ライフサイエンスコーパス: cytoplasmic domain

1 equires its transmembrane domain but not its cytoplasmic domain.

2 o induce important allosteric changes in the cytoplasmic domain.

3 e domain, serine rich region and a conserved cytoplasmic domain.

4 exinA4 requires the Sema domain, but not the cytoplasmic domain.

5 ssociate with actin filaments and the ICAM-1 cytoplasmic domain.

6 rane-distal NPxY motif in the beta1 integrin cytoplasmic domain.

7 eir dendrites, an effect that requires Drl's cytoplasmic domain.

8 se cleavage, or nuclear translocation of its cytoplasmic domain.

9 rolling expression of multiple genes via its cytoplasmic domain.

10 binding to 2 sites within the integrin beta cytoplasmic domain.

11 the phosphorylation state of Ser-811 in its cytoplasmic domain.

12 the extreme C terminus of the beta4 integrin cytoplasmic domain.

13 y latrunculin B treatment or by deleting the cytoplasmic domain.

14 ent of proteins onto the beta integrin chain cytoplasmic domain.

15 channel, feeding the regulatory sites in the cytoplasmic domain.

16 r potassium (Kir) channels is the unique Kir cytoplasmic domain.

17 se function but was dependent upon an intact cytoplasmic domain.

18 similarly interacts with the PilC C-terminal cytoplasmic domain.

19 with increased contractility in the central cytoplasmic domain.

20 om2 but not by iRhom2 lacking its N-terminal cytoplasmic domain.

21 pH, independent of SLC4A2's long N-terminal cytoplasmic domain.

22 osmotic stress by binding to its C-terminal cytoplasmic domain.

23 line mutagenesis to modulate disorder in the cytoplasmic domain.

24 on to both the stalk region and parts of the cytoplasmic domain.

25 Y6 of a potential hemi-ITAM motif in BST2's cytoplasmic domain.

26 d by two transmembrane segments and a single cytoplasmic domain.

27 ossibly due to aggregation propensity of its cytoplasmic domain.

28 iplasmic domains and transcription activator cytoplasmic domains.

29 /Toll-7 in wiring specificity, nor are their cytoplasmic domains.

30 with the participation of extracellular and cytoplasmic domains.

31 ST-2 by Vpu involved an interaction of their cytoplasmic domains.

32 ATPases via their interactions with its two cytoplasmic domains.

33 horylation sites of the tomato BRI1 and BAK1 cytoplasmic domains.

34 between fluorescent proteins fused to SERCA cytoplasmic domains.

35 to characterize the regulatory roles of CLC cytoplasmic domains.

36 protein-protein interactions involving their cytoplasmic domains.

37 ed sites were found in the N- and C-terminal cytoplasmic domains.

38 tructurally, BST-2 consists of an N-terminal cytoplasmic domain, a transmembrane domain, an ectodomai

39 In the structure, the cytoplasmic domain adopts a closed conformation and the

40 ndicate a means for how the K(2P) C-terminal cytoplasmic domain affects the C-type gate which lies ap

41 tromal cells lacking the signaling SIRPalpha cytoplasmic domain also had a defect in osteogenic diffe

42 in (part of V0) that possesses an N-terminal cytoplasmic domain and a C-terminal hydrophobic domain.

43 es, an effect that depended on the TbetaRIII cytoplasmic domain and did not require TbetaRIII ectodom

44 is a conserved property of the MLV glycoGag cytoplasmic domain and involves AP-2-mediated endocytosi

45 CaMK2D also phosphorylates CEACAM1 on its cytoplasmic domain and mutation of these phosphorylation

46 t with human BST-2 carrying the rhesus BST-2 cytoplasmic domain and partially neutralized the ability

47 on reminiscent to the PRC but located in the cytoplasmic domain and possibly stabilized by D38.

48 g through an ER retention motif, whereas the cytoplasmic domain and prodomain processing are not requ

49 dues in different protein domains, the first cytoplasmic domain and the first membrane-spanning domai

50 is report, we investigated the role of CD103 cytoplasmic domain and the focal adhesion-associated pro

51 red a novel interaction between the calnexin cytoplasmic domain and UBC9, a SUMOylation E2 ligase, wh

52 pressing FcgammaRIIa and FcgammaRIIb lacking cytoplasmic domains and in which the transmembrane domai

53 teracts with VEGFRs through their respective cytoplasmic domains and promotes VEGFR activation in flo

54 of a protein complex containing Vpu and BST2 cytoplasmic domains and the core of the clathrin adaptor

55 of arid3a from the plasma membrane while the cytoplasmic domain appears critical for the cleavage of

56 rk between the ligand-binding pocket and the cytoplasmic domains appears to play a similar role in si

57 ple for how the widespread four-helix bundle cytoplasmic domain architecture can control VGIC respons

58 dynamics within the intrinsically disordered cytoplasmic domain are important for the allosteric regu

59 the last C-terminal 10 amino acids in Cad11 cytoplasmic domain are required for Amot binding.

60 trated that the ectodomain and transmembrane-cytoplasmic domains are connected via a membrane-proxima

61 imal hinge region, thus merely transmembrane-cytoplasmic domains are modeled.

62 as well as throughout the transmembrane and cytoplasmic domains as a result of the elimination of th

63 er mobility (configurational entropy) in the cytoplasmic domain, as confirmed through an order parame

64 ial roles for the receptor transmembrane and cytoplasmic domains, as well as for the TARP extracellul

65 Binding of ICAP1 (integrin cytoplasmic domain-associated protein-1) to the cytoplas

66 he R165A mutation results in splaying of the cytoplasmic domains away from the central axis and that

67 eptor tyrosine-based activation motif in its cytoplasmic domain, binding of FcgammaRI can result in a

68 infusion of an antibody targeting the GluN1 cytoplasmic domain blocks agonist-driven FRET changes in

69 anchored to the alpha6beta4 integrin via its cytoplasmic domain, but the activation of cell motility

70 ation E2 ligase, which modified the calnexin cytoplasmic domain by the addition of SUMO.

71 g transiently reduces FRET between the NMDAR cytoplasmic domain (cd) and the associated protein phosp

72 ly, V459K and K461G mutations within the GP2 cytoplasmic domain (CD) of rCl-13/LASV-GPC were shown to

73 independent coupling of agonist to the NMDAR cytoplasmic domain (cd).

74 Isoforms of PCDH15 differ in their cytoplasmic domains (CD1, CD2, and CD3), but share the e

75 ts, including cleavage of the integrin beta3 cytoplasmic domain, coincided closely with integrin alph

76 E-Syt cytoplasmic domains comprise a synaptotagmin-like mitoch

77 WC1 cytoplasmic domains contains multiple tyrosines, one of

78 c domain implicated in signal sensing, and a cytoplasmic domain controlling activation of the regulat

79 Moreover, we show that the SorCS3 cytoplasmic domain conveys internalization through canon

80 se findings suggest that Phb1/2 and the CD86 cytoplasmic domain cooperate to mediate CD86 signaling i

81 a-secretase 1 (BACE1), whose ectoplasmic and cytoplasmic domains could both be specifically targeted

82 e-gated sodium channel (BacNa(V)) C-terminal cytoplasmic domain (CTD) affects function.

83 n activatory mutation (S205L) located in the cytoplasmic domain (CTD).

84 sion appears restricted by its intraviral or cytoplasmic domain (cytodomain) because mutations within

85 r ezrin/radixin/moesin (ERM) proteins on its cytoplasmic domain (DeltaANKDeltaERM) did not cluster.

86 t coagulation factor VIIa (FVIIa) elicits TF cytoplasmic domain-dependent proangiogenic cell signalin

87 cement of S1248, an ERK2 substrate on the L1 cytoplasmic domain, did not decrease L1 adhesion, but ab

88 PlxnA signaling requires cytoplasmic domain dimerization, but extracellular regul

89 ization of Cebpb transcripts to a peripheral cytoplasmic domain distinct from the PSC region.

90 To uncover the role(s) of the CD21 cytoplasmic domain during infection initiation, the full

91 iently disordered is a structural feature of cytoplasmic domain dynamics that varies with functional

92 increased only modestly, suggesting that the cytoplasmic domain engages the cytoskeleton by an additi

93 M, leading to nuclear internalization of its cytoplasmic domain EpICD.

94 , we report that these N-terminal ARs form a cytoplasmic domain essential for NOMPC mechanogating in

95 ng a high-mobility ICAM-1 mutant lacking the cytoplasmic domain exhibit diminished antigen-dependent

96 Thus, the cytoplasmic domain facilitates proton conduction through

97 ical among integrins in lacking sites in its cytoplasmic domain for binding to actin cytoskeleton ada

98 t genotypic determinants in gag and the gp41 cytoplasmic domain (gp41-CD) reduce protease inhibitor (

99 Here we investigate the role that the cytoplasmic domain has in MscS channel function by recor

100 tic processing of cadherin extracellular and cytoplasmic domains has been reported to regulate cadher

101 cently, interactions mediated via the CTLA-4 cytoplasmic domain have been shown to preferentially aff

102 Amino acid substitutions in PhoQ's cytoplasmic domain hindered activation by acidic pH and

103 a mutant isoform of IgSF9 lacking the entire cytoplasmic domain (IgSF9(DeltaC/DeltaC) mice) had no de

104 residue (Leu-919) upstream of the C-terminal cytoplasmic domain in AHA2.

105 cribe an unexpected function for the MT1-MMP cytoplasmic domain in imprinting spatial memory for podo

106 way analyses support a separate role for the cytoplasmic domain in initiation of intracellular signal

107 but distinct sites within the integrin beta3 cytoplasmic domain in opposing waves.

108 Using the human Cad11 cytoplasmic domain in pulldown assays, we identified hum

109 Immunization with AChR cytoplasmic domains in adjuvant is promising as a safe,

110 of PARKIN-dependent ubiquitylation sites on cytoplasmic domains in vertebrate and Drosophila melanog

111 the dimer interface, whereas the N-terminal cytoplasmic domain includes a rhodanese-fold in accordan

112 ization is facilitated by interactions among cytoplasmic domains, including amino-terminal ankyrin re

113 It interacts with Munc18-1 through its cytoplasmic domains, including the N-terminal peptide (N

114 as that of its contiguous transmembrane and cytoplasmic domain, inclusive of the ITAM (immunorecepto

115 increased talin interactions with the beta3 cytoplasmic domain, indicating that the alphaIIbbeta3 in

116 n of VWF (VWF-A1) on GPIb-IX captured by its cytoplasmic domain induced unfolding of a hitherto unide

117 gth HA binds multiple HARE proteins to allow cytoplasmic domain interactions that stimulate intracell

118 igomerization is indirect and depends on its cytoplasmic domain interactions with scaffold proteins (

119 retase cleavage and the translocation of the cytoplasmic domain into the nucleus.

120 In addition, the adam13 cytoplasmic domain is cleaved by gamma secretase, transl

121 Kir6.2 than to the N terminus; 2) the Kir6.2 cytoplasmic domain is not essential for complexation wit

122 In contrast, Pcdh15a lacking the entire cytoplasmic domain is not functional.

123 We propose that the function of CTLA-4 cytoplasmic domain is not to transmit inhibitory signals

124 n on specific Ser and/or Thr residues in the cytoplasmic domain is often critical for the activation

125 lls and that the remaining membrane spanning cytoplasmic domain is processed by gamma-secretase compl

126 Allosteric regulation of the pore by the cytoplasmic domains is mediated through extensive intera

127 binding of cytoskeletal adaptors to integrin cytoplasmic domains is sufficient for activation or whet

128 Phosphorylation of Thr-457 on the short cytoplasmic domain isoform (CEACAM1-SF) that is predomin

129 1 and Tmc2a can interact with the CD1 or CD3 cytoplasmic domain isoforms of Pcdh15a, and this interac

130 ack of the putative endocytosis motif in its cytoplasmic domain largely abolished the sensitivity of

131 M-MLV glycoGag construct, truncations of the cytoplasmic domain led to a near total loss of activity.

132 ce of typical SLAM signaling motifs in their cytoplasmic domains, likely reflecting the evolutionary

133 FtsN function, a variant of FtsN lacking the cytoplasmic domain localized to the divisome but failed

134 , including the transmembrane region and the cytoplasmic domain, may be necessary to establish and ma

135 bserved during binding are propagated to the cytoplasmic domain, multiple mutations were introduced i

136 t conformation by integrin transmembrane and cytoplasmic domains must be overcome by cellular energy

137 ed to suppress the syncytial phenotype of gB cytoplasmic domain mutant A855V in infected cells.

138 he VEGF164-binding site of NRP1 and the NRP1 cytoplasmic domain (NCD), but not the known NCD interact

139 or complex and ITIM tyrosine residues in the cytoplasmic domain of 3DL1.

140 The cytoplasmic domain of a disintegrin and metalloprotease

141 Here we show that a recombinant cytoplasmic domain of ADAM10 (A10Cp) is unstructured as

142 In comparison, recombinant transmembrane-cytoplasmic domain of ADAM10 (A10TmCp) reconstituted in

143 Thus, the cytoplasmic domain of ADAM10 negatively influences const

144 We report that the cytoplasmic domain of ADAM10 negatively regulates its co

145 c transmembrane domain of L-selectin and the cytoplasmic domain of ADAM10 produces a similar dimeriza

146 to the adjacent and intrinsically disordered cytoplasmic domain of ADAM10 to form a homodimer in the

147 shedding by ADAM17 may help explain why the cytoplasmic domain of ADAM17 is not required for stimula

148 embrane domain of ADAM17 with or without the cytoplasmic domain of ADAM17 show reduced stimulated she

149 Our results indicate that the cytoplasmic domain of atlastin acts as a tether and homo

150 s, we found a direct interaction between the cytoplasmic domain of ATP1A1 and FGF2 with submicromolar

151 t features of structure and signaling in the cytoplasmic domain of bacterial chemoreceptors.

152 R; (ii) it binds the tyrosine phosphorylated cytoplasmic domain of band 3 (cdb3-PO4) with Kd = 14 nM;

153 INCH-parvin (IPP) complex interacts with the cytoplasmic domain of beta-integrin subunits and is crit

154 ain to the membrane-distal NPxY motif in the cytoplasmic domain of beta1 integrin in early endosomes.

155 ctrometry, we confirmed that the recombinant cytoplasmic domain of BRI1 generates pmol amounts of cGM

156 nzee BST-2 involves a 5-residue motif in the cytoplasmic domain of BST-2 previously identified as imp

157 g stable and transient overexpression of the cytoplasmic domain of CD44, we determined that the intra

158 ate a synthetic peptide corresponding to the cytoplasmic domain of CEACAM1-SF and was covalently boun

159 rt that mutations K465V and G467K within the cytoplasmic domain of Cl-13 GP2 resulted in a virus, rCl

160 sensitive fluorescent probe attached to the cytoplasmic domain of CLS and the nitroxide quencher att

161 ain induced the desorption of the basic-rich cytoplasmic domain of CLS from the anionic membrane surf

162 enabled subsequent association of CaM to the cytoplasmic domain of CLS.

163 The dNP2-conjugated cytoplasmic domain of cytotoxic T-lymphocyte antigen 4 (

164 tyrosine- and asparagine-based motif in the cytoplasmic domain of DNAM-1.

165 at conserved positions within the C-terminal cytoplasmic domain of each protein is required for optim

166 ontribution of signaling orchestrated by the cytoplasmic domain of EphB2 (a newly discovered Eph kina

167 Here we describe the structure of the 60-kDa cytoplasmic domain of EzrA, which comprises five linear

168 We conclude that the cytoplasmic domain of FcgammaR is not required for promo

169 These lie in a small, well-conserved cytoplasmic domain of FlhA, located between transmembran

170 Hog1 was recruited to the N-terminal cytoplasmic domain of Fps1, which it uses as a platform

171 new requirement for interaction between the cytoplasmic domain of FtsN ((N) FtsN) and FtsA.

172 N bypassed ZipA and a conserved motif in the cytoplasmic domain of FtsN was required for both the byp

173 CSF and shared signature truncations in the cytoplasmic domain of gp41, consistent with a common ori

174 hed from Nef to Vpu due to a deletion in the cytoplasmic domain of human tetherin, HIV-1 group O, whi

175 blasts through the signaling function of the cytoplasmic domain of ICAM-1.

176 ength ICAM-1 or a truncated form lacking the cytoplasmic domain of ICAM-1.

177 pproaches to examine the likelihood that the cytoplasmic domain of ICAM-2 binds directly to alpha-act

178 Mechanistically, the cytoplasmic domain of IL-13Ralpha2 specifically binds to

179 ns, the mobility of helical backbones in the cytoplasmic domain of intact chemoreceptor Tar homodimer

180 y recruiting and activating caspase 8 to the cytoplasmic domain of integrin alphavbeta3.

181 ly we found that Galpha13 interacts with the cytoplasmic domain of integrin beta3 subunits in platele

182 rt that fortilin directly interacts with the cytoplasmic domain of IRE1alpha, inhibits both kinase an

183 The requirement for the cytoplasmic domain of iRhom2 for stimulated shedding by

184 of key regulatory residues within the large cytoplasmic domain of KCC2 in neurons.

185 drolyzable analog of ATP, which binds to the cytoplasmic domain of Kir6.2 and causes channel closure,

186 requires subunit-subunit interactions in the cytoplasmic domain of Kir6.2; selective mutagenesis and

187 , coupled with the contrasting intracellular cytoplasmic domain of LAG3 as compared with other IRs, h

188 Furthermore, the cytoplasmic domain of M-MLV glycoGag was fully sufficien

189 for phosphorylation of tyrosine Y573 in the cytoplasmic domain of MT1-MMP by LIMK.

190 l or transcriptional mechanisms and that the cytoplasmic domain of MT2 is necessary for its regulatio

191 SK2 can phosphorylate the cytoplasmic domain of N-cadherin, a major component of a

192 d a protein transduction approach, where the cytoplasmic domain of Neph1 (Neph1CD) tagged with a prot

193 ns except for a single point mutation in the cytoplasmic domain of NLGN4X in which an arginine is mut

194 specific for the extracellular, but not the cytoplasmic domain of PECAM-1, consistent with accumulat

195 in microarray AtPMA-5000 with the N-terminal cytoplasmic domain of PEN3.

196 led FKBP (FK506-binding protein 12.6) on the cytoplasmic domain of RyR in isolated sarcoplasmic retic

197 oxidation are distributed widely within the cytoplasmic domain of RyR1 in multiple functional domain

198 addition, we determined that the N-terminal cytoplasmic domain of SAC1 also promotes Golgi localizat

199 Binding of the cytoplasmic domain of sAnk1 to SERCA1 was also detected

200 Interaction between SigG and the predicted cytoplasmic domain of SapG was observed in vitro.

201 dence that GIE stiffness is dependent on the cytoplasmic domain of STEVOR that interacts with ankyrin

202 e identify gain-of-function mutations in the cytoplasmic domain of STIM1 (p.R304W) associated with th

203 urther identify critical residues within the cytoplasmic domain of STIM1 (STIM1-CT) that entail autoi

204 when V1 is released from Vo, the N-terminal cytoplasmic domain of subunit a (aNT) changes conformati

205 is study, we report a connection between the cytoplasmic domain of TANGO1 and SLY1, a protein that is

206 uced in high-fat diet-fed mice that lack the cytoplasmic domain of TF (F3) (TF(DeltaCT)) or that are

207 study, a yeast two-hybrid approach using the cytoplasmic domain of TfR2 identified CD81 as an interac

208 lobin and key EMP enzymes for binding to the cytoplasmic domain of the Band 3 membrane protein (cdB3)

209 g, we examine the structural dynamics of the cytoplasmic domain of the beta2-adrenergic receptor (bet

210 of the Galpha13 protein from binding to the cytoplasmic domain of the beta3 integrin prevents outsid

211 atrix receptor syndecan (Sdc)-1 engaging the cytoplasmic domain of the beta4 integrin and coupling of

212 syndecan-1 (Sdc1), in which Sdc1 engages the cytoplasmic domain of the beta4 integrin subunit allowin

213 direct interaction between Galpha13 and the cytoplasmic domain of the integrin beta1 subunit plays a

214 Immunization with a cytoplasmic domain of the protein or with peptides predi

215 illogenesis, stable interactions between the cytoplasmic domain of the type II TGF-beta receptor (Tbe

216 examines the role of a lysine cluster in the cytoplasmic domain of the VZV fusion protein, gB, in the

217 dies was localized within the amino-terminal cytoplasmic domain of TRPM1.

218 rin through a membrane-proximal motif in the cytoplasmic domain of VE-cadherin.

219 Using NMR spectroscopy, we find that the cytoplasmic domain of Vpu and Trp-76 specifically intera

220 The cytoplasmic domain of VZV gB (gBcyt) has been implicated

221 extracellular CD4 and the transmembrane and cytoplasmic domain of WC1.

222 Placing the transmembrane and cytoplasmic domains of ADAM10, but not the transmembrane

223 ar the junction of the membrane-spanning and cytoplasmic domains of band 3, and this binding site was

224 ain of syndecan-4, and the transmembrane and cytoplasmic domains of cadherin-11.

225 interaction of SET with the newly translated cytoplasmic domains of CD47 and results in subsequent tr

226 that reconstitution of the transmembrane and cytoplasmic domains of EGFR in vesicles leads to a pecul

227 ifferentiation, we show that Ser(779) in the cytoplasmic domains of FGFR1 and FGFR2 is required for t

228 el based on proton-actuated movements in the cytoplasmic domains of FlhA.

229 postherpetic neuralgia, is regulated by the cytoplasmic domains of gB (gBcyt) via an immunoreceptor

230 We measure FRET between fluorescently tagged cytoplasmic domains of GluN1 subunits of NMDARs expresse

231 summarize what is currently known about the cytoplasmic domains of HIV-1 and SIV and attempt to inte

232 vaccine consisting of bacterially expressed cytoplasmic domains of human AChR subunits reduced the d

233 functional interactions between the pore and cytoplasmic domains of Kir6.2 during gating.

234 rotein regions are widely distributed in the cytoplasmic domains of many transmembrane receptors.

235 To evaluate the role of cytoplasmic domains of membrane-spanning proteins in dir

236 The cytoplasmic domains of microvillar protocadherins intera

237 n ectodomains fused to the transmembrane and cytoplasmic domains of NDV F and HN proteins, respective

238 The cytoplasmic domains of prokaryotic and eukaryotic Kir ch

239 These data reveal an interaction between the cytoplasmic domains of Ptch1 and that these domains modu

240 rified proteins to assess interaction of the cytoplasmic domains of SPCA1 with actin and CFL-1.

241 ptor tyrosine-based activation motifs in the cytoplasmic domains of the CD79a and CD79b signaling sub

242 nd communication between the periplasmic and cytoplasmic domains of the Escherichia coli aspartate ch

243 ) ectodomains fused to the transmembrane and cytoplasmic domains of the NDV F and HN proteins, respec

244 is defined by conformational changes in the cytoplasmic domains of the protein that are allosterical

245 s on polybasic sequences in HIV-1 Gag and in cytoplasmic domains of the transmembrane proteins.

246 Sorting motifs contained within the cytoplasmic domains of transmembrane proteins, post-tran

247 ne system uses chaperones to detect unfolded cytoplasmic domains of transmembrane proteins, whereas t

248 Overexpression of the cytoplasmic domain or full-length EDTB induces transloca

249 ion by transfection of either the N-cadherin cytoplasmic domain or shRNA specific to N-cadherin aboli

250 for anterograde axonal transport, and gE/gI cytoplasmic domains play important roles in sorting of v

251 ignal in the SIVmac239 envelope glycoprotein cytoplasmic domain, producing a virus termed DeltaGY, le

252 r containing both the fusion peptide and the cytoplasmic domain, providing insights into the mechanis

253 The cadherin cytoplasmic domain recruits several partners, including

254 Alternative splicing of the PCDH15 cytoplasmic domain regulates formation of this ternary c

255 ot its truncated form lacking the C-terminal cytoplasmic domain, rescued these effects.

256 ice expressing a truncated Robo4 lacking the cytoplasmic domain (Robo4DeltaCD).

257 M2 distal cytoplasmic domain sequences were still required for opt

258 in heptad repeat 2 (HR2), transmembrane, and cytoplasmic domain sequences, creating a chimera with tw

259 , which lacks the transmembrane spanning and cytoplasmic domains, serves as a homology model of the e

260 esion kinase (FAK) via a constant C-terminal cytoplasmic domain shared by all 22 proteins.

261 trast to the TM peptide, indicating that the cytoplasmic domain shifts the protonation equilibria.

262 esence of a polybasic sequence in the PSGL-1 cytoplasmic domain significantly enhanced this cocluster

263 of the endocytic dileucine motif in the WC1 cytoplasmic domain significantly reduced PMA-induced end

264 fying potassium (Kir) channel family share a cytoplasmic domain structure that serves as an unusual A

265 y we showed that salt bridges located at the cytoplasmic domain subunit interfaces (CD-Is) of eukaryo

266 er resistance to trypsin digestion, with its cytoplasmic domain taking on a significant ordered struc

267 llular level, we demonstrate that the SorCS3 cytoplasmic domain targets receptors to the Golgi appara

268 ted zebrafish bearing a deletion in the Flt4 cytoplasmic domain that eliminates tyrosines Y1226 and 1

269 tional change that affects the other, larger cytoplasmic domain that interacts with the export cargo.

270 erized, 12-amino acid region within the NRP1 cytoplasmic domain that mediates HH signal promotion.

271 oltage-gated K(+) channel motif coupled to a cytoplasmic domain that mediates subfamily-exclusive ass

272 channels (VGICs) are outfitted with diverse cytoplasmic domains that impact function.

273 tion of Asp351 causes areorganization of the cytoplasmic domains that subsequently drives the opening

274 osing of luminal gate induces a shift in the cytoplasmic domains that subsequently enables the dephos

275 dependent unfolding transition in a discrete cytoplasmic domain, the neck domain, proximal to the por

276 nding are dependent on proper folding of the cytoplasmic domains, the signal provides a common qualit

277 talin-1 and kindlin-3 to the beta2 integrin cytoplasmic domain, thereby being indispensable for beta

278 Effector binding at the cytoplasmic domain tightly controls gating of the pore d

279 Binding of FtsN's cytoplasmic domain to a protein named FtsA recruits a sm

280 cit significant remodeling of the C-terminal cytoplasmic domain to expose docking sites for signaling

281 e-inactivating point mutation or lacking the cytoplasmic domain to uncouple the enzymatic and noncata

282 cAMP binding rotates cytoplasmic domains to favor opening of the inner helica

283 We used His-tagged constructs of complete cytoplasmic domains to identify a total of 592 phosphory

284 nk1 interacts with SERCA1 through its TM and cytoplasmic domains to regulate SERCA1 activity and modu

285 6 kinase-mediated phosphorylation of the Boi cytoplasmic domain, triggering Hh release and FSC prolif

286 Collectively, we identify a cytoplasmic domain, unique to BASIC, that controls chann

287 C3 isoform, we show that its unique variable cytoplasmic domain (VCD) is the critical one for Wnt pat

288 -signaling autoinhibitory separation for the cytoplasmic domains via intermolecular head-to-stalk int

289 Unexpectedly, however, GPP130's cytoplasmic domain was not required, and redistribution

290 Interestingly, the periplasmic and cytoplasmic domains were somewhat dispensable for flagel

291 een investigated in the presence of the full cytoplasmic domain, which increases the proton conductiv

292 er pKa to direct and indirect effects of the cytoplasmic domain, which is rich in acidic residues.

293 tegrins transduce signals from ECM via their cytoplasmic domains, which bind to intracellular integri

294 triggers tyrosine autophosphorylation of the cytoplasmic domains, which stimulates catalytic activity

295 and vessel permeability independently of its cytoplasmic domain, while activating VEGFR2-Y951 via ROB

296 the norm, with an average of seven sites per cytoplasmic domain, while some proteins showed more than

297 chored to actin through interaction of their cytoplasmic domains with related tripartite complexes co

298 Cs enhances interactions of their respective cytoplasmic domains with the plasma membrane and stabili

299 the BACE1 transmembrane sequences (TMSs) and cytoplasmic domains, with residues Ala(463) and Cys(466)

300 eads to tyrosine phosphorylation of the LRP1 cytoplasmic domain within endosomes and generates an LRP