ライフサイエンスコーパス: cytosolic

1 -derived acetate is being used to synthesize cytosolic Ac-CoA by ACSS2.

2 CLY is the primary enzyme involved in making cytosolic Ac-CoA in cells with abundant nutrients.

3 ytic uptake followed by endosomal escape and cytosolic access.

4 utilize extracellular glutamine, leading to cytosolic accumulation of NADH and increased oxidative s

5 defend against infections, whereas aberrant cytosolic accumulation of self-DNA results in pathologic

6 he central precursor for lipid biosynthesis, cytosolic acetyl CoA (Ac-CoA), is produced by ATP-citrat

7 cularly, the citrate-malate shuttle supplies cytosolic acetyl-CoA and plastidic glycolysis and malic

8 olic regulation and apoptosis in response to cytosolic acidification during cellular stress.

9 er assembly (CIA) system, converting it into cytosolic aconitase (c-acon), but can also involve iron-

10 s how discovery of the role of the mammalian cytosolic aconitase, known as iron regulatory protein 1

11 VASP on site-specific, lamellipodial versus cytosolic actin assembly and resulting consequences on p

12 Indeed, excess cytosolic actin assembly prevented actin monomer from ra

13 nely tuned balance between lamellipodial and cytosolic actin assembly.

14 This process is controlled by cytosolic actin-based constriction machinery and dynamin

15 5 and SNAP23 are proteins that are initially cytosolic after translation, but then become stably atta

16 Timely dissolution of cytosolic aggregates requires the mitochondrial import m

17 ol (PI) species, directly interacts with the cytosolic amino terminal (NT) domain of the yeast Golgi

18 sphorylation of a conserved threonine in the cytosolic AMT1 C terminus, which allosterically inactiva

19 Simultaneous confocal imaging of cytosolic and intra-SR calcium revealed a transient elev

20 of GSH and ascorbic acid and accumulation of cytosolic and lipid ROS.

21 at Ca(2+) release from nj-SR is activated by cytosolic and luminal Ca(2+) (tandem RyR activation) via

22 is based on tandem activation of the RyRs by cytosolic and luminal Ca(2+) through a 'fire-diffuse-upt

23 ochondria, our results support a view of the cytosolic and mitochondrial dNTP pools in frequent excha

24 ates that form under heat shock contain both cytosolic and mitochondrial proteins and interact with t

25 In this article, we (1) review cytosolic and nuclear Ca(2+) dynamics in cardiomyocytes

26 The latter treatment also led to elevated cytosolic and nuclear Ca(2+) levels.

27 hways are predominantly bacterial, but their cytosolic and nuclear target Fe/S proteins are mainly ar

28 olic pathways were identified, including the cytosolic and plastidic isoprenoid and the phenylpropano

29 2+) transient loss without marked changes in cytosolic and sarcoplasmic reticulum Ca(2+) levels, like

30 ribution of DAD amplitude and timing include cytosolic and sarcoplasmic reticulum Ca2+ concentrations

31 ne to serine/threonine residues of membrane, cytosolic, and nuclear proteins.

32 ) 21 as an intracellular Fc receptor linking cytosolic antibody recognition to the ubiquitin proteaso

33 Fe/S cluster transfer to IRP1, recycling the cytosolic apo-IRP1 into holo-aconitase.

34 permeases similarly involves unmasking of a cytosolic Art1-target region coupled to activation of Ar

35 ndrial integrity using MitoTracker Green and cytosolic ATP levels.

36 compartment at the expense of a reduction in cytosolic ATP pools.

37 ties by catalyzing unregulated conversion of cytosolic ATP to the key second messenger molecule cAMP.

38 f planaria and resulted in the appearance of cytosolic axonemes lacking a ciliary membrane.

39 lammasomes that are important in immunity to cytosolic bacteria, DNA viruses, or HIV.

40 N-methyltransferase (NNMT) is a fundamental cytosolic biotransforming enzyme that catalyzes the N-me

41 of both parameters depended on the extent of cytosolic but not lamellipodial actin assembly.

42 es protein synthesis of the myofibrillar and cytosolic, but not the mitochondrial fraction, in muscle

43 Four cytosolic C-terminal domains form an umbrella-like struc

44 nels from Tric-a KO mice respond normally to cytosolic Ca(2+) , ATP, adenine, caffeine and to luminal

45 t cations, although they respond normally to cytosolic Ca(2+) , ATP, caffeine and luminal Ca(2+) .

46 hate often evokes repetitive oscillations in cytosolic Ca(2+) .

47 uminal RyR sensitization and lowering of the cytosolic Ca(2+) activation threshold.

48 lsa6f, which permits real-time monitoring of cytosolic Ca(2+) along with cell motility, we show that

49 ntial plateau, as well as by the increase of cytosolic Ca(2+) associated with the Ca(2+) transient it

50 induced concentration-dependent increases in cytosolic Ca(2+) concentration ([Ca(2+)]c), which was in

51 was silenced, and blocking NCX1/3 increased cytosolic Ca(2+) concentration and cell migration.

52 alpha1D reduced the migration and the basal cytosolic Ca(2+) concentration of HCT116 colon cancer ce

53 subsets of transporters associated with free cytosolic Ca(2+) concentration that represent key target

54 Cytosolic Ca(2+) concentrations in unwounded fou2 were f

55 Transient and highly regulated elevations of cytosolic Ca(2+) control a variety of cellular processes

56 does not contribute significantly to shaping cytosolic Ca(2+) except during prolonged repetitive firi

57 dependent protein kinases (CDPKs) transduces cytosolic Ca(2+) flux into enzymatic activity, but how t

58 zing a novel ratiometric genetically encoded cytosolic Ca(2+) indicator, Salsa6f, which permits real-

59 red respiratory capacity, while induction of cytosolic Ca(2+) is sufficient to attenuate thermogenic

60 ntrations of Tg and Tg analogs, whereas high cytosolic Ca(2+) levels and SOCE are not required.

61 ed a slowly developing dilation at unchanged cytosolic Ca(2+) levels in potassium chloride-constricte

62 tive stress, we identified two regulators of cytosolic Ca(2+) levels, transient receptor potential A1

63 d and not activated by luminal Ca(2+) at low cytosolic Ca(2+) levels.

64 thermogenic gene expression, indicating that cytosolic Ca(2+) mediates mitochondria-nucleus crosstalk

65 , we describe a mechanism by which increased cytosolic Ca(2+) negatively regulates adipokine secretio

66 T116 colon cancer cell line and modified the cytosolic Ca(2+) oscillations induced by the sodium/calc

67 ced increase in the amplitude of endothelial cytosolic Ca(2+) oscillations.

68 localized AGPs as the source of tip-focussed cytosolic Ca(2+) oscillations: Hechtian adhesion between

69 Reducing cytosolic Ca(2+) reverses the attenuation of thermogenic

70 e results highlight a potential link between cytosolic Ca(2+) signaling and the posttranslational con

71 vitro and in vivo coincide with episodes of cytosolic Ca(2+) signaling.

72 pathway is an important route for generating cytosolic Ca(2+) signals that regulate a diverse array o

73 omone, budding yeast cells undergo a rise of cytosolic Ca(2+) that is mediated by two import systems

74 that Ca(2+) release from j-SR resulted in a cytosolic Ca(2+) transient of higher amplitude compared

75 o a blunted increase in the concentration of cytosolic Ca(2+), activation-dependent increases of alph

76 optimized for cell tracking while monitoring cytosolic Ca(2+), and a transgenic Ca(2+) reporter mouse

77 s been associated with abnormal increases in cytosolic Ca(2+), mitochondrial dysfunction, impaired au

78 globally) and can be triggered by elevating cytosolic Ca(2+).

79 Simultaneous confocal measurements of cytosolic ([Ca(2+) ]i ; with the fluorescent Ca(2+) indi

80 CK-2066260 has no effect on free cytosolic [Ca(2)(+) ] during contractions of isolated mu

81 odel with regard to reactive oxygen species, cytosolic Ca2+ (Ca2+c), and heterotrimeric G-protein sig

82 cerk1 plants had an irregular increase of cytosolic calcium ([Ca(2+) ]cyt ) after NaCl treatment.

83 AM was used to measure the concentrations of cytosolic calcium ([Ca(2+)]c).

84 ncer-like phenotype is promoted by increased cytosolic calcium ([Ca(2+)]cyto), aerobic glycolysis, an

85 itochondrial axonal transport in response to cytosolic calcium (Ca2+) levels ([Ca2+]c) and mitochondr

86 ms, it is unknown what initiates the rise of cytosolic calcium across the wound field.

87 Cytosolic calcium concentrations were assessed under the

88 fission is disabled, AC-induced increase in cytosolic calcium is blunted owing to mitochondrial calc

89 ilization (LMP), a sustained accumulation of cytosolic calcium, and eventually cell death in pancreat

90 The increased cytosolic calcium, in turn, led to the phosphorylation o

91 ntracellular signaling via second messengers-cytosolic calcium, reactive oxygen species, and nitric o

92 actomyosin contractility through increasing cytosolic calcium.

93 osphorylation in response to oscillations in cytosolic calcium.

94 CCP1) defines the 6-member cytosolic carboxypeptidase (CCP) family that metabolizes

95 , secretory autophagy utilizes a specialized cytosolic cargo receptor and a dedicated SNARE system.

96 he endosomal microautophagy that rely on the cytosolic chaperone hsc70 for substrate targeting.

97 coordinate the function of ER-associated and cytosolic chaperone systems in protein quality control.

98 Here the authors show that cytosolic chaperones shift the F508del channel conformat

99 e K(+) channel gated by membrane voltage and cytosolic Cl(-) and Ca(2+).

100 Access of DNA to the cytosolic compartment is mediated by hemozoin, because i

101 ures that are typical of eukaryotes, such as cytosolic compartmentalization and endocytosis-like macr

102 yomavirus SV40, a decisive infection step, a cytosolic complex composed of Hsc70-SGTA-Hsp105 was prev

103 Inflammasomes are high-molecular-weight cytosolic complexes that mediate the activation of caspa

104 One enigmatic step is whether host cytosolic components are co-opted to transport the viral

105 was associated with increased expression of cytosolic components of the NADPH oxidase complex.

106 clear uptake allows development of a nuclear/cytosolic concentration gradient against a background of

107 BAX expression levels and cytosolic conformation regulate sensitivity to BTSA1.

108 tophagy coordinates lysosomal destruction of cytosolic constituents and is systemically induced by st

109 Cytosolic contents were repeatedly sampled from the same

110 tactic assembly of enzymes occurs even under cytosolic crowding conditions.

111 ores represent conduits for the secretion of cytosolic cytokines under conditions of cell hyperactiva

112 After patch clamp-mediated dialysis of cytosolic DAF, the remaining NO signals (mostly mitochon

113 nucleus to orchestrate the formation of the cytosolic death complexes.

114 ensor (qRAS) for the real-time monitoring of cytosolic delivery of macromolecules.

115 a panel of polymer carriers toward efficient cytosolic delivery of model proteins on a plate reader.

116 and potency, and provide a platform for the cytosolic delivery of nucleic acids.

117 oaded with photoresponsive polymers, we show cytosolic delivery of small molecules with the spatial r

118 hanistically, the PC7A NP achieves efficient cytosolic delivery of tumour antigens to antigen-present

119 s1a double mutants lacking both PHS1 and the cytosolic DISPROPORTIONATING ENZYME2 (DPE2) displayed on

120 uired for antimicrobial host defense through cytosolic distribution of interferon-inducible GTPases.

121 Here we show that cytosolic DNA activates STAT3, another member of the STA

122 receptors, cyclic GMP-AMP synthase, binds to cytosolic DNA and generates dicyclic nucleotides that ac

123 Instead, detection of cytosolic DNA by the cGAS-STING axis induces a cell deat

124 Detection of cytosolic DNA constitutes a central event in the context

125 Cytosolic DNA engages stimulator of interferon genes (ST

126 at infection creates an endogenous source of cytosolic DNA in infected cells through the release of m

127 eveal a new signaling axis downstream of the cytosolic DNA pathway and suggest potential interactions

128 of exogenous DNA during infection though the cytosolic DNA receptor cyclic GMP-AMP synthase (cGAS), w

129 ammatory conditions that are associated with cytosolic DNA sensing.

130 cGMP-AMP (cGAMP) synthase (cGAS) is a cytosolic DNA sensor that activates innate immune respon

131 Cytosolic DNA stimulates secretion of interferon-beta by

132 Taken together, our results suggest that cytosolic DNA-induced STAT3 activation via IFNbeta and I

133 Moreover, Ser(754) phosphorylation inhibits cytosolic DNA-induced STAT3 transcriptional activity and

134 smic chromatin activates the innate immunity cytosolic DNA-sensing cGAS-STING (cyclic GMP-AMP synthas

135 t genes that are up-regulated in response to cytosolic DNA.

136 Furthermore, as cytosolic dNTP pool imbalances were transmitted equally

137 ed juxtamembrane DEGSY motif of the syndecan cytosolic domain and syntenin tyrosine 46.

138 lated intramembrane proteolysis to release a cytosolic domain containing a basic leucine zipper (bZIP

139 Our experiments with full-length Cya and its cytosolic domain link the mutations to protein stability

140 nsor-like domain is linked to the pore via a cytosolic domain that we term the mucolipin domain.

141 tination was markedly stimulated by the GDU1 cytosolic domain, suggesting that GDU1 functions as an a

142 conducted yeast two-hybrid screens using the cytosolic domains of ETR1 and ETR2 as bait.

143 Exocytosis depends on cytosolic domains of SNARE proteins but the function of

144 TRPM4 consists of multiple transmembrane and cytosolic domains, which assemble into a three-tiered ar

145 reported spatial information about the large cytosolic dynein/dynactin complex in living cells.

146 ive, but several signaling events, including cytosolic efflux and influx of select ions, have been su

147 on transfer process between mitoNEET and the cytosolic electron-donor Ndor1/anamorsin complex, a comp

148 e carboxylase (PEPC) is a tightly controlled cytosolic enzyme situated at a crucial branch point of c

149 rms, while they were ineffective against the cytosolic enzymes hCAs I and II.

150 omplex antibodies are often directed against cytosolic epitopes of Kv1 subunits and occasionally agai

151 CER1 levels or Alu-RNA accumulation triggers cytosolic escape of mitochondrial DNA, which engages cGA

152 d a flow-cytometry-based assay that measures cytosolic exchange across the conjugation junction to ra

153 ot-and-mouth disease (FMD) vaccines requires cytosolic expression of the FMDV 3C protease to cleave t

154 acrophages, NLRP3 activation promoted excess cytosolic extrusion of mitochondrial DNA along with incr

155 ediated by tau-associated antibodies and the cytosolic Fc receptor tripartite motif protein 21 (TRIM2

156 limiting IRP1 and IRP2 overaccumulation when cytosolic Fe-S cluster assembly is impaired in order to

157 used for metabolic functions, stored within cytosolic ferritin, or exported from the cell via FPN1.

158 nd a significant decrease in the activity of cytosolic FeS enzymes such as aconitase and aldehyde oxi

159 form a dimer, and DRE2 acts upstream in the cytosolic FeS protein assembly pathway.

160 aggregated form at synapses, indicating that cytosolic forms of the protein are likely to be the toxi

161 r blebbing correlated with a 25% decrease in cytosolic free Ca(2+) transient at 30 s after nanoporati

162 tions in both endoplasmic reticulum (ER) and cytosolic free calcium levels are known to play a role i

163 chondrial tricarboxylic acid (TCA) cycle and cytosolic fumarate metabolism, in normal and leukemic he

164 establishment depends on the activity of the cytosolic GLXI;3 isoform.

165 while PGK2 and PGK3 were the plastidial and cytosolic glycolytic isoforms, respectively.

166 additional phenotype, the ability to support cytosolic growth of the facultative intracellular bacter

167 chondrial glutathione (GSH) levels, although cytosolic GSH remained normal.

168 Decreasing the cytosolic GTP:GDP ratio increases the incorporation of S

169 d the acetylation of the N-terminal tails of cytosolic histones.

170 ed lipolysis requires the phosphorylation of cytosolic hormone-sensitive lipase (HSL) and perilipin 1

171 We previously demonstrated that the cytosolic Hsc70-SGTA-Hsp105 complex is tethered to the E

172 cture of a plant sHsp published, that of the cytosolic Hsp16.9.

173 This pathway also requires the cytosolic Hsp70 protein Ssa1, but whether Ssa1 associate

174 successfully heterodimerized with the yeast cytosolic Hsp70s Ssa and Ssb and promoted normal growth,

175 ADP inhibition of human and yeast cytosolic Hsp90 can be relieved by the cochaperone aha1.

176 results imply that an ATP/ADP heterodimer of cytosolic Hsp90 is the predominant active state under ph

177 h the risk of being eliminated by the cell's cytosolic immune defence.

178 and host cyclic dinucleotides (cdNs) mediate cytosolic immune responses through the STING signaling p

179 when expressed alone, NaStEP remains mostly cytosolic, implicating NaSIPP-mediated translocation of

180 ucine-rich repeat (NLR) proteins function as cytosolic innate immune sensors in plants and animals.

181 RIG-I-like receptors (RLRs) are cytosolic innate immune sensors that detect pathogenic R

182 thetic reactions; they are essential for low cytosolic inorganic phosphate.

183 s in the cytoplasm but rather is targeted to cytosolic insoluble protein deposits (IPODs).

184 ntrolled by a set of soluble proteins at the cytosolic interface of the membrane spanning type III se

185 compartments function primarily to decouple cytosolic intermediate concentrations from the concentra

186 ntramembrane cleavage and the release of its cytosolic intracellular domain (CD74-ICD), which regulat

187 olves insertion of a [4Fe-4S] cluster by the cytosolic iron-sulfur cluster assembly (CIA) system, con

188 Ndor1/anamorsin complex, a component of the cytosolic iron-sulfur protein assembly (CIA) machinery.

189 The T. hominis cytosolic iron-sulfur protein assembly (CIA) pathway inc

190 The group IVA cytosolic isoform of PLA2 (cPLA2alpha) was activated upo

191 t marked effects on ascorbate pools, (2) the cytosolic isoforms are particularly important in couplin

192 n and proteasome activity, a higher level of cytosolic K6a results in enhanced KAMP production.

193 e, Plasmodium falciparum, we have quantified cytosolic labile heme levels in intact, blood-stage para

194 caused substantial LD loss via activation of cytosolic lipases adipose triglyceride lipase (ATGL) and

195 drenergic (beta-AR)/cAMP pathway to activate cytosolic lipases and induce their recruitment to the LD

196 s suggest that beta-AR stimulation mobilizes cytosolic lipases for LD breakdown in hepatocytes, and p

197 Plant cytosolic lipid droplets (LDs) are covered with a layer

198 f caspase-1 and caspase-11 upon detection of cytosolic lipopolysaccharide (LPS).

199 n fluorescent protein demonstrated vesicular cytosolic localization associated with the endoplasmic r

200 nylyl cyclase activator forskolin diminishes cytosolic localization of the Rpl13a snoRNAs through a m

201 unity; however, a major hindrance is STING's cytosolic localization which requires intracellular deli

202 ry confirmed that LOG2 ubiquitinates GDU1 at cytosolic lysines, and GDU1 protein levels decreased upo

203 ophagy is a ubiquitous pathway that degrades cytosolic macromolecules or organelles, as well as intra

204 s as well as activated primary T cells, that cytosolic malate dehydrogenase 1 (MDH1) is an alternativ

205 in mice in 2-day hypoxia and is mediated by cytosolic malate whereas in 10-day hypoxia the rewiring

206 A variety of mechanisms deliver cytosolic materials to the lysosomal compartment for deg

207 strongly limits the rate of dye entry via a cytosolic mechanism.

208 m targeting diverse pathogens replicating in cytosolic membrane structures.

209 nlighting protein, with two biotin-dependent cytosolic metabolic roles and a distinct biotin-independ

210 but they do not support the hypothesis that cytosolic metabolite availability alters the response of

211 Inflammasomes are cytosolic multiprotein complexes in macrophages.

212 se labeling approach is demonstrated for the cytosolic mutants due to a significantly smaller loss in

213 Omission of extracellular Na(+) prevents the cytosolic Na(+) rise, inhibits NCLX activity, and impair

214 reveal that SOCE is accompanied by a rise in cytosolic Na(+) that is critical in activating the mitoc

215 cells rely on both MDH1 and LDH to replenish cytosolic NAD, and that therapies designed at targeting

216 porters for AMPK activity, Akt activity, and cytosolic NADH/NAD(+) redox.

217 SA facilitates the reduction of cytosolic NPR1 oligomers into monomers, which enter the

218 ors that serve as iron ion chaperones in the cytosolic/nuclear compartment, binding iron at import an

219 Cytosolic nucleic acid sensing elicits interferon produc

220 The interface between its two cytosolic nucleotide binding domains and coupling helice

221 The cytosolic nucleotide binding site-leucine rich repeat (N

222 Sensing of cytosolic nucleotides is a critical initial step in the

223 lusive dimer found in vivo, whether SecA was cytosolic or in lipid or SecYEG-bound states.

224 pacemaking that diminishes mitochondrial and cytosolic oxidative stress.

225 we hypothesized that thioredoxin-1 (Trx1), a cytosolic oxidoreductase, could be involved in restoring

226 fense, and inflammasomes represent a central cytosolic pattern recognition receptor pathway leading t

227 NLRP3 is a cytosolic pattern recognition receptor that senses micro

228 on-defective mutants via a pathway requiring cytosolic pattern recognition receptors and NF-kappaB.

229 ger-associated molecular patterns (DAMPS) by cytosolic pattern recognition receptors such as NOD-like

230 oplast as the result of enhanced activity of cytosolic PEP carboxylase or by limited supply of energe

231 vating enzyme E1 inhibitor, to block overall cytosolic peptide generation and generation of specific

232 and can profoundly reduce the generation of cytosolic peptides.

233 ves binding of newly synthesized proteins by cytosolic peroxisomal biogenesis factor 5 (PEX5) followe

234 e cavity-forming protein assembly into which cytosolic PEX5 can enter to release its cargo.

235 of presynaptic terminals, and such shifts in cytosolic pH (pHcyto ) probably influence mechanisms und

236 included measurement of prostaglandin E2 and cytosolic phospholipase A2 activity in membrane fraction

237 ein's ability to induce prostaglandin E2 and cytosolic phospholipase A2 synthesis in patients' fibrob

238 prevented CLR endocytosis and activation of cytosolic PKC and nuclear ERK, which derive from endosom

239 we demonstrate that regulated expression of cytosolic poly(A)-binding protein 1 (PABPC1) modulates p

240 ly on downstream organelles by building up a cytosolic pool that is used to feed target compartments.

241 cuolar EhRab35 and its exchange with soluble cytosolic pool were monitored by fluorescence recovery a

242 dA3, as well as MadB1, partition between the cytosolic pools of motile endomembrane vesicles that col

243 Doc2B is a cytosolic protein with binding sites for Munc13 and Tcte

244 Armadillo repeat containing 5 (ARMC5) is a cytosolic protein with no enzymatic activities.

245 Bacteria possess cytosolic proteins (Csp3s) capable of binding large quan

246 directly interacts with several membrane and cytosolic proteins at neuronal plasma membranes, leading

247 conditions through selective degradation of cytosolic proteins in lysosomes.

248 Transport of membrane and cytosolic proteins in primary cilia is thought to depend

249 al locations of transport routes for various cytosolic proteins in the 250-nm-wide shaft of live prim

250 el where Hsc70 activity dynamically clusters cytosolic proteins into cargo complexes, allowing transp

251 d except HspB7 suppressed the aggregation of cytosolic proteins of HEK293 cells.

252 Here we show that, in yeast, cytosolic proteins prone to aggregation are imported int

253 he interleukin-1 (IL-1) family cytokines are cytosolic proteins that exhibit inflammatory activity up

254 urred during evolution, whenever ancestrally cytosolic proteins were recruited to the secretory pathw

255 Pontin protein is enriched in cytosolic puncta in ciliated cells in zebrafish embryos.

256 We demonstrate that cytosolic Rasa3 translocates to the plasma membrane in a

257 cytosolic translation, thus highlighting the cytosolic rather than the mitochondrial ribosome as the

258 sporter, is a novel transporter facilitating cytosolic recognition of TCT, and plays a crucial role i

259 e pathway as this is accompanied with higher cytosolic reduced glutathione (GSH) levels.

260 A crystal structure of the Msp1 cytosolic region modeled into a ring hexamer suggests th

261 ox-active [2Fe-2S] cluster in its C-terminal cytosolic region.

262 concomitantly exhibited heightened levels of cytosolic ribonuclease activity that corresponded to sub

263 nously generated H2O2 Prx1 is synthesized on cytosolic ribosomes as a preprotein with a cleavable N-t

264 d1, a multi-spanning membrane protein with a cytosolic RING finger domain.

265 l-terminal region, forms a large two-layered cytosolic ring that extensively interacts with the trans

266 In this study, we show that the cytosolic RNA-binding protein clustered mitochondria hom

267 mitochondrial membrane potential and higher cytosolic ROS production.

268 sponse to lysosomal damage, the prototypical cytosolic secretory autophagy cargo IL-1beta is recogniz

269 PGL activated the STING cytosolic sensing pathway in resident macrophages, induc

270 Thus, RECON functions as a cytosolic sensor for bacterial cdNs, shaping inflammator

271 ing leucine, which mTORC1 senses through the cytosolic Sestrin proteins.

272 Mammals have both cytosolic SHMT1 and mitochondrial SHMT2, with the mitoch

273 responsible for SOAT1 that is located on the cytosolic side of the ER, while BeauIII is not accessibl

274 ilamentous structures and was present on the cytosolic side of the ER.

275 However, autophagy does not terminate cytosolic signal transduction by TGFbeta.

276 the surface of T lymphocytes that initiates cytosolic signaling cascades upon binding antigens prese

277 ogether with the accumulation of R-loops and cytosolic ssDNA.

278 en explained either by limited supply of the cytosolic substrate precursor, phosphoenolpyruvate (PEP)

279 ant amyotrophic lateral sclerosis-associated cytosolic superoxide dismutase 1 (SOD1) protein between

280 de ions, but NRAMP2 can functionally replace cytosolic superoxide dismutase in yeast, indicating that

281 estraints enable us to position Psb28 on the cytosolic surface of PSII directly above cytochrome b559

282 -Ara mutases that are located outside on the cytosolic surface of the Golgi.

283 d catenins, binds directly to the E-cadherin cytosolic tail and thereby localizes at cell-cell adhesi

284 spindle orientation machinery that binds the cytosolic tail of E-cadherin.

285 that an amphipathic helix in the C-terminal cytosolic tail of RHD3 has a membrane anchoring ability

286 al change unveils a region of the N-terminal cytosolic tail targeted by the Art1 alpha-arrestin, whic

287 hrough recognition of sorting signals in the cytosolic tails of the cargos by adaptor proteins, leadi

288 Both cytosolic targets and targets localized in subcellular c

289 vior, but delivered more antibodies to their cytosolic targets at a faster rate.

290 that PAR interferes with several aspects of cytosolic translation, thus highlighting the cytosolic r

291 protein, by functioning as a spacer to which cytosolic translocators can bind.

292 s insight into the molecular organization of cytosolic transport complexes and identifies a novel reg

293 ts altered in the arginine-binding site or a cytosolic tripeptide sequence permanently expose the alp

294 In HEK293T cells, most cytosolic tRNAs are charged at >80% levels, whereas tRNA

295 nvolved its dissociation into two parts: the cytosolic V1 and the integral membrane V0 subcomplex.

296 by complementation with either glycosomal or cytosolic versions of ARG.

297 n proteins revealed that DHAR1 and DHAR2 are cytosolic while DHAR3 is chloroplastic, with no evidence

298 reduced glutathione prevents TRPM7-dependent cytosolic Zn(2+) influx.

299 cute neuronal death; under these conditions, cytosolic Zn(2+) rises persisted for 10-30 min after OGD

300 Cytosolic Zn2+ measurements in HEK293 cells overexpressi