ライフサイエンスコーパス: cytosine residue

1 fts methylation exclusively to the mispaired cytosine residue.

2 tein and a phosphate two bases away from the cytosine residue.

3 sence of the C-5 methyl group at neighboring cytosine residues.

4 s caused by APOBEC3-catalyzed deamination of cytosine residues.

5 ith templates incorporating atactic glyceryl cytosine residues.

6 ed by sequences that are rich in guanine and cytosine residues.

7 causing them to become stably methylated at cytosine residues.

8 ntact with the methyl-groups of the modified cytosine residues.

9 ects of the interaction between two adjacent cytosine residues.

10 DNA methylation at selective cytosine residues (5-methylcytosine (5mC)) and their rem

11 ty may relate to repair of oxidized 5-methyl cytosine residues (5meCyt).

12 these codons leading to translation of more cytosine residues: a shift that leads to more proline, a

13 ch contains glucosylated, 5-hydoxymethylated cytosine residues, affects the ability of particular Mot

14 proteins involved in the modification of DNA cytosine residues and enzymes which catalyze posttransla

15 otide substrate contains three C5-methylated cytosine residues and one unmethylated 5'-CG-3' site.

16 l-L-methionine (AdoMet) to the 5-position of cytosine residues and thereby silence transcription of r

17 Eukaryotic DNA is methylated at some cytosine residues, and this epigenetic feature performs

18 spectra in H2O showed that the third strand cytosine residues are fully paired with the guanine resi

19 histones and methylation of histones and DNA cytosine residues are part of the complex epigenetic reg

20 J CH) conclusively showed that the Hoogsteen cytosine residues are protonated at N3.

21 nd how methylated and unmethylated states of cytosine residues are transmitted during DNA replication

22 expression in mammals through methylation of cytosine residues at CpG dinucleotides is involved in th

23 The specificity of the reaction of cytosine residues at ss- versus dsDNA loci after endonuc

24 system was likely to be 5' GATC 3', with the cytosine residue being modified to 5-methylcytosine.

25 ellite DNA is normally heavily methylated at cytosine residues, but in ICF syndrome it is almost comp

26 CpG site could affect the methylation of the cytosine residue by both methyltransferases and the effe

27 he Watson-Crick face of unpaired adenine and cytosine residues by dimethyl sulfate, result in a stop

28 ic analyses have suggested that a particular cytosine residue (C(75)) with a pK(a) close to neutralit

29 ve structure with protonation of the crucial cytosine residue, C8(N3+).

30 DNA fragments with stretches of cytosine residues can fold into four-stranded structures

31 specific contacts between ppGpp and specific cytosine residues during both transcription initiation a

32 NA is drastically remodeled, with the target cytosine residue extruded from the DNA helix and plunged

33 th were poor targets for A3G activity unless cytosine residues flanked the cytosine dinucleotide.

34 vidual sites highlighted the importance of a cytosine residue flanking the core CSL binding sequence.

35 single methyl group at the 5-position of the cytosine residue flanking the lesion on the 5'-side, is

36 spots is enhanced by the methylation of the cytosine residue flanking the target guanine residue on

37 DMS), which reacts with unpaired adenine and cytosine residues, followed by deep sequencing to monito

38 t brain is to remethylate newly incorporated cytosine residues from G.T mismatch repair after deamina

39 ty of DNA duplexes bearing isolated glyceryl cytosine residues has also been investigated.

40 The cytosine residue immediately 5' to the cleavage site for

41 Partially methylated cytosine residues in 13.5 d.p.c. embryos and undifferent

42 Further investigation revealed that the cytosine residues in a CpG cluster in the promoter regio

43 ression levels correlated with the number of cytosine residues in a string of cytosines located close

44 RIP is often associated with methylation of cytosine residues in and around the mutated sequences.

45 ponsible for de novo methylation of specific cytosine residues in CpG dinucleotides during mammalian

46 Methylation of cytosine residues in CpG dinucleotides is generally asso

47 Methylation of cytosine residues in CpG dinucleotides plays an importan

48 Epigenetic modifications of cytosine residues in DNA and the amino termini of histon

49 Epigenetic methylation of cytosine residues in DNA is an essential element of geno

50 ups from S-adenosyl-l-methionine (AdoMet) to cytosine residues in DNA is the transient formation of a

51 bisulphite sequencing we mapped the methyl- cytosine residues in DNA methylated in vitro and in vivo

52 pairs and is triggered by the deamination of cytosine residues in DNA to uracil; phase 2 affects most

53 the model that AID functions by deaminating cytosine residues in DNA.

54 se (Dnmt)-catalyzed methyl group transfer to cytosine residues in gene-regulatory regions.

55 by the transcription-coupled deamination of cytosine residues in Ig genes.

56 d somatic hypermutation (SHM) by deaminating cytosine residues in immunoglobulin genes (Igh, Igkappa,

57 AID) initiates both processes by deaminating cytosine residues in immunoglobulin genes.

58 Cytosine residues in mammalian DNA occur in at least thr

59 Cytosine residues in mammalian DNA occur in five forms:

60 ly of enzymes responsible for methylation of cytosine residues in mammals.

61 ine, and cytidine 5'-phosphate, and also for cytosine residues in single-stranded DNA generated from

62 ass tagging, involves the labeling of target cytosine residues in synthetic DNA duplexes with stable

63 ted to spontaneous deamination of methylated cytosine residues in the colon and small intestine, prob

64 restrict retroviral infection by deaminating cytosine residues in the first cDNA strand of a replicat

65 amolecular DNA triple helix possessing three cytosine residues in the Hoogsteen strand (1) and a disu

66 a and base pairing characteristics as native cytosine residues in the human telomeric repeat sequence

67 is extremely sensitive to methylation of the cytosine residues in the invariant CpG half-site core, s

68 EC 2.1.1.37) maintain patterns of methylated cytosine residues in the mammalian genome; faithful main

69 ewly synthesized strand does not contain any cytosine residues in the recognition sequence.

70 Cytosine residues in the sequence 5'CpG (cytosine-guanin

71 tly of the S type, except for the protonated cytosine residues in the third strand which show hybrid

72 Cytosine residues in the vertebrate genome are enzymatic

73 At least 12 of the cytosine residues in this region are exclusively methyla

74 s and RNA-directed DNA methylation (RdDM) at cytosine residues in three DNA sequence contexts (CG, CH

75 be responsible for the repair of deaminated cytosine residues in vivo.

76 ignment displaced along with the 5'-flanking cytosine residue into the major groove.

77 lesions in a DNA template, providing that a cytosine residue is incorporated opposite anti-BPDE-modi

78 o acid long peptide with C-terminal modified cytosine residue is produced.

79 yotic DNA by methylation of the 5' carbon of cytosine residues is frequently associated with transcri

80 fer of the shared proton between the 2AP and cytosine residues is indicated by the rapid exchange of

81 The pK of terminal cytosine residues is much lower, in the range 6.2 to 7.2

82 Specific recognition of the three cytosine residues is realized by a dense network of hydr

83 hermore, removal of the Watson-Crick partner cytosine residue (leaving an abasic site) in the complem

84 utation is due to (i) the amino group of the cytosine residue making an intra-RNA hydrogen bond that

85 as histone acetylation and methylation, and cytosine residue methylation in CpG dinucleotides, have

86 vocally showed that the pK of the protonated cytosine residue must be at least 9.5 for internal posit

87 m was located in the C5 position of a single cytosine residue of an oligonucleotide designed to form

88 aceum, the targets for RIP mutations are the cytosine residues of TCG trinucleotide combinations.

89 We show that the cytosine residues of the Hoogsteen C+.G pairs in this tr

90 on of protonation at the N3 of the Hoogsteen cytosine residue on the stability of various sequences o

91 ic sites, apyrimidinic sites, and deaminated cytosine residues on human topoisomerase IIalpha were as

92 methylation at both symmetric and asymmetric cytosine residues on the MITE sequences, possibly induce

93 te group linking U5 and U6, which favors the cytosine residue over uracil by about 6.0 kcal/mol.

94 DNA methylation in cytosine residues plays an important role in regulating

95 irpin aligned as d(GCC).d(GCC) with unpaired cytosine residues possibly turned outwards and stacked i

96 igh chi angle (> -80 degrees) for the target cytosine residue reduces the distances for both SG-C6 an

97 s 544 RNA-directed DNA methylation (RdDM) at cytosine residues regulates gene expression, silences tr

98 Residual unconverted cytosine residues shared many attributes with bisulfite

99 e fimN promoter region contains a stretch of cytosine residues similar in length to those of other fi

100 the alignment d(CCG).d(CCG) with mismatched cytosine residues stacked into the helix but with 15 or

101 high frequency of C-->G transversions at the cytosine residues targeted by both enzymes, allowing ide

102 o a syn conformation, pairing to its counter cytosine residue that is protonated at pH 5.9.

103 d-type, which contains a modification of the cytosine residues that projects into the major groove: a

104 quences of 33 nt with or without symmetrical cytosine residues, the methylation was distributed throu

105 sis to understand the effect of mutating the cytosine residue to uracil on the thermodynamic stabilit

106 Posttranscriptional methylation of RNA cytosine residues to 5-methylcytosine (m(5)C) is an impo

107 ade use of site-specific 15N-labeling of the cytosine residues to investigate their protonation statu

108 ion-induced cytidine deaminase that converts cytosine residues to uracils in a transcription-dependen

109 proton sources for protonation of N3 of the cytosine residue upon formation of the covalent intermed

110 Epigenetic changes in several cytosine residues were detected in a fragment of 4,700 b

111 The sugar conformations of the two adjacent cytosine residues were different and the 5'-residue was

112 Methyl-cytosine residues were observed in multiple sequence con

113 dine sequence by substitution of 5 of the 23 cytosine residues with adenine prevented triple helix fo

114 Cytosine residues within CpG dinucleotides at the enhanc

115 Across vertebrate genomes methylation of cytosine residues within the context of CpG dinucleotide