ライフサイエンスコーパス: cytolytic

1 of gamma-secretase inhibitor, the antitumor cytolytic ability of gammadelta T cells was inhibited wi

2 Here we show that long after their peak in cytolytic activation, NK cells continue to support viral

3 Apoptotic and cytolytic activities of Abs and pharmacokinetic fluctuat

4 s LukSF-PV and LukED antagonize each other's cytolytic activities on leukocytes and erythrocytes by f

5 ells are innate immune cells known for their cytolytic activities toward tumors and infections.

6 ent proinflammatory and receptor-independent cytolytic activities.

7 t study, we analyzed PD-L1, PD-L2, PD-1, and cytolytic activity (CYT) expression, as well as mutation

8 uch as the complement system, can also exert cytolytic activity against host cells.

9 tes produced negligible IFN-gamma and lacked cytolytic activity against leukemia cells.

10 ased proliferation, cytokine production, and cytolytic activity against melanoma cells.

11 and gammadeltaT cells strongly reduced their cytolytic activity against NKG2D-L(+) targets; this seem

12 th consequent impairment of NK cell-mediated cytolytic activity against various melanoma cell lines.

13 his state was characterized by impairment of cytolytic activity and cytokine secretion, reduced expre

14 he NK and target cells but decreased NK cell cytolytic activity and degranulation.

15 in vivo, demonstrating a link between NKG2D cytolytic activity and EBV antiviral immunity in humans.

16 ion of T-bet and granzyme B and induces weak cytolytic activity and effector IFN-gamma production.

17 exhibited cholesterol-dependent binding and cytolytic activity and formed the typical large CDC memb

18 omotes CD8(+) T cell and natural killer cell cytolytic activity and modulates T cell differentiation

19 st virus infections and cancer through their cytolytic activity and production of cytokines.

20 in the absence of AhR, NK cells have reduced cytolytic activity and reduced capacity to control RMA-S

21 ortant, NKp46(High) NK cells showed a higher cytolytic activity and stronger IFN-gamma secretion than

22 I-associated neoantigens was correlated with cytolytic activity and was lower than expected in colore

23 and shifted animals, and gene, protein, and cytolytic activity assays were performed.

24 Cytolytic activity by CD8(+) cytotoxic T lymphocytes (CT

25 the effector cells regulate the kinetics of cytolytic activity by the effector cells.

26 proinflammatory cytokines and do not display cytolytic activity characteristic of effector CD8(+) T c

27 ytotoxicity receptor (NCR)-dependent NK-cell cytolytic activity directed at HCV-infected and uninfect

28 healthy donor and HCV-infected donor NK-cell cytolytic activity directed at HCV-infected target cells

29 ector memory phenotype, and present a strong cytolytic activity ex vivo.

30 T cell compartment led to markedly increased cytolytic activity following an allogeneic MLR in vitro,

31 ed than uninfected cells, the selectivity of cytolytic activity for infected targets was lower during

32 erferon-gamma signalling, and correlate with cytolytic activity in patient tumours from The Cancer Ge

33 ived from patients with MS exhibit a reduced cytolytic activity in response to antigen-activated CD4(

34 ells that can induce cytokine production and cytolytic activity in resting NK cells.

35 ls demonstrated high IFNgamma production and cytolytic activity in vitro Upon systemic administration

36 PVL and LukGH have potent cytolytic activity in vitro, and both toxins are proinfl

37 trate that AMG 330 has potent CD33-dependent cytolytic activity in vitro, which can be further enhanc

38 Later, in vivo cytolytic activity is detectable, coincident with the in

39 netics of granule delivery and efficiency of cytolytic activity is not well understood.

40 rease in NCR expression and IL28B-associated cytolytic activity may participate in host response to I

41 of the integrin receptor ligation may alter cytolytic activity of CD16.NK-92 cells, we analyzed mole

42 exhibited severely reduced degranulation and cytolytic activity of CTL and NK cells and developed all

43 strate for the first time that hemolytic and cytolytic activity of GBS is due to the ornithine rhamno

44 e intrinsic resistance of tumor cells to the cytolytic activity of immune effectors.

45 The cytolytic activity of Mamu-KIR3DL01(+) NK cells was supp

46 ply that STAT3 inhibitors will stimulate the cytolytic activity of NK cells against leukemia, thereby

47 rom viremic patients with HBV did not induce cytolytic activity of NK cells.

48 n of CD155-expressing CD4(+) T cells and the cytolytic activity of NK cells.

49 (IL-15) and IL-2 in inducing activation and cytolytic activity of NK cells.

50 Of note, high cytolytic activity of NKp46(High) NK cells was also conf

51 causes defective degranulation and impaired cytolytic activity of T and NK cells.

52 lid tissue tumor biopsies, we quantified the cytolytic activity of the local immune infiltrate and id

53 ecule, Mamu-B*017:01, failed to suppress the cytolytic activity of these NK cells.

54 Membrane cholesterol is required for the cytolytic activity of this toxin, but it is not clear wh

55 l recruitment and occurred instead by direct cytolytic activity on free stages of the parasite.

56 fic CD8+ T cell-mediated IL-10 production or cytolytic activity or Foxp3+ regulatory T cell populatio

57 T-cell cytolytic activity targeting epidermal melanocytes is sh

58 during influenza virus infection can acquire cytolytic activity that contributes to protection agains

59 emains unclear whether, in addition to their cytolytic activity that is important in antimicrobial de

60 ion-induced cell death and mediates specific cytolytic activity toward autologous tumor cells upon bl

61 Furthermore, cytolytic activity was associated with higher serum aspa

62 were CD4 T cells, not CD8 T cells, and this cytolytic activity was not dependent on granzyme A/B or

63 Enhanced cytolytic activity was observed for CD8(+) T cells cocul

64 d 1) and programmed cell death 1, markers of cytolytic activity, and fewer chromosomal aberrations.

65 on of PTEN in NK cells resulted in decreased cytolytic activity, and loss of PTEN in CD56(bright) NK

66 APOBEC-mediated mutagenesis, upregulation of cytolytic activity, and PD-L1 positivity.

67 pecific CD4 T cell functions, such as direct cytolytic activity, can contribute to control of HIV vir

68 genes that showed positive association with cytolytic activity, including beta-2-microglobulin (B2M)

69 mplifications were also associated with high cytolytic activity, including immunosuppressive factors

70 FcgammaRs may be essential to achieve a high cytolytic activity, it may be advantageous for other app

71 r profile of cytokines but displayed greater cytolytic activity, secreting perforin, granzyme B, and

72 hese cells have direct ex vivo DENV-specific cytolytic activity.

73 mechanisms of tumor-intrinsic resistance to cytolytic activity.

74 xpansion and allow the acquisition of robust cytolytic activity.

75 potentiates NK cell IFN-gamma production and cytolytic activity.

76 g is needed for IFNgamma release but not for cytolytic activity.

77 , production of intracellular cytokines, and cytolytic activity.

78 anced virus-specific cytokine production and cytolytic activity.

79 d with suppressed circadian expression of NK cytolytic activity.

80 esting that this residue was crucial for VP4 cytolytic activity.

81 ma (IFN-gamma), but not by granzyme-mediated cytolytic activity.

82 n CD56(bright) NK cells resulted in elevated cytolytic activity.

83 apoptosis as key strategies of resistance to cytolytic activity.

84 Although recombinant 9 kDa granulysin is cytolytic against a variety of tumors and microbes, reco

85 eta treatment of NK cells rendered them less cytolytic against oHSV-infected glioblastoma cells and s

86 hile HCV-specific CD8 T-cell activation with cytolytic and antiviral effects was blunted by PD-L1 exp

87 P2X7 receptor channel (P2X7R) operates as a cytolytic and apoptotic receptor but also controls susta

88 f NK cells shows a significant impairment of cytolytic and degranulation activities in patients with

89 mids or the genome had significantly reduced cytolytic and pro-inflammatory capacities, including in

90 N-AgrD displays cytolytic and proinflammatory properties that are abroga

91 ubstitution library of PSMalpha3, a strongly cytolytic and proinflammatory PSM of Staphylococcus aure

92 Antimicrobial, cytolytic, and cell-penetrating peptides induce pores or

93 The cytolytic animal virus equine herpesvirus type 1 (EHV-1)

94 d by the secretion of multiple cytokines and cytolytic antigen-specific T cell responses that were ab

95 he diminished cross-priming and expansion of cytolytic antiviral CD8(+) T cells.

96 Using an in vitro cytolytic assay that involved NK cells primed by wild-ty

97 HLA-A2-expressing but gBK(+) target cells in cytolytic assays.

98 as gC1q receptor, protects host cells from a cytolytic attack by antimicrobial peptides (AMPs), such

99 R-CAR-engineered NK cells displayed enhanced cytolytic capability and IFN-gamma production when co-cu

100 ore strongly expressed but has only moderate cytolytic capacities.

101 , and eomesodermin expression, and increased cytolytic capacity as compared with empty vector control

102 +)2B4(+) CD8(+) T cells that correlates with cytolytic capacity, as measured by perforin expression,

103 increased proliferation, IFNgamma secretion, cytolytic capacity, expression of stemness gene signatur

104 V retain CD8(+) T-cell polyfunctionality and cytolytic capacity.

105 -15-induced effector molecule expression and cytolytic capacity.

106 ffector molecule expression as well as their cytolytic capacity.

107 61(+)CD56(+)LFA-1(-) and more differentiated cytolytic CD161(+)CD56(+)LFA-1(+) NK cells.

108 Identification of latency-associated cytolytic CD4 T cells will aid in dissecting mechanisms

109 Our data suggest cytolytic CD4+ T cells as an independent subset distinct

110 Interestingly, we found that cytolytic CD4+ T cells emerge early during acute HIV inf

111 effects have been described, and a role for cytolytic CD4+ T cells in the control of HIV infection h

112 ter flow cytometric analysis of HIV-specific cytolytic CD4+ T cells revealed a distinct transcription

113 Furthermore, HIV-specific cytolytic CD4+ T cells showed comparable killing activit

114 pic, and functional profiles of HIV-specific cytolytic CD4+ T cells.

115 the noncytolytic CD56(bright) NK cell to the cytolytic CD56(dim) NK cells.

116 tients in MMR and MR(4.5) had a more mature, cytolytic CD57(+)CD62L(-) NK cell phenotype, consistent

117 per cell cytokines or increased migration of cytolytic CD8 T cells within normal tissues.

118 tissue-derived epitopes to directly activate cytolytic CD8 Tcells.

119 n and bone loss by activating tumor-specific cytolytic CD8(+) T cells and decreasing suppressor cell

120 of CD160 and 2B4 delineates a population of cytolytic CD8(+) T cells important for the control of HI

121 BL on tBregs to elicit granzyme B-expressing cytolytic CD8(+) T cells, offering some explanative powe

122 ng MDSC and redox signaling greatly enhanced cytolytic CD8(+) T-cell response and further decreased r

123 ut shared similar features with HIV-specific cytolytic CD8+ T cells.

124 able to clearance by immune cells, including cytolytic CD8+ T cells.

125 ogy allowed analysis of specific circulating cytolytic cells and GNLY contents.

126 yme A expression in CD4 T cells and produces cytolytic cells that can be detected in vivo.

127 ave historically been considered short-lived cytolytic cells that can rapidly respond against pathoge

128 Peripheral LCMV infection can lead to rapid cytolytic clearance or chronic viral persistence; centra

129 Finally, we also elicited cytolytic CMV-specific responses using specific allogene

130 The overall functional status of the cytolytic compartment was studied through epigenetic ana

131 f HIV-specific CD4+ T cells cooperate in the cytolytic control of HIV replication.

132 in proliferation and cytotoxicity, with the cytolytic defect caused by impaired granzyme packaging i

133 ough exocytosis, piecemeal degranulation, or cytolytic degranulation.

134 to loss of cellular membrane integrity with cytolytic disruption and release of intact membrane-boun

135 are attached to the carboxy-terminus of the cytolytic domain and contain a beta-trefoil fold and a b

136 xin (LeTx) are refractory to subsequent high cytolytic doses of LeTx, termed toxin-induced resistance

137 and CD16, Notch signaling induces increased cytolytic effector capacity and cytokine secretion, even

138 of naive CD8+ T cells into fully functional cytolytic effector cells and mediated the production of

139 MHC class Ib-restricted cytolytic effector cells specifically eliminated ERAAP-d

140 The acknowledgment of their cytolytic effector function and the finding that endogen

141 EBV-seropositive donors gained EBV-specific cytolytic effector function following specific allo-HLA

142 ly requires transfer of cells with immediate cytolytic effector function to kill the bulk of fast-gro

143 fectors that can exhibit a helper as well as cytolytic effector function, in an epitope-specific and

144 infected cells from targeted elimination by cytolytic effector functions of the immune system.

145 Importantly, ablation of the cytolytic effector molecule perforin fully protected aga

146 gle dose of the vaccine, with an increase in cytolytic effector molecules.

147 a highly plastic, hyperinflammatory, poorly cytolytic effector population, which we term "inflammato

148 he capacity to produce a continual supply of cytolytic effector progeny until all malignant cells are

149 onovalent CD3 binding arm designed to engage cytolytic effector T cells (referred to as HIVxCD3 DARTs

150 CTL expansion and delayed the expression of cytolytic effectors during activation.

151 mphocytes that can function either as direct cytolytic effectors or to initiate and regulate adaptive

152 illing kinetics of these cells by CD16.NK-92 cytolytic effectors suggesting that changes in integrin

153 CD8+ T cells are primed and differentiate to cytolytic effectors through cross-dressing, and indeed w

154 es at cytolytic synapses, and the ability of cytolytic effectors to kill in an iterative manner has b

155 in cancer clinical trials due to the direct cytolytic effects of this treatment that appear to provo

156 e that reduced viral replication and limited cytolytic efficacy.

157 ade reversed this effect, producing enhanced cytolytic elimination of HCV-infected Huh7.5A2 cells.

158 ctors T-bet and eomesodermin, as well as the cytolytic enzyme perforin, required for the cytotoxic ty

159 ivated by tumor antigens, and to express the cytolytic factor granzyme B.

160 ing the directional release of cytokines and cytolytic factors toward the antigen-presenting cell.

161 bles the directional secretion of cytokines, cytolytic factors, and other soluble molecules toward th

162 s the directional secretion of cytokines and cytolytic factors.

163 Ig-like receptor(+)CD85j(+)) phenotype, with cytolytic function also against immature dendritic cells

164 ts NK cell function via direct inhibition of cytolytic function as well as indirectly by increasing t

165 otein-1beta, and a significant impairment in cytolytic function associated with decreased killer immu

166 ar stomatitis virus infection but comparable cytolytic function at the peak of response.

167 Rab27A missense (p.A87P) mutation on NK cell cytolytic function by cloning it into a lentiviral expre

168 crotubule organizing center polarization and cytolytic function in CD8(+) T cells.

169 lls, accompanied by IFN-gamma production and cytolytic function in T cells.

170 pretreatment of NK cells in vitro inhibited cytolytic function of both human and mouse NK cells.

171 d by an increase of similar magnitude in the cytolytic function of LN lymphocytes.

172 ave impaired T-cell activation and decreased cytolytic function of natural killer (NK) and CD8 T cell

173 s in CD4(+) T cells and was required for the cytolytic function of the in vitro- and in vivo-generate

174 Cytolytic function of the PRF1 p.A91V mutation was teste

175 However, IFN-alpha-enhanced NK cytolytic function was lower in HCV-infected subjects, a

176 load during the early phase of the response; cytolytic function was restored when T cells primed unde

177 R) interact in a feedback manner to regulate cytolytic function with an unknown mechanism.

178 ted by increased NK cell and effector T-cell cytolytic function, reduced T-cell PD-1 expression and r

179 cells, lactic acid causes the loss of their cytolytic function.

180 ells from LDH-A-depleted tumors had improved cytolytic function.

181 or cells require CD4 help for activation and cytolytic function.

182 ession of CD16, perforin, CD57, and impaired cytolytic function.

183 utation, which was shown to decrease NK cell cytolytic function.

184 limumab targeted CTLA-4(+) Treg and restored cytolytic functions of NK cells mediating ADCC.

185 ted the binding of T-bet to the promoters of cytolytic genes in CD4(+) T cells and was required for t

186 pression of genes controlling tissue homing, cytolytic granule composition, type 1 CD8 cytotoxic T ce

187 iminate pathogen-infected cells by releasing cytolytic granule contents--granzyme (Gzm) proteases and

188 I-expressing orexin(+) neurons, resulting in cytolytic granule polarization toward neurons.

189 e Sec/Munc (SM) protein Munc18-2, facilitate cytolytic granule release by cytotoxic T lymphocytes (CT

190 function depends upon directed secretion of cytolytic granules at the immunological synapse (IS) and

191 including novel distribution of F-actin and cytolytic granules at the IS, programed death protein-1

192 tivation and antiviral activity, and produce cytolytic granules during clinical and virological quies

193 Hence, by virtue of the NAADP/TPC pathway, cytolytic granules generate Ca(2+) signals that lead to

194 mic mice displayed a marked reduction in the cytolytic granules perforin and granzyme B.

195 Nine kilodalton granulysin is confined to cytolytic granules that are directionally released follo

196 logical synapse (IS) and the polarization of cytolytic granules toward target cells are essential to

197 ecreased polarization of LFA-1, F-actin, and cytolytic granules toward the cytotoxic synapse.

198 Content in cytolytic granules, as well as cytotoxic activity, of EB

199 the infected epithelial cell exfoliation via cytolytic granules.

200 le organizing center, and the convergence of cytolytic granules.

201 hat lytic granules are highly dynamic at the cytolytic human NK cell IS prior to degranulation and th

202 ively activated and induced proliferation of cytolytic human T cells that killed cells from multiple

203 Finally, expression of IL-15 correlated with cytolytic immune functions in patients with B-cell lymph

204 infection induces a virus-specific adaptive/cytolytic immune response that impacts the plasma viral

205 he AAT-specific T cells in this patient were cytolytic in phenotype, mapped to a peptide in the endog

206 9 secreted different cytokines and were less cytolytic in vitro but surprisingly elicited greater ant

207 Despite being poorly cytolytic in vivo and failing to expand after encounteri

208 y KTX were included, 16,927 (67.5%) received cytolytic induction and 8157 (32.5%) received IL-2RA ind

209 on, and steroid withdrawal; in these groups, cytolytic induction substantially improved clinical outc

210 , and transplant characteristics, the use of cytolytic induction therapy reduced the risk of acute re

211 These data demonstrate that cytolytic induction therapy, as compared with IL-2RA, re

212 ths worldwide, ultimately the consequence of cytolytic infection of CD4(+) T cells.

213 tophagy during the dynamic response of these cytolytic innate lymphocytes.

214 enge, memory CD8(+) T cells are required for cytolytic killing of infected cells, but primary effecto

215 ion of activating receptors, polarization of cytolytic machinery and key signaling molecules, and act

216 Although bidirectional trafficking of cytolytic machinery components along the endosomal pathw

217 of the SNARE protein family, is part of the cytolytic machinery of T and NK cells and involved in th

218 associated gp350(+) particles may divert the cytolytic machinery, impairing its direct action on the

219 evel, particularly greater expression of the cytolytic marker CD107a from TCD4+ following ECTV infect

220 nal load, neoantigen load, and expression of cytolytic markers in the immune microenvironment were si

221 D8(+) T-cells, do not contain high levels of cytolytic markers, and exhibit low levels of activation

222 ively, these results outline RIPK3-activated cytolytic mechanisms essential for controlling respirato

223 F-alpha], and interleukin-2 [IL-2]), and the cytolytic mediator granzyme B.

224 ctivation and the consequent mobilization of cytolytic mediators toward the target cell and suggest t

225 Unlike the potently cytolytic melittin, the loss-of-function peptides, inclu

226 ous combinations of cytokines as well as the cytolytic molecule granzyme B.

227 a [TNF-alpha], and interleukin 2 [IL-2]) and cytolytic molecules (granzyme B) and reduced lung viral

228 d, but most cells lost the expression of all cytolytic molecules and Eomesodermin and T-bet by chroni

229 , and LAG3, accompanied by low expression of cytolytic molecules suggests that the decidual microenvi

230 that T-bet is required for the induction of cytolytic molecules, including perforin and granzyme B i

231 s also secreted IFN-gamma, IL-13, IL-22, and cytolytic molecules.

232 ative response or the secretion of cytokines/cytolytic molecules.

233 Sorafenib-treated Mvarphi increased cytolytic NK cell function against K562, Raji, and HepG2

234 active NADPH oxidase-dependent mechanism of cytolytic, nonapoptotic eosinophil death initiates nucle

235 we also considered viral dynamic models with cytolytic or noncytolytic effector cell responses.

236 cal, alternative, and lectin) and a terminal cytolytic pathway common to all.

237 H is associated with mutations in lymphocyte cytolytic pathway genes, which have not been previously

238 om homozygous mutations in NK and CD8 T cell cytolytic pathway genes.

239 , other amyloidogenic peptides, as well as a cytolytic peptide and a synthetic gel-forming peptide, w

240 identify the first, to our knowledge, fungal cytolytic peptide toxin in the opportunistic pathogen Ca

241 We propose the name 'Candidalysin' for this cytolytic peptide toxin; a newly identified, critical mo

242 e to elucidate the effects of polymyxin-B (a cytolytic peptide), valproic acid (a lipophilic drug), a

243 Spider venom neurotoxins and cytolytic peptides are expressed as elongated precursor

244 An involvement in the maturing of cytolytic peptides is very likely, due to high similarit

245 Granule cytolytic perforin/granzyme C from this cell subsequentl

246 Intermedilysin (ILY), a cytolytic pore-forming toxin that is secreted by Strepto

247 conformational changes occurring in a large cytolytic pore-forming toxin.

248 emonstrated decreased cytokine secretion and cytolytic potential after specific activation.

249 1 T cells characterized by a remarkably high cytolytic potential against cancer cells.

250 d tissue factor production, as well as their cytolytic potential and their helper function for Ab pro

251 tive CTLs have substantial proliferative and cytolytic potential.

252 ector CD8(+) T-cell activation with enhanced cytolytic profiles and, importantly, more powerful memor

253 act through Dicer and miRNAs to control the cytolytic program and other aspects of effector CTL diff

254 master regulator ThPOK, which suppresses the cytolytic program in major histocompatibility complex (M

255 hile significant research has focused on the cytolytic properties of antibodies in acquisition and co

256 venom is stonustoxin (SNTX), a heterodimeric cytolytic protein that induces cardiovascular collapse i

257 Cytolytic proteins and peptide toxins are classical viru

258 rs showed higher levels of expression of the cytolytic proteins granzymes A and B.

259 forin and granzymes A and B (GzmA and GzmB), cytolytic proteins linked to CD8(+) cell effector functi

260 by promoting polarized secretion of soluble cytolytic proteins toward the intended target.

261 cating that PSMalpha3 has evolved to exhibit cytolytic rather than antimicrobial activity.

262 ability to initiate an immediate and direct cytolytic response to virally infected or malignantly tr

263 l killer (NK) and CD8(+) T cells and impairs cytolytic responses against EBV.

264 mune responses, including excessively robust cytolytic responses to M. tuberculosis in vitro, at the

265 leukin-2 and interferon-gamma production and cytolytic responses.

266 These findings provide new insights into the cytolytic signaling pathway of NKG2D and the pathogenesi

267 and cytolysis correlate for weakly adherent/cytolytic strains, and a threshold of attachment was fou

268 y releasing the content of lytic granules at cytolytic synapses, and the ability of cytolytic effecto

269 transcriptional programs that determine CD8+ cytolytic T cell (CTL) fate.

270 Importantly, high intra-tumoral cytolytic T cell inflammation prior to MAPKi therapy pre

271 n of antigenic peptides recognized by CD8(+) cytolytic T cells (CTL).

272 Cytolytic T cells eliminate infected or cancer cells by

273 , a major population of innate-like resident cytolytic T cells, have remained elusive.

274 ector mechanisms used by allospecific CD8(+) cytolytic T cells.

275 proposed to be mediated by hapten-primed CD8 cytolytic T cells.

276 an be used to perform drug screens, to study cytolytic T lymphocyte (CTL) responses to HIV-1, to comp

277 l (Treg) numbers with enhanced expression of cytolytic T lymphocyte-associated antigen 4, potentiatin

278 Natural killer (NK) cells and cytolytic T lymphocytes (CTLs) eliminate pathogen-infect

279 effects, even in the presence of autologous cytolytic T lymphocytes (CTLs) from most patients on HAA

280 and subsequent killing of infected cells by cytolytic T lymphocytes (CTLs) or viral cytopathic effec

281 targeted broadly neutralizing antibodies and cytolytic T lymphocytes, and animal models for the study

282 epitope from PD-L1, and we describe natural, cytolytic T-cell reactivity against PD-L1 in the periphe

283 stimulating robust autologous, WT1-specific cytolytic T-lymphocytes (CTLs).

284 o IFN-gamma- and granzyme-B (GrzB)-producing cytolytic Tc1-like effector cells.

285 l genetic loci that affect the expression of cytolytic toxicity and biofilm formation.

286 Whereas elevated cytolytic toxicity in combination with low levels of bio

287 ytolysin (VCC) is a potent membrane-damaging cytolytic toxin that belongs to the family of beta barre

288 P3 activation requires GBS expression of the cytolytic toxin, beta-hemolysin, lysosomal acidification

289 amino acids in one of three loops of the Bt cytolytic toxin, Cyt2Aa, resulted in enhanced binding an

290 tify novel loci that alter the expression of cytolytic toxins, a polymorphism in the cyoE gene, which

291 s were repressed in their ability to secrete cytolytic toxins, and this appears to be mediated throug

292 Among these molecules are pore-forming cytolytic toxins, including Panton-Valentine leukocidin

293 daptomycin, Agr-triggered secretion of small cytolytic toxins, known as phenol soluble modulins, prev

294 l within a host, including the production of cytolytic toxins.

295 r reducing the ability of HA-MRSA to secrete cytolytic toxins.

296 d RNAIII transcription prevents synthesis of cytolytic toxins.

297 Determine the impact of cytolytic versus IL-2 receptor antibody (IL-2RA) inducti

298 e ability of NK cells to degranulate CD107a+ cytolytic vesicles was reduced (11% vs 22%; P = 0.02), a

299 Given that CVB3 is a cytolytic virus and may therefore damage target cells, w

300 velope, it has been thought to be inherently cytolytic, wherein CVB can escape from the infected host