ライフサイエンスコーパス: cytosine deaminase

1 versification enzyme AID (activation-induced cytosine deaminase).

2 that 5-FC is a poor substrate for bacterial cytosine deaminase.

3 rvival, and expression of activation-induced cytosine deaminase.

4 virus thymidine kinase and 5-fluorocytosine/cytosine deaminase.

5 rsion of pyrimidine supplements to uracil by cytosine deaminase.

6 ; and demonstrates DNA breakage via APOBEC3A cytosine deaminase.

7 ions, isoguanine is the better substrate for cytosine deaminase.

8 fied by peptide mass fingerprint analysis as cytosine deaminase.

9 actor-1-alpha antibodies, interleukin-2, and cytosine deaminase.

10 low dCK, hENT1, and 2 transporters, and high cytosine deaminase.

11 diversification by an ancestral AID-like DNA cytosine deaminase.

12 cytosine deaminase alone, or endostatin plus cytosine deaminase.

13 en annotated as a probablechlorohydrolase or cytosine deaminase.

14 version mechanism involving lineage-specific cytosine deaminases.

15 r VLRB assembly, together with expression of cytosine deaminase 1 (CDA1) or 2 (CDA2), respectively.

16 -6) and the bacterial metabolic suicide gene cytosine deaminase (205-IL6-CD) become highly immunogeni

17 ed the efficacy of adenoviral (Ad5)-directed cytosine deaminase/5-fluorocytosine (CD/5-FC) enzyme/pro

18 Cytosine deaminase/5-fluorocytosine (CD/5-FC) is a promi

19 thymidine kinase/ganciclovir (TK/GCV), yeast cytosine deaminase/5-fluorocytosine (yCD/5-FC) and nitro

20 Yeast cytosine deaminase, a zinc metalloenzyme, catalyzes the

21 ating that R-loops limit activation-induced (cytosine) deaminase access to the transcribed DNA strand

22 suggest that Vif binds and inhibits the non-cytosine deaminase activities of intact A3G and intact A

23 thereby causing elevated A3B expression and cytosine deaminase activity in cancer cells.

24 Cancer genome sequencing has implicated the cytosine deaminase activity of apolipoprotein B mRNA edi

25 poration into virus particles and subsequent cytosine deaminase activity that attacks the nascent vir

26 o elaborate a simple method for assaying DNA cytosine deaminase activity that eliminates potential po

27 Low cytosine deaminase activity was detected when guanines f

28 Its single-stranded DNA cytosine deaminase activity, located in its C-terminal d

29 Here we show that although Apobec2a,2b lack cytosine deaminase activity, they require a conserved zi

30 ated male donor mice were incubated with the cytosine deaminase adenoviral vector and then exposed to

31 the mutagenic actions of activation induced cytosine deaminase (AICDA).

32 enes are initiated by the activation-induced cytosine deaminase AID.

33 essibility and/or recruit activation-induced cytosine deaminase (AID) and its associated processes to

34 B-cell clones manifesting activation-induced cytosine deaminase (AID) and up-regulated p53 following

35 anslocations prefer known activation-induced cytosine deaminase (AID) hotspots such as WGCW and WRC (

36 Activation-induced cytosine deaminase (AID) is a cytosine deaminase that is

37 Activation-induced cytosine deaminase (AID) is essential for both somatic h

38 Does the activation-induced cytosine deaminase (AID) that initiates SHM not gain acc

39 ed since the discovery of activation-induced cytosine deaminase (AID), the molecule responsible for t

40 gulates the expression of activation-induced cytosine deaminase (AID), which is critical for antibody

41 e dependent on the enzyme activation-induced cytosine deaminase (AID).

42 imiting the expression of activation-induced cytosine deaminase (AID).

43 ymphoid tissue expressing activation-induced cytosine deaminase (AID).

44 on (CSR) are initiated by activation-induced cytosine deaminase (AID).

45 red with the treatments of endostatin alone, cytosine deaminase alone, or endostatin plus cytosine de

46 nce identity of 29 and 25%, respectively, to cytosine deaminase and dihydroorotase, both members of a

47 Incorporating cytosine deaminase and Herpes simplex virus thymidine ki

48 The cytosine deaminase and herpes simplex virus-1 thymidine

49 The Escherichia coli gene, codA, encodes cytosine deaminase and is introduced into cancer cells f

50 osine in DNA to uracil by activation-induced cytosine deaminase and its removal by uracil-DNA glycosy

51 us type 1-thymidine kinase, Escherichia coli cytosine deaminase, and human deoxycytidine kinase were

52 A likely cause is the DNA cytosine deaminase APOBEC3B (A3B).

53 Overexpression of the antiviral DNA cytosine deaminase APOBEC3B has been linked to somatic m

54 Here we show that the DNA cytosine deaminase APOBEC3B is a probable source of thes

55 wide variation in the expression of the DNA cytosine deaminase APOBEC3B, with elevated expression in

56 n specifically induces the innate immune DNA cytosine deaminase APOBEC3B.

57 The DNA cytosine deaminase APOBEC3G (A3G) is capable of blocking

58 or by infecting with virus that contains the cytosine deaminase APOBEC3G (A3G), the proportion of rev

59 The cytosine deaminase APOBEC3G, in the absence of the human

60 APOBEC3H and homologous single-stranded DNA cytosine deaminases are unique to mammals.

61 quences, and neomycin phosphotransferase and cytosine deaminase as positive and negative markers, res

62 The enzyme/prodrug strategy using bacterial cytosine deaminase (bCD) and 5-fluorocytosine (5-FC) is

63 We previously observed that bacterial cytosine deaminase (bCD) conjugated with multimodal imag

64 The crystal structure of bacterial cytosine deaminase (bCD) reveals that a loop structure i

65 in the substrate binding pocket of bacterial cytosine deaminase (bCD) that result in marginal improve

66 icacy of cancer gene therapy using bacterial cytosine deaminase (bCD)/5-fluorocytosine (5-FC) enzyme/

67 Activation-induced cytosine deaminase begins the process by deaminating cyt

68 talytic polypeptide-like 3 (APOBEC3; A3) DNA cytosine deaminases can be incorporated into progeny vir

69 The Apobec/AID family of cytosine deaminases can deaminate cytosine and thereby c

70 estion that remains unanswered is how AID, a cytosine deaminase, causes mutations at both G:C and A:T

71 We used the cytosine deaminase (CD) 5-fluorocytosine (5-FC) enzyme/p

72 The combination of cytosine deaminase (CD) and herpes simplex virus thymidi

73 a fusion gene comprised of Escherichia coli cytosine deaminase (CD) and herpes simplex virus type 1

74 s using AdCMV.CD, an adenovirus that encodes cytosine deaminase (CD) and is capable of metabolizing 5

75 d that requires the activity of two enzymes: cytosine deaminase (CD) and UPRT.

76 Cytosine deaminase (CD) catalyzes the deamination of cyt

77 5-fluorouracil (5-FU) by monoclonal antibody-cytosine deaminase (CD) conjugates.

78 The Escherichia coli enzyme cytosine deaminase (CD) converts the prodrug 5-fluorocyt

79 C members with two Zn-coordinated homologous cytosine deaminase (CD) domains, with the others being A

80 The enzyme cytosine deaminase (CD) encoded by codA catalyzes deamin

81 ' to the LacZ gene (Ad-Lp-LacZ) or 5' to the cytosine deaminase (CD) gene (Ad-Lp-CD) in a replication

82 Suicide gene therapy using the cytosine deaminase (CD) gene and 5-fluorocytosine (5-FC)

83 adenoviral vector (Ad.CMV.CD) containing the cytosine deaminase (CD) gene under the control of a cyto

84 of an RCR vector (ACE-CD) carrying the yeast cytosine deaminase (CD) gene, which converts the nontoxi

85 virus (CMV)-driven transcription unit of the cytosine deaminase (CD) gene.

86 Cytosine deaminase (CD) is a microbial gene undergoing c

87 reporter gene or the prodrug converter gene cytosine deaminase (CD) was constructed.

88 One of the most promising PGT enzymes is cytosine deaminase (CD), a microbial salvage enzyme that

89 Cytosine deaminase (CD)-based gene therapy has been show

90 g strategy is limited by the inefficiency of cytosine deaminase (CD)-catalyzed conversion of 5-FC int

91 er the bystander or protective effect of the cytosine deaminase (CD)/5-flucytosine (5-FC) gene therap

92 Adenovirus (Ad) vector-mediated cytosine deaminase (CD)/5-fluorocytosine (5-FC) gene the

93 competent, oncolytic adenovirus containing a cytosine deaminase (CD)/herpes simplex virus thymidine k

94 sed the fusion suicide gene Escherichia coli cytosine deaminase (CD)/uracil phosphoribosyltransferase

95 Cytosine deaminase (CDA) from Escherichia coli was shown

96 T MRI approach for detecting the activity of cytosine deaminase (CDase), an enzyme that catalyzes the

97 selection against stable integration of the cytosine deaminase (codA) gene-containing T-DNA.

98 product of ORF2 shows high similarity to the cytosine deaminase (CodA) of Escherichia coli.

99 Transcription of the cytosine deaminase (codBA) operon of Escherichia coli is

100 Cytosine deaminase converts 5-FC into cytotoxic 5-fluoro

101 While AID acts as a single-strand DNA-cytosine deaminase creating U .

102 Deficiency in activation-induced cytosine deaminase diminishes but does not ablate murine

103 nase domain from APOBEC3G and the C-terminal cytosine deaminase domain from APOBEC3F elicited a dinuc

104 A chimeric protein with the N-terminal cytosine deaminase domain from APOBEC3G and the C-termin

105 Here, we show that only the C-terminal cytosine deaminase domain of APOBEC3F and -3G governs re

106 BEC3F proteins have an active N-terminal DNA cytosine deaminase domain, which elicits a broader dinuc

107 In lung adenocarcinoma cell lines, cytosine deaminase, driven by the CMV promoter, was supe

108 Cytosine deaminase (EC 3.5.4.1), a non-mammalian enzyme,

109 Therefore, cytosine deaminase expressed from the CMV promotor seems

110 Cytosine deaminase expression in Klebsiella pneumoniae w

111 Deletion of yeast cytosine deaminase Fcy1 significantly decreased the rate

112 Several members of the APOBEC3 family of DNA cytosine deaminases function to limit the replication of

113 This endostatin-cytosine deaminase fusion approach opens an avenue for c

114 When we used the endostatin-cytosine deaminase fusion protein to treat s.c. grafted

115 ly engineered to express the E. coli-derived cytosine deaminase gene are effective in converting syst

116 Thus, only cells expressing the cytosine deaminase gene can be rescued in a positive sel

117 ther, we have developed the Escherichia coli cytosine deaminase gene codA as a conditional negative s

118 diated gene transfer of the Escherichia coli cytosine deaminase gene followed by exposure to the nont

119 e been genetically modified with a bacterial cytosine deaminase gene to express a functional enzyme.

120 AdGVCD.10 (carrying the Escherichia coli cytosine deaminase gene) was administered (8 x 10(8) to

121 tion method based upon the expression of the cytosine deaminase gene.

122 neumoniae differs from E. coli in having two cytosine deaminase genes, an intervening open reading fr

123 e APOBEC3B (A3B) single-stranded DNA (ssDNA) cytosine deaminase has important roles in innate immunit

124 The APOBEC3 family of DNA cytosine deaminases has important roles in innate immuni

125 etent adenovirus (Ad5-CD/TKrep) to deliver a cytosine deaminase/herpes simplex virus-1 thymidine kina

126 ence of AtzC was compared to that of E. coli cytosine deaminase in the regions containing the five li

127 n cancer genomes have implicated the APOBEC3 cytosine deaminases in oncogenesis, possibly offering a

128 ell AICD, indicating that activation-induced cytosine deaminase-induced DNA damage is only in part re

129 Cytosine deaminase is used in combination with 5-fluoroc

130 The APOBEC3 family of DNA cytosine deaminases is capable of restricting the replic

131 The designed photocontrolled cytosine deaminases may also aid in improving chemothera

132 f these proteins has elicited polynucleotide cytosine deaminase or anti-viral activity.

133 one coherent model, and further suggest that cytosine deaminases, particularly AID, might have a broa

134 Activation-induced cytosine deaminase preferentially deaminates C in DNA on

135 The endostatin-cytosine deaminase protein significantly inhibited the g

136 ound to RNA, perhaps resembling APOBEC-3G, a cytosine deaminase related to AID that inhibits HIV repl

137 3G is a member of a family of polynucleotide cytosine deaminases, several of which also target distin

138 sociated with altered CpGs and APOBEC-family cytosine deaminases similar to mutation signatures deriv

139 Cytosine deaminases, such as activation-induced cytidine

140 deliver a therapeutically relevant molecule-cytosine deaminase-such that quantifiable reduction in t

141 pendent adenosine deaminase and Fe-dependent cytosine deaminase, suggesting that ACMSD may share cert

142 of herpes simplex virus thymidine kinase or cytosine deaminase suicide genes.

143 POBEC3G (Apo3G) is a single-stranded (ss)DNA cytosine deaminase that eliminates HIV-1 infectivity by

144 APOBEC3B is a single-stranded DNA cytosine deaminase that functions normally as a nuclear-

145 vation-induced cytosine deaminase (AID) is a cytosine deaminase that is critical to immunoglobulin hy

146 BEC3G or A3G) is an evolutionarily conserved cytosine deaminase that potently restricts human immunod

147 APOBEC3G belongs to a family of DNA cytosine deaminases that are involved in the restriction

148 a family of single-stranded DNA (ssDNA) DNA cytosine deaminases that are known for restriction of HI

149 G, the artiodactyl APOBEC3F proteins are DNA cytosine deaminases that locate predominantly to the cyt

150 APOBEC3F (A3F) and APOBEC3G (A3G) are DNA cytosine deaminases that potently restrict human immunod

151 APOBEC3s (A3s) are single-stranded DNA cytosine deaminases that provide innate immune defences

152 mentation assay based on the optimized yeast cytosine deaminase to systematically identify candidate

153 d to remove RNA allowing activation-induced (cytosine) deaminase to promote somatic hypermutation on

154 s tumors, our results showed that endostatin-cytosine deaminase treatment provided stronger tumor gro

155 ate both the concentration and activity of a cytosine deaminase-uracil phosphoribosyltransferase (CD-

156 highly potent prodrug activating gene [yeast cytosine deaminase/uracil phospho-ribosyltransferase fus

157 of a single bifunctional yeast fusion gene, cytosine deaminase/uracil phosphoribosyltransferase (FCU

158 a secreted form of beta-glucuronidase and a cytosine deaminase/uracil phosphoribosyltransferase, whi

159 toxicity by secreted beta-glucuronidase and cytosine deaminase/uracil phosphoribosyltransferase.

160 uding TK (TK007 and TK(SR39) mutants), yeast cytosine deaminase:uracil phosphoribosyltransferase (yCD

161 amidohydrolase protein family that includes cytosine deaminase, urease, adenine deaminase, and phosp

162 ain of APOBEC3G (A3G-CTD), an ssDNA-specific cytosine deaminase, was expressed in an Escherichia coli

163 d to the therapeutically useful enzyme yeast cytosine deaminase, we obtained a approximately 3-fold c

164 de deformylase, threonine dehydrogenase, and cytosine deaminase, were rapidly damaged by micromolar h

165 cacy of endostatin, we fused endostatin with cytosine deaminase, which converts a prodrug 5-flucytosi

166 The bacterial codA gene encoding cytosine deaminase, which converts the non-toxic 5-fluor

167 ene is disrupted by sequences encoding yeast cytosine deaminase, which efficiently metabolizes the pr

168 iched with a motif targeted by APOBEC family cytosine-deaminases, which strongly prefer ssDNA.

169 EC3A (A3A) is a myeloid lineage-specific DNA cytosine deaminase with a role in innate immunity to for

170 APOBEC3A and APOBEC3G are DNA cytosine deaminases with biological functions in foreign

171 resent study, we show that the K(m) of yeast cytosine deaminase (yCD) for 5-FC was 22-fold lower when

172 the deamination reaction catalyzed by yeast cytosine deaminase (yCD), a zinc metalloenzyme of signif

173 Yeast cytosine deaminase (yCD), a zinc metalloenzyme, catalyze

174 noembryonic antigen (CEA) promoter for yeast cytosine deaminase (yCD), which converts 5-fluorocytosin

175 Yeast cytosine deaminase (yCD)-based gene therapy offers the p