ライフサイエンスコーパス: cytokine receptor

1 VS13 as novel cytokines that bind to a novel cytokine receptor.

2 t signaling pathway associated with a type I cytokine receptor.

3 ell as aberrant activation of non-B lymphoid cytokine receptors.

4 s (JAKs) are regulators of signaling through cytokine receptors.

5 hain (gammac) is a key component of multiple cytokine receptors.

6 todomain shedding of cytokine precursors and cytokine receptors.

7 s model may well generalize to other class I cytokine receptors.

8 olecules, which impairs signaling of several cytokine receptors.

9 urgery to determine the presence of selected cytokine receptors.

10 through the B-cell receptor (BCR), CD40, and cytokine receptors.

11 tion of many type I and type II inflammatory cytokine receptors.

12 y regulates JAK family kinases downstream of cytokine receptors.

13 th targeted defects in specific cytokines or cytokine receptors.

14 l form four-helix bundles and bind to type I cytokine receptors.

15 30, a common component of many heterodimeric cytokine receptors.

16 amilies of cell surface receptors, including cytokine receptors.

17 any cell surface receptors, including Ag and cytokine receptors.

18 ell antigen receptors and common gamma chain cytokine receptors.

19 and regulating the expression of epithelial cytokine receptors.

20 otein that mediates signalling from multiple cytokine receptors.

21 t sharing any structural similarity with the cytokine receptors.

22 egulating NK ligands, adhesion molecules and cytokine receptors.

23 rincipal transcription factors downstream of cytokine receptors.

24 onse through negative-feedback inhibition of cytokine receptors.

25 ivation required the full pathway, including cytokine receptors acting as scaffolds and docking sites

26 Cytokine receptor activation through loss of O-glycosyla

27 ion of mutual rotations of the TM domains in cytokine receptor activation.

28 d elevated levels of the proosteoclastogenic cytokine receptor activator for nuclear factor-kappaB li

29 ng osteoclast differentiation induced by the cytokine receptor activator of NF-kappaB ligand (RANKL).

30 Production of the cytokine receptor activator of NFkappaB ligand (RANKL) b

31 ic precursors depends upon expression of the cytokine receptor activator of NFkappaB ligand (RANKL) b

32 The cytokine receptor activator of NFkappaB ligand (RANKL) p

33 The cytokine receptor activator of nuclear factor-kappaB lig

34 ogen-associated molecular pattern receptors, cytokine receptors, adipokine receptors, and hormones.

35 gonists, antigen receptor cross-linking, and cytokine receptors, all rely on ubiquitination events to

36 Shedding of the extracellular domain of cytokine receptors allows the diffusion of soluble recep

37 ature, and is enriched for genes involved in cytokine receptor and JAK-STAT signaling.

38 Frequent mutations in cytokine receptor and Janus kinase (JAK)/signal transduc

39 terized by genomic alterations that activate cytokine receptor and kinase signaling.

40 gh rates of mutations in factors involved in cytokine receptor and RAS signaling (62.2%), hematopoiet

41 by activating mutations in genes regulating cytokine receptor and RAS signalling (67% of cases; NRAS

42 expression of genes encoding key cytokines, cytokine receptors and adhesion molecules that determine

43 xperiments were performed to determine which cytokine receptors and cell types are involved in the pa

44 ontrolled by the integration of signals from cytokine receptors and germline-encoded activation and i

45 study, we considered the cooperation between cytokine receptors and integrin pathways in Th17-osteocl

46 at associates with the common gamma chain of cytokine receptors and is recurrently mutated in T-cell

47 latory cytokines uses the type I and type II cytokine receptors and pharmacological targeting of thes

48 etween high sequence conservation of TMDs of cytokine receptors and the ability to transmit structura

49 mplexes of the common gamma-chain (gamma(c)) cytokine receptors and their cytokines have been solved.

50 Aberrant signaling through cytokine receptors and their downstream signaling pathwa

51 erged that upregulated key memory-associated cytokine receptors and transcription factors and showed

52 that integrates signals from Toll receptors, cytokine receptors, and inhibitor of kappa-B kinase-beta

53 mechanism whereby receptor tyrosine kinases, cytokine receptors, and integrins activate Src is not kn

54 g transcription factors, signaling pathways, cytokine receptors, and microRNAs.

55 receptors, toll-like receptors, inflammatory cytokine receptors, and mitogens.

56 tion markers (CD69 and CD154), chemokine and cytokine receptors, and proliferation potential.

57 lly involve genes encoding tyrosine kinases, cytokine receptors, and transcription factors.

58 g signaling components of antigen receptor-, cytokine receptor-, and chemokine receptor-mediated sign

59 soluble cytokine receptor (sIL-2R), and one cytokine receptor antagonist (IL-1RA) were significantly

60 ntified a role for the IL-27p28 subunit as a cytokine receptor antagonist.

61 findings demonstrate that such specific anti-cytokine receptor antagonists represent a new class of d

62 mab, tumor necrosis factor-alpha inhibitors, cytokine receptor antagonists, and bronchial thermoplast

63 Pattern recognition receptors (PRRs) and cytokine receptors are key players in the initiation of

64 Soluble cytokine receptors are normal constituents of body fluid

65 ling for IFNgamma and other myelosuppressive cytokine receptors as a common mediator of signals for h

66 ular membrane proximal domain of homodimeric cytokine receptors as a key regulator of intracellular s

67 ly upregulation of a number of cytokines and cytokine receptors, as key molecular components of an in

68 splayed elevated expression of cytokines and cytokine receptors, as well as neutrophil influx consist

69 illuminating the molecular basis of the JAK-cytokine receptor association.

70 Mutations in signaling molecules of the cytokine receptor axis play a central role in myeloproli

71 ength and duration because of differences in cytokine-receptor binding affinity, receptor expression

72 rations of the cytokines, with the resulting cytokine-receptor binding rates very close to the limits

73 o calculate the rate constant of the initial cytokine-receptor binding to form a 1ratio1 complex.

74 r has served a pivotal role as the prototype cytokine receptor both structurally and functionally.

75 T cells encompass a variety of cytokines and cytokine receptors but are controlled by a 'guardian' tr

76 mediated directly via activation of neuronal cytokine receptors, but rather, indirectly via IL-1 rece

77 man single-pass TM proteins and validated in cytokine receptors by the TM domain structure of the cyt

78 demonstrate that components of heterodimeric cytokine receptors can also activate JAK2-V617F.

79 Recent findings, however, indicate that cytokine receptors can regulate immune cell functions by

80 Downregulation of HIF-1alpha suppressed WBC cytokine receptors CCR1, -2, and -4, which are necessary

81 on of the transcription factor T-bet and the cytokine receptor chain IL-12Rbeta2, which enabled the c

82 re combined immunodeficient mice lacking the cytokine receptor common gamma chain (gammac(-/-)) and c

83 receptors by the TM domain structure of the cytokine receptor common subunit beta and its P441A-subs

84 igenetic impairment of the tightly regulated cytokine-receptor communications in tumor microenvironme

85 tations are drivers of T-ALL and require the cytokine receptor complex for transformation.

86 JAK3 mutants needed to bind to a functional cytokine receptor complex to constitutively activate STA

87 Receptor activation involves a cytokine-receptor complex with a 1ratio2 stoichiometry.

88 fferent receptor polypeptide to complete the cytokine-receptor complex.

89 Sharing of receptor subunits among different cytokine receptor complexes adds to the intricate landsc

90 s has impeded efforts aimed at crystallizing cytokine-receptor complexes.

91 ces in charge complementarity among the four cytokine-receptor complexes.

92 aracterized by high expression of the type I cytokine receptor CRLF2 caused by either immunoglobulin

93 novel link between the ECM protein Matn4 and cytokine receptor CXCR4 involved in the regulation of HS

94 1 viral replication by selectively targeting cytokine receptor CXCR4.

95 Analysis of cytokine receptor deficient mice demonstrated that type

96 Using cytokine receptor-deficient mice, we show that interleuk

97 ling modulated STAT activation downstream of cytokine receptors differently to control the TH17 cell-

98 rigidification in the context of a liganded cytokine receptor dimer is a key mechanism for the trans

99 okines (synthekines) that drive formation of cytokine receptor dimer pairings that are not formed by

100 mode of cytokine action in which DL1 changes cytokine receptor distributions on hematopoietic cells,

101 ciation of the cytokine p28 with the soluble cytokine receptor EBV-induced gene 3 (EBI3).

102 Cytokine receptors elicit several signaling pathways, bu

103 stream effectors of the IFN-gamma and gammac cytokine receptors, eliminated the IFN signature and pre

104 ion, JAK2V617F, activates the 3 main myeloid cytokine receptors (erythropoietin receptor, granulocyte

105 is detected with a battery of type I and II cytokine receptors, except granulocyte colony-stimulatin

106 lt provides the first full view of a class I cytokine receptor, exemplifying the architecture of more

107 We therefore assessed the effects of EBI3 on cytokine receptor-expressing cells.

108 of Th2 cell differentiation by orchestrating cytokine receptor expression and cytokine responsiveness

109 Cytokine receptor expression and signaling upon exposure

110 dulating IL-12-STAT4 and IL-6-STAT3 axes and cytokine receptor expression at the DC-T cell interface.

111 L-12 and IL-18 correlated with the levels of cytokine receptor expression by NK and NKT cells.

112 Transcription factor-mediated regulation of cytokine receptor expression is a common mode of alterin

113 This was not due to downregulation of cytokine receptor expression or an inability to signal t

114 TCR signal strength controlled downstream cytokine receptor expression, linking the two components

115 genic responses by controlling hematopoietic cytokine receptor expression.

116 ceptor is unrelated to previously identified cytokine receptor families.

117 d that ORF54 can also target proteins of the cytokine receptor family and the mechanism of downregula

118 ents targeting BLyS or other members of this cytokine receptor family are also being tested in clinic

119 ceptor is an archetype member of the class I cytokine receptor family, comprising receptors with fund

120 ectin glycoprotein ligand-1 (PSGL-1, CD162), cytokine receptors, Fc receptors, integrins including al

121 Despite the importance of the cytokine receptor flt3 in dendritic cell (DC) homeostasi

122 The development of NH cells depends on the cytokine receptor Flt3, which is required for the effici

123 g signal derived from pattern recognition or cytokine receptors, followed by a second signal derived

124 this study, we used mice in which the common cytokine receptor for IL-4 and IL-13, namely the IL-4Ral

125 matory marker myeloperoxidase (MPO), and the cytokine receptor for nuclear factor kappa-B ligand (RAN

126 Although there are dozens of cytokines and cytokine receptors, four Jaks, and seven Stats, it seems

127 Deletion of the gp130 cytokine receptor from sympathetic neurons prevented the

128 ukemogenesis: mutations in the hematopoietic cytokine receptor (G-CSFR) in combination with the secon

129 be activated via receptor tyrosine kinases, cytokine receptors, G-protein coupled receptors and liga

130 knockout mice in which IL-7Ralpha or common cytokine receptor gamma chain (gamma(c)) genes were dele

131 -9, IL-15, and IL-21, IL-2 shares the common cytokine receptor gamma chain, gamma(c), which is mutate

132 subunit that is highly related to the common cytokine receptor gamma chain, gamma(c).

133 ropic type 1 cytokine that shares the common cytokine receptor gamma-chain, gamma(c), with IL-2, IL-4

134 IFNG, IL10, IL12B, IL18, IL1beta, IL8) and 1 cytokine receptor gene (IL12RB1).

135 a role for cytokine proteins and cytokine or cytokine receptor gene polymorphisms in smallpox vaccine

136 plored associations between SNPs in cytokine/cytokine receptor genes and cellular immunity in subject

137 fied, including four involving new kinase or cytokine receptor genes and seven involving new partners

138 t roles in normal hemopoiesis, including the cytokine receptor genes CRLF2 and EPOR, all members of t

139 -gene genetic screen (across 32 cytokine and cytokine receptor genes) in a racially diverse cohort of

140 ted by genetic polymorphisms in cytokine and cytokine receptor genes.

141 lls, caused by down-regulation of the common cytokine receptor, glycoprotein 130.

142 es such as TCR, costimulatory molecules, and cytokine receptors governs the magnitude of Akt activati

143 Disruption of the cytokine receptor gp130 gene in Muller glia reduces CNTF

144 sed pairing of the OSMR subunit with another cytokine receptor, gp130, resulting in overrepresentatio

145 pharmacological targeting of these cytokines/cytokines receptors has proven to be efficacious in trea

146 nstrate that impaired expression of a single cytokine receptor helps maintain Treg cell-suppressive f

147 We show that a wide range of non-natural cytokine receptor hetero-dimers are competent to elicit

148 iated with an amino acid substitution in the cytokine receptor homology domain 1 of LEPR.

149 g creates active receptor dimers for class 1 cytokine receptors; however, the detailed molecular mech

150 ke receptor 9 (TLR9) along with inflammatory cytokine receptor IFN-gamma receptor (IFN-gammaR) as ess

151 17 cells in part by inhibiting expression of cytokine receptor IL-1R1.

152 ged approach of sustaining expression of the cytokine receptors IL-6Ralpha and gp130, enhancing expre

153 e gene programs, including expression of the cytokine receptors IL-6Ralpha and IL-7R.

154 ar to human MAITs, mouse MAITs expressed the cytokine receptors IL-7R, IL-18Ralpha, and IL-12Rbeta an

155 he expression of Bcl6 and the TFH-associated cytokine receptor Il6ra Importantly, in vivo studies rev

156 frequencies and expression levels of Flt3, a cytokine receptor important for lymphoid priming and the

157 Indeed, IL7R was the only cytokine receptor in CRLF2-rearranged B-ALL cells signif

158 rotein-coupled receptor, and a heterodimeric cytokine receptor in living cells with excellent sensiti

159 The thrombopoietin receptor, MPL, is the key cytokine receptor in MPN development, and these mutation

160 e to be a new concept for ITAM regulation of cytokine receptors in different tissue microenvironments

161 gp130, the signaling subunit of neuropoietic cytokine receptors in peripheral nerve regeneration.

162 The spatiotemporal organization of cytokine receptors in the plasma membrane is still debat

163 egulated expression of several cytokines and cytokine receptors, including interleukin 15 receptor al

164 gulated by coordinated signals from multiple cytokine receptors, including KIT.

165 receptor tyrosine kinases or JAK-associated cytokine receptors, including leptin, insulin, growth ho

166 ed in expression of a panel of cytokines and cytokine receptors, including several ligand-receptor pa

167 The same cytokine receptor independence as for JAK3(L857P) was ob

168 Antibody blockade of cytokine receptors inhibited invasion and confirmed that

169 ogy and medicine, yet the mechanism by which cytokine receptors initiate signaling is enigmatic.

170 ion of functional clusters, such as cytokine-cytokine receptor interaction (especially CXC-chemokine)

171 ups, enriched for genes involved in cytokine-cytokine receptor interaction and glutamate receptor sig

172 l signaling pathways, including the cytokine-cytokine receptor interaction pathway, which can promote

173 ithin the inflammatory response and cytokine-cytokine receptor interaction pathways, including Csf1 a

174 a molecular signature of inhibited cytokine-cytokine receptor interaction with downregulation of IL-

175 enes involved in cytokine activity, cytokine-cytokine receptor interaction, chemokine activity, and G

176 genes encoding proteins involved in cytokine-cytokine receptor interactions and NK cell-mediated cyto

177 ith PFS more than 6 months included cytokine-cytokine receptor interactions, drug transporters, and m

178 nrichment for MAP kinase signaling, cytokine-cytokine receptor interactions, JAK-STAT signaling, and

179 nderstanding of the structural principles of cytokine-receptor interactions has advanced, mechanism-b

180 ies to common gamma cytokines, inhibitors of cytokine-receptor interactions, and JAK kinase inhibitor

181 alt bridges are present at the high affinity cytokine-receptor interfaces, whereas hydrophobic intera

182 n levels, physiological cytokine levels, and cytokine-receptor intracellular trafficking kinetics.

183 e 2 (TYK2) participates in signaling through cytokine receptors involved in immune responses and infl

184 Signalling in lymphocytes through cytokine receptors is critical for their development, ac

185 Insight in the complex formation of cytokine receptors is crucially important for engineerin

186 A hallmark of the class I cytokine receptors is the class I cytokine receptor sign

187 eukemia virus (MPL), abnormally activate the cytokine receptor/JAK2 pathway and their downstream effe

188 ell-cycle regulation, and tumor suppression; cytokine receptor, kinase, and Ras signaling; and chroma

189 that commonly perturb lymphoid development, cytokine receptors, kinase and Ras signaling, tumor supp

190 e marrow chimeras, we compared wild-type and cytokine receptor knockout CD8(+) T cells within the sam

191 aling events and show that relatively simple cytokine receptors like GHRs are able to form higher ord

192 Cytokine receptor-like factor 1 (CRLF1) was among the mo

193 This gene set includes cytokine receptor-like factor 1 (CRLF1), which is up-reg

194 Cytokine receptor-like factor 2 (CRLF2) and mutated Janu

195 Expression of cytokine receptor-like factor 2 (CRLF2) has recently bee

196 D) in interleukin-7 receptor alpha (IL7R) or cytokine receptor-like factor 2 (CRLF2) have been descri

197 Within the Ph-like ALL cohort, 61% had cytokine receptor-like factor 2 (CRLF2) overexpression.

198 rrangements of the cytokine receptor subunit cytokine receptor-like factor 2 (CRLF2), and other tumor

199 lisib resulted in near eradication of ALL in cytokine receptor-like factor 2 (CRLF2)/JAK-mutant model

200 with markedly elevated expression of CRLF2 (cytokine receptor-like factor 2).

201 igration by regulating the expression of the cytokine receptor M-CSFR and the chemokine receptor CXCR

202 Hence, type I cytokine receptors may be activated in leukemia through

203 ic neurodegeneration may be accelerated by a cytokine-receptor mediated apoptotic pathway, as shown i

204 impaired ability to secrete IFN-gamma during cytokine receptor-mediated responses, whereas immunorece

205 ponents that mediate B cell receptor- and or cytokine receptor-mediated signaling to promote the diff

206 T1E28z is coexpressed with a chimeric cytokine receptor named 4alphabeta (combination termed T

207 T1E28z was coexpressed with a chimeric cytokine receptor named 4alphabeta (combination termed T

208 nd/or environmental cues and act via cognate cytokine receptors on target cells, stimulating specific

209 genes important in homeostatic regulation of cytokine receptors or TLR-mediated signal transduction p

210 Here, we identified the cytokine receptor OSMR as a direct target gene of the tr

211 Thus, our work has identified a cytokine-receptor pair with important function in regula

212 rent study, we investigated the role of this cytokine/receptor pair in acute intestinal injury/repair

213 We show here that, unlike other cytokine receptors, phosphorylation of STRA6 is not simp

214 ck of efficacy, either of which results from cytokine receptor pleiotropy and/or undesired activation

215 provide the rheostat-like regulation for the cytokine receptor PRLR in its cytoplasmic loop dimerizat

216 To test the hypothesis that serum cytokines/cytokine receptors provide prognostic information in the

217 nd most transcription factors, cytokines and cytokine receptors related to the CD4 lineage, despite t

218 This different cytokine receptor requirement correlated with different

219 Genetic ablation of individual cytokine receptors revealed that both IFN-gamma and IL-1

220 Alterations in cytokine receptor signal transduction have emerged as on

221 transcription 5) is an essential mediator of cytokine receptor signaling and plays important roles in

222 s by which TCR signaling and proinflammatory cytokine receptor signaling cooperate in these processes

223 lterations that lead to activated kinase and cytokine receptor signaling in Ph-like ALL and demonstra

224 Our data suggest that cytokine receptor signaling is required for tumor cell s

225 erapeutic targets in ALL, including aberrant cytokine receptor signaling mediated by rearrangements a

226 The evolution of cytokine receptor signaling parallels that of the immune

227 he inhibitory effects were downstream of TH2 cytokine receptor signaling pathways.

228 We focus on cytokine receptor signaling that is mimicked by activati

229 ssue, Cui et al. and Siegel et al. show that cytokine receptor signaling through the transcription fa

230 oss-functional negative regulator of TLR and cytokine receptor signaling via degradation of the recep

231 This review describes the evolution of cytokine receptor signaling, focusing on the class I and

232 included IL-1R/TLR signaling, type I and II cytokine receptor signaling, mitochondrial dysfunction,

233 genomic alterations that activate kinase and cytokine receptor signaling.

234 s shared with conventional costimulatory and cytokine receptor signaling.

235 ldren initiated by mutations that deregulate cytokine receptor signaling.

236 CS) proteins serve as negative regulators of cytokine receptor signaling.

237 s a cytokine-inducible negative regulator of cytokine receptor signaling.

238 a mutated chaperone constitutively activates cytokine receptor signaling.

239 by which the extracellular matrix regulates cytokine receptor signaling.

240 Genes for chemokines, cytokine receptors, signaling molecules, complement, and

241 ed beta2-integrin tail interactions restrict cytokine receptor signalling, survival, maturation and m

242 e deficiency of Lnk, a negative regulator of cytokine receptor signalling.

243 Lymphocytes integrate Ag and cytokine receptor signals to make cell fate decisions.

244 he class I cytokine receptors is the class I cytokine receptor signature motif (WSXWS).

245 rosis factor-alpha (TNF-alpha)), one soluble cytokine receptor (sIL-2R), and one cytokine receptor an

246 expression or an inability to signal through cytokine receptors since phosphorylation of STAT protein

247 enalidomide on receptor turnover were Type I cytokine receptor specific, as evidenced by coregulation

248 IL-2Rbeta induce marked subunit- and soluble cytokine receptor-specific behavioral disturbances, whic

249 hoblastic leukemias (B-ALLs) overexpress the cytokine receptor subunit CRLF2, which may confer a poor

250 leukemia (B-ALL) with rearrangements of the cytokine receptor subunit cytokine receptor-like factor

251 mutations in the common gamma (gammac) chain cytokine receptor subunit give rise to severe combined i

252 Using multiple cytokine and cytokine receptor subunit knockout mice, we demonstrate

253 ry factor (LIF), signal via the common GP130 cytokine receptor subunit.

254 y all TLRs, RLRs and IL-1R, as well as other cytokine receptors such as IL-18 receptor.

255 yrosine kinases associate with heterodimeric cytokine receptors such as IL-7 receptor or IL-9 recepto

256 eceptors (RLRs; RIG-I and MDA-5), as well as cytokine receptors such as interleukin 1 receptor (IL-1R

257 ne receptors such as Toll-like receptors and cytokine receptors such as those in the TNF (tumor necro

258 -inflammatory, highly relevant cytokines and cytokine receptors, such as IL-4Ralpha, IL-13, IL-31, an

259 sociate with a functional homodimeric type I cytokine receptor, suggesting that, although acquiring J

260 lso demonstrated in mRNAs encoding six other cytokine receptors, suggesting a novel mode through whic

261 eric architectures that are unique among the cytokine receptor superfamily but conserved between diff

262 e a common signaling intermediate in diverse cytokine receptor systems.

263 io2 native complex are similar for the three cytokine-receptor systems.

264 canonical TGF-beta signaling mediated by the cytokine receptor TGFbetaR1 in NK cells.

265 the thrombopoietin receptor (TpoR), a type 1 cytokine receptor that controls the production of blood

266 or-inducible 14 (Fn14) is a highly inducible cytokine receptor that engages multiple intracellular si

267 rally occurring splice isoform of the gammac cytokine receptor that is produced by activated T cells

268 1 receptor alpha (IL-31RA) is a novel Type I cytokine receptor that pairs with oncostatin M receptor

269 l from RBP into cells, and it functions as a cytokine receptor that, on binding holo-RBP, activates J

270 llular RBP into cells, and it functions as a cytokine receptor that, upon binding holo-RBP, triggers

271 ation involves a persistent loss of specific cytokine receptors that determines the functional potent

272 cell memory by modulating the expression of cytokine receptors that influence the differentiation an

273 anus kinase (JAK) inhibitors have shown that cytokine receptors that signal through the JAK/STAT sign

274 late expression on memory precursor cells of cytokine receptors that support terminal differentiation

275 receptor-bound JAK2, based on an archetypal cytokine receptor, the growth hormone receptor.

276 Common to both cytokine receptors, the IL-2 receptor beta (IL2Rbeta) ch

277 minor effects, and in the presence of type I cytokine receptors, the mutations do not affect JAK2 act

278 Despite the myriad of cytokines and cytokine receptors, there are relatively few signaling m

279 via Toll-like Receptor (TLR) and TNF-family cytokine receptor (TNFR) signaling pathways.

280 that the signaling pathways triggered by the cytokine receptor TNFR1 play a more significant role in

281 recognition receptor TLR2- and inflammatory cytokine receptor TNFR1-mediated signaling pathways.

282 integrate signals from G protein-coupled and cytokine receptor to evoke neurite outgrowth in Neuro2A

283 rmore, we describe the molecular switch from cytokine receptor to pre-BCR signaling, how this pathway

284 ly replaced the requirement of a homodimeric cytokine receptor to promote the activation and transfor

285 eceptor as an archetype model of homodimeric cytokine receptors to address the role of the extracellu

286 ignals from Ag, costimulatory receptors, and cytokine receptors to control cell division, differentia

287 ijacked cellular genes encoding cytokines or cytokine receptors to disrupt host cell communication.

288 V617F requires interactions with homodimeric cytokine receptors to elicit its transforming signal.

289 ferentiation by modulating the expression of cytokine receptors to help specify and maintain differen

290 To assess the contribution of cytokine receptors to the differentiation of T cell subs

291 further revealed significant differences in cytokine receptor transcript levels (including IL-22RA1

292 delicate, intracellular feedback loop among cytokine receptors, transcription factors and miRNAs.

293 k2, the cognate tyrosine kinase for numerous cytokine receptors, undergoes multisite phosphorylation

294 pairs Stat3 responses downstream of multiple cytokine receptors via selective, posttranscriptional su

295 We found that cytokines and cytokine receptors were the dominant class of genes exhi

296 (RBP) into cells, and it also functions as a cytokine receptor which activates JAK/STAT signaling.

297 lecules mediate their effects through type 1 cytokine receptors, which bind cytokines with a characte

298 come by costimulation through CD28 or innate cytokine receptors, which dictated the fate of their pro

299 ranscription-factors (T-bet and Blimp-1) and cytokine receptors while paradoxically repressing genes

300 synthekine ligands that dimerized a JAK/STAT cytokine receptor with a receptor tyrosine kinase (RTK)