ライフサイエンスコーパス: cytoplasmic microtubule

1 of BIM1 eliminated Kar9p localization along cytoplasmic microtubules.

2 envelope proteins, such as SUN-1, to access cytoplasmic microtubules.

3 the cell, often coincident with the ends of cytoplasmic microtubules.

4 im1p localizes to dots at the distal ends of cytoplasmic microtubules.

5 e mitotic spindle and the orientation of the cytoplasmic microtubules.

6 the pheromone-induced reorganization of the cytoplasmic microtubules.

7 t of a cortical adaptor complex that orients cytoplasmic microtubules.

8 d for the Kar9p-dependent orientation of the cytoplasmic microtubules.

9 reas GFP-Kip3p localized to both spindle and cytoplasmic microtubules.

10 gene product, neurofibromin, interacts with cytoplasmic microtubules.

11 les and chromosomes toward the minus ends of cytoplasmic microtubules.

12 ses of the cell cycle, connecting the DSB to cytoplasmic microtubules.

13 and flagellar enrichment are facilitated by cytoplasmic microtubules.

14 f Drosophila melanogaster that depolymerizes cytoplasmic microtubules.

15 interact with the nuclear envelope (NE) and cytoplasmic microtubules.

16 microtubules without significantly altering cytoplasmic microtubules.

17 rtant for the organization/nucleation of all cytoplasmic microtubules.

18 oogenesis for the structure and function of cytoplasmic microtubules.

19 onfunctional spindle poles or the absence of cytoplasmic microtubules.

20 tion of KAR3 leads to a dramatic increase in cytoplasmic microtubules, a phenotype which is most pron

21 ether, we propose that kinesin-1 slides free cytoplasmic microtubules against cortically immobilized

22 In yeast, oriented cytoplasmic microtubules align the mitotic spindle betwe

23 of dynein-green fluorescent protein (GFP) to cytoplasmic microtubules allowed us to obtain one of the

24 ther and bud via dynein-dependent sliding of cytoplasmic microtubules along the cortex of the bud.

25 her-bud neck via dynein-dependent sliding of cytoplasmic microtubules along the cortex of the bud.

26 somal region, induces profound disruption of cytoplasmic microtubules and a nuclear distortion phenot

27 In the yeast Saccharomyces cerevisiae, both cytoplasmic microtubules and actin filaments are needed

28 tribution but retain the ability to organize cytoplasmic microtubules and actin in anucleate hyphae.

29 ing of the mitotic spindle requires both the cytoplasmic microtubules and actin.

30 lights a framework for communication between cytoplasmic microtubules and chromatin.

31 ivity resulted in assembly of unusually long cytoplasmic microtubules and defects in spindle position

32 These bidirectional movements require cytoplasmic microtubules and microfilaments and depend o

33 uring mitosis, leading to the coexistence of cytoplasmic microtubules and nuclear spindles with massi

34 sembly of subdistal appendages, which anchor cytoplasmic microtubules and prime the mother centriole

35 iae that is mediated by interactions between cytoplasmic microtubules and the cell cortex.

36 in fungi have been shown to be dependent on cytoplasmic microtubules and the microtubule-associated

37 t depends on persistent interactions between cytoplasmic microtubules and the mother-bud neck, the fu

38 show that Myo2 localizes to the plus ends of cytoplasmic microtubules, and that the rate of movement

39 Secondly, abnormally long cytoplasmic microtubules appear that do not stop at the

40 Cytoplasmic microtubules are critical for establishing a

41 Here, we show that cytoplasmic microtubules are mechanically coupled to the

42 In vivo, cytoplasmic microtubules are nucleated and anchored by t

43 Consistent with this, cytoplasmic microtubules are often highly curved and app

44 yeast Schizosaccharomyces pombe, interphase cytoplasmic microtubules are organized into antiparallel

45 Our findings suggest that cytoplasmic microtubules are used to monitor the locatio

46 portant for establishing a normal interphase cytoplasmic microtubule array.

47 At 30 degrees C cytoplasmic microtubule arrays are abnormal and bundle i

48 rmal mitotic spindles and some have abnormal cytoplasmic microtubule arrays.

49 layed unusually long and numerous bundles of cytoplasmic microtubules as revealed by immunofluorescen

50 targeted to the distal plus ends of dynamic cytoplasmic microtubules, as is HC, and their targeting

51 t anaphase onset, the FEAR pathway activates cytoplasmic microtubule-associated forces that facilitat

52 d lack of TINA causes enhanced production of cytoplasmic microtubules at metaphase arrest, we suggest

53 osaccharomyces pombe, longitudinal arrays of cytoplasmic microtubule bundles regulate cell polarity a

54 A simple self-assembly pathway generates cytoplasmic microtubule bundles that can locate the cell

55 lpha 85E does not disrupt meiotic spindle or cytoplasmic microtubules but causes defects in morphogen

56 g a stochastic simulation that confirms that cytoplasmic microtubules can compete with flagella for a

57 stent with Bud6's role as a cortical cue for cytoplasmic microtubule capture.

58 other- bud axis through interactions between cytoplasmic microtubules (CMs) and the cell cortex.

59 The 'cMT-bud neck model' posits that cytoplasmic microtubule (cMT)-bud neck interactions prev

60 to the conclusion that biased nucleation of cytoplasmic microtubules (cMTs) is essential for directi

61 ughter cell by linking the associated set of cytoplasmic microtubules (cMTs) to the polarized actin n

62 sponsible for establishing cell polarity and cytoplasmic microtubules collaborate to establish MEN as

63 pression of the entire SPC72 results in more cytoplasmic microtubules compared with wild-type.

64 ed to returned to interphase retain a normal cytoplasmic microtubule complex.

65 st cell elongates toward its mating partner, cytoplasmic microtubules connect the nucleus to the cell

66 rity relies on a precise temporal program of cytoplasmic microtubule-cortex interactions throughout s

67 The average number of cytoplasmic microtubules decreased from 3 in wild-type t

68 This correlated with cytoplasmic microtubule defects.

69 induced rapid, anterograde IFT-independent, cytoplasmic microtubule-dependent redistribution of the

70 Stathmin (STMN), a cytoplasmic microtubule-destabilizing phosphoprotein, re

71 Saccharomyces cerevisiae cells lacking She1, cytoplasmic microtubules detach from the spindle pole bo

72 lagellar transport and cargo transport along cytoplasmic microtubules, differ from motors in the cano

73 In germlings, cytoplasmic microtubules disassembled completely in mito

74 ghout the vegetative cell cycle as they bind cytoplasmic microtubules during interphase, spindle micr

75 nation of metachronic cilia beating, whereas cytoplasmic microtubule dynamics are required for local

76 Our findings highlight the regulation of cytoplasmic microtubule dynamics as a role of the IFT54

77 The reduction in cytoplasmic microtubule dynamics is due primarily to dec

78 The pattern and extent of cytoplasmic microtubule dynamics modulation through the

79 highly conserved EB1 family, Bim1p, promotes cytoplasmic microtubule dynamics specifically during G1.

80 These movements depend on cytoplasmic microtubules emanating from the nuclei that

81 oncentrate at cell ends by attaching it to a cytoplasmic microtubule end-binding protein.

82 chanism to delay cell cycle progression when cytoplasmic microtubules fail to orient the spindle.

83 gests a model in which flagella compete with cytoplasmic microtubules for a fixed pool of tubulin, wi

84 lium, with Gli2 but not Smo requiring intact cytoplasmic microtubules for ciliary entry and both requ

85 that a novel complex links the nucleus with cytoplasmic microtubules for the promotion of DNA repair

86 To ensure proper mitotic spindle and cytoplasmic microtubule formation, the cell must maintai

87 leted variant of SPC72 (DeltaN-SPC72) impair cytoplasmic microtubule formation.

88 cells, mitotic exit was preceded by loss of cytoplasmic microtubules from the neck.

89 f TINA enhanced the nucleation of bundles of cytoplasmic microtubules from the spindle pole bodies.

90 Removal of the forces exerted by the cytoplasmic microtubules had no effect on fragmentation.

91 Although effects of XMAP215/TOG proteins on cytoplasmic microtubules have not previously been shown

92 functions to limit the number and length of cytoplasmic microtubules in a cell cycle-specific manner

93 ons essential to mitosis and organization of cytoplasmic microtubules in addition to its well-documen

94 nuclear distribution phenotype but affected cytoplasmic microtubules in an unexpected manner.

95 ion of Stu2p leads to fewer and less dynamic cytoplasmic microtubules in both G1 and preanaphase cell

96 We also identify defects in cytoplasmic microtubules in both the germ and follicle c

97 tion of microtubules in vitro and stabilizes cytoplasmic microtubules in heterologous cells.

98 assembly and cause breakdown of preassembled cytoplasmic microtubules in human polymorphonuclear leuk

99 EB1 colocalized both to cytoplasmic microtubules in interphase cells and to spin

100 By indirect immunofluorescence, the cytoplasmic microtubules in kip2Delta were consistently

101 a similar process plays a role in orienting cytoplasmic microtubules in mating yeast cells.

102 , the bni1Delta mutant exhibited misoriented cytoplasmic microtubules in shmoos.

103 localized to the plus ends (distal tips) of cytoplasmic microtubules in the bud.

104 unctions without Lte1p and apparently senses cytoplasmic microtubules in the mother/bud neck [7-9].

105 avy chain Dyn1 also localized to the tips of cytoplasmic microtubules in wild-type cells.

106 nd yeast cells, this process is dependent on cytoplasmic microtubules interacting with the cortical a

107 By indirect immunofluorescence, cytoplasmic microtubules intersected the GFP-Kar9p dot.

108 and cell polarization, as well as Kar9p and cytoplasmic microtubule localization.

109 niversal function of kinesin-1 is to mediate cytoplasmic microtubule-microtubule sliding.

110 These results suggest that cytoplasmic microtubules might be arranged with plus end

111 The cytoplasmic microtubule modulator RanBP10 is a Ran and b

112 Cytoplasmic microtubules (MTs) continuously grow and sho

113 Cytoplasmic microtubules (MTs) continuously grow and sho

114 evisiae kinesin-14 that functions to shorten cytoplasmic microtubules (MTs) during yeast mating yet m

115 CB also disrupted the organization of cytoplasmic microtubules (MTs) in stage VI oocytes.

116 The ability to nucleate cytoplasmic microtubules (MTs) is a property of the surr

117 Cytoplasmic microtubules (MTs) serve as a rate-limiting

118 osome positioning requires a radial array of cytoplasmic microtubules (MTs) that can exert pushing or

119 Polarized radial arrays of cytoplasmic microtubules (MTs) with minus ends clustered

120 n fission yeast (Schizosaccharomyces pombe), cytoplasmic microtubules must be reorganized into the sp

121 They have a reduced cytoplasmic microtubule network and display severe morph

122 d molecular motors and they travel along the cytoplasmic microtubule network towards the minus end of

123 iod marked by dramatic reorganization of the cytoplasmic microtubule network, endogenous MLK3 transie

124 nters establish transient connections to the cytoplasmic microtubule network.

125 knockdown causes the disorganization of the cytoplasmic microtubule network.

126 KIF3A but not by chemical disruption of the cytoplasmic microtubule network.

127 Furthermore, in the bim1 mutants, the cytoplasmic microtubules no longer intersected the corti

128 in fission yeast Schizosaccharomyces pombe, cytoplasmic microtubule nucleation ceases simultaneously

129 Cytoplasmic microtubule nucleation in fission yeast depe

130 rmation of these microtubule bundles include cytoplasmic microtubule nucleation, microtubule release

131 ein is targeted to the dynamic plus end of a cytoplasmic microtubule, offloads to the cortex, becomes

132 nclude that Kar9p's function is specific for cytoplasmic microtubule orientation and that Kar9p's rol

133 In fission yeast, interphase cytoplasmic microtubules originate from poorly character

134 important to prevent excessive detachment of cytoplasmic microtubules, particularly in G1 cells.

135 Unexpectedly, BBIP10 is required for cytoplasmic microtubule polymerization and acetylation,

136 tip-ward movement is similar to the rate of cytoplasmic microtubule polymerization toward the hyphal

137 Thus, SPBs are able to sense cytoplasmic microtubule properties and regulate the Bfa1

138 Further, Kms1 and the cytoplasmic microtubule regulator Mto1 promote the repai

139 The behavior of cytoplasmic microtubules revealed distinct interactions

140 2, bld1 mutants have normal basal bodies and cytoplasmic microtubule rootlets.

141 ted tubulin pool, showing that alteration of cytoplasmic microtubule severing could be sufficient to

142 We further observe cytoplasmic microtubule sliding in Xenopus and Ptk2 cell

143 On cytoplasmic microtubules, Stu2 and Bim1 act cooperativel

144 cells lack cytoplasmic microtubules; the few cytoplasmic microtubules that are observed are excessive

145 ch a highly elastic nucleus is surrounded by cytoplasmic microtubules that behave as a jelly-like vis

146 oison thiabendazole and have abnormally long cytoplasmic microtubules that can curl around the ends o

147 ubules anchored to the actin cortex and free cytoplasmic microtubules that moved in the ooplasm.

148 In addition, most spc72 mutant cells lack cytoplasmic microtubules; the few cytoplasmic microtubul

149 Klp5p-GFP and Klp6p-GFP both localize to cytoplasmic microtubules throughout the cell cycle and t

150 alization studies found Kip2p exclusively on cytoplasmic microtubules throughout the cell cycle, wher

151 marker protein, Tea1, that is transported by cytoplasmic microtubules to cell tips and recruits other

152 Others operate on the cytoplasmic microtubules to effect spindle and nuclear p

153 These findings support that nuclei use cytoplasmic microtubules to establish "cells within cell

154 In response to defects of cytoplasmic microtubules to interact with the cell corte

155 the cell because they impede the ability of cytoplasmic microtubules to orient the spindle.

156 ules, and that the rate of movement of these cytoplasmic microtubules to the bud neck depends on the

157 elative contributions of the kinetochore and cytoplasmic microtubules to the forces involved in forma

158 mutants retain the ability to generate long cytoplasmic microtubule tracks, suggesting that the nucl

159 rc activity regulates the transition between cytoplasmic microtubule transport and actin-based motili

160 Indeed, while cytoplasmic microtubules vanish, the spindle pole body (

161 Cytoplasmic microtubules were largely bundled, spindle a

162 cells with nuclear positioning defects, the cytoplasmic microtubules were misoriented and failed to

163 tic nuclei remained widely separated and the cytoplasmic microtubules were misoriented.

164 In contrast, in kip3Delta strains, the cytoplasmic microtubules were significantly longer than

165 e pole body (SPB), organizes the nuclear and cytoplasmic microtubules which are functionally and spat

166 ver, alp16 deletion displays abnormally long cytoplasmic microtubules, which curve around the cell ti

167 itotic spindle depends on the interaction of cytoplasmic microtubules with the cell cortex.

168 Both movements depend on interactions of cytoplasmic microtubules with the cortex.

169 eriments demonstrate that the interaction of cytoplasmic microtubules with the Kar9p cortical attachm

170 It is the differential interaction of cytoplasmic microtubules with the mother and bud cortex