 cells express cytokeratins 5 and 14, but not cytokeratin 18, consistent with a basal epithelial cell

35 itative Insulin-Sensitivity Check Index, and cytokeratin-18 correlated with NASH.

36 rly reactive RPE (7 days in culture) express cytokeratin 18, cytokeratin 19, and vimentin.

37 he cells accumulated lipid droplets, and the cytokeratin 18 cytoskeleton was reorganized.

38 brils with active caspase-3, caspase-cleaved cytokeratin-18, death-effector-domain containing DNA-bin

39 amplification loop to facilitate cleavage of cytokeratin-18, disruption of the cytoskeleton and the e

40 of differentiation as shown by expression of cytokeratin 18, E-cadherin, thyroglobulin, TTF-1 and Pax

41 lesterol and adiponectin concentrations, and cytokeratin-18 fragment elevation.

42 Cytokeratin-18 fragment levels independently predicted N

43 rum levels of M30 and M65 antigen (the total cytokeratin-18 fragment, a marker of apoptosis and necro

44 3 +/- 1.5 vs. 1.7 +/- 1.4; P = 0.004), serum cytokeratin-18 fragments (283 vs. 404 U/L; P < 0.001) an

45 Plasma levels of cytokeratin-18 fragments are reliable noninvasive marker

46 labeling-positive nuclei and accumulation of cytokeratin-18 fragments in the liver, was independent o

47 Plasma cytokeratin-18 fragments were markedly increased in pati

48 Caspase-3-generated cytokeratin-18 fragments were measured in situ via immun

49 cytokines, markers of hepatocyte apoptosis (cytokeratin-18 fragments), and hepatic fibrogenesis (hya

50 ed low-density lipoproteins, adipokines, and cytokeratin-18 fragments, and an oral glucose tolerance

51 Cytokeratin-18 fragments, controlled attenuation paramet

52 ment of plasma lipoproteins, adipokines, and cytokeratin-18 fragments.

53 ment of plasma lipoproteins, adipokines, and cytokeratin-18 fragments.

54 fferentially expressed genes: cytokeratin 8, cytokeratin 18, Hsp27 and GPCR -Br.

55 4% as quantified in the lung interstitium by cytokeratin 18 immunostaining.

56 That protein is tentatively identified as cytokeratin 18 in a companion paper.

57 of lactate dehydrogenase and caspase-cleaved cytokeratin 18 in the perfused medium.

58 helial cell markers pan-cytokeratin (Pan-K), cytokeratin-18 (K-18), and occludin.

59 erotypic complexes of cytokeratin 8 (K8) and cytokeratin 18 (K18).

60 alpha, ERbeta, cytokeratin 14 (basal cells), cytokeratin 18 (luminal cells), and dorsolateral protein

61 enterocyte proliferation and migration, (2) cytokeratin-18 M30-immunohistochemistry to compare level

62 Total and caspase-cleaved cytokeratin-18 (M65 and M30) measured at admission and s

63 strogen, and progesterone receptor-positive, cytokeratin 18-positive (ER(+)PR(+)CK18(+)) subtype, and

64 zyme-linked immunosorbent assays for various cytokeratin 18 products (eg, M65, cell death, M30, and a

65 Notably, mice expressing hDPP4 with the cytokeratin 18 promoter developed progressive, uniformly

66 trol of the surfactant protein C promoter or cytokeratin 18 promoter that are susceptible to infectio

67 ling-positive cells, caspase-3 activity, and cytokeratin-18 staining in the liver.

68 Elevated total cytokeratin 18 suggested the presence of necrotic cell d

69 umin, alpha-fetoprotein, cytochrome P4502E1, cytokeratin-18, type-1 collagen, transforming growth fac

70 cirrhosis contained hepatocyte-derived MPs (cytokeratin-18(+)), whereas plasma from controls did not

71 re used to identify five proteins, including cytokeratin 18, which is the product of the most highly

72 markers of colonic epithelial cells such as cytokeratin 18, zonula occludens-1, mucins-1 and -2, ant