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2 LI2DeltaN in human keratinocytes resulted in cytoplasmic accumulation and nuclear relocalization of b
4 n most cases of ALS is nuclear depletion and cytoplasmic accumulation of the protein TDP-43 in degene
6 urin inhibitor-induced tubular SNAI1 protein cytoplasmic accumulation, possibly because of impaired S
9 S or Act1) is an oxidative stress-responsive cytoplasmic adapter molecule that is an upstream regulat
11 generative disorders are associated with the cytoplasmic aggregation of microtubule-associated protei
12 horylation and 14-3-3 protein binding of the cytoplasmic amino-terminus of iRhom2 alter its interacti
14 s and had an intermediary distribution (both cytoplasmic and cortical, but restricted to the cell api
16 capsid protein revealed differences in their cytoplasmic and nuclear accumulation, and data from quan
18 ntitative large-scale proteomics analysis of cytoplasmic and nuclear fractions from normal versus reg
21 nsional single-cell measurements of size and cytoplasmic and nuclear morphology in high throughput, b
22 rties, we determined that this dye defect is cytoplasmic and occurs due to a highly elevated dye iont
23 ure-function analysis suggests that the NRP1 cytoplasmic and transmembrane domains are necessary and
24 romote greater antibiotic influx to increase cytoplasmic antibiotic concentration for enhanced cytoto
25 ctin cytoskeleton is a critical regulator of cytoplasmic architecture and mechanics, essential in a m
27 hiostrepton acted synergistically to inhibit cytoplasmic AURKA activity and disrupt the nuclear AURKA
28 Supraphysiologic doses induced formation of cytoplasmic autophagic vacuoles and activation of protea
29 disabilities and psychiatric disorders.Brain cytoplasmic (BC1) RNA is a non-coding RNA that has been
31 form of the full-length approximately 7-kDa cytoplasmic C terminus in cultured cells and purified fr
34 Ca(2+)-permeable channels that can regulate cytoplasmic Ca(2+) and are needed to induce the expressi
36 pped attachment to the pore and contacts the cytoplasmic Ca(2+)-binding domain from a neighbouring su
38 ndings guided development of an inhibitor of cytoplasmic cap methylation whose action resulted in a s
40 at has proven to be capable of following the cytoplasmic changes of iron concentration dynamics and w
43 ; the cytoplasmic Cu(+) sensor CueR controls cytoplasmic chaperones and plasma membrane transporters,
45 In this study, we focus on the LPS-induced cytoplasmic circRNA, mcircRasGEF1B, and combine targeted
46 activated chloride channel (CaCC), regulates cytoplasmic Cl(-) homeostasis and promotes plasma membra
47 ncovers a critical function of CaCC-mediated cytoplasmic Cl(-) homeostasis in controlling the organiz
51 strate RNA to nuage, a distinct membraneless cytoplasmic compartment, which surrounds the nucleus of
52 NAs and small noncoding RNAs, but also their cytoplasmic compartmentalization during spermiogenesis.
54 hway that involves sequestration of selected cytoplasmic components by multilayered vesicles called a
56 trides have been made toward elucidating the cytoplasmic components of MAPK signaling, the key downst
57 adian regulation of membrane conductance and cytoplasmic conductivity that depends on the cycling of
58 lular mitochondrial modifications that alter cytoplasmic conductivity, and these changes are benchmar
59 operatively enable the efficient severing of cytoplasmic connections between dividing daughter cells.
60 ns mainly support exchange of lipids but not cytoplasmic content between cells, resembling hemifusion
61 as the passive outcome of the difference in cytoplasmic content of egg and sperm; however, active pr
63 levels appear independently controlled; the cytoplasmic Cu(+) sensor CueR controls cytoplasmic chape
66 the mouse, the protein had a broad punctate cytoplasmic distribution in the vestibular hair cells, w
69 he VEGF164-binding site of NRP1 and the NRP1 cytoplasmic domain (NCD), but not the known NCD interact
71 is report, we investigated the role of CD103 cytoplasmic domain and the focal adhesion-associated pro
76 , coupled with the contrasting intracellular cytoplasmic domain of LAG3 as compared with other IRs, h
77 when V1 is released from Vo, the N-terminal cytoplasmic domain of subunit a (aNT) changes conformati
78 of the Galpha13 protein from binding to the cytoplasmic domain of the beta3 integrin prevents outsid
80 y we showed that salt bridges located at the cytoplasmic domain subunit interfaces (CD-Is) of eukaryo
81 erized, 12-amino acid region within the NRP1 cytoplasmic domain that mediates HH signal promotion.
85 t conformation by integrin transmembrane and cytoplasmic domains must be overcome by cellular energy
87 ial roles for the receptor transmembrane and cytoplasmic domains, as well as for the TARP extracellul
89 rotubules are polarity sorted in the axon by cytoplasmic dynein but that additional factors are also
93 sitioning, are mediated by the motor protein cytoplasmic dynein, which produces force on the microtub
97 gical and genetic manipulation, we show that cytoplasmic dynein-1, which localizes to the junction be
98 sitive to BFA treatment, indicating that the cytoplasmic effector follows an alternative route for de
101 us sites for delivery of both apoplastic and cytoplasmic effectors during infection, following distin
103 ner pore formed by the criss-crossing of the cytoplasmic ends of the S6 segments (the S6 bundle cross
104 changes in mitochondrial positioning affect cytoplasmic energy distribution and cell migration, an e
105 cation, gene expression, capsid assembly and cytoplasmic envelopment, and transcellular transmission
107 great interest to study the contribution of cytoplasmic Esrp1 in maintenance of epithelial cell func
108 rate that the production of both nuclear and cytoplasmic Esrp1 isoforms through alternative splicing
109 ntegrates nuclear and previously unsuspected cytoplasmic events of centriole amplification, providing
110 ncrease in K(+) selectivity at low pH on the cytoplasmic face, for instance, appeared to be associate
118 CLIP), in which chromatin, nucleoplasmic and cytoplasmic fractions are prepared from UV-crosslinked c
121 it both specific and overlapping nuclear and cytoplasmic functions, have different expression levels
123 and water sites and a helix controlling the cytoplasmic gate of KdpA is linked to the phosphorylatio
124 entiation was accompanied by upregulation of cytoplasmic gelsolin (cGSN), an abundant actin-severing
125 e differentiation and maturation through the cytoplasmic gelsolin signaling pathway, providing new dr
127 in development and is localized in distinct cytoplasmic granules where its target mRNA can be detect
131 emistry (IHC) showed increased expression of cytoplasmic HMGB1 in dengue-extracted tissues when compa
132 rmoxia, miR-574-3p, acting as a decoy, binds cytoplasmic hnRNP L and prevents its binding to the CARE
135 and nestin, we show that the distribution of cytoplasmic IFs results from a continuous turnover based
136 2R-MIP was diminished and almost exclusively cytoplasmic in the HeLa cells; whereas the WT-MIP was st
137 he ER in wild-type plants but accumulated as cytoplasmic inclusions in get1, get3, or get4 mutants.
141 zannae (iES), infected by Cardinium inducing cytoplasmic incompatibility (CI), and its sibling specie
142 hia parameters including, bacterial density, cytoplasmic incompatibility, or resistance to infection
143 The most common reproductive manipulation is cytoplasmic incompatibility, which results in embryonic
145 formation, it almost exclusively focused on cytoplasmic interactions among receptors and other chemo
149 Truncation experiments revealed that the cytoplasmic juxtamembrane domain is necessary for maxima
151 Mass spectrometry analysis demonstrated that cytoplasmic LANA isoforms were full length, containing t
153 o have different proportions of nucleoid and cytoplasmic localization by altering their length and/or
154 e activity, L290P/V mutations enhance ERK3's cytoplasmic localization by increasing the interaction w
159 apping experiments identified histidine-rich cytoplasmic loops within the ZIP6/ZIP10 heteromer as a n
160 ily in the carboxyl terminus but also in the cytoplasmic loops, and subsequent binding of arrestins.
162 f intercellular connectivity is to transport cytoplasmic materials from 'nurse' cells to oocytes, a c
164 enerate holes in the cell wall through which cytoplasmic membrane material protrudes and is released
166 ation of a galactoside and a H(+) across the cytoplasmic membrane of Escherichia coli (galactoside/H(
167 nic pathway for protein secretion across the cytoplasmic membrane or insertion of integral membrane p
168 led cytochrome bd 1 ubiquinol oxidase in the cytoplasmic membrane show that CpcA-PEB and CpcA-PCB are
169 are unclear, as these cells possess a single cytoplasmic membrane that is surrounded by a thick cell
170 , predicted to export the protein beyond the cytoplasmic membrane, resulted in loss of functional tra
173 ains the so-called common region (CR) at the cytoplasmic/membrane interface still has the ability to
175 ir proteins to segregate away from DNA, with cytoplasmic mis-localization sustained for many hours as
176 ase in secreted MMP-9 and an accumulation of cytoplasmic MMP-2 over time, but no significant MMP-3 or
177 umor cell contact allows for the transfer of cytoplasmic molecules from macrophages to tumor cells co
181 ansfer energy metabolites to neurons through cytoplasmic "myelinic" channels and monocarboxylate tran
182 s present in skeletal muscle and has a large cytoplasmic N-terminal domain and smaller C-terminal por
183 nd cell volumes decrease with the nuclear-to-cytoplasmic (N/C) volume ratio reaching a maximum at the
184 te-aspartate shuttle, which is important for cytoplasmic NAD(+) regeneration that sustains rapid gluc
185 nd low-molecular-weight isoform of cyclin E (cytoplasmic)-negative) is a reliable prognostic biomarke
187 ing (SHAPE-MaP) to probe PAN in its nuclear, cytoplasmic or viral environments or following cell/viri
190 ttenuated glucose consumption, Bcl-xL blocks cytoplasmic p53 from triggering intrinsic apoptosis.
191 inds and suppresses over half of nuclear and cytoplasmic p53 under normal conditions, independent of
192 oncogene signaling, glucose metabolism, and cytoplasmic p53, which may potentially be exploited for
196 ead-to-tail" dimer upon binding ATP; and the cytoplasmic pathway, found closed off in other ATP-bindi
197 liferation-associated 1 like 1) binds to the cytoplasmic PDZ-ligand motif of aquaporin-2 and accelera
198 dynamics, imaged in Colo357 spheroids using cytoplasmic pH as a read-out, indicated that lactate ani
202 protein level and shortens the half-life of cytoplasmic Plk3 in a ubiquitin-proteasome-dependent man
204 ipt each terminating ribosome returns to the cytoplasmic pool before initiating anew on a different t
207 l expansion, and an accelerated severance of cytoplasmic projections between the cumulus cells outsid
208 we show that Beclin 1 is a prenatal primary cytoplasmic protein but rapidly relocated into the nucle
209 s as an example, we study the influence of a cytoplasmic protein domain on the clustering behaviour.
210 mbrane segment produce loose clusters, while cytoplasmic protein interactions mediate a tightly packe
213 tners and localizes to both intranuclear and cytoplasmic protein quality control (PQC) aggregates und
217 ndings reveal information encoded within the cytoplasmic proteins required for their unconventional s
222 e Cat L inhibitor Z-FY-CHO led to nuclear-to-cytoplasmic relocalization of Cat L, decreased binding o
223 To investigate the potential role of MT1-MMP cytoplasmic residue Thr(567) phosphorylation in regulati
225 d to be mediated through phosphorylation and cytoplasmic retention of YAP and reduced expression of d
226 sugar modifications can become localized to cytoplasmic ribonucleoprotein granules such as stress gr
227 PSI (+)] shows the appearance of fluorescent cytoplasmic rings when the prion domain is fused with GF
230 omic RNA within incoming virus particles via cytoplasmic RNA sensors to produce type I interferon (IF
231 whereas the lumenal loop and the N-terminal cytoplasmic segment are necessary for the functional int
232 subsequent YAP Ser-127 phosphorylation, YAP cytoplasmic sequestration, and reduction in YAP target g
233 ergistic effect on hD4R levels is noted when cytoplasmic serine (Ser) and threonine (Thr) residues ar
234 s 176-192) that contributes to CASZ1 nuclear-cytoplasmic shuttling in a chromosomal maintenance 1-dep
244 lecules despite the apparent lack of an open cytoplasmic sleeve, forcing the reassessment of the mech
245 A poorly understood adaptive pathway links cytoplasmic slicing of target RNA by the PIWI protein MI
247 f Pseudomonas aeruginosa catalyzes the first cytoplasmic step in recycling of muropeptides, cell-wall
248 a B12-processing enzyme involved in an early cytoplasmic step in the cofactor-trafficking pathway.
251 significant degradation in cell membrane and cytoplasmic structures, compared to expression of cataly
252 localized to the periphery of virus-encoded cytoplasmic structures, termed virus factories (VFs), wh
253 addition to their canonical function at the cytoplasmic surface of the plasma membrane (PM), where t
254 tion creates high-contrast, 3D images of the cytoplasmic surface of the plasma membrane but is more c
255 ring metaphase and early anaphase and to the cytoplasmic surface of the SPBs during late anaphase.
256 ions of transmembrane helices 6 and 7 at the cytoplasmic surface using site-directed spin labeling an
257 cts with a soluble transducer protein on its cytoplasmic surface, and its binding affinity is modulat
258 h interactions with host cell machinery, the cytoplasmic tail (CT) of F is a likely interactive domai
259 chimeric form in which its transmembrane and cytoplasmic tail (TMCT) domains were replaced with those
260 ermining talin binding to the beta3-integrin cytoplasmic tail and inducing a kink in the transmembran
263 al regulation of the Thr(567) in the MT1-MMP cytoplasmic tail may function as a regulatory mechanism
265 tinin competes with talin for binding to the cytoplasmic tail of beta3-integrin, whereas it cooperate
269 nomodulatory fusion proteins (IFPs) with the cytoplasmic tail replaced by the signaling domain of the
270 ur results show how Pxn binding to the CD103 cytoplasmic tail triggers alphaEbeta7 integrin outside-i
271 in the membrane-proximal region of the GluA2 cytoplasmic tail, and suggest a distinct model for the r
276 omal protein, RACK1, and that an increase in cytoplasmic TDP-43 represses global protein synthesis, a
278 vely exports phospholipid complexes from the cytoplasmic to the exocytoplasmic leaflet of membranes.
280 Cell, Roh-Johnson et al. (2017) reveal that cytoplasmic transfer from macrophages to melanoma cells
281 HIV genomic DNA within infected cells during cytoplasmic transit, nuclear import, and mRNA synthesis.
282 increases Akt phosphorylation, which induces cytoplasmic translocation of FoxO1 and suppression of No
284 pathways, including RNA splicing and nuclear-cytoplasmic transport have been increasingly linked both
288 d cells lacking all ATG8 proteins accumulate cytoplasmic UB aggregates, which are resolved following
289 ines RNF8 and UBC13 as components of a novel cytoplasmic ubiquitin-signaling network that suppresses
291 opathy biopsy specimens suggested that SNAI1 cytoplasmic up-regulation was preceded by a transient in
296 e a means to unravel the significance of the cytoplasmic versus the secreted form of mutant SOD1 in t
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