ライフサイエンスコーパス: cytokinesis

1 st cortical localization of the ActBD during cytokinesis.

2 ion, and the stalled cells arrested prior to cytokinesis.

3 g membrane in the narrow time frame of plant cytokinesis.

4 together with water permeation to facilitate cytokinesis.

5 rotein involved in cell-cycle regulation and cytokinesis.

6 ntractile protein and a crucial regulator of cytokinesis.

7 wo nuclei, indicating defects in mitosis and cytokinesis.

8 performed image analyses of cells undergoing cytokinesis.

9 in lagging chromosomes and an inhibition of cytokinesis.

10 ive cellular morphogenetic processes such as cytokinesis.

11 on modes promote the faithful progression of cytokinesis.

12 eins are essential for efficient mitosis and cytokinesis.

13 directs envelope invagination for bacterial cytokinesis.

14 and a greatly diminished ability to support cytokinesis.

15 hibits Chs3-mediated chitin synthesis during cytokinesis.

16 , where it is required for the completion of cytokinesis.

17 force generator to limit the progression of cytokinesis.

18 sassembly, nuclear envelope reformation, and cytokinesis.

19 receptor down-regulation to viral budding to cytokinesis.

20 lt in defective septum and cell lysis during cytokinesis.

21 , and dimethylation of histone H3 in mitosis/cytokinesis.

22 kinase (CIT), which has established roles in cytokinesis.

23 critical roles in chromosome segregation and cytokinesis.

24 omosome segregation as limiting processes of cytokinesis.

25 nation of membrane-trafficking events during cytokinesis.

26 ocal environment to coordinate completion of cytokinesis.

27 synthases for successful septum formation in cytokinesis.

28 tight junctions flank the midbody following cytokinesis.

29 during the metaphase-anaphase transition and cytokinesis.

30 in the regulation of distinct events during cytokinesis.

31 Mapre1, Nedd4l, and Slc25a34) that regulate cytokinesis.

32 ion through exocyst-tethered vesicles during cytokinesis.

33 a role in determining the cell shape during cytokinesis.

34 al assembly factors in controlling stem cell cytokinesis.

35 y for furrow formation and the completion of cytokinesis.

36 in-like protein 1 and consequently prevented cytokinesis.

37 on, but also acts as a critical regulator of cytokinesis.

38 essential for the completion of mitosis and cytokinesis.

39 idization involves cell division with failed cytokinesis.

40 ses, including oogenesis, wound healing, and cytokinesis.

41 esting defects in intercellular adhesion and cytokinesis.

42 endent MT nucleation to complete mitosis and cytokinesis.

43 hat tyrosine phosphorylation of CitK impairs cytokinesis.

44 in-V on linear actin cables in fission yeast cytokinesis.

45 e ring assembly and furrow ingression during cytokinesis.

46 xocytosis at the division site at the end of cytokinesis.

47 s, chromosome missegregation, and failure in cytokinesis.

48 tsZ-ring structure and function in bacterial cytokinesis.

49 metaphase and was relatively constant during cytokinesis.

50 cell cycle-dependent process associated with cytokinesis.

51 d actomyosin network that contracts to drive cytokinesis.

52 ivated an alternative, posterior-to-anterior cytokinesis.

53 ryotic actomyosin structure that facilitates cytokinesis.

54 companied by binucleation through incomplete cytokinesis.

55 ow that KIF20B has a cell-autonomous role in cytokinesis.

56 functional RMA biosynthesis and male meiotic cytokinesis.

57 ivity opposes Rac (and perhaps Cdc42) during cytokinesis.

58 ng membrane-cytoskeleton coordination during cytokinesis.

59 aughter cells regrow a new process following cytokinesis.

60 sequence maintain their spindle tilt through cytokinesis.

61 tinucleated cells that result from defective cytokinesis.

62 o the dynamics of cell wall synthesis during cytokinesis.

63 ase signaling modules to properly coordinate cytokinesis.

64 ta and is required for cortical polarity and cytokinesis.

65 g in vitro assay, impaired cell motility and cytokinesis.

66 on in the phragmoplast and cause failures in cytokinesis.

67 on with Pom1 signaling for cell polarity and cytokinesis.

68 its called nodes for force production during cytokinesis.

69 ia lamblia uses an alternative mechanism for cytokinesis.

70 nisms for extracellular matrix synthesis and cytokinesis.

71 alization and restrict Cdc42 activity during cytokinesis.

72 the force-feedback loops that ensure robust cytokinesis.

73 One example is PRC1 (protein regulator of cytokinesis 1), which cross-links antiparallel MTs and i

74 e by avoiding the costly and slow process of cytokinesis [1, 3, 4].

75 eavage furrow and maintain cell shape during cytokinesis [1-14].

76 on of the cytokinetic ring during incomplete cytokinesis [1].

77 eotide exchange factor known as Dedicator of cytokinesis 2 (DOCK2).

78 livered to the division site at the onset of cytokinesis [6, 20].

79 Dedicator of cytokinesis 8 (DOCK8) deficiency can be cured by allogen

80 Dedicator of cytokinesis 8 (DOCK8) deficiency is a combined immunodef

81 r-IgE syndrome (HIES) caused by dedicator of cytokinesis 8 (DOCK8) deficiency shares clinical feature

82 d overlaps with the symptoms of dedicator of cytokinesis 8 (DOCK8) deficiency, suggesting that the 2

83 Mutations in the dedicator of cytokinesis 8 (DOCK8) gene cause an autosomal recessive

84 During cytokinesis, a contractile actomyosin ring constricts an

85 d us to account for furrow ingression during cytokinesis, a model cell-shape-change process.

86 in two different and essential modes during cytokinesis: a motor activity-independent form that can

87 caused by alteration of the ultimate step of cytokinesis, abscission.

88 e layer (80-160 nm) consists of a network of cytokinesis accessory proteins as well as multiple signa

89 rrant septin bundle formation and defects in cytokinesis after furrow ingression.

90 Depolymerizing the actin cytoskeleton during cytokinesis also does not affect the contraction speed.

91 on of microtubules occurs during mitosis and cytokinesis and can be ablated by SETD2 deletion, which

92 spindle organization, chromosome alignment, cytokinesis and cell cycle progression.

93 In budding yeast, proper execution of cytokinesis and cell division requires the formation of

94 ile forces for biological processes, such as cytokinesis and cell migration.

95 Cell division terminates with cytokinesis and cellular separation.

96 ne the contributions of the three myosins to cytokinesis and concluded "that Myo2p is the major motor

97 f1 controls timely activation of Chs3 during cytokinesis and defines a novel interaction and function

98 ic exit is important for proper execution of cytokinesis and efficient cell separation.

99 growth, but also cellular processes such as cytokinesis and endocytosis.

100 actin, an interaction that is important for cytokinesis and for midzone MT stabilization following f

101 challenge a Z-ring-centric view of bacterial cytokinesis and identify cell wall synthesis and chromos

102 Knockdown of ANLN in liver cells blocks cytokinesis and inhibits development of liver tumors in

103 ial barrier function is not disrupted during cytokinesis and is mediated by sustained tight junctions

104 This myosin efflux is a novel feature of cytokinesis and its duration is coupled to nuclear envel

105 ronous rounds of genome replication prior to cytokinesis and little is known about the control of DNA

106 oskeletal scaffolding protein that regulates cytokinesis and might promote tumorigenesis, in mice wit

107 However, the mechanisms that coordinate cytokinesis and MyoII activity in the neighbours are unk

108 ases, which are involved in various steps of cytokinesis and other processes.

109 AS2L3 plays a specific role in cardiomyocyte cytokinesis and proliferation during heart development.

110 acellular vesicle formation and trafficking, cytokinesis and receptor endocytosis.

111 Abscission is the final step of cytokinesis and results in the physical separation of tw

112 preciation for the roles of cross-linkers in cytokinesis and reveal that they not only drive but also

113 5-4 gene significantly suppressed defects in cytokinesis and seedling growth caused by map65-3 becaus

114 The cytokinesis and separation defects are rescued by adding

115 otubule cytoskeletons are coordinated during cytokinesis and suggests that the CPC is integral for co

116 for membrane extension in processes such as cytokinesis and syncytial nuclear division cycles in Dro

117 We show that ZitP regulates cytokinesis and the localization of ParB and PopZ, targe

118 inhibited the normal, anterior-to-posterior cytokinesis and triggered the alternative, posterior-to-

119 ase upon egg activation, failure to complete cytokinesis, and abnormal cell wound healing.

120 ns in MELK exhibit wild-type doubling times, cytokinesis, and anchorage-independent growth.

121 undetectable and negatively affects fitness, cytokinesis, and germination.

122 ormal septa, unstable septin assembly during cytokinesis, and prolonged exocytosis at the division si

123 kinase that has been implicated in mitosis, cytokinesis, and smooth muscle cell proliferation.

124 iggering the induction of autophagy, reduced cytokinesis, and substrate adhesion.

125 d by knockdown of the essential regulator of cytokinesis anillin, which resulted in cytokinesis failu

126 Cell shape changes in cytokinesis are driven by a cortical ring rich in actin

127 Cell shape changes such as cytokinesis are driven by the actomyosin contractile cyt

128 Cell movement and cytokinesis are facilitated by contractile forces genera

129 Most of the major players required for cytokinesis are known, but the temporal regulation and a

130 mutant revealed that defects in male meiotic cytokinesis are not caused by alterations in meiosis I (

131 of SpAin1 and whether they are tailored for cytokinesis are not known.

132 We have previously shown that HU can induce cytokinesis arrest in the erg11-1 mutant of fission yeas

133 found that dynamic bundling is critical for cytokinesis, as cells expressing SpAin1(R216E) display d

134 K), which has known functions in mitosis and cytokinesis, as induced in erythroblasts in an E2F-2-dep

135 We also find that TbMTase37 plays a role in cytokinesis, as loss of the protein leads to multi-flage

136 ound that INP1 assembly occurs after meiotic cytokinesis at the interface between the plasma membrane

137 f the central spindle and midbody throughout cytokinesis, at sites distinct from the other Kinesin-6

138 In this study, we have employed the cytokinesis block micronucleus cytome (CBMN-Cyt) assay w

139 inhibited the normal, anterior-to-posterior cytokinesis but activated an alternative, posterior-to-a

140 ristoylated isoform is essential to complete cytokinesis by activating motility of the male flagellum

141 rotein, localizes at the midbody to finalize cytokinesis by interacting with CRIK.

142 mitotic spindle to the predetermined site of cytokinesis by pulling on astral microtubules.

143 propose that ZapA and ZauP promote efficient cytokinesis by stabilizing the midcell Z-ring through a

144 ctile ring for cell division, the process of cytokinesis can be divided into four distinct stages.

145 BACKGROUND & AIMS: Cytokinesis can fail during normal postnatal liver devel

146 hat Ptpn11 GOF mutations disturb mitosis and cytokinesis, causing chromosomal instability and greatly

147 Cytokinesis cleaves a cell into two daughters at the end

148 Tetraploidy, arising from a cytokinesis defect, is known to have a deleterious effec

149 We show that the cytokinesis defects are associated with aberrant cytoske

150 twin-celled pollen arising from polarity and cytokinesis defects at pollen mitosis I in Arabidopsis.

151 Consistent with cytokinesis defects attributed to CIT, multinucleated ne

152 In vivo, overproduction of FzlC causes cytokinesis defects whereas deletion of fzlC causes synt

153 2 deletion, which causes mitotic spindle and cytokinesis defects, micronuclei, and polyploidy.

154 he depletion of ELKS and Rab8A also leads to cytokinesis defects.

155 howed cell-cycle progression, migration, and cytokinesis defects.

156 Cytokinesis depends on a contractile actomyosin ring in

157 Binding of p120 to MKLP1 during cytokinesis depends on the N-terminal coiled-coil domain

158 equired for proper actin organization during cytokinesis, distribution of type V myosin Myo52 to the

159 ge factor (GEF)1 (ARHGEF1), and dedicator of cytokinesis (DOCK)2 GEFs mediate CXCL12-induced LFA-1 ac

160 f cell polarity with the physical process of cytokinesis during asymmetric cell division to ensure th

161 t for critical cellular processes, including cytokinesis, endocytosis, exocytosis, and organelle traf

162 ill focus on four aspects of corticogenesis: cytokinesis events that follow apical mitoses of NSCs; c

163 or of cytokinesis anillin, which resulted in cytokinesis failure and formation of binucleate cells, o

164 Inhibition of each target induced cytokinesis failure and promoted hepatic binucleation.

165 f Diaph3 has been constantly associated with cytokinesis failure ascribed to impaired accumulation of

166 oses that Rac inactivation generally rescues cytokinesis failure by reducing cortical tension, thus m

167 SseF/SseG-dependent manner, suggesting that cytokinesis failure caused by S Typhimurium delays epith

168 lure: inhibition of Rac specifically rescues cytokinesis failure due to disruption of CYK-4 or ECT-2

169 uption of CYK-4 or ECT-2 but does not rescue cytokinesis failure due to disruption of two other contr

170 Megakaryocyte polyploidy is characterized by cytokinesis failure resulting from defects in contractil

171 Klp2 depletion impairs cytokinesis; however, cytokinesis failure stems from furrow regression rather

172 the finding that Rac inactivation can rescue cytokinesis failure when the GTPase-activating protein (

173 bited growth through the combined effects of cytokinesis failure, CDKN1A/p21-mediated RB1 inhibition,

174 romosomes in anaphase, frequently leading to cytokinesis failure, multinucleation and cell death.

175 sponse to centrosome loss but did not affect cytokinesis failure-induced arrest or p53 elevation afte

176 gulated endoreplication, caused primarily by cytokinesis failure.

177 hat Rac disruption does not generally rescue cytokinesis failure: inhibition of Rac specifically resc

178 Concurrently, cardiomyocytes undergoing cytokinesis from embryonic hearts exhibited midbody form

179 hat is clearly distinct from the mitotic and cytokinesis functions of Cdc14/Flp1 in budding and fissi

180 phase spindle determines the position of the cytokinesis furrow, such that the contractile ring assem

181 endosome (RE)-based vesicle delivery to the cytokinesis furrow.

182 n already known as a key player in bacterial cytokinesis, had the "tubulin signature sequence" presen

183 hough many factors that regulate RhoA during cytokinesis have been characterized, the spatiotemporal

184 upport of this idea, MKlp2 depletion impairs cytokinesis; however, cytokinesis failure stems from fur

185 Cytokinesis in animal cells requires the constriction of

186 Cytokinesis in animals, fungi, and amoebas depends on th

187 implicated in central spindle formation and cytokinesis in animals, yeasts, and plants-is a genuine

188 n of KHARON mRNA induces a lethal failure of cytokinesis in both bloodstream (mammalian host) and pro

189 We inhibited cytokinesis in cancer cells by knocking down ANLN, a cyt

190 eriments on model systems have revealed that cytokinesis in cells with contractile rings (amoebas, fu

191 Instead, we found that the rescue of cytokinesis in CYK-4 mutants by Rac inactivation was Cdc

192 ross-linked actin filaments that facilitates cytokinesis in dividing cells.

193 During cellularization, the first cytokinesis in Drosophila embryos, a reservoir of microv

194 ion limits the rate of septum closure during cytokinesis in Escherichia coli cells.

195 Cell shape changes during cytokinesis in eukaryotic cells have been attributed to

196 Cytokinesis in eukaryotic cells is often accompanied by

197 ne whether dynamic bundling is important for cytokinesis in fission yeast, we created the less dynami

198 regulated by a novel protein, Rng10, during cytokinesis in fission yeast.

199 siRNA knockdown of ANLN blocked cytokinesis in H2.35 liver cells.

200 idzone MTs with low amounts of Taxol rescues cytokinesis in INCENP actin-binding mutant-expressing ce

201 rate that AREG controls G2/M progression and cytokinesis in keratinocytes via activation of a FoxM1-d

202 Cytokinesis in many eukaryotes requires an actomyosin-ba

203 dle organization, chromosome segregation and cytokinesis in meiotic cells.

204 f septin proteins has important functions in cytokinesis in mitotically proliferating cells.

205 to a contractile ring structure required for cytokinesis in most bacteria.

206 , and acts as an abscission inhibitor during cytokinesis in response to chromatin bridges.

207 During cytokinesis in Saccharomyces cerevisiae, damaged protein

208 Our data corroborate the role of an impaired cytokinesis in the etiology of primary and syndromic mic

209 We investigated whether inhibiting cytokinesis in the liver slows tumor growth without comp

210 Our results highlight the importance of cytokinesis in the pathology of primary microcephaly.

211 explore the mechanistic basis for asymmetric cytokinesis in theCaenorhabditis eleganszygote, with the

212 d barrier function are maintained throughout cytokinesis in vertebrate epithelial tissue.

213 complex cell shape changes that occur during cytokinesis in vertebrate epithelial tissue.

214 e RNAi library for modulators of mitosis and cytokinesis inDrosophilaS2 cells.

215 ns that function in polarized growth, and in cytokinesis inhibition in response to chromosome bridges

216 naling pathway composed of polo-like kinase, cytokinesis initiation factor 1 (CIF1), and aurora B kin

217 ein, named CIF2, and its mechanistic role in cytokinesis initiation.

218 us revealing the mechanistic role of CIF2 in cytokinesis initiation.

219 ts in concert at the new FAZ tip to regulate cytokinesis initiation.

220 Animal cytokinesis involves both actin-myosin-based contraction

221 In fission yeast, cytokinesis involves the type II myosins Myo2p and Myp2p

222 Consequently, cytokinesis is a highly robust process impervious to dis

223 Cytokinesis is a tightly regulated process that until re

224 es throughout constriction and suggests that cytokinesis is accomplished by contractile modules that

225 Bacterial cytokinesis is accomplished by the essential 'divisome'

226 Abnormal cytokinesis is also markedly increased in these cells.

227 rmation of giant cells due to failed mitosis/cytokinesis is common in the blastomere stage of the pre

228 Cytokinesis is driven by constriction of an actomyosin c

229 However, whether the role of LET-99 in cytokinesis is specific to asymmetric division and wheth

230 Cytokinesis is the last step of cell division, culminati

231 Contraction of actomyosin rings during cytokinesis is typically attributed to actin filaments s

232 ughter parasites are formed by a specialized cytokinesis known as segmentation.

233 is and envelope constriction at the onset of cytokinesis, later increasing in length and number to en

234 ifically affects the process of male meiotic cytokinesis leading to meiotic restitution and the produ

235 he germline precursor blastomere, P4 , fails cytokinesis, leaving a stable cytoplasmic bridge between

236 moval predominates during the late stages of cytokinesis, mediated by both dynamin and the ESCRT (end

237 dary between them, focusing on the conserved cytokinesis midzone proteins Prc1 and Kif4A.

238 n and function of two kinesins essential for cytokinesis, Mklp2 and Kif14.

239 n microscopy now reveals the organization of cytokinesis nodes and contractile rings in live fission

240 ers of constituent proteins, as observed for cytokinesis nodes.

241 Surprisingly, Giardia cytokinesis occurred with a median time that is approxim

242 A different form of cytokinesis occurs during gametogenesis in Saccharomyces

243 Cytokinesis of animal cells requires the assembly of a c

244 Organizing Protein (PfMOP), as essential for cytokinesis of blood-stage parasites.

245 coordinate vital cellular processes, such as cytokinesis, pathogen defense, and ion transport regulat

246 ulatory pathway and reiterated that a backup cytokinesis pathway is activated by inhibiting the norma

247 athway is activated by inhibiting the normal cytokinesis pathway.

248 ne affects anillin's localization and causes cytokinesis phenotypes.

249 Cytokinesis physically separates dividing cells by formi

250 Surprisingly, the post-cytokinesis plasmodesmata allow diffusion of macromolecu

251 Instead of being open pores, post-cytokinesis plasmodesmata present such intimate ER-PM co

252 assemble by Search-Capture-Pull-Release from cytokinesis precursor nodes that include the molecular m

253 ical laser microsurgery revealed that during cytokinesis progression, mechanical tension increased su

254 We also find that mitosis/cytokinesis proteins are especially important for male G

255 n and septin in the anterior pole, which are cytokinesis proteins that our genetic data suggest act a

256 shortening of these overlaps at the onset of cytokinesis proved to be required to spatially confine m

257 ze checkpoint is not the trigger for G2/M or cytokinesis, refuting the unexamined assumption that mer

258 To identify new cytokinesis regulators, we carried out proximity-depende

259 se results identified a new regulator in the cytokinesis regulatory pathway and reiterated that a bac

260 Cytokinesis requires the cooperation of many cytoskeleta

261 nto known regulatory complexes of mitosis or cytokinesis, respectively, and predicted previously unch

262 DNA replication and nuclear division without cytokinesis, resulting in a multinucleated cell.

263 s through structural reorganizations such as cytokinesis (Rho1 dependent) and polarity establishment

264 e the events leading to noncanonical zygotic cytokinesis, segregating the parental genomes into disti

265 ved the dynamics of the actin network during cytokinesis, starting with the extension of short actin

266 nes as well as genes involved in mitosis and cytokinesis such as CHFR, LARP1 and YWHAE.

267 gered the alternative, posterior-to-anterior cytokinesis, suggesting a tight control of CIF2 protein

268 re fibers are not obviously discernable, and cytokinesis takes place following the formation of elong

269 tional Kin1 substrates for cell polarity and cytokinesis (Tea4, Mod5, Cdc15, and Cyk3) were also phos

270 ucleated and apoptotic cells-signs of failed cytokinesis that we also observed in experimentally KIF1

271 During cytokinesis, the antiparallel array of microtubules form

272 During cytokinesis, the cell undergoes a dramatic shape change

273 During cytokinesis, the chromosomal passenger complex (CPC) pro

274 he contractile ring and midbody required for cytokinesis, the final stage of mitosis, have not previo

275 Stable cytoplasmic bridges arise from failed cytokinesis, the last step of cell division, and are a k

276 Cytokinesis, the physical division of one cell into two,

277 During epithelial cytokinesis, the remodelling of adhesive cell-cell conta

278 equired for normal cell-cycle regulation and cytokinesis, this transcript's ability to support viabil

279 Second, if CYK-4 regulates cytokinesis through Rho rather than Rac, then CYK-4 inhi

280 Kin1 regulates cell polarity and cytokinesis through unknown mechanisms [4-7].

281 missive temperature for myo2-E1, we compared cytokinesis timings in myo2-E1 and myo2Delta at 25 degre

282 an increase in constriction velocity allows cytokinesis to complete at the same time as controls.

283 rce generation in morphogenesis ranging from cytokinesis to epithelial extension or invagination.

284 romatid segregation must be coordinated with cytokinesis to preserve genomic stability.

285 romatid segregation must be coordinated with cytokinesis to preserve genomic stability.

286 Trypanosoma brucei undergoes cytokinesis uni-directionally from the anterior tip of t

287 other eukaryotes, which undergo contractile cytokinesis upon completion of mitosis, plants instead s

288 We report that Cdc42 promotes cytokinesis via a unique spatiotemporal activation patte

289 nomously, by mediating anchorage-independent cytokinesis via RhoA.

290 on to its role in membrane abscission during cytokinesis, viral budding, endosomal sorting, and plasm

291 nce of PLST-1, polarization was compromised, cytokinesis was delayed or failed, and 50% of embryos di

292 sal body, bilobe, kinetoplast, nucleus), and cytokinesis was obtained.

293 st, myosin II filaments in earlier stages of cytokinesis were organized into small, discrete, and reg

294 m a cleavage furrow [3] and during monopolar cytokinesis when myosin contractility is blocked by bleb

295 Septin-deficient T cells failed to complete cytokinesis when prompted by pharmacological activation

296 idly during the transition from telophase to cytokinesis, whereas cell volume increased slightly in m

297 bud neck, which is the site where subsequent cytokinesis will occur.

298 uals with these mutations exhibited abnormal cytokinesis with delayed mitosis, multipolar spindles, a

299 ing independently with growth anisotropy and cytokinesis without disrupting default membrane traffick

300 achieve the same type of shape change during cytokinesis without myosin contraction.