ライフサイエンスコーパス: cytoplasmic retention

1 no acids 112 and 164 apparently required for cytoplasmic retention.

2 cytochalasin B and nocodazole did not affect cytoplasmic retention.

3 xport and by an uncharacterized mechanism of cytoplasmic retention.

4 wever, homodimerization was not required for cytoplasmic retention.

5 with p40 is necessary but not sufficient for cytoplasmic retention.

6 -terminal coiled-coil domain responsible for cytoplasmic retention.

7 nd cytoplasm and ultimately resulting in its cytoplasmic retention.

8 es act additively to fine-tune signaling via cytoplasmic retention.

9 127, which results in YAP 14-3-3 binding and cytoplasmic retention.

10 noubiquitination masks its NLS, resulting in cytoplasmic retention.

11 ics the monoubiquitinated enzyme resulted in cytoplasmic retention.

12 the cell-cycle inhibitor p27, promoting its cytoplasmic retention.

13 leads Smad1 alternatively to degradation or cytoplasmic retention.

14 ed BR transcription factors, largely through cytoplasmic retention.

15 ct maternal mRNA by MSY2 is required for its cytoplasmic retention.

16 rom regulatory mechanisms that control their cytoplasmic retention.

17 to exert some redundant effect on Ci such as cytoplasmic retention.

18 level through a mechanism involving coupled cytoplasmic retention and degradation.

19 inhibits YAP through phosphorylation-induced cytoplasmic retention and degradation.

20 onformational motif in AID that dictates its cytoplasmic retention and demonstrate that the translati

21 o(107), respectively, in HA-Myb1 resulted in cytoplasmic retention and elevated nuclear translocation

22 a J-domain-dependent fashion and led to the cytoplasmic retention and enhanced stability of IkappaB.

23 inase cascade that leads to phosphorylation, cytoplasmic retention and functional inactivation of the

24 kt) pathway, which leads to phosphorylation, cytoplasmic retention and inactivation of FoxO1.

25 ed YAP1/SMAD2 interaction and leads to SMAD2 cytoplasmic retention and inefficient transcription of T

26 d by dAkt upon insulin treatment, leading to cytoplasmic retention and inhibition of its transcriptio

27 the death domain alone is not sufficient for cytoplasmic retention and instead functions only in conj

28 nucleus through a combined disruption of its cytoplasmic retention and its nuclear export, this oncog

29 ino acids in extramembrane domains represent cytoplasmic retention and membrane translocation forces,

30 unctional NES is required for both efficient cytoplasmic retention and post-induction control of c-Re

31 ntain more than one region that functions as cytoplasmic retention and/or nuclear export sequences.

32 other regions mediate its nuclear export (or cytoplasmic retention) and nuclear import.

33 clear localization signal (NLS) promotes its cytoplasmic retention, and cytoplasmic Skp2 enhances cel

34 or complex are tightly regulated through its cytoplasmic retention by an ankyrin-rich inhibitory prot

35 aB is thought to be regulated mainly through cytoplasmic retention by IkappaB molecules.

36 lternative and classical NF-kappaB caused by cytoplasmic retention by p100.

37 istinguished JNK-2 as responsible for NFATc2 cytoplasmic retention by PEDF and JNK-1 and JNK-2 as med

38 transcription factor Smad2 is released from cytoplasmic retention by TGFbeta receptor-mediated phosp

39 In addition, nuclear export and cytoplasmic retention cooperate to exclude AID from the

40 results elucidate the molecular basis of AID cytoplasmic retention, define its functional relevance a

41 y two distinct activities: it functions as a cytoplasmic retention determinant and an Asi-dependent d

42 C-terminal domain that is distinct from the cytoplasmic retention domain, (ii) interference with tra

43 ity is both necessary and sufficient for its cytoplasmic retention during early development.

44 associated protein enigma homolog (ENH) is a cytoplasmic retention factor for Id2.

45 nt susceptibility to inhibition of import by cytoplasmic retention factor SARA (Smad anchor for recep

46 CAN/Nup214 and Nup153 compete with the cytoplasmic retention factor SARA and the nuclear Smad2

47 present a crystal structure of Bag6 and its cytoplasmic retention factor TRC35, revealing that TRC35

48 consensus sites is not necessary for Ace2's cytoplasmic retention, indicating that these mechanisms

49 the cytoplasm past the MBT, indicating that cytoplasmic retention is a phosphorylation dependent pro

50 To investigate the cytoplasmic retention machinery that keeps YA from enter

51 lized p53 in REF52/N-myc cells suggests that cytoplasmic retention may help to inactivate the growth-

52 ombine to suggest that monocytic cells use a cytoplasmic retention mechanism to control A3A and avert

53 dicate that whereas positive charges promote cytoplasmic retention, negative charges promote transloc

54 accumulation involves neither a release from cytoplasmic retention nor an increase in Smad2 import ra

55 endogenous conditions, GI stabilization and cytoplasmic retention occurs naturally through a LOV dom

56 e-induced autophagy combined with the longer cytoplasmic retention of ARpolyQ bound to Bicalutamide.

57 Cytoplasmic retention of beta-catenin is effected by sta

58 Cytoplasmic retention of both Dorsal and Dif depends on

59 ization signal and phosphorylation-dependent cytoplasmic retention of both proteins.

60 DNA damage-induced Rad51 foci and results in cytoplasmic retention of BRCA1.

61 demonstrate that Tax is able to override the cytoplasmic retention of c-Rel by 1kappaBbeta in transie

62 he human thrombin receptor revealed that the cytoplasmic retention of CCR2A was due to its terminal c

63 ect on embryonic patterning, but compromises cytoplasmic retention of Ci.

64 nal Cos2 binding domains are involved in the cytoplasmic retention of Ci155 in imaginal discs.

65 s nuclear translocation, suggesting that the cytoplasmic retention of Ci155 may also depend on NLS ma

66 ubule network plays an important role in the cytoplasmic retention of Ci155.

67 yclin B1, whereas C53 deficiency led to more cytoplasmic retention of cyclin B1, suggesting that C53

68 trate that the ability of MKP-3 to cause the cytoplasmic retention of ERK2 requires both a functional

69 in the cytoplasm is largely responsible for cytoplasmic retention of ERK2.

70 unctional activity, loss of FAC binding, and cytoplasmic retention of FAA.

71 l surface, and loss of LLG1 function induces cytoplasmic retention of FER, consistent with transport

72 r transcriptional activity and increased the cytoplasmic retention of FKHRL1.

73 ion of Akt, which led to phosphorylation and cytoplasmic retention of FoxO3a.

74 gen sources controls the phosphorylation and cytoplasmic retention of Gln3 via the target of rapamyci

75 role of the IkappaBbeta insert in regulating cytoplasmic retention of IkappaBbeta.NF-kappaB complexes

76 Cytoplasmic retention of IMP-3 and HNRNPM in human cance

77 he interaction of NP with F-actin causes the cytoplasmic retention of influenza virus ribonucleoprote

78 JIP-1 caused cytoplasmic retention of JNK and inhibition of JNK-regul

79 Cytoplasmic retention of NF-kappaB and reduction of its

80 e nuclear levels of NF-kappaB indicates that cytoplasmic retention of NF-kappaB may be compensated fo

81 nd that growth inhibition is associated with cytoplasmic retention of NF-kappaB.

82 R-mediated activation by phosphorylation and cytoplasmic retention of NFATc1.

83 esidue by JNK in infected GECs, which caused cytoplasmic retention of Noxa.

84 nly reveal the molecular mechanism involving cytoplasmic retention of NPMc but also suggest cytoplasm

85 agent of cervical cancer, enhanced both the cytoplasmic retention of p27 and the migration of human

86 sequestration in yeast, we demonstrate that cytoplasmic retention of p65 (also called RelA) by Ikapp

87 16), ERK/pGSK3beta(Tyr-216) association, and cytoplasmic retention of pERK1/2.

88 ation from the reference OCTN2, with diffuse cytoplasmic retention of Phe17Leu, in contrast to refere

89 nistically, we determined that YAP1 mediates cytoplasmic retention of phosphorylated SMAD3 and suppre

90 Cytoplasmic retention of PKCdelta and its transport into

91 f negative residues working in opposition to cytoplasmic retention of positive residues, thus allowin

92 Furthermore, our results showed that the cytoplasmic retention of RARgamma was due to the presenc

93 The cytoplasmic retention of RARgamma was inhibited by ligan

94 as an inhibitor of Rel/NF-kappaB activity by cytoplasmic retention of Rel/NF-kappaB complexes, like o

95 ation of the NTD C terminus the relieves the cytoplasmic retention of RHA.

96 This may indicate that cytoplasmic retention of RSK2 is also required for PEA-1

97 induces a less extensive phosphorylation and cytoplasmic retention of Smad2 and Smad3.

98 s necessary for both V protein shuttling and cytoplasmic retention of STAT1 and STAT2 proteins.

99 Cytoplasmic retention of TFE3 by mTOR is sensitive to am

100 fic deletion of FLCN relieves mTOR-dependent cytoplasmic retention of TFE3, leading to direct inducti

101 beta (TGF beta) induced phosphorylation and cytoplasmic retention of the Forkhead factor FKHRL1, whi

102 lassically, NF-kappaB activity is limited by cytoplasmic retention of the NF-kappaB dimer through bin

103 s, continuous nuclear export is required for cytoplasmic retention of the v-Rel-IkappaB alpha complex

104 that activation of the PI3K pathway mediated cytoplasmic retention of the Wilms tumor (WTI) protein,

105 n the PABPC RRMs, thereby ensuring efficient cytoplasmic retention of this protein in normal cells.

106 markers of lysosome function, accompanied by cytoplasmic retention of transcription factor EB (TFEB),

107 e principally responsible for PEST-dependent cytoplasmic retention of v-Rel by p40.

108 ltered upon PKA activation, resulting in the cytoplasmic retention of WT1.

109 We suggest that the cytoplasmic retention of xnf7 depends on the phosphoryla

110 d to be mediated through phosphorylation and cytoplasmic retention of YAP and reduced expression of d

111 At high cell density, Hippo-mediated cytoplasmic retention of YAP facilitates p72 association

112 aining how F-actin inhibits AMOT130-mediated cytoplasmic retention of YAP.

113 ion factors by phosphorylating and promoting cytoplasmic retention of YAP.

114 tential of negative residues in favor of the cytoplasmic retention potential of positive residues, th

115 ely charged amino acids, thus increasing the cytoplasmic retention potential of positively charged am

116 e results imply that BRAP2 may function as a cytoplasmic retention protein and play a role in regulat

117 M phase, cyclin B1 is phosphorylated in the cytoplasmic retention sequence (CRS), which is required

118 show here that the previously characterized cytoplasmic retention sequence of Cyclin B1, responsible

119 omain sequences of RGS6 proteins function as cytoplasmic retention sequences to prevent their nuclear

120 rminus of APOBEC-1 with characteristics of a cytoplasmic retention signal (CRS) or a nuclear export s

121 this specialized property of hA3G is a novel cytoplasmic retention signal (CRS) that is necessary and

122 , four of which map to a recently identified cytoplasmic retention signal (CRS).

123 -canonical signal for nuclear export or as a cytoplasmic retention signal of PTEN.

124 cation of the carboxyl tail indicated that a cytoplasmic retention signal(s) was located between resi

125 s phosphorylation within a region called the cytoplasmic retention signal, which also contains a nucl

126 understand the mechanism responsible for its cytoplasmic retention, studies were undertaken to determ

127 in both Ad12- and Ad5-transformed cells via cytoplasmic retention, though only Ad12-transformed cell

128 C4 has been proposed to be important for its cytoplasmic retention, we find this interaction to be in

129 s interaction with 14-3-3beta leading to XLF cytoplasmic retention, where cytosolic XLF is subsequent

130 junctions to induce Yap phosphorylation and cytoplasmic retention, which drive cell differentiation.