ライフサイエンスコーパス: cytokinetic

1 probed in animal or in vitro studies include cytokinetics, aberrant crypt foci, eicosanoids and hydro

2 Our findings thus link cytokinetic abnormalities to a hereditary cancer syndrom

3 the PRD is required for ALIX to function in cytokinetic abscission and retroviral budding, but not i

4 ncreases this postmitotic process and delays cytokinetic abscission by keeping the abscission checkpo

5 the absence of ESCRT function in C. elegans, cytokinetic abscission is delayed but can be completed,

6 We propose that cytokinetic abscission is driven by an ESCRT-III fission

7 ate quantitative imaging of ESCRT-III during cytokinetic abscission with biophysical properties of ES

8 During cytokinetic abscission, the endosomal sorting complex re

9 Cytokinetic abscission, the final stage of cell division

10 ry plays an evolutionarily conserved role in cytokinetic abscission, the final step of cell division

11 est a computational model for ESCRT-mediated cytokinetic abscission.

12 ays critical roles in retroviral budding and cytokinetic abscission.

13 cal separation between daughter cells during cytokinetic abscission.

14 between postmitotic genome surveillance and cytokinetic abscission.

15 , HIV budding, nuclear envelope closure, and cytokinetic abscission.

16 ctility and formin-dependent assembly of the cytokinetic actin contractile ring.

17 Cytokinetic actin ring (CAR) formation in Schizosaccharo

18 e IQGAP-related protein Iqg1 (Cyk1) promotes cytokinetic actin ring formation and is required for cyt

19 mto2Delta cells fail to anchor the cytokinetic actin ring in the medial region of the cell

20 and the EMTOC are critical for anchoring the cytokinetic actin ring to the medial region of the cell

21 pparatus determine the position at which the cytokinetic actomyosin array forms, but the molecular me

22 uctures, such as actin stress fibers and the cytokinetic actomyosin contractile ring.

23 g protein, Rho1/RhoA plays a central role in cytokinetic actomyosin ring (CAR) assembly and cytokines

24 atids are separated to opposite sides of the cytokinetic actomyosin ring (CAR).

25 s regulatory proteins play a central role in cytokinetic actomyosin ring assembly and cytokinesis.

26 that did not constrict with actomyosin ring (cytokinetic actomyosin ring) invagination; instead, it s

27 chain that is an essential component of the cytokinetic actomyosin ring.

28 m a three-component system that co-ordinates cytokinetic and cell wall homeostatic processes.

29 aneous gcrA/ccrM disruption ameliorating the cytokinetic and growth defect of DeltagcrA cells.

30 Animal cells decide where to build the cytokinetic apparatus by sensing the position of the mit

31 However, once the cytokinetic apparatus expands into a ring the MAP become

32 In normal cells, the cytokinetic apparatus forms in a region of lower cortica

33 l by which the central spindle organizes the cytokinetic apparatus is premised on an antiparallel arr

34 The cytokinetic apparatus of bacteria is initially formed by

35 In plant cells, microtubules (MTs) in the cytokinetic apparatus phragmoplast exhibit an antiparall

36 We conclude that microtubules specify the cytokinetic apparatus via a dynamic zone of local RhoA a

37 lp1 out of the nucleolus, 2) maintaining the cytokinetic apparatus, and 3) halting the cell cycle unt

38 The current model of the plant cytokinetic apparatus, describing it as being composed o

39 is in plant cells depends on guidance of the cytokinetic apparatus, the phragmoplast, to a cortical "

40 cortex is contacted by the outwardly growing cytokinetic apparatus.

41 otic spindle and cleavage of the cell by the cytokinetic apparatus.

42 e our model to estimate the duration of post-cytokinetic attachment between a S.cerevisiae mother and

43 e specificity is unclear but could involve a cytokinetic birth scar that marks the newborn pole as th

44 h genes resulted in lethality and a complete cytokinetic block, suggesting overlapping function.

45 two-pronged recruitment of ESCRT-III to the cytokinetic bridge and implicates ALIX in abscission che

46 c spindle function and the resolution of the cytokinetic bridge because its depletion resulted in spi

47 an opportunity to study chromosomal damage, cytokinetics, changes in molecular genetic markers, and

48 epithelial cell preparation with morphology, cytokinetics, chromosomal, and DNA analyses characterist

49 tomyosin ring generates force to ingress the cytokinetic cleavage furrow in animal cells, yet its fil

50 We suggest that chromatin trapped in the cytokinetic cleavage furrow is the more likely reason fo

51 The cytokinetic cleavage furrow is typically positioned symm

52 not localize to the interphase cortex or the cytokinetic cleavage furrow, whereas a 500-residue regio

53 on promotes filament reorientation along the cytokinetic cleavage furrow, which might have implicatio

54 calizes to the interphase cortex but not the cytokinetic cleavage furrow.

55 n cytoskeleton, lamellipodia, and actin-rich cytokinetic cleavage furrow.

56 d with the assembly of the actin ring in the cytokinetic cleavage furrow.

57 omyces pombe proteins that contribute to the cytokinetic contractile ring accumulate during interphas

58 proteins to test the popular model that the cytokinetic contractile ring assembles from a single myo

59 that fission yeast assemble and constrict a cytokinetic contractile ring in a precisely timed, seque

60 assembly of cortical nodes that generate the cytokinetic contractile ring in fission yeast.

61 Assembly of a cytokinetic contractile ring is a form of cell polarizat

62 gether and mature into the precursors of the cytokinetic contractile ring.

63 in patches, polarizing actin cables, and the cytokinetic contractile ring.

64 2) and other proteins that condense into the cytokinetic contractile ring.

65 most advanced models of the dynamics of the cytokinetic contractile ring.

66 Formins polymerize actin filaments for the cytokinetic contractile ring.

67 ivation, Rng3p colocalizes with Myo2p in the cytokinetic contractile ring.

68 of the proteins in the functional units of a cytokinetic contractile ring.

69 processive elongation of actin filaments for cytokinetic contractile rings and other cellular structu

70 n yeast lacking Aip1 are viable and assemble cytokinetic contractile rings normally, but rings in the

71 regulators of the MEN, failed to remedy the cytokinetic defect of these mutants, indicating that Cdc

72 a variety of abnormalities subsequent to the cytokinetic defect, including fusion of nuclei, formatio

73 ween the connected cell bodies, indicating a cytokinetic defect.

74 er-associated mutations results in increased cytokinetic defects but has no effect on BRCA2-dependent

75 d midzone formation can be restored, and the cytokinetic defects can be rescued in Kif4 esiRNA-treate

76 in cell plate formation are seedling lethal, cytokinetic defects in et2 predominantly occur in flower

77 use attenuation of MOR signaling rescued the cytokinetic defects of SIN mutants and allowed weak SIN

78 erations in cell wall formation, and similar cytokinetic defects were sporadically observed in other

79 terol biosynthesis enzyme, also lead to weak cytokinetic defects, primarily in the flowers.

80 e formation of multipolar spindle arrays and cytokinetic defects.

81 The cytokinetic division ring of Escherichia coli comprises

82 -to-pole oscillation to help ensure that the cytokinetic division septum forms only at the mid-cell p

83 An extreme example of this post-cytokinetic DNA segregation occurs during spore formatio

84 f metazoans, and the third gives rise to the cytokinetic dynamins of amoebozoans and plants and to ch

85 demonstrate that bcl-XS can have substantial cytokinetic effects under circumstances that produce rel

86 e we use cellularization, the first complete cytokinetic event in Drosophila embryos, to show that cl

87 he Drosophila embryo undergoes a large-scale cytokinetic event that packages thousands of syncytial n

88 y contribute a signal to initiate or promote cytokinetic event(s) and that an intact polo-box is requ

89 me segregation, the mitotic spindle controls cytokinetic events at the cell envelope.

90 ormed a Z-ring at a time in development when cytokinetic events normally have ceased.

91 1 is also required for the highly asymmetric cytokinetic events that extrude the two polar bodies dur

92 at recruit specific proteins and orchestrate cytokinetic events, such as sister nuclei being kept apa

93 Similarly, the essential cytokinetic factor anillin, which functions at the cell

94 ated spindles with a diffuse distribution of cytokinetic factors.

95 of MICAL3 leads to an increased frequency of cytokinetic failure and a delayed abscission.

96 Additionally, cytokinetic failure at meiosis II gives rise to bi-nucle

97 The frequent cytokinetic failure caused by loss of MAP65-3 was not re

98 cally, NMIIB-deficient spermatocytes exhibit cytokinetic failure in meiosis I, resulting in bi-nuclea

99 mentin mutant in T24 cultured cells leads to cytokinetic failure, resulting in binucleation (multinuc

100 n, slower gravitropic response in roots, and cytokinetic failure.

101 Here, we identify the essential cytokinetic formin Cdc12 as a key CR substrate of SIN ki

102 N-triggered oligomeric switch that modulates cytokinetic formin function, revealing a novel mechanism

103 rcumferential ring structures that flank the cytokinetic FtsZ ring and appear to be associated with d

104 ter membrane depends on the formation of the cytokinetic FtsZ ring at midcell.

105 a formin Cdc12 recruitment, defining a novel cytokinetic function for an F-BAR domain.

106 robably provides both the structural and the cytokinetic functions required for elaboration and closu

107 localizations of the CPC are coupled to its cytokinetic functions.

108 per execution of cytoskeletal remodeling and cytokinetic functions.

109 s are required for proper positioning of the cytokinetic furrow [1] [2], the role of pre-anaphase mic

110 to sense micron-scale contours, such as the cytokinetic furrow and base of neuronal branches.

111 ere is micron-scale curvature, including the cytokinetic furrow and the base of cell protrusions.

112 The cytokinetic furrow arises from spatial and temporal regu

113 The cytokinetic furrow cleaves the cell by ingressing from b

114 gross defects in chromosome segregation and cytokinetic furrow ingression.

115 Initiation of the cytokinetic furrow occurs at the normal time and place,

116 Chiral morphogenesis is timed by the cytokinetic furrow of a neighbor of the sister pair, pro

117 ionship between microtubule organization and cytokinetic furrow position.

118 nd GEF-H1, LARG depletion does not result in cytokinetic furrow regression nor does it affect interna

119 Loss of Nm23-H1 in diploid cells leads to cytokinetic furrow regression, followed by cytokinesis f

120 In animal cells, formation of the cytokinetic furrow requires activation of the GTPase Rho

121 disjunction, anaphase B, and formation of a cytokinetic furrow, which split the spindle.

122 idzone coordinately directs formation of the cytokinetic furrow.

123 cortex and, thus, blocking initiation of the cytokinetic furrow.

124 targeting, is required for elongation of the cytokinetic furrow.

125 yosin can both determine the position of the cytokinetic furrow.

126 vity in mammalian cells and demonstrate that cytokinetic furrowing is primarily regulated at the leve

127 nonmotor cross-linkers affects the speed of cytokinetic furrowing.

128 which occurs during anaphase B and prior to cytokinetic furrowing.

129 contractility is responsible for asymmetric cytokinetic furrowing.

130 broader region of ingressing membrane during cytokinetic furrowing.

131 ion of RhoA activity, leading to assembly of cytokinetic furrows that partially ingress.

132 thought to provide the ingression force for cytokinetic furrows, but the role of membrane traffickin

133 division proteins, ultimately assembling the cytokinetic machine that splits the cell.

134 protein initiates assembly of the bacterial cytokinetic machinery by polymerizing into a ring struct

135 ins are likely to be a common feature of the cytokinetic machinery in bacteria.

136 evidence indicates that ZapA is part of the cytokinetic machinery of the cell and acts by promoting

137 estricts growth to cell ends and targets the cytokinetic machinery to the middle of the cell.

138 ocalization, microtubule biogenesis, and the cytokinetic machinery, as well as a substantial uncoupli

139 ules and without canonical components of the cytokinetic machinery.

140 These PRC1-mediated modifications to the cytokinetic mechanism may be related to the specializati

141 essful cytokinesis in budding yeast, but new cytokinetic mechanisms can evolve through genetic change

142 suggests a direct role for these proteins in cytokinetic membrane abscission.

143 ed precise co-localization to interphase and cytokinetic microtubule arrays.

144 ESCRT-III polymerization at the edge of the cytokinetic midbody structure, located at the center of

145 ulating these events, as it localizes to the cytokinetic midbody.

146 all stubs observed upon drug treatment or in cytokinetic mutants.

147 tation, to localize to the spindle poles and cytokinetic neck filaments, and to induce elongated cell

148 ition to localizing at the spindle poles and cytokinetic neck filaments, Cdc5 induces and localizes t

149 ddition to localization at spindle poles and cytokinetic neck filaments, Plk induces and localizes to

150 that Plk localizes at the spindle poles and cytokinetic neck filaments.

151 y of Cdc5p to spindle pole bodies (SPBs) and cytokinetic neck-filaments.

152 dies concluded that cells without Mid1p lack cytokinetic nodes and assemble rings unreliably from myo

153 -II, Rng2p, and Cdc15p to nodes and to place cytokinetic nodes around the cell equator.

154 Myo2 appears in cytokinetic nodes around the equator 10 min before spind

155 How cytokinetic nodes assemble, whether the order of assembl

156 eral kinases appear early in G2, mature into cytokinetic nodes by adding anillin Mid1p, myosin-II, fo

157 Assembly of cytokinetic nodes requires Mid1p, which recruits IQGAP-r

158 n Deltamid1 cells that Cdc12p accumulates in cytokinetic nodes scattered in the cortex and produces a

159 During mitosis, cytokinetic nodes with Mid1p and all of the type 2 node

160 g and de novo assembly of the plant-specific cytokinetic organelle, the cell plate, which develops ac

161 niques provide different perspectives on the cytokinetic parameters.

162 roliferative population and the magnitude of cytokinetic parameters.

163 complex activation and a polo-box-dependent cytokinetic pathway.

164 n inhibition of Cyk2/Hof1- and Myo1-mediated cytokinetic pathways.

165 ediated lethality could not be attributed to cytokinetic perturbations, nor did ara-CTP formation or

166 nd other drugs, we showed that exit from the cytokinetic phase of the cell cycle depends on ubiquitin

167 either cyk3 or hof1 alone results in a mild cytokinetic phenotype [5-7], but deletion of both genes

168 Depletion of MITD1 causes a distinct cytokinetic phenotype consistent with destabilization of

169 Following nuclear division, a cytokinetic phragmoplast forms between the daughter nucl

170 itosis, and relocates to the recently formed cytokinetic plane, where it establishes a fully polarize

171 Microtubules direct cytokinetic polarization via the central spindle and ast

172 If this interaction is compromised, cytokinetic precursors are asymmetrically distributed in

173 network (SIN) induces Cdr2 dissociation from cytokinetic precursors at this stage [12-14].

174 sion are mediated in part by the actin-like, cytokinetic protein FtsA.

175 formation of higher-order assemblies of the cytokinetic protein in vitro.

176 id-cell was dependent on the presence on the cytokinetic protein, FtsZ.

177 Our data demonstrate that the cytokinetic proteins epithelial cell transforming 2 and

178 as a mechanical scaffold that recruits other cytokinetic proteins to establish functional divisomes.

179 Chk1 in mitotic mammalian cells resulted in cytokinetic regression and binucleation, increased chrom

180 We observed that Aurora B, a critical cytokinetic regulator and a recently identified Chk1 sub

181 s-Galbraith and colleagues report that a key cytokinetic regulator in fission yeast, Cdc15, is phosph

182 factor ECT2, an orthologue of the Drosophila cytokinetic regulator Pebble, providing a direct means f

183 otes the equatorial recruitment of important cytokinetic regulators.

184 s approach identifies Aip1, Ede1 and Inn1 as cytokinetic regulators.

185 Cytokinetic RhoA activity zones are common to four echin

186 We propose that the most active form of the cytokinetic RhoGEF involves complex formation between EC

187 g and constricting a medial actomyosin-based cytokinetic ring (CR).

188 FtsA are recruited independently to the FtsZ cytokinetic ring (Z ring) and are essential for cell div

189 Gef1 localizes first to the cytokinetic ring and promotes timely constriction, where

190 ount of FtsZ available for assembly into the cytokinetic ring and with it cell size.

191 Assembly of proteins into the cytokinetic ring appears to occur in a hierarchial order

192 tile ring assembly in vivo.The fission yeast cytokinetic ring assembles by Search-Capture-Pull-Releas

193 ization, the small GTPase Rho and formins in cytokinetic ring assembly.

194 l player in the cytoskeletal family, forms a cytokinetic ring at mid-cell, and recruits the division

195 The bacterial GTPase FtsZ forms a cytokinetic ring at midcell, recruits the division machi

196 hen it is synthesized and assembles into the cytokinetic ring at the beginning of the cell cycle.

197 event in cell division is the formation of a cytokinetic ring at the future site of division.

198 that the amidases require activation at the cytokinetic ring by proteins with LytM domains, of which

199 Thus, cytokinetic ring closure is promoted by moderate levels

200 Before cytokinetic ring constriction, Cdc42 activation, is Gef1

201 In addition, the inhibition of cytokinetic ring contraction can be reversed by exposure

202 us reveal a key role for amidase activity in cytokinetic ring contraction.

203 cles through contraction and relaxation, the cytokinetic ring disassembles during contraction through

204 es of FtsZ, a bacterial protein that forms a cytokinetic ring during cell division, are essential for

205 zone from late anaphase and localizes to the cytokinetic ring during cytokinesis.

206 proposed to arise from stabilization of the cytokinetic ring during incomplete cytokinesis [1].

207 B, but not delta N592, were localized to the cytokinetic ring during mitosis, indicating that, in ver

208 mbly and in maintaining the integrity of the cytokinetic ring during the early stages of division.

209 nt tubulin homolog, FtsZ, for assembling the cytokinetic ring essential for cell division, but are ot

210 ation may help bridge two existing models of cytokinetic ring formation.

211 EzrA also concentrates at the cytokinetic ring in an FtsZ-dependent manner, although i

212 to filaments in interphase cells and to the cytokinetic ring in dividing cells.

213 n-related protein Mid1 does not position the cytokinetic ring in the fission yeast Schizosaccharomyce

214 esis is the assembly of a stable but dynamic cytokinetic ring made up of the essential tubulin homolo

215 earlier than normal, shortening the stage of cytokinetic ring maturation by 50%.

216 Pom1 restricts to the cell middle cortical cytokinetic ring precursor nodes organized by the SAD-li

217 is high, which ensures proper positioning of cytokinetic ring precursors at the cell geometrical cent

218 s, first promotes the medial localization of cytokinetic ring precursors organized by the SAD kinase

219 tly disrupt the assembly or stability of the cytokinetic ring protein FtsZ, nor does it affect the re

220 tubulins, is a GTPase that assembles into a cytokinetic ring structure essential for cell division i

221 during cytokinesis at midcell, FtsZ forms a cytokinetic ring that constricts as septation progresses

222 its bacterial homologue FtsZ establishes the cytokinetic ring that constricts during cell division.

223 -like FtsZ GTPase into a membrane-associated cytokinetic ring that defines the division plane in bact

224 orescent phalloidin into the medium, and the cytokinetic ring was disrupted after injection of the my

225 The accumulation of actin in the cytokinetic ring was not observed in cells depleted of C

226 ordinates assembly and placement of the FtsZ cytokinetic ring with bipolar localization of the newly

227 multinucleate cells, failure to maintain the cytokinetic ring, and compromised SPB association of the

228 to perform two functions: stabilize the FtsZ cytokinetic ring, and facilitate septal peptidoglycan sy

229 FtsZ forms a cytokinetic ring, designated the Z ring, that directs cy

230 Cytokinesis in bacteria is mediated by a cytokinetic ring, termed the Z ring, which forms a scaff

231 pombe, cytokinesis also involves a conserved cytokinetic ring, which has been generally assumed to pr

232 ents of the tubulin-like protein FtsZ into a cytokinetic ring, which then constricts.

233 nd concentrated at the cell poles and/or the cytokinetic ring.

234 of downstream proteins to form a functional cytokinetic ring.

235 overned by conserved subcomplexes within the cytokinetic ring.

236 tsW to prevent the final constriction of the cytokinetic ring.

237 ling their activation to the assembly of the cytokinetic ring.

238 ynamics in the Caenorhabditis elegans zygote cytokinetic ring.

239 at is required for the dynamic nature of the cytokinetic ring.

240 has been shown to inhibit contraction of the cytokinetic ring.

241 ytoplasmic actin cables, and the actin-based cytokinetic ring.

242 cell division and final constriction of the cytokinetic ring.

243 II may be necessary for localization to the cytokinetic ring.

244 -bud neck late in the cell cycle -a putative cytokinetic ring.

245 age of cell wall material synthesized by the cytokinetic ring.

246 AR protein Cdc15, a central component of the cytokinetic ring.

247 may be in scaffolding, not positioning, the cytokinetic ring.

248 mation, maintenance, and constriction of the cytokinetic ring.

249 dge stability by anillins, key regulators of cytokinetic rings and cytoplasmic bridges [1, 4-7].

250 assembly of diverse actin structures such as cytokinetic rings and filopodia.

251 adoxically, proteins that promote closure of cytokinetic rings are enriched on stably open intercellu

252 ity of myo2-E1-Sup1 cells depend on the late cytokinetic S. pombe myosin II isoform, Myp2p, a non-ess

253 nvestigate the F-BAR domain of the essential cytokinetic scaffold, Schizosaccharomyces pombe Cdc15, d

254 In the presence of dicentrics, the cytokinetic septa pinch the nucleus, suggesting that dic

255 represents a key step in the delivery of the cytokinetic signal to the cortex.

256 ses, the cell assembles essentially the same cytokinetic signaling ensemble-opposed astral microtubul

257 e cell cycle in a ring that marks the future cytokinetic site.

258 e polar and new static complexes form at pre-cytokinetic sites, ensuring positioning at the new pole

259 These inactive cytokinetic SNARE complexes were already assembled at th

260 FtsZ is part of a mid-cell cytokinetic structure termed the Z-ring that recruits a

261 es have noted important distinctions between cytokinetic structures in dividing cells and muscle sarc

262 cates from the pericentrosomal region to key cytokinetic structures including the cleavage furrow, an

263 nderlying the assembly and regulation of the cytokinetic structures.

264 subcellular locations and induce or organize cytokinetic structures.

265 tes the DivJ kinase and directly acts on the cytokinetic tubulin, FtsZ, to tune cytokinesis with the

266 ial tubulin homolog required to assemble the cytokinetic Z ring and recruit the components of the div

267 n Escherichia coli, precise placement of the cytokinetic Z ring at midcell requires the concerted act

268 lis involves a switch in the location of the cytokinetic Z ring from midcell to the pole.

269 The cytokinetic Z ring is required for bacterial cell divisi

270 og of eukaryotic tubulin, assembles into the cytokinetic Z ring that directs cell division in bacteri

271 ell division protein FtsZ assembles into the cytokinetic Z ring that directs cytokinesis in prokaryot

272 gulatory system that limits formation of the cytokinetic Z ring to midcell by preventing its formatio

273 local negative control over assembly of the cytokinetic Z ring to prevent potential cutting of the c

274 n-like FtsZ protein, helping to assemble the cytokinetic Z ring, anchor it to the cytoplasmic membran

275 inD is involved in spatial regulation of the cytokinetic Z ring, and ParAs are involved in chromosome

276 ght about by a change in the location of the cytokinetic Z ring, which is composed of the tubulin-lik

277 erizes in a GTP-dependent manner to form the cytokinetic Z ring.

278 ation required for spatial regulation of the cytokinetic Z ring.

279 , forming a complex that can destabilize the cytokinetic Z ring.

280 ted by FtsZ, which polymerizes to create the cytokinetic Z ring.

281 The formation of the cytokinetic Z-ring by the tubulin homologue FtsZ is regu

282 GTPase FtsZ assemble at midcell to form the cytokinetic Z-ring, which coordinates peptidoglycan (PG)

283 e tubulin-like GTPase, FtsZ, which forms the cytokinetic Z-ring.

284 protein FtsZ assemble at midcell to form the cytokinetic Z-ring.

285 This process requires cytokinetic Z-rings formed by the bacterial tubulin homo

286 symmetric division involves the formation of cytokinetic Z-rings near both poles of the developing ce