ライフサイエンスコーパス: cytokine signal

1 ion from mast cells and basophils requires 2 cytokine signals.

2 Th17 cell genetic programs independently of cytokine signals.

3 racellular signals such as costimulation and cytokine signals.

4 xpression to protect cancer cells from death cytokine signals.

5 an important transducer of growth factor and cytokine signals.

6 zing the need for spatially resolved data on cytokine signaling.

7 L-10, indicating a broader role for ISG15 in cytokine signaling.

8 proliferation, immune synapse formation, and cytokine signaling.

9 s a cytoplasmic tyrosine kinase critical for cytokine signaling.

10 me activation, and autocrine proinflammatory cytokine signaling.

11 that suppress COX-2 as well as inflammatory cytokine signaling.

12 nce by regulating cross talk between TCR and cytokine signaling.

13 etic diseases of immune deficiency affecting cytokine signaling.

14 mature lymphocytes or of Stat6-dependent Th2 cytokine signaling.

15 ein hypothetically involved in regulation of cytokine signaling.

16 responsiveness, whereas PD-1 TILs had normal cytokine signaling.

17 an important negative regulator of IL-6-type cytokine signaling.

18 newly minted ASCs, by enhancing pro-survival cytokine signaling.

19 gamma-secretase protease to pro-inflammatory cytokine signaling.

20 ced by activated T cells and inhibits gammac cytokine signaling.

21 e effects on adipocyte-derived NF-kappaB and cytokine signalling.

22 t these pathways converge on pro-tumorigenic cytokine signalling.

23 en endocytosis in the positive regulation of cytokine signalling.

24 155 (miR-155) and its target, suppressor of cytokine signaling 1 (SOCS-1).

25 on of the antifibrotic protein suppressor of cytokine signaling 1 (SOCS1) and upregulated profibrotic

26 the direct microRNA-155 target suppressor of cytokine signaling 1 (Socs1) because Socs1 knockdown in

27 ifferentially targets Noxa and suppressor of cytokine signaling 1 (SOCS1) in NK cells at distinct sta

28 p120-induced IL-23 upregulated suppressor of cytokine signaling 1 (SOCS1) protein in T cells, which i

29 e use of bioinformatics tools, suppressor of cytokine signaling 1 (SOCS1), a negative regulator of IF

30 phages leads to proteolysis of suppressor of cytokine signaling 1 (SOCS1), alleviating its repression

31 inducible negative regulators suppressor of cytokine signaling 1 (SOCS1), SOCS3, and ubiquitin-speci

32 ates with a high expression of suppressor of cytokine signaling 1 (SOCS1).

33 ng that 1,25(OH)2D3 stimulates suppressor of cytokine signaling 1 by downregulating miR-155.

34 on that excessively suppresses suppressor of cytokine signaling 1, a key regulator that enhances the

35 Furthermore, suppressor of cytokine signaling 1, an immune suppressive molecule in

36 inishes expression of CD95 and suppressor of cytokine signaling 1, both regulatory molecules.

37 Basal expression levels of Suppressor of Cytokine Signalling 1 (chSOCS1), a negative regulator of

38 MyD88 expression by decreasing suppressor of cytokine signaling-1 (SOCS-1) mRNA stability.

39 1 and also blocked LPS-induced suppressor of cytokine signaling-1 (SOCS1) expression, contributing to

40 he kinase-inhibitory region of suppressor of cytokine signaling-1 (SOCS1) regulatory protein protects

41 f transcription-3 (pSTAT3) and suppressor of cytokine signaling-1 (SOCS1)] were also elevated by exen

42 ented by overexpression of the suppressor of cytokine signaling-1 or inactivation of the BH3-only pro

43 Increased activity of suppressor of cytokine signaling-1 was accompanied by reduced phosphor

44 iated with increased levels of suppressor of cytokine signaling-1, implicating increased degradation

45 sion, with a resulting loss of suppressor of cytokine signaling-1.

46 dentified the ubiquitin ligase suppressor of cytokine signaling 2 (SOCS2) as a direct, biologically r

47 interleukin (IL)-8, IL-11, and suppressor of cytokine signaling 2 (SOCS2) messenger RNAs confirmed st

48 screen for candidates revealed suppressor of cytokine signaling 2 (SOCS2), an inhibitor of growth hor

49 mbrane proteolipid (Pllp), and suppressor of cytokine signaling 2 (Socs2).

50 ocarbon receptor (AHR) and the suppressor of cytokine signaling 2 (SOCS2).

51 counter of inflammatory signals alters their cytokine (signal 3) secretion pattern.

52 regulator/effector STAT-3, and suppressor of cytokine signaling 3 (a proinflammatory cytokine regulat

53 -associated kinase M (IRAK-M), suppressor of cytokine signaling 3 (SOCS-3), and activating transcript

54 is factor alpha (TNFalpha) and suppressor of cytokine signaling 3 (SOCS3) activities in whole retina

55 Here, we show that host suppressor of cytokine signaling 3 (SOCS3) can also bind to EBOV VP40,

56 ng, concomitant with increased suppressor of cytokine signaling 3 (SOCS3) expression.

57 d with enhanced expression of suppressors of cytokine signaling 3 (SOCS3) in the presence of erlotini

58 ted Janus kinase 2 (JAK2), and suppressor of cytokine signaling 3 (SOCS3) protein abundance was incre

59 Suppressor of cytokine signaling 3 (SOCS3) regulates STAT3 activation

60 on proteolytic degradation of suppressor of cytokine signaling 3 (SOCS3) resulting in low levels of

61 Epigenetic changes in suppressor of cytokine signaling 3 (SOCS3) were determined by using me

62 sed the gene transcription of suppressors of cytokine signaling 3 (SOCS3), a critical negative regula

63 find that deletion of cortical suppressor of cytokine signaling 3 (SOCS3), a negative regulator of cy

64 nd TNF-alpha) via induction of suppressor of cytokine signaling 3 (SOCS3), an effect mediated by solu

65 ile comprising upregulation of suppressor of cytokine signaling 3 (SOCS3), glycoprotein A repetitions

66 to decrease the expression of Suppressor of Cytokine Signaling 3 (SOCS3), leading to increases in ST

67 e regulator of IL-6 signaling, suppressor of cytokine signaling 3 (SOCS3).

68 vered that CD37 interacts with suppressor of cytokine signaling 3 (SOCS3); therefore, absence of CD37

69 itor of the JAK/STAT3 pathway [suppressor of cytokine signaling 3 (SOCS3)].

70 constitutive, independent from suppressor of cytokine signaling 3 activity.

71 Th17 cells due to induction of suppressor of cytokine signaling 3 and 5.

72 F can escape regulation by the suppressor of cytokine signaling 3 and p27/Kip1, JAK2R564Q-expressing

73 Suppressor of cytokine signaling 3 elicited the immunosuppressive acti

74 ges was accompanied by reduced suppressor of cytokine signaling 3 expression and an inadequacy of IL-

75 Restoring suppressor of cytokine signaling 3 expression under TAM knockdown cond

76 penditure, and reduced arcuate suppressor of cytokine signaling 3 expression, indicative for enhanced

77 s, which, in turn, upregulated suppressor of cytokine signaling 3 expression.

78 Interestingly, suppressor of cytokine signaling 3 knockdown in GEnCs upregulated duff

79 Rosi-mediated upregulation of suppressor of cytokine signaling 3 leads to an altered ratio of nuclea

80 STAT3 and suppressor of cytokine signaling 3 protein levels were measured by imm

81 n, which, in turn, may inhibit suppressor of cytokine signaling 3 transcription.

82 led that levels of IL-10R1 and suppressor of cytokine signaling 3 were increased in the epithelium an

83 h IL-22 in upregulating SOCS3 (suppressor of cytokine signaling 3), a key regulator of STAT3 (signal

84 ated TNFAIP3 suppressed SOCS3 (suppressor of cytokine signaling 3)-activated STAT3/VEGFA indirectly.

85 ne-mediated signaling pathway (suppressor of cytokine signaling 3, C-X-C ligand 8 [CXCL8]), and respo

86 nal deletion in basal cells of suppressor of cytokine signaling 3, encoding a negative regulator of t

87 nsitive to the STAT3 inhibitor suppressor of cytokine signaling 3.

88 STAT3 pathway inhibitor called suppressor of cytokine signalling 3 (SOCS3).

89 was mediated through transient suppressor of cytokine signaling-3 (SOCS3) inhibition of the STAT5b tr

90 diet-induced up-regulation of suppressor of cytokine signaling-3 (SOCS3) occurs in AgRP neurons befo

91 nalyzed interleukin (IL)-6 and suppressor of cytokine signaling-3 (SOCS3), 2 key factors of the JAK/S

92 l adipose tissue expression of suppressor of cytokine signaling-3 (Socs3), a target of resistin and h

93 ssion and with upregulation of suppressor of cytokine signaling-3 and phosphotyrosine phosphatase 1B,

94 IL-22/STAT3 axis, among others suppressor of cytokine signaling-3, lipocalin-2, and alpha1-antichymot

95 , rs4251961; IL-10, rs1800871; suppressor of cytokine signaling-3, rs4969170; nucleotide-binding olig

96 tes that DRD3 signaling evokes suppressor of cytokine signaling 5 expression, a negative regulator of

97 ppel-like factor 4 (KLF4), and suppressor of cytokine signaling 5.

98 Here we show that suppressor of cytokine signaling 6 (SOCS6) and Cullin 5, two component

99 re we developed antibody-based activators of cytokine signaling (AcCS), which recognize cytokines onl

100 IL-6-type cytokine signalling additionally involves the recruitmen

101 To explore how anti-inflammatory cytokine signaling affects Abeta pathology, we investiga

102 It can both enhance and suppress cytokine signalling, although the role of endocytosis fo

103 , was critical for generation of both innate cytokine signaling and Ag-specific B and T cell response

104 We, therefore, examined cytokine signaling and CD4(+) T cell differentiation in

105 here it functions as a negative regulator of cytokine signaling and cell proliferation.

106 we demonstrated an "outside-in" mechanism of cytokine signaling and consequent inflammation that faci

107 urring immunomodulator that regulates gammac cytokine signaling and controls T cell activation and di

108 This gain-of-function mutation dysregulates cytokine signaling and is associated with increased accu

109 roach for identifying new genes that promote cytokine signaling and leukemogenesis.

110 by eosinophil infiltration, enhanced type 2 cytokine signaling and M2 macrophage polarization in the

111 e SH2B3 gene encodes a negative regulator of cytokine signaling and naturally occurring loss-of-funct

112 nvolved in lipid metabolism, immune response/cytokine signaling and other diverse pathways, including

113 and its receptor c-Mpl regulates downstream cytokine signaling and platelet homeostasis.

114 1 is a critical effector of pro-inflammatory cytokine signaling and plays important roles in immune f

115 nd IL-7Ralpha proteins on T cells to inhibit cytokine signaling and promote inflammation.

116 of inflammasomes results in proinflammatory cytokine signaling and pyroptosis.

117 e-BII cell stage was exacerbated by abnormal cytokine signaling and repetitive inflammatory stimuli.

118 ed from reduced survival following deficient cytokine signaling and STAT5 activation.

119 c instruments to clarify the causal roles of cytokine signaling and upstream inflammation in immune-r

120 p OA exhibited differential pro-inflammatory cytokine signalling and peripheral and local lymphocyte

121 by regulating the intensity and duration of cytokine signals and inflammatory responses.

122 thin the innate immune system as chemotactic cytokines, signaling and recruiting host immune cells to

123 to regulate differentiation, lineage choice, cytokine signaling, and cell cycle.

124 ncluding matrix remodeling, chemokine and/or cytokine signaling, and immunological functions such as

125 Pases in early erythropoiesis, downstream of cytokine signaling, and in terminal erythroblast maturat

126 n peripheral organ inflammation, circulating cytokine signaling, and microglial activation remains po

127 to function in apoptosis, redox regulation, cytokine signaling, and other processes.

128 face receptors to regulate STAT3 activation, cytokine signaling, and the induction of both vascular e

129 at are impaired by the suppression of type 2 cytokine signaling, and they are reversed by recolonizat

130 were seen in pathways involved in apoptosis, cytokine signaling, and TLR pathways.

131 We have identified cytokine, signaling, and transcription factors that are

132 cells harvested from peritoneal cavities, 2 cytokine signals are required for IL-13 production: IL-3

133 which offers novel approaches for targeting cytokine signaling as well as potential therapeutic appl

134 progenitor cells exhibited severely impaired cytokine signaling as well as upregulation of p53 and ex

135 Cytokine array analysis suggested changes to cytokine signaling associated with iAs exposure.

136 ns active transcription of the Suppressor of cytokine signaling at 36E (Socs36E) gene by removing the

137 Here, we find that Suppressor of cytokine signaling at 36E (Socs36E) is a necessary negat

138 eaction-diffusion models for the dynamics of cytokine signaling at two successive scales: in immunolo

139 ted in vivo, and about the potential role of cytokine signaling between stem and progenitor cells and

140 SPRY domain-containing suppressor of cytokine signaling box protein (SPSB) 2-deficient macrop

141 The ankyrin and SOCS (suppressor of cytokine signaling) box (ASB) family of proteins functio

142 Interruption of cytokine signaling by CYT387 in vivo impaired the growth

143 uncover the targeting of a lineage-specific cytokine signaling by miRNAs as a mechanism regulating i

144 In turn, miR-193b restricts cytokine signalling, by targeting the receptor tyrosine

145 In contrast, aberrant cytokine signaling can also result in conditions of immu

146 IL-6 cytokine signaling can enhance ASC production and has be

147 Single-cell analysis now suggests that cytokine signaling can instruct lineage choice in blood

148 lk between sphingosine-1-phosphate (S1P) and cytokine signaling cascades in astrocyte activation and

149 pathogen binding, TLRs initiate specialized cytokine signaling catered to the class of invading path

150 resistant cells through an IL1beta/IL8/CXCR1 cytokine signaling circuit.

151 deficient in Toll-like receptors (TLRs) and cytokine signaling components (TLR-2(-/-), TLR-4(-/-), T

152 ddition of IL-12 to cultures, revealing that cytokine signaling could restore the acquisition of effe

153 Cytokine signaling dependent on JAK3 and JAK1 is critica

154 ed by specific receptor-mediated and soluble cytokine signals, depends on a directly downstream early

155 iseases provides new opportunities to target cytokine signaling directly as a novel treatment strateg

156 line of transgenic mice, we show that these cytokines signal directly into cardiomyocytes, limiting

157 CA/B) and not to be associated with specific cytokine signaling events.

158 -31 induces expression of four suppressor of cytokine signaling family members and provide evidence t

159 rotein (CISH), a member of the suppressor of cytokine signaling family of negative feedback regulator

160 encoding members of the SOCS (suppressor of cytokine signaling) family are critical targets of ThPOK

161 This suggests AcCS can be used to manipulate cytokine signaling for basic science and possibly for th

162 ymphoid progenitor cells required additional cytokine signaling for diversion into the myeloid lineag

163 hem to convert danger signals into versatile cytokine signals for the regulation of stress hematopoie

164 lls depend on host-derived costimulation and cytokine signals for their full and sustained activation

165 hat p38alpha alone controls acute stress and cytokine signaling from p38 MAPK to translation machiner

166 The essential role of cytokine signalling has been established not only by the

167 Therefore, blocking IL-6 cytokine signaling in (mesenteric) adipocytes may be a n

168 recently showed that interleukin (IL)-6-type cytokine signaling in adipocytes induces free fatty acid

169 We thus hypothesized that IL-6-type cytokine signaling in adipocytes may regulate insulin se

170 tly, targeting PERK neither disrupted normal cytokine signaling in astrocytes or microglia nor impair

171 signaling and pathways related to chemokine/cytokine signaling in both compartments.

172 role of genetic background, lymphocytes, and cytokine signaling in diet-induced obesity and insulin r

173 in conformation changes that reveal roles of cytokine signaling in effector T cell programming, the w

174 In summary, our dissection of cytokine signaling in embryonic HSCs has uncovered uniqu

175 Inhibition of cytokine signaling in mice with X-CGD reduced HPC number

176 ficial effects of blocking anti-inflammatory cytokine signaling in preclinical mouse models provide s

177 between NQO1 expression and proinflammatory cytokine signaling in prostate cancer.

178 However, little is known about how cytokine signaling in the brain may influence higher-ord

179 of TLR4, TLR5, and TLR9 and their downstream cytokine signaling in the gingival epithelial cells in p

180 nd in vitro culture of FL TILs could restore cytokine signaling in the PD-1(hi) subset.

181 nalling 1 (chSOCS1), a negative regulator of cytokine signalling in mammals, are 16-fold higher in DF

182 arisons support a role for IL-6 inflammatory cytokine signalling in OCCC pathogenesis.

183 luding epigenetic, cell-fate regulation, and cytokine signaling, in MF tumors and CTCL cell lines.

184 This reduces cytokine signaling including IL6 that is implicated in m

185 of gamma-secretase substrates have a role in cytokine signaling, including the IL-6 receptor, IL-1 re

186 While it is known that cytokine signals induce thymocytes to express Runx3, it

187 Unexpectedly, IL6-type cytokine signaling inducing STAT3 activation rendered ce

188 nd whether such T cells are sensitive to the cytokine-signaling inhibitor tofacitinib, a Janus kinase

189 Aberrant cytokine signaling initiated from mutant receptor tyrosi

190 active but could be activated by appropriate cytokine signals [interleukin (IL)-2 or IL-15], and coul

191 lambdaR expression was independent of direct cytokine signaling into T cells.

192 findings provide evidence that inflammatory cytokine signaling is a key process underlying epilepsy

193 Surprisingly, type 2 cytokine signaling is also required in FAPs, but not in

194 n of a functional pre-B-cell receptor (BCR), cytokine signaling is attenuated and the tonic/autonomou

195 s of P. aeruginosa We demonstrate that IL-17 cytokine signaling is essential for mouse survival and p

196 that targeting both JAK1- and TYK2-mediated cytokine signaling is more effective than TYK2 inhibitio

197 How structural dynamics affects cytokine signaling is under debate.

198 d lymphocyte activation, but its function in cytokine signaling is unknown.

199 h codes for a receptor implicated in myeloid cytokine signaling, is a direct target for both Rcor1 an

200 gnaling; (2) removal of keratinocyte-induced cytokine signaling, leading to reductions in pathologic

201 GF-beta, although they clearly require other cytokine signals, leading to the activation of transcrip

202 Aside from downstream cytokine signaling, little is known about the regulation

203 vealing their contribution to a feed-forward cytokine-signaling loop.

204 been proposed to have a central role in the cytokine signaling machinery that allows the survival of

205 aling pathway, suggesting alternative gammac cytokine signaling may support TEM homeostasis in the ab

206 Thus, intracellular cytokine signalling may serve as 'fate determinants' use

207 Therefore, the local interference of cytokine signaling mediated by siRNA-loaded nanoparticle

208 DNA regulatory protein and an extracellular cytokine signaling molecule that promotes airway inflamm

209 a acts through upregulation of suppressor of cytokine signaling molecules, which impairs signaling of

210 on and JAK/STAT pathway activation compose a cytokine signaling network in the immune-activated subse

211 contribute to treatment tolerance through a cytokine-signaling network that involves macrophage-deri

212 rter of TCR signaling that is insensitive to cytokine signaling, Nur77-eGFP, we identify a sharp, min

213 es and offer new insights into the impact of cytokine signaling on leukemia development.

214 of IL-2R gamma-chain (Il-2rgamma)-dependent cytokine signaling only to donor cells in NSG recipients

215 In addition to involvement in downstream cytokine signaling, p38 MAPK was important for VEGF, bFG

216 ns affecting the common gamma-chain (gammac) cytokine signaling pathway and mice with similar mutatio

217 anism dependent on NF-kappaB proinflammatory cytokine signaling pathway in both normal and steatotic

218 Focusing on a key cytokine signaling pathway previously implicated in cuta

219 nitial interaction with APCs, altering early cytokine signal pathways and leading to T cell unrespons

220 ), which is a negative regulator of multiple cytokine signaling pathways and is associated with incre

221 signaling (SOCS) proteins are inhibitors of cytokine signaling pathways and may play a role in restr

222 afenib would also have inhibitory effects on cytokine signaling pathways in immune cells.

223 We set out to investigate the role that cytokine signaling pathways play in these early processe

224 ssociated with AEC2-derived up-regulation of cytokine signaling pathways that are known to provoke in

225 anus kinases (JAKs) is required for multiple cytokine signaling pathways, and as such, JAK inhibitors

226 iption factor network, chromatin remodeling, cytokine signaling pathways, cell adhesion, and cell pro

227 which activate DNA damage response (DDR) and cytokine signaling pathways, including the ataxia telang

228 stem signaling, cellular immune response and cytokine signaling pathways.

229 ed kinase 1 (TAK1) is activated in different cytokine signaling pathways.

230 naling, T cell activation, and chemokine and cytokine signaling pathways.

231 gy to identify known oncogenic components of cytokine signaling pathways.

232 of toll-like receptors and pro-inflammatory cytokine signaling pathways.

233 e cross talk between the T-cell receptor and cytokine signalling pathways to limit inappropriate T-ce

234 -related genes that are involved in multiple cytokine signalling pathways.

235 Cytokine-signaling pathways are very tightly regulated b

236 cally focus on the roles of pro-inflammatory cytokine signaling, peripheral monocyte infiltration, mi

237 ing that hepatic NKT cells provide essential cytokine signals perpetuating hepatic inflammation and f

238 these findings reveal that IKBKE-associated cytokine signaling promotes tumorigenicity of immune-dri

239 nscription factor NF-kappaB, ubiquitination, cytokine signaling, protein folding, type I interferon p

240 at this mechanism integrating BCR, TLR9, and cytokine signals provides a peripheral checkpoint for DN

241 iers, transcription factors and mediators of cytokine signaling, recapitulating the combinations of m

242 By contrast, long-range cytokine signaling requires a high density of cytokine p

243 s, expression of AhR/cytokines/suppressor of cytokine signaling (SOCS) (spleen/heart), and production

244 Suppressors of cytokine signaling (SOCS) 1 and 3 proteins and reactive

245 mma also induced expression of suppressor of cytokine signaling (SOCS) 1 in HSCs, and we demonstrate

246 investigate the expression of suppressor of cytokine signaling (SOCS) 1 in tissues from asthmatic pa

247 Suppressors of cytokine signaling (SOCS) are important regulators of li

248 Interestingly, expression of Suppressor of Cytokine Signaling (SOCS) domain-containing viral protei

249 anistically distinct from the suppressors of cytokine signaling (SOCS) family of genes.

250 und that Cish, a member of the suppressor of cytokine signaling (SOCS) family, is induced by TCR stim

251 tokines induce members of the suppressors of cytokine signaling (SOCS) genes, CISH and SOCS1.

252 Suppressor of cytokine signaling (SOCS) proteins are feedback inhibito

253 Suppressor of cytokine signaling (SOCS) proteins are inhibitors of cyt

254 Suppressor of cytokine signaling (SOCS) proteins are key regulators of

255 The suppressor of cytokine signaling (SOCS) proteins are negative regulato

256 Suppressors of cytokine signaling (SOCS) proteins are negative-feedback

257 Suppressors of cytokine signaling (SOCS) proteins function as feedback

258 Suppressors of cytokine signaling (SOCS) proteins inhibit signaling by

259 The suppressors of cytokine signaling (SOCS) proteins play important roles

260 etermined that AMs can secrete suppressor of cytokine signaling (SOCS) proteins within microparticles

261 endogenous inhibitors, namely, suppressor of cytokine signaling (SOCS) proteins, phosphatases, and pr

262 egative feedback inhibition by suppressor of cytokine signaling (SOCS) proteins.

263 Interestingly, suppressor of cytokine signaling (SOCS)-1 directly associated with TLR

264 Suppressor of cytokine signaling (SOCS)-3 expression is increased in s

265 s like cyclooxygenase (COX)-2, suppressor of cytokine signaling (SOCS)-3, and matrix metalloproteinas

266 peat families, but not for the suppressor of cytokine signaling (SOCS)-box-containing ankyrin repeat

267 Suppressor of cytokine signaling (SOCS)1 is a cross-functional negativ

268 Following IL-4 exposure, suppressor of cytokine signaling (SOCS)1 is highly induced in human mo

269 ut may involve upregulation of suppressor of cytokine signaling (SOCS-3) proteins that are associated

270 Members of the suppressor of cytokine signalling (SOCS) family have been implicated i

271 b, a negative regulator of the suppressor of cytokine signalling (SOCS) genes, which inhibit HSC migr

272 transcription (e.g., IRF1 and suppressor of cytokine signaling [SOCS] 1) was strongly impaired.

273 tutive activation of STAT1 through autocrine cytokine signaling, suggesting that subclinical endotoxe

274 Inflammation by chemokine and cytokine signaling, T-cell activation, and B-cell activa

275 Thus, Otop1 defines a unique target of cytokine signaling that attenuates obesity-induced adipo

276 mology 2 (SH2)B3) is a negative regulator of cytokine signaling that has an essential, nonredundant r

277 is limiting and counteracts proinflammatory cytokine signaling that leads to the loss of Foxp3.

278 p among the B cell receptor (BCR), TLR9, and cytokine signals that regulate B cell responses to DNA-c

279 hrough a temporally orchestrated sequence of cytokine signals that sustain division rather than survi

280 ted by common gamma chain (gammac)-dependent cytokine signals that were present in the thymus in limi

281 that, in response to antigen receptor and/or cytokine signaling, the E-Id protein axis modulates the

282 erefore, in addition to established roles in cytokine signaling, the JAK/STAT pathway is involved in

283 controlling TLR4 signaling and inflammatory cytokine signaling through a negative feedback regulatio

284 rotein that functions to negatively regulate cytokine signaling through GP130 and pSTAT3Y705 and is m

285 as advanced, mechanism-based manipulation of cytokine signaling through protein engineering has becom

286 Moreover, these three cytokines signal through a common beta-chain receptor bu

287 IL-36 cytokines signal through the IL-36 receptor (IL-36R) and

288 Multiple cytokines, signaling through receptor tyrosine kinases (

289 ressing marrow stroma collaborate to provide cytokine signaling to HSCs and more committed hematopoie

290 inase is essential for coupling inflammatory cytokine signals to the cell death machinery in the diff

291 ization ratio" as a metric to understand how cytokine signaling translates into polarization of singl

292 gival epithelial cells expressing diminished cytokine signaling upon P. gingivalis stimulation.

293 Coal tar interfered with Th2 cytokine signaling via dephosphorylation of STAT6, most

294 Transforming growth factor (TGF)-beta cytokines signal via a complex network of pathways to re

295 Upon inhibition of cytokine signaling, we observed the classic mutual exclu

296 pathways related to pathogen recognition and cytokine signaling were significantly enriched under the

297 F signaling system indicates perceiving more cytokine signals which in fact do not exist at the syste

298 t with antigen-presenting cells, and augment cytokine signals, which are all factors that influence p

299 (SH2B3) gene encodes a negative regulator of cytokine signaling with a critical role in the homeostas

300 Elucidating the complexity of cytokine signaling within the normal mucosa and during a