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1 nhibition of the minus-end microtubule motor cytoplasmic dynein .
2 for the minus-end-directed microtubule motor cytoplasmic dynein.
3 first specific small-molecule antagonists of cytoplasmic dynein.
4 of the cellular functions and regulation of cytoplasmic dynein.
5 f two ~300-kilodalton motor domains of yeast cytoplasmic dynein.
6 1 in the regulation of the microtubule motor cytoplasmic dynein.
7 interact directly with one another and with cytoplasmic dynein.
8 e force-dependent stepping behavior of yeast cytoplasmic dynein.
9 back to the cytoplasm (retrograde) driven by cytoplasmic dynein.
10 gene, which is involved in the regulation of cytoplasmic dynein.
11 d by myosin V, heterotrimeric kinesin-2, and cytoplasmic dynein.
12 directly modulates the enzymatic activity of cytoplasmic dynein.
13 orged between Lis1 and the microtubule motor cytoplasmic dynein.
14 amine the interaction of neurofilaments with cytoplasmic dynein.
15 s partially dependent on Aurora-A kinase and cytoplasmic dynein.
16 oposed to regulate the multiple functions of cytoplasmic dynein.
17 ormation through developmental regulation of cytoplasmic dynein.
18 forces on astral microtubules (MTs) through cytoplasmic dynein.
19 driven exclusively by the microtubule motor cytoplasmic dynein.
26 novel model by which stationary complexes of cytoplasmic dynein-1 are responsible for the shuttling o
30 gical and genetic manipulation, we show that cytoplasmic dynein-1, which localizes to the junction be
33 re, we report that the retrograde IFT motor, cytoplasmic dynein 1b, is required in the cytoplasm for
36 his identifies potential novel components of cytoplasmic dynein 2 and furthermore provides fresh insi
38 , a mammalian homologue of the Chlamydomonas cytoplasmic dynein 2 intermediate chain that also locali
40 Wdr34 gene encodes an intermediate chain of cytoplasmic dynein 2, the motor for retrograde intraflag
42 the light intermediate chain (D2LIC) of the cytoplasmic dynein-2 complex are essential for retrograd
45 the first time, that the dync2-i1 subunit of cytoplasmic dynein-2 is necessary for retrograde IFT.
46 y mutations in a new disease-producing gene, cytoplasmic dynein-2 light intermediate chain 1, DYNC2LI
47 e present the crystal structure of the human cytoplasmic dynein-2 motor bound to the ATP-hydrolysis t
48 nally, the ERG results indicate that loss of cytoplasmic dynein-2 reduces the photoreceptor light res
49 nd intermediate chain (dync2-i1) subunits of cytoplasmic dynein-2 were injected into zebrafish embryo
54 nhibitor nocodazole and by the inhibition of cytoplasmic dynein, a microtubule-associated motor prote
56 , Nudel/NudE, and dynactin are regulators of cytoplasmic dynein, a minus end-directed, microtubule (M
59 nding immunophilins that link the complex to cytoplasmic dynein, a molecular motor that processes alo
60 is central to the functional versatility of cytoplasmic dynein, a motor involved in intracellular tr
61 uggesting that dop is involved in regulating cytoplasmic dynein activity through direct or indirect m
63 bunit forms two separate complexes, one with cytoplasmic dynein ("aggregation complex") and one with
65 antibody-Fab tag to mark the position of the cytoplasmic dynein amino-terminal tail domain, as it eme
67 r migration (INM) that is driven apically by cytoplasmic dynein and basally by the kinesin KIF1A, whi
71 the trafficking of TYR and Pmel17 depends on cytoplasmic dynein and its interaction with the spectrin
73 implicated others [encoding neurofilaments, cytoplasmic dynein and its processivity factor dynactin,
75 t, bidirectional capsid motility mediated by cytoplasmic dynein and kinesin during entry, whereas egr
78 endosomes are transported bidirectionally by cytoplasmic dynein and kinesin-3, but how the movements
80 1 in developing hair cells causes defects in cytoplasmic dynein and microtubule organization, resulti
84 in is a multiprotein complex that works with cytoplasmic dynein and other motors to support a wide ra
85 that kinesin-5 works in part by antagonizing cytoplasmic dynein and that these motor-driven forces fu
86 telomere attachment sites must be coupled to cytoplasmic dynein and the microtubule system to ensure
87 chain is a bona fide component of Drosophila cytoplasmic dynein and use P element excision to generat
88 ation activities associated with NuMA (i.e., cytoplasmic dynein) and HSET are not necessary for pole
89 d moved by microtubule motors (kinesin-1 and cytoplasmic dynein), and that binding of motors and move
91 ransport machinery: specifically, kinesin-1, cytoplasmic dynein, and the dynein regulators Lis1 and d
96 are integral parts of the microtubule motor cytoplasmic dynein, as they directly associate with dyne
97 ts, but not control transcripts, recruit the cytoplasmic Dynein-associated co-factors Bicaudal D (Bic
100 itotic checkpoint protein and the anchor for cytoplasmic dynein at mitotic kinetochores, though it is
103 rotubules are polarity sorted in the axon by cytoplasmic dynein but that additional factors are also
105 cellular functions of the microtubule motor cytoplasmic dynein, but the mechanism by which dynactin
106 in vivo evidence that distinct mutations in cytoplasmic dynein can either result in a pure sensory n
107 l trap, we were now able to demonstrate that cytoplasmic dynein can generate a discrete power stroke
108 tubule movements so that polarity sorting by cytoplasmic dynein can occur in a manner unimpeded by ot
109 ncoding the heavy chain subunit (DYNC1H1) of cytoplasmic dynein cause spinal muscular atrophy with lo
112 at mutations in the minus-end-directed motor cytoplasmic dynein, completely block the increased DCVs
113 microtubule transport, the recombinant human cytoplasmic dynein complex is an active, microtubule min
114 n performed either with the native mammalian cytoplasmic dynein complex purified from tissue or, more
118 his nomenclature recognizes the two distinct cytoplasmic dynein complexes and has the flexibility to
121 essing of tagged and truncated Dictyostelium cytoplasmic dynein constructs, we show that the heart of
122 TrkB) signaling endosomes are transported by cytoplasmic dynein containing the neuron-specific IC-1B
124 minus-end directed microtubule motor protein cytoplasmic dynein contributes to many aspects of cell d
125 sitive to the addition of ATP, a hallmark of cytoplasmic dynein-dependent microtubule interactions.
129 o measure stall forces of both kinesin-1 and cytoplasmic dynein-driven lipid droplets in Drosophila e
130 r et al. and Hashimoto-Tane et al. show that cytoplasmic dynein drives microcluster centralization al
132 ei migrate basally during G1, apically using cytoplasmic dynein during G2, and undergo mitosis at the
135 mutation in p150(Glued), a component of the cytoplasmic dynein/dynactin microtubule motor complex, r
136 of either kinesin-1 (kinesin heavy chain) or cytoplasmic dynein (dynein heavy chain) by RNA interfere
139 plicated in targeting and binding cargoes to cytoplasmic dynein for retrograde or apical transport.
140 ond switch, depending on magnesium, converts cytoplasmic dynein from a nonprocessive to a processive
146 The microtubule-associated molecular motor, cytoplasmic dynein, has been implicated in the retrograd
148 ioning in different systems, associates with cytoplasmic dynein heavy chain (DYNC1H1) in a Galphai-re
150 ant, c.917A>G, in DYNC1H1, which encodes the cytoplasmic dynein heavy chain 1 (here, novel refers to
151 to identify a nine base-pair deletion in the cytoplasmic dynein heavy chain 1 gene (Dync1h1) in this
155 of CLIPA, green fluorescent protein-labeled cytoplasmic dynein heavy chain, p150(Glued) dynactin, an
157 n hexon recruits the molecular motor protein cytoplasmic dynein in a pH-dependent manner, a function
160 RNA interference to investigate the role of cytoplasmic dynein in powering these transport events.
162 at both Hook1 and Hook3 effectively activate cytoplasmic dynein, inducing longer run lengths and high
163 d a genomic region that contained DYNC2H1, a cytoplasmic dynein involved in retrograde transport in t
184 in vivo and in vitro, we found evidence that cytoplasmic dynein is active during minus- and plus-end
186 Here, we report that the stalk shaft of rat cytoplasmic dynein is an antiparallel alpha-helical coil
193 endosomes from the axon to the cell body by cytoplasmic dynein is necessary for axonal and neuronal
201 The minus end-directed microtubule motor cytoplasmic dynein is responsible for the intracellular
218 ture of isoform 1 of the mouse Roadblock/LC7 cytoplasmic dynein light chain (robl1_mouse) by NMR spec
219 nal kinesin, reductions in the levels of the cytoplasmic dynein light chain Tctex type 3 subunit were
221 studies, we show that in rodents Tctex-1, a cytoplasmic dynein light chain, is selectively enriched
223 MTOC, in which the minus end-directed motor cytoplasmic dynein, localized at the synapse through an
224 This is especially important for mammalian cytoplasmic dyneins, many subunits of which are encoded
225 is a highly conserved protein necessary for cytoplasmic dynein-mediated nuclear migration in Aspergi
226 say was used to evaluate the hypothesis that cytoplasmic dynein mediates AAV interaction with microtu
230 Recently, an x-ray structure of the murine cytoplasmic dynein microtubule binding domain (MTBD) in
231 a mutation in dhc-1, the heavy chain of the cytoplasmic dynein minus-end directed microtubule motor,
234 ight chain LC8 is an integral subunit of the cytoplasmic dynein motor complex that binds directly to
235 Tctex-1, a light-chain component of the cytoplasmic dynein motor complex, can function independe
238 ion of a specific role for these proteins in cytoplasmic dynein motor regulation has remained elusive
239 lization to elucidate relative kinesin-1 and cytoplasmic dynein motor subunit composition of individu
243 re under the influence of forces mediated by cytoplasmic dynein motors associated with the cell corte
244 MTs to test the hypothesis that immobilized cytoplasmic dynein motors transport short MTs with their
248 microtubules in the cell periphery, whereas cytoplasmic dynein moves to the minus ends in the cell c
249 We report the crystal structure of the mouse cytoplasmic dynein MTBD and a portion of the coiled coil
250 single molecule motility properties of yeast cytoplasmic dynein mutants bearing mutations that preven
251 (chromokinesin and Eg5) and minus-directed (cytoplasmic dynein oligomers) motors walking on microtub
253 y distribution of melanosomes transported by cytoplasmic dynein or kinesin-2 under conditions of aggr
254 terfering RNA (siRNA)-mediated inhibition of cytoplasmic dynein or the kinesin 1 heavy chain KIF5B de
257 phenotype than the control, indicating that cytoplasmic dynein plays a role in chromosome segregatio
262 e compelling evidence that the motor protein cytoplasmic dynein provides the necessary force for micr
266 It is specifically blocked by RNAi for the cytoplasmic dynein regulators LIS1 and NudE/L (Nde1/Ndel
270 motor axons are kinesin-1 (anterograde) and cytoplasmic dynein (retrograde), and interestingly that
273 motor, the function of NUDF is important for cytoplasmic dynein's targeting to the spindle poles.
277 ctions in levels of conventional kinesin and cytoplasmic dynein subunits were recapitulated in a rat
278 is a highly conserved light-chain subunit of cytoplasmic dynein that interacts with a wide variety of
280 an interaction between the microtubule motor cytoplasmic dynein, the adenomatous polyposis coli tumor
281 contain a large number of kinesins but lack cytoplasmic dynein, the foremost processive retrograde t
283 orted to regulate the mechanical behavior of cytoplasmic dynein, the primary minus-end-directed micro
285 binding to Trk initiates the recruitment of cytoplasmic dynein to signaling endosomes through ERK1/2
286 es attachment of the microtubule-based motor cytoplasmic dynein to the cortex, where it exerts a pull
287 nuclear INT complex promotes recruitment of cytoplasmic dynein to the NE, possibly via a mechanism i
288 pAR63, nearly eliminates the localization of cytoplasmic dynein to the spindle poles, but it has no a
293 The minus end-directed microtubule motor cytoplasmic dynein transports various cellular cargoes,
294 s proplatelet elongation and is dependent on cytoplasmic dynein under static and physiological shear
297 s varying DNA sequences, and to myosin V and cytoplasmic dynein, which may advance by variable increm
298 sitioning, are mediated by the motor protein cytoplasmic dynein, which produces force on the microtub
299 We also predict that acute inhibition of cytoplasmic dynein will disrupt the polarity sorting of
300 oups of motor proteins, such as kinesins and cytoplasmic dynein, work together to ensure the supply a
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