ライフサイエンスコーパス: cytoprotective

1 n greatly enhances eEF2K activity and may be cytoprotective.

2 atocyte-derived Gal-9 is both diagnostic and cytoprotective.

3 nt to oxidative modification, C73A-KCNB1, is cytoprotective.

4 The iPLA(2)gamma pathway is cytoprotective.

5 ng, while in normal cells CD40 signalling is cytoprotective.

6 Attenuated reactivity unmasked the cytoprotective actions of NO in contrast to the cytotoxi

7 peptide-1 is an incretin hormone capable of cytoprotective actions that reduces inflammation and end

8 2S produced by the endogenous enzymes exerts cytoprotective actions.

9 The direct cytoprotective activities of activated protein C (APC) o

10 ding is necessary for lacritin mitogenic and cytoprotective activities, TGM2 cross-linking negatively

11 s controlling intracellular localization and cytoprotective activity are incompletely understood.

12 extract of M. pajang and quercetin displayed cytoprotective activity in HepG2 cells, with EC(50) valu

13 e that innate immune pathways have important cytoprotective activity in neurons and contribute to lim

14 t, again suggesting their involvement in the cytoprotective activity of bambangan kernel extract.

15 ercetin, suggesting their involvement in the cytoprotective activity of quercetin.

16 indings highlight the strong antioxidant and cytoprotective activity of the extract components, and i

17 The same was found for cytoprotective activity on lymphocytes, lipid peroxidati

18 e PPF were potent antioxidants and displayed cytoprotective activity through the activation of nuclea

19 A significant cytoprotective activity was observed when AGS cells were

20 meta-position of the B-ring exhibit improved cytoprotective activity, which is believed to result fro

21 the highest GluN2B affinity and the highest cytoprotective activity.

22 nsights into TMBIM-mediated calcium leak and cytoprotective activity.

23 ydroxyl radicals, low cytotoxicity, and high cytoprotective activity.

24 phenolic composition, antioxidant power and cytoprotective activity.

25 endent phospholipase A2gamma (iPLA2gamma) is cytoprotective against complement-mediated GEC injury.

26 endent phospholipase A2gamma (iPLA2gamma) is cytoprotective against complement-mediated glomerular ep

27 anion channel antagonist that is putatively cytoprotective against ischemic insult.

28 NO) produced by bacterial NOS functions as a cytoprotective agent against oxidative stress in Staphyl

29 The cytoprotective agent amifostine protected rats from long

30 AAP-induced toxicity and may be considered a cytoprotective agent in this in vitro model of drug indu

31 ritransplant administration of an epithelial cytoprotective agent, fibroblast growth factor-7, mainta

32 ry compound worth further investigation as a cytoprotective agent.

33 human activated protein C (rhAPC) has shown cytoprotective and anti-inflammatory functions in some c

34 to the discovery of its role in vasoactive, cytoprotective and anti-inflammatory responses.

35 CXCR3-B down-regulated the expression of the cytoprotective and antiapoptotic molecule heme oxygenase

36 end-organ protective properties mediated via cytoprotective and antiinflammatory mechanisms.

37 tion by activated protein C (APC) stimulates cytoprotective and antiinflammatory signaling.

38 isms that allow rapid switch on/off of their cytoprotective and apoptosis-inducing signaling pathways

39 ein C (APC) and thrombin elicits paradoxical cytoprotective and cytotoxic signaling responses in vasc

40 Glutathione S-transferase P1 is a Phase II cytoprotective and detoxifying enzyme that is widely exp

41 gulates the expression of a large network of cytoprotective and metabolic enzymes and proteins.

42 cytoplasmic ribonucleoprotein complexes with cytoprotective and pro-survival properties.

43 present evidence that PINK1-Parkin has both cytoprotective and proapoptotic functions.

44 identify the role of NF-kappaB in mediating cytoprotective and proinflammatory responses to inflamma

45 ral well-established and recently discovered cytoprotective and RNA-based Hsp70 functions.

46 nctional serine protease with anticoagulant, cytoprotective, and anti-inflammatory activities.

47 o examine expression levels of inflammatory, cytoprotective, and injury genes at different time point

48 in appears to play a prominent prosecretory, cytoprotective, and mitogenic role.

49 Possibly underlying its cytoprotective, anti-apoptotic, anti-oxidative effects,

50 endothelial growth factor (VEGF)-B activates cytoprotective/antiapoptotic and minimally angiogenic me

51 The cytoprotective antioxidant N-acetylcysteine inhibited Dp

52 rates the plasticity and cell-specificity of cytoprotective aPC signaling.

53 nt with simple ion channel block, were fully cytoprotective at concentrations that gave submaximal in

54 c apoptotic pathway which could overcome the cytoprotective autophagic mechanism.

55 ent, ATF4 activated a coordinated program of cytoprotective autophagy and antioxidant responses, incl

56 ement for functional p53 in the promotion of cytoprotective autophagy by radiation was confirmed by t

57 Because SFN treatment induces cytoprotective autophagy in cultured human prostate canc

58 ying a critical role for HSF1 in controlling cytoprotective autophagy through regulation of ATG7, whi

59 required for chemotherapeutic agent-induced cytoprotective autophagy through transcriptional up-regu

60 tosis, wherein targeting SQSTM1/p62 converts cytoprotective autophagy to an inefficient form due to c

61 lines, BRAFi or BRAF/MEK inhibition induced cytoprotective autophagy, and autophagy inhibition enhan

62 stress response that subsequently activated cytoprotective autophagy.

63 increased cell survival via the induction of cytoprotective autophagy.

64 s are the first to define an Hsp70-TLR4-Trif cytoprotective axis in the lung and endothelial cells.

65 amined the calcium-induced expression of the cytoprotective beta cell transcription factor Npas4.

66 On the basis of the cytoprotective capabilities of antifreeze proteins (AFPs

67 FBSH-III retained antioxidant activity and cytoprotective capacity after in vitro simulated gastroi

68 mitochondria-associated peptide that offers cytoprotective, cardioprotective, and neuroprotective ef

69 ozyme, was identified as a novel and leading cytoprotective compound.

70 Prestwick drug library to identify putative cytoprotective compounds against light-induced, syntheti

71 , C. album (poly)phenols appear as promising cytoprotective compounds, modulating central events in t

72 trials is that therapy-induced autophagy is cytoprotective; consequently, inhibition of autophagy is

73 s), furan compounds (HMF and furfural F) and cytoprotective/cytotoxic effects upon Caco-2 cells (MTT,

74 iates activated nuclear translocation of the cytoprotective DAF-16/FOXO transcription factor and prot

75 Since eEF2K is cytoprotective during hypoxia and other conditions of nu

76 ith the microwave system showed an increased cytoprotective effect against H2O2 induced oxidation in

77 The coffee samples exerted a cytoprotective effect against oxidative stress, with imp

78 Activation of IRE-1 RNase function exerts a cytoprotective effect and has been implicated in the pro

79 however Ulva compressa presented the highest cytoprotective effect by blunting the apoptosis process.

80 ely deregulated in cancer cells, mediating a cytoprotective effect during blood-borne metastasis.

81 oneal administration of PC-S195A conferred a cytoprotective effect for thrombin in an in vivo inflamm

82 tivation by IGF-I is crucial to preserve its cytoprotective effect in astrocytes and may form part of

83 s identify a unique mechanism underlying the cytoprotective effect of aPC.

84 This study aimed to investigate the cytoprotective effect of chemical agonist-mediated M3R a

85 Here, we explore mechanisms underlying the cytoprotective effect of ferritin in endothelial cells e

86 culum (ER), this study addressed whether the cytoprotective effect of iPLA2gamma involves the ER stre

87 The cytoprotective effect of tPA required its receptor, LDL

88 The cytoprotective effect of tucuma was evaluated in lymphoc

89 data support a model in which H2S exerts its cytoprotective effect on ISR signaling by inducing a tra

90 hage migration inhibitory factor (MIF) has a cytoprotective effect on lung endothelial cells; however

91 e stress after DETA-NO preconditioning; this cytoprotective effect was abolished by the NO scavenger.

92 This cytoprotective effect was associated with enterocyte-med

93 hypoxia/reoxygenation (H/R) stages to exert cytoprotective effects against H/R injury.

94 Moreover, H2S elicits cytoprotective effects against stressors in various cell

95 showed the highest antioxidant activity and cytoprotective effects against tert-butyl hydroperoxide

96 le heat shock protein 70, Hsp72, has broadly cytoprotective effects and improves outcome following st

97 hat RBC-targeted scFv/TM exerts multifaceted cytoprotective effects and may find utility in systemic

98 ion of heme oxygenase 1 (HO-1), which exerts cytoprotective effects and modulates the renal response

99 Shh coacervate also demonstrates cytoprotective effects for cardiomyocytes in a hydrogen

100 hough adiponectin has been reported to exert cytoprotective effects in acute cardiac diseases, its ef

101 exerts anti-inflammatory, antiapoptotic, and cytoprotective effects in addition to its hematopoietic

102 17-mer, 17-mer[H105A], and 44-mer exhibited cytoprotective effects in cultured retina R28 cells.

103 Whether TNF-alpha also exerts cytoprotective effects in heart failure is not known.

104 r concentrations, STS-E412 provided EPO-like cytoprotective effects in primary neuronal cells and ren

105 n protease activated protein C (aPC) confers cytoprotective effects in various in vitro and in vivo d

106 In addition to the cytoprotective effects of APC on endothelial cells, podo

107 d ARE-containing mRNAs may contribute to the cytoprotective effects of Hsp70 following cellular stres

108 These findings imply the cytoprotective effects of NF-kappaB activation on oligod

109 mplete or partial loss, respectively, of the cytoprotective effects of partial beclin-1 knockdown, in

110 The cytoprotective effects of pigment epithelium-derived fac

111 Here, we investigated whether the cytoprotective effects of Tbeta4 can increase the effect

112 ed blood cell production and exert important cytoprotective effects on select vascular, immune, and c

113 Understanding how EPCR-APC induces cytoprotective effects through activation of PAR1, whose

114 ndicate that similar to APC, thrombin exerts cytoprotective effects via beta-arrestin-2 biased PAR1 s

115 Similar cytoprotective effects were observed after transient shR

116 HGF), a healing factor with regenerative and cytoprotective effects, are associated with inflammatory

117 mediating activated protein C (APC)-induced cytoprotective effects, including antiapoptotic, anti-in

118 on substrate translocation and abolishes the cytoprotective effects.

119 ectedly high GluN2B affinity but do not show cytoprotective effects.

120 AR1, but its effects on cells contrast APC's cytoprotective effects.

121 C at Arg41 can initiate distinctive APC-like cytoprotective effects.

122 AR3 in the complex mechanisms underlying APC cytoprotective effects.

123 e propose that polySia in semen represents a cytoprotective element to increase the number of vital s

124 s a stress-inducible, anti-inflammatory, and cytoprotective enzyme expressed in most cell types in th

125 Expression of the cytoprotective enzyme heme oxygenase-1 (HO-1) is signifi

126 osine kinase c-Met and overexpression of the cytoprotective enzyme heme oxygenase-1 (HO-1) play a cri

127 KEY POINTS: Haem oxygenase 1 (Hmox1) is a cytoprotective enzyme with anti-inflammatory and anti-ox

128 Heme oxygenase-1 (HO-1), a pivotal cytoprotective enzyme, has antiviral activity for a numb

129 d cancers, where increased expression of the cytoprotective enzyme, heme oxygenase-1 (HO-1) is often

130 ession of heme oxygenase-1 (HO-1), a pivotal cytoprotective enzyme, postinfection and that overexpres

131 sion of heme oxygenase-1, an antioxidant and cytoprotective enzyme.

132 Nrf2, which regulates the expression of many cytoprotective enzymes including heme oxygenase-1 (HO-1)

133 ependent on STAT3 signaling and induction of cytoprotective factors in epithelial cells.

134 The benefits resulted from cytoprotective factors including vascular endothelial gr

135 ure assays, DAR did not stimulate release of cytoprotective factors, such as vascular endothelial gro

136 st marked changes, we found up-regulation of cytoprotective factors; a shift from oxidative phosphory

137 se optimum, the same domain is mitogenic and cytoprotective for epithelia via a syndecan-1 targeting

138 ther the drugs or radiation used promote the cytoprotective form of autophagy in the tumor cells as w

139 53 null H1299 cells but was converted to the cytoprotective form with induction of p53.

140 tial for mitochondrial turnover and serves a cytoprotective function in dopaminergic neurons in vivo.

141 intermediate filament protein that exerts a cytoprotective function in mature sensory and motor neur

142 This cytoprotective function of ATG16L1 was associated with t

143 The study further characterizes the cytoprotective function of DJ-1 and PD-mutated variants

144 The importance of Trx1 in the cytoprotective function of DJ-1 is confirmed using a pha

145 mic mRNA complexes and is sufficient for the cytoprotective function of TSN during stress.

146 Furthermore, our work connects the cytoprotective function of TSN with its positive role in

147 One is the cytoprotective function that can in theory be inhibited

148 pe digestive epithelia and provide important cytoprotective function.

149 th Ly294002 resulted in loss of MOR-mediated cytoprotective function.

150 Holo-RBP4 is recognized to possess cytoprotective function.

151 ion factor well known for its cell-intrinsic cytoprotective function.

152 that might have significant implications for cytoprotective functions and therapeutic targeting of th

153 MDP cytoprotective functions are generally attributed to ant

154 he integrated stress response (ISR) that has cytoprotective functions as well as apoptotic signals th

155 nism of the signaling pathways mediating the cytoprotective functions of H2S is not well understood.

156 2 transcription factor is well known for its cytoprotective functions through regulation of genes inv

157 s a transcription factor that is crucial for cytoprotective gene expression and is generally thought

158 nstressed adult mouse hepatocytes produces a cytoprotective gene expression profile and induces lipog

159 vated activation of Nrf2 and upregulation of cytoprotective gene expression.

160 ession of injury markers Kim-1, p21, and the cytoprotective gene heme oxygenase-1 accompanied this.

161 n as NF-E2-related factor 2 (Nrf2), is a key cytoprotective gene that regulates critical antioxidant

162 In summary, fish-derived omega-3s increase cytoprotective genes and decrease proapoptotic genes, im

163 ro-oxidant, tBHQ regulates the expression of cytoprotective genes by activation of redox-sensing tran

164 , presumably to ensure maximum activation of cytoprotective genes during potentially fatal conditions

165 This compound induced the expression of cytoprotective genes in keratinocytes isolated from wild

166 regulator that promotes the transcription of cytoprotective genes in response to oxidative/electrophi

167 SKN-1/Nrf transcription factors activate cytoprotective genes in response to reactive small molec

168 species (ROS) that lead to the induction of cytoprotective genes such as the UDP-glucuronosyltransfe

169 ttractive possibility is the exploitation of cytoprotective genes that exist solely for self-preserva

170 er cells provokes NRF2-mediated induction of cytoprotective genes, because it logjams the ubiquitin l

171 lated factor 2 (Nrf2), a master regulator of cytoprotective genes, is controlled by dimeric Kelch-lik

172 Instead, ATF4 activates the expression of cytoprotective genes, which reprogram cellular metabolis

173 responds by activating the transcription of cytoprotective genes.

174 idative stress by the regulation of multiple cytoprotective genes.

175 nvolved in the activation of antioxidant and cytoprotective genes.

176 by increasing the expression of a number of cytoprotective genes.

177 constitutive NRF2-mediated transcription of cytoprotective genes.

178 by inducing the transcription of an array of cytoprotective genes.

179 n expression and increased the expression of cytoprotective H-ferritin.

180 ich also led to suppressed expression of the cytoprotective heat shock protein 72.

181 tional responses, controls the expression of cytoprotective heat shock proteins (HSPs), molecular cha

182 es (2-37) and compared their cytotoxicity to cytoprotective heat-shock-inducing activity (HSA).

183 The master regulator of the classical cytoprotective "heat shock" response, heat shock factor

184 enoprotection corresponded with increases in cytoprotective heme oxygenase 1 and IL-10 mRNAs, selecti

185 unction is a consequence of induction of the cytoprotective, heme-degrading enzyme heme oxygenase-1 (

186 t, whereas low-concentration thrombin may be cytoprotective, higher thrombin concentrations may contr

187 it was associated with the overexpression of cytoprotective HO-1 and anti-apoptotic Bcl-2/Bcl-xL.

188 oxide (NO), a gaseous messenger known to be cytoprotective; however, the underlying mechanism remain

189 , this is caused by compromised secretion of cytoprotective IL-18 from IKKalpha-mutant intestinal epi

190 nt tumors, the autophagy is not of necessity cytoprotective in function.

191 ducible factor-1alpha (HIF-1alpha), which is cytoprotective in ischemia.

192 trongly suggests that chaperone proteins are cytoprotective in neurodegenerative proteinopathies invo

193 We conclude that eIF2alpha-P is cytoprotective in response to UVB by a mechanism featuri

194 is lethal when exposure is extreme but also cytoprotective in that sublethal exposure leads to the s

195 2 p45-related factor 2 (Nrf2) orchestrates a cytoprotective inducible program, which counteracts the

196 ce, suppresses toxic inflammation, increases cytoprotective insulin-like growth factor 1 (IGF1) signa

197 sented here show that the anti-inflammatory, cytoprotective intracellular and extracellular chaperone

198 urodegeneration and that the balance between cytoprotective JNK and cytotoxic p38 signaling dictates

199 ation, and also enhanced the accumulation of cytoprotective markers.

200 ugh binding to the 3'UTR constitutes a novel cytoprotective mechanism of Hsp27 during stress in neuro

201 ulation of iNOS levels may remove a critical cytoprotective mechanism of importance in tumour angioge

202 dings suggest a novel role of autophagy as a cytoprotective mechanism to negatively regulate and prev

203 Proteins which might be involved in the cytoprotective mechanism were investigated using western

204 erated by pathological stress, possibly as a cytoprotective mechanism.

205 of antioxidant, anti-inflammatory, and other cytoprotective mechanisms important in protection from k

206 e transfer is sufficient to recapitulate the cytoprotective mechanisms in CD31(-) pancreatic beta cel

207 nt for bladder cancer therapy, but inducible cytoprotective mechanisms may limit its potential effica

208 ls, which can promote cardiac repair through cytoprotective mechanisms.

209 o potentiate TKI anti-leukemia activity in a cytoprotective microenvironment.

210 suggest that we have discovered a conserved cytoprotective modifier of amyloidogenic processes.

211 on monoxide (CO), one of the products of the cytoprotective molecule heme oxygenase-1 (HO-1) in cance

212 gulates the transcription of several hundred cytoprotective molecules, including antioxidants, detoxi

213 idated, Plin5 provides a basis for the novel cytoprotective nature of lipid droplets.

214 These data demonstrate that MP4CO induces cytoprotective Nrf2 and HO-1 and decreases NF-kB activat

215 of rapamycin (mTOR) signaling and activated cytoprotective Nrf2 signaling.

216 tion of clotting factors Va and VIIIa; (2) a cytoprotective on the basis of endothelial barrier stabi

217 at radiation-induced autophagy can be either cytoprotective or nonprotective, a functional difference

218 The unfolded protein response (UPR) is a cytoprotective pathway that relieves endoplasmic reticul

219 hat CDK20 positively modulate the KEAP1-NRF2 cytoprotective pathway to regulate tumor progression and

220 Both cytoprotective pathways have been well studied in isolat

221 rrier function and induces proliferative and cytoprotective pathways in the small bowel.

222 block pathologic signaling while preserving cytoprotective pathways.

223 tional factor that induces antioxidative and cytoprotective pathways.

224 ghest antioxidant activity were screened for cytoprotective potential in MCF-7 cells, including the m

225 tivity may not be directly related with high cytoprotective potential.

226 nfolded protein response (UPR), an important cytoprotective program induced by hypoxia, affects the b

227 n elicit differentiation, proliferation, and cytoprotective programs, underscoring the rising recogni

228 Hsp70 has potent cytoprotective properties and has been described as a TL

229 rate) was shown to have antiinflammatory and cytoprotective properties in preclinical experiments and

230 Nitric oxide (NO) has demonstrated cytoprotective properties in various cells, but its bene

231 polyphenols, and to evaluate antioxidant and cytoprotective properties of the partridgeberry polyphen

232 iPSC-derived EVs impart cytoprotective properties to cardiac cells in vitro and

233 roadly used antibiotic also known to possess cytoprotective properties, enhances survival of grafted

234 GRP78, a multifunctional protein with potent cytoprotective properties, is an emerging therapeutic ta

235 , Lauraceae; BL) were examined for potential cytoprotective properties.

236 , Lauraceae; BL) were examined for potential cytoprotective properties.

237 n miRNAs and proteins with proangiogenic and cytoprotective properties.

238 ion of PERK signaling in oligodendrocytes is cytoprotective, protecting mice against EAE.

239 nstrate a corresponding up-regulation of the cytoprotective protein heme oxygenase-1 (HO-1) which is

240 alphaKlotho is a cytoprotective protein, the expression of which is reduc

241 eded to investigate the involvement of other cytoprotective proteins in the cytoprotection mechanism.

242 ated factor (Nrf2) induces the expression of cytoprotective proteins that maintain and restore redox

243 Stress pathways coordinate a cytoprotective repair response, while simultaneously ini

244 e subpopulations can be modulated to mediate cytoprotective, reparative, and even regenerative functi

245 ches, we demonstrate that HIPK2 can elicit a cytoprotective response in cancer cells via NRF2.

246 Such a mechanism allows for a greater cytoprotective response in human AML cells and encourage

247 Previously, we had shown that this conserved cytoprotective response is regulated by the thermosensor

248 of bixin derived from induction of the NRF2 cytoprotective response since it was only observed in Nr

249 sion in the liver produces a Notch-dependent cytoprotective response through direct transcriptional a

250 SG formation is a cytoprotective response to environmental stress and resu

251 ponents within the lysosome, is an essential cytoprotective response to pathologic stresses that occu

252 P1 is the key regulator of the NRF2-mediated cytoprotective response, and increasingly recognized as

253 g oxidative stress and, as such, represent a cytoprotective response.

254 rf2) is a transcription factor that mediates cytoprotective responses against stress.

255 unexpected interaction between two important cytoprotective responses that are likely to have signifi

256 coordinately regulates basal metabolism and cytoprotective responses to radiation injury.

257 tophagy are engaged as primary and secondary cytoprotective responses, respectively, to Sigma1 ligand

258 f TCF7 in human and mouse islets impairs the cytoprotective responsiveness to GIP and enhances the ma

259 induced hepatic lipophagy plays an important cytoprotective role against liver injury, but its mechan

260 e cellular prion protein (PrP) often plays a cytoprotective role by regulating autophagy in response

261 Analogous to its established cytoprotective role during nutrient starvation, autophag

262 sorafenib/obatoclax lethality, indicating a cytoprotective role for autophagy in this setting.

263 Here, we reveal a cytoprotective role for mitochondrial ROS (mtROS) in Cae

264 These data suggest a cytoprotective role for Plin5 to promote lipid storage b

265 While UPF1 is best known for its basal cytoprotective role in degrading aberrant RNAs, UPF1 als

266 MiR-150 conferred a cytoprotective role in lung epithelial cells after oxida

267 n the kidney during endotoxemia and served a cytoprotective role in mitigating acute kidney injury.

268 bound transcription factor ATF6alpha plays a cytoprotective role in the unfolded protein response (UP

269 is induced in normoxic myofibers, playing a cytoprotective role.

270 The cytoprotective secretory form of clusterin, as evaluated

271 (TRAF2), an E3 ubiquitin ligase, coordinates cytoprotective signaling downstream of both TNF receptor

272 otential of novel APC variants with superior cytoprotective signaling function as enhanced therapeuti

273 hat block proinflammatory pathways but spare cytoprotective signaling in endothelial cells.

274 Our results suggest that H2S-mediated cytoprotective signaling in the setting of I/R injury is

275 helial cells and suggest that SGK1-dependent cytoprotective signaling involves effects on maintaining

276 ter, we identified a novel aPC/PAR-dependent cytoprotective signaling mechanism.

277 This study elucidated a novel cytoprotective signaling pathway initiated by the APP tr

278 elopment and function and promotes cell-cell cytoprotective signaling responses.

279 APC elicits cytoprotective signaling through activation of protease

280 at a cleavage site that selectively mediates cytoprotective signaling.

281 effector, which contributes to TRAF2-induced cytoprotective signaling.

282 by crosstalking with c-Met to potentiate its cytoprotective signals in airway epithelial cells during

283 ponse to influenza infection by facilitating cytoprotective signals through c-Met signaling to limit

284 ession in beta-cells should be explored as a cytoprotective strategy in type 1 diabetes.

285 sis in the presence of stromal co-culture or cytoprotective survival signals.

286 FLT3 is a cytoprotective system in the heart and a potential thera

287 cies (ROS) production and the ability of the cytoprotective system to detoxify the reactive intermedi

288 aracterised by the upregulated expression of cytoprotective target genes.

289 target for a first-in-class mechanism-based, cytoprotective therapy in the unmet high medical need in

290 Here we show that ER-localized THBS1 is cytoprotective to rat, mouse, and human beta-cells expos

291 lated factor 1 (Nrf1, also called NFE2L1), a cytoprotective transcription factor critical for the exp

292 Here we demonstrate that the key cytoprotective transcription factor NRF2 controls lncRNA

293 tified novel crosstalk between HIPK2 and the cytoprotective transcription factor NRF2.

294 eic acid and is coupled to activation of the cytoprotective transcription factor SKN-1 in both labora

295 e demonstrate genetic ablation of the master cytoprotective transcription factor, nuclear factor (ery

296 its splicing target, bZIP60, govern the two cytoprotective UPR signaling pathways known to date.

297 cetin) and quercetin have shown antioxidant, cytoprotective, vasoprotective, antiproliferative and an

298 ts help explain the differentiation of APC's cytoprotective versus thrombin's proinflammatory effects

299 Whether DAR was directly cytoprotective was examined in cultured rat hepatocytes

300 of ubiquitin-tagged damaged mitochondria is cytoprotective, we tested the hypothesis that TRAF2 medi