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1 se to these molecules or their activities is cytopathic.
2 ions of many cell types in vitro are rapidly cytopathic.
3 infection in vertebrate cell lines is highly cytopathic.
4 cell lines, YF infection of immature DCs is cytopathic.
5 latter, we tested XMRV for related MCF-like cytopathic activities in cultured mink cells but found n
6 ) of uropathogenic Escherichia coli exhibits cytopathic activity upon incubation with HEp-2 cells.
7 nto CD4+ T cells intensifies proinflammatory cytopathic allogeneic response and inhibits the developm
8 IN and other alphaviruses and replicons less cytopathic and capable of persisting in some vertebrate
9 agenized forms of the LC correlated with the cytopathic and growth properties of the corresponding en
10 utralizing activity, which quenches both the cytopathic and inflammatory potential of invading microo
12 e 100- to 1,000-fold less permissive to both cytopathic and noncytopathic BVDV infection compared to
16 r interferon activity, measured with a viral cytopathic assay, in CSF and serum from mutation-positiv
17 NV was detected in the brains of hamsters by cytopathic assay, quantitative reverse-transcription pol
19 These mutations made VEEV dramatically less cytopathic but had no effect on infectious virus product
20 y the fusion (F) glycoprotein and is clearly cytopathic, but other aspects of RSV infection may also
24 mmon (21.4%) and was characterized by sparse cytopathic changes but significant inflammation and fibr
25 means of EGFP fluorescence in the absence of cytopathic changes increases the sensitivity of virus de
26 ve DRG tissue damage and cell loss such that cytopathic changes observed at day 70 were more severe t
27 dendrocytes in prephagocytic lesions exhibit cytopathic changes that include apoptosis of oligodendro
29 s and epithelial bovine cells indicated that cytopathic (cp) BVDV induces IFN-alpha/beta very ineffic
30 s, we investigated the effects of the highly cytopathic CXCR4-tropic HIV-1 variant ELI6 on primary CD
32 d duck myotubes was accompanied by extensive cytopathic damage with marked myotube apoptosis (widespr
35 gy that almost exclusively targets activated cytopathic donor reactive T cells and spares immunoregul
36 reatment that selectively destroys activated cytopathic donor reactive T cells while sparing resting
37 SVV-infected Vero cells at the height of the cytopathic effect (3 days after infection) and chemilumi
40 usion and ionic exchange and then tested for cytopathic effect (CPE) and collagenolytic activity in v
41 ir replication and their ability to generate cytopathic effect (CPE) and to interfere with other vira
42 The observed antiviral activities from the cytopathic effect (CPE) based assay were confirmed throu
43 protection against the Acanthamoeba-induced cytopathic effect (CPE) by an additional mechanism that
45 displayed extensive syncytium formation and cytopathic effect (CPE) following infection with MV, con
46 to cause disease can be correlated to their cytopathic effect (CPE) in tissue culture characterized
47 the V protein (rSV5VDeltaC) induces a severe cytopathic effect (CPE) in tissue culture whereas wild-t
48 to adhesion, the parasites produce a potent cytopathic effect (CPE) leading to target cell death.
51 ltiplicity of infection does not result in a cytopathic effect (CPE) within 14 days postinfection (dp
52 rom this clade was found to induce a variant cytopathic effect (CPE), different from the canonical ar
53 DA) and monitored infected cell cultures for cytopathic effect (CPE), intra- and extracellular viral
54 rtebrate origin, is the rapid development of cytopathic effect (CPE), which is strongly dependent upo
57 ssion of dominant negative Akt induced early cytopathic effect and caspase-mediated cell death in ade
58 d stress conditioned mice lacked significant cytopathic effect and clearance was demonstrated in 95%
59 linical isolate and examined in situ for CMV cytopathic effect and immediate-early and early antigens
60 irulence, as indicated by decreased observed cytopathic effect and inflammatory biomarker production.
61 s (Ed MeV) transcription caused an increased cytopathic effect and mortality in transgenic hsp70-over
62 U/ml) in mosquito cells, producing extensive cytopathic effect and plaques, but they do not appear to
63 transfected into both cell types resulted in cytopathic effect and recovery of functional virus, indi
64 ent reduced the number of cells displaying a cytopathic effect and the accumulation of immediate earl
66 were rescued, 3 mutant viruses generated no cytopathic effect but were competent to synthesize viral
67 he concentration of acyclovir that inhibited cytopathic effect by 50% (EC50) was > or = 3 microg/mL w
68 pression of miR-155 rescued cells undergoing cytopathic effect caused by infection with subgroup B av
69 atitis C viral load in vitro and reduced the cytopathic effect caused by the fully replicating flaviv
70 hanced interferon-mediated resistance to the cytopathic effect caused by VSV and Sindbis virus (SNV).
71 MOIs 0.1, 1, and 10 resulted in significant cytopathic effect consisting of excessive syncycial form
72 e eliminated by the immune response or viral cytopathic effect have failed, indicating the need for a
74 als based on the alleviation of HCV-mediated cytopathic effect in an engineered cell line-n4mBid.
75 6, and MA104 cells, but there was no visible cytopathic effect in Caco-2, Mv 1 Lu, or PK(15) cells.
79 observed previously, HCMV induced a typical cytopathic effect in human aortic endothelial cells (HAE
80 g that the SV5 P/V mutant has both a reduced cytopathic effect in human DC compared to WT SV5 and an
84 ute virus of canines (MVC) produces a strong cytopathic effect in permissive Walter Reed/3873D (WRD)
85 n compound 5o that inhibited a virus-induced cytopathic effect in the entry stage of infection (EC(5)
88 lly characterized the MVC infection-produced cytopathic effect in WRD cells, namely, the cell death a
92 results in 50% protection from virus-induced cytopathic effect is approximately 2.2 microM, with a th
94 in the in vitro replication, plaque size, or cytopathic effect morphology of HVP2ap versus HVP2nv iso
96 enhanced toxin production and increased the cytopathic effect of C. difficile on cultured fibroblast
97 a protein responsible for the characteristic cytopathic effect of clinical HCMV strains that also pro
98 ne thymus protects human thymocytes from the cytopathic effect of HIV-1, suggesting a possible approa
99 inhibit HIV-1 reverse transcriptase and the cytopathic effect of HIV-1RF and HIV-1IIIB at submicromo
101 e treatment can increase gene expression and cytopathic effect of neurotropic paramyxoviruses, includ
104 esis of Acanthamoeba keratitis by inducing a cytopathic effect on the corneal epithelial and stromal
105 more slowly in Vero cells and had less of a cytopathic effect on tissue culture cells but caused sev
107 Analysis of SAFV-2 revealed virus growth and cytopathic effect only in human cell lines, with large p
109 C is primarily attributable to direct viral cytopathic effect or to an immune-mediated response.
110 ng a surrogate cell entry system resulted in cytopathic effect rates similar to those of other LCTs a
111 lebbing also frequently occur as part of the cytopathic effect seen during many different viral infec
113 ortive infection in limited cell lines and a cytopathic effect suggestive of herpes simplex virus.
115 V-IFNbeta was greatly reduced and diminished cytopathic effect was observed due to the production of
122 mmalian cells in culture results in a severe cytopathic effect within 24 to 48 h postinfection manife
123 in three fates: 1) cell death due to a viral cytopathic effect, 2) cell death due to immune clearance
124 and formation of NS1 tubules, a decrease in cytopathic effect, an increased release of infectious vi
125 -challenged macrophages include an apoptotic cytopathic effect, an innate antiviral response, and a m
126 plicity of infection leads to no discernible cytopathic effect, and low virus titers are produced.
128 with replicating CCR5-tropic HIV-1, without cytopathic effect, exhibit selective attenuation of the
129 g virus clearance without the development of cytopathic effect, may prove crucial in the design of ne
130 e protease inhibitors do not abolish the Cif cytopathic effect, suggesting that another enzymatic act
131 n of SRSF2 enhanced reovirus replication and cytopathic effect, suggesting that T1L mu2 modulation of
132 NA can persist for weeks in the absence of a cytopathic effect, yet viral RNA remains detectable.
148 cked collagenolytic activity, migration, and cytopathic effects (CPE) against corneal cells in vitro.
150 fected with TR showed delayed development of cytopathic effects (CPE) and replication centers and she
151 F-1, but RCASBP M2C (4070A) caused extensive cytopathic effects (CPE) in DF-1 cells whereas RCASBP M2
153 this paradox, we studied the replication and cytopathic effects (CPE) of late-stage R5 HIV-1 biologic
155 uggested that the delay in the production of cytopathic effects after transfection may have been due
156 ular virus exhibited a significantly reduced cytopathic effects and apoptosis in infected cells, impl
159 y, DC infected with WT rSV5 showed extensive cytopathic effects and increased levels of active caspas
160 ivalent to that of rOka, causing significant cytopathic effects and infectious virus production by da
161 ine 40 of NEDD8 to glutamate (Q40E), causing cytopathic effects and inhibiting cell proliferation.
163 nhibitor to DC infected with WT rSV5 reduced cytopathic effects and resulted in higher surface expres
164 on (MV-Edm) and wtF (MV-wtF) confer distinct cytopathic effects and strengths of hemagglutinin (H) in
165 ycle and a main viral factor responsible for cytopathic effects and subversion of antiviral defense.
166 tease activity is critical for TcdB-mediated cytopathic effects and TcdB systemic toxicity, highlight
167 tion, protect resting CD4 T cells from these cytopathic effects and, primarily through this protectio
172 ese cell types include direct infection with cytopathic effects as a consequence of replication.
173 of these siRNAs to prevent or reduce certain cytopathic effects associated with HCMV infection was al
174 tem eliminates the negative influence of the cytopathic effects associated with replication of SIVMne
176 steine proteases were identified as enabling cytopathic effects by promoting adhesion of T. foetus to
179 uch more resistant than control cells to the cytopathic effects caused by influenza virus infection.
180 3k and Akt, we show that VSV replication and cytopathic effects do not require activation of these ki
181 y as a discipline has depended on monitoring cytopathic effects following virus culture in vitro.
183 educed viral proliferation and virus-induced cytopathic effects in glial cell lines and human astrocy
186 d that cholesterol supplementations increase cytopathic effects in tissue culture and also intensify
189 ters in human lung grafts and caused similar cytopathic effects irrespective of the presence of human
190 it does in B cells, but instead resulted in cytopathic effects more commonly associated with product
192 , and 40, which exhibit EC(50)'s against the cytopathic effects of HIV-1 of 9.0, 1.0, and 4.0 nM, res
194 eplicated readily in cell culture, producing cytopathic effects of rounding, detachment, and syncytiu
197 ly indirect in nature and possibly linked to cytopathic effects of these robustly replicating viruses
200 of other viral components causes many of the cytopathic effects of VSV, including an inhibition of ho
203 e cell-associated and purified form elicited cytopathic effects on cultured kidney and bladder epithe
205 combinant vectors exhibited virus yields and cytopathic effects similar to the parental G47Delta.
206 lular expression of the protein could induce cytopathic effects similar to those observed when the to
208 V protein is capable of inducing more severe cytopathic effects than the wild type, implicating measl
214 cat with chronic sinusitis and rhinitis when cytopathic effects were observed in Crandall-Reese felin
217 n bronchial epithelial Calu-3 cells, causing cytopathic effects, a process reflective of its natural
218 icantly lowering viral load and direct viral cytopathic effects, and aborting the potential downstrea
219 for viral propagation, enteroviral-mediated cytopathic effects, and the development of cardiomyopath
220 , starting at 24 h, RAW264.7 cells exhibited cytopathic effects, annexin V staining, and cleaved casp
221 proach, infected cells will not die of viral cytopathic effects, but might be eliminated if HIV-speci
222 esting CD4(+) T cells survived despite viral cytopathic effects, even in the presence of autologous c
223 heless, A28-deficient virions did not induce cytopathic effects, express early genes, or initiate a p
224 range of anogenital HPV genotypes to induce cytopathic effects, we examined the influences of HPV ty
226 can perturb nuclear architecture and induce cytopathic effects, which ultimately lead to disease pat
241 emyelination can be independent direct viral cytopathic events, and suggest that similar direct axona
249 he non-heated animals supported a persistent cytopathic infection at 21-day post infection (PI) based
251 howed that the NiV Bangladesh strain induced cytopathic lesions in lung grafts similar to those descr
252 studies suggest that, although production of cytopathic lipids is relatively common among mycobacteri
253 ral strains of mycobacteria studied produced cytopathic lipids, none of these produced a phenotype on
254 It replicates in hepatocytes but is non-cytopathic; liver damage is thought to be immune mediate
260 lication, mediated the development of a more cytopathic phenotype, and made viruses capable of develo
262 of correlation between entry efficiency and cytopathic properties of envelope glycoproteins with vir
265 dicate that cytokines that promote antiviral cytopathic responses also regulate expression of the cyt
268 IG-I/MAVS in response to superinfection with cytopathic RNA viruses, virus-induced mitochondrial apop
270 from enteroaggregative Escherichia coli is a cytopathic serine protease, which is prototypical of a l
271 es replicate faster in ECs and are partially cytopathic, suggesting enhanced virulence of these isola
272 ur results provide proof of principle that a cytopathic SV5 P/V mutant can serve as an oncolytic viru
273 y virus type 1 (HIV-1) infection and promote cytopathic syncytium formation in infected cells commenc
274 demonstrated that deletion of donor-reactive cytopathic T cell clones is indeed profound in tolerant
276 nd Pit1, that are necessary for infection by cytopathic, T-cell-tropic feline leukemia viruses (FeLV-
277 VEE and EEE replicons appeared to be less cytopathic than Sindbis virus-based constructs that we d
278 r domain that were proteolytic but no longer cytopathic; these mutants displayed decreased binding an
279 al isolates contained cell-associated lipids cytopathic to fibroblasts at concentrations of 33 to 1,0
281 s, including dentilisin, a protease which is cytopathic to host cells, and FhbB, a unique T. denticol
282 ed in the appearance of Cp aggregates around cytopathic vacuole type I (CPV-I) structures, the absenc
283 In this study, we investigated the role of cytopathic vacuole type II (CPV-II) through in situ elec
284 own to lead to formation of so-called type 1 cytopathic vacuoles (CPV1s), whose distinguishing featur
287 iral hepatitis, CCL5 and CXCL10 regulate the cytopathic versus antiviral immune responses of T cells
288 Because IAV has long been characterized as a cytopathic virus (based on its ability to rapidly lyse m
289 during infection, was converted to a mildly cytopathic virus after NF-kappaB induction before virus
291 Vesicular stomatitis virus (VSV) is a highly cytopathic virus being developed as a vaccine vector due
293 Human parainfluenza virus type 3, a mildly cytopathic virus that induced NF-kappaB very early durin
296 ons of the central nervous system (CNS) with cytopathic viruses require efficient T cell responses to
298 o be required for protection against acutely cytopathic viruses, such as the neurotropic vesicular st
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