ライフサイエンスコーパス: cytosolic phospholipase

1 PCR and gene silencing experiments show that cytosolic phospholipase 2 (cPLA2) is the key enzyme medi

2 Activation of cytosolic phospholipase A(2 )(cPLA(2)) is a prerequisite

3 on ([Ca(2+)](i)) by the fura-2 ratio method, cytosolic phospholipase A(2) (cPLA(2)) activation and P-

4 activated protein kinase (MAPK) isoforms and cytosolic phospholipase A(2) (cPLA(2)) activation in hum

5 he current study, we have probed the role of cytosolic phospholipase A(2) (cPLA(2)) activity in the c

6 ed with increased expression and activity of cytosolic phospholipase A(2) (cPLA(2)) and cyclooxygenas

7 ls is associated with elevated expression of cytosolic phospholipase A(2) (cPLA(2)) and cyclooxygenas

8 cascades are responsible for this response: cytosolic phospholipase A(2) (cPLA(2)) and diacylglycero

9 d the binding of the C2 domains of group IVa cytosolic phospholipase A(2) (cPLA(2)) and protein kinas

10 ated MIN6 beta-cells that stably overexpress cytosolic phospholipase A(2) (cPLA(2)) and show a ninefo

11 Both the constitutive Group IV cytosolic phospholipase A(2) (cPLA(2)) and the inducible

12 tic signaling events, we studied the role of cytosolic phospholipase A(2) (cPLA(2)) and the Jak/STAT

13 Cyclooxygenase 2 (COX-2) and cytosolic phospholipase A(2) (cPLA(2)) are the crucial r

14 Here, we identify cytosolic phospholipase A(2) (cPLA(2)) as a central mole

15 ation of BK channels in GH(3) cells involves cytosolic phospholipase A(2) (cPLA(2)) as a potential pr

16 In the present work, we have identified cytosolic phospholipase A(2) (cPLA(2)) as an effector mo

17 th negatively charged phospholipids, and the cytosolic phospholipase A(2) (cPLA(2)) C(2) domain, whic

18 Cytosolic phospholipase A(2) (cPLA(2)) comprises a widel

19 We have previously reported that cytosolic phospholipase A(2) (cPLA(2)) expression and ac

20 , we have demonstrated that STAT-3-dependent cytosolic phospholipase A(2) (cPLA(2)) expression is nee

21 The group IV cytosolic phospholipase A(2) (cPLA(2)) has been localize

22 Group IV cytosolic phospholipase A(2) (cPLA(2)) has been shown to

23 e demonstrated a crucial regulatory role for cytosolic phospholipase A(2) (cPLA(2)) in monocyte chemo

24 holine (LPC), catalyzed by the activation of cytosolic phospholipase A(2) (cPLA(2)) in the PPT1-KO mo

25 phosphorylation by Ang II was attenuated by cytosolic phospholipase A(2) (cPLA(2)) inhibitor pyrroli

26 Cytosolic phospholipase A(2) (cPLA(2)) is a Ca(2+)-sensi

27 Cytosolic phospholipase A(2) (cPLA(2)) is a key enzyme i

28 s of human calcium-independent (iPLA(2)) and cytosolic phospholipase A(2) (cPLA(2)) lipase activity r

29 examined the effect of deleting the group IV cytosolic phospholipase A(2) (cPLA(2)) locus (Pla2g4).

30 The 85-kDa cytosolic phospholipase A(2) (cPLA(2)) mediates agonist-

31 The 85-kDa cytosolic phospholipase A(2) (cPLA(2)) plays an importan

32 Cytosolic phospholipase A(2) (cPLA(2)) releases arachido

33 lling via a cAMP-independent mechanism, i.e. cytosolic phospholipase A(2) (cPLA(2)) signalling.

34 es whether 5LO interacts with the membranous cytosolic phospholipase A(2) (cPLA(2)) to produce leukot

35 Ca(2+) concentrations ([Ca(2+)](i)) promote cytosolic phospholipase A(2) (cPLA(2)) translocation to

36 tudy, we demonstrate that down-regulation of cytosolic phospholipase A(2) (cPLA(2)) using RNA interfe

37 of p38 MAPK, ERK-1/2, and [Ca(2+)]-dependent cytosolic phospholipase A(2) (cPLA(2)) was determined in

38 coupling the receptor-mediated activation of cytosolic phospholipase A(2) (cPLA(2)) with isotetrandri

39 ination, substantially altered the levels of cytosolic phospholipase A(2) (cPLA(2)), 5-lipoxygenase (

40 kinase II), a decoder of Ca(2+) signals, and cytosolic phospholipase A(2) (cPLA(2)), an enzyme involv

41 /2 by EGF was followed by phosphorylation of cytosolic phospholipase A(2) (cPLA(2)), and blocking ERK

42 We have used RT-PCR to identify mRNAs for cytosolic phospholipase A(2) (cPLA(2)), COX-1, COX-2, 5-

43 also interacts with the C-terminal region of cytosolic phospholipase A(2) (cPLA(2)), inhibiting cPLA(

44 To apply this approach to the C2 domain of cytosolic phospholipase A(2) (cPLA(2)), single cysteines

45 tors of transcription (Jak/STAT) pathway and cytosolic phospholipase A(2) (cPLA(2)).

46 ond messenger in the apoptotic activation of cytosolic phospholipase A(2) (cPLA(2)).

47 c dyad and an active site like that of human cytosolic phospholipase A(2) (cPLA(2)).

48 (CaM)-dependent protein kinase II-dependent cytosolic phospholipase A(2) (cPLA(2)).

49 tions results from the activity of a type IV cytosolic phospholipase A(2) (cPLA(2)).

50 nding of two Ca(2+) ions to the C2 domain of cytosolic phospholipase A(2) (cPLA(2)-alpha) induces doc

51 We reported that mice deficient for cytosolic phospholipase A(2) (cPLA(2)-KO) are protected

52 Group IVA cytosolic phospholipase A(2) (cPLA(2)alpha) catalyzes re

53 Although group IVA cytosolic phospholipase A(2) (cPLA(2)alpha) has been rep

54 Group IVA cytosolic phospholipase A(2) (cPLA(2)alpha) initiates ei

55 Group IVA cytosolic phospholipase A(2) (cPLA(2)alpha) is regulated

56 lbicans that mediate activation of group IVA cytosolic phospholipase A(2) (cPLA(2)alpha), a regulator

57 ed to study the interaction of C2 domains of cytosolic phospholipase A(2) (cPLA(2)alpha-C2) with a La

58 that in thrombin-stimulated human platelets, cytosolic phospholipase A(2) (cPLA2) is phosphorylated o

59 Activation of group IV cytosolic phospholipase A(2) (gIV-PLA(2)) is the essenti

60 ts indicate that this involves activation of cytosolic phospholipase A(2) (PLA(2)) and eicosanoid syn

61 The results suggest that cytosolic phospholipase A(2) activation triggered by the

62 Upstream, MAPK-p38 mediates cytosolic phospholipase A(2) activation, which is requir

63 e causally associated with the inhibition of cytosolic phospholipase A(2) activity and the PI3K/ERK/N

64 It is postulated that inhibition of cytosolic phospholipase A(2) alpha (cPLA(2)alpha) can re

65 The arachidonic acid-generating enzyme cytosolic phospholipase A(2) alpha (cPLA(2)alpha) has be

66 Cytosolic phospholipase A(2) alpha (cPLA(2)alpha, type I

67 g and the associated augmentation of ERK1/2, cytosolic phospholipase A(2) alpha, and cysteinyl-leukot

68 Phosphorylation of ERK1/2 and cytosolic phospholipase A(2) alpha, known to enhance the

69 nterestingly, expression of COX-2 as well as cytosolic phospholipase A(2) and 5-lipoxygenase were mar

70 rough p38 MAPK-activated c-Src subsequent to cytosolic phospholipase A(2) and generation of AA metabo

71 ted by the concerted actions of the group IV cytosolic phospholipase A(2) and the group V secretory p

72 p38 mitogen-activated protein kinase (MAPK), cytosolic phospholipase A(2) and urokinase type plasmino

73 A(2) expression and activity indicated that cytosolic phospholipase A(2) did not account for AA mobi

74 erexpressed secretory phospholipase A(2) and cytosolic phospholipase A(2) during sepsis benefits the

75 A decrease in both cytosolic phospholipase A(2) expression and activity ind

76 nd associated with increased 5-LO, FLAP, and cytosolic phospholipase A(2) expression.

77 labeling was carried out on the C2 domain of cytosolic phospholipase A(2) in order to determine the d

78 eicosanoids is mediated by the activation of cytosolic phospholipase A(2) in resident peritoneal macr

79 Cytosolic phospholipase A(2) is activated during phagocy

80 moenol lactone, indicating that the group IV cytosolic phospholipase A(2) is also involved in the pro

81 against secretory phospholipase A(2) IIa and cytosolic phospholipase A(2) IVa can inhibit their targe

82 y phospholipase A2 IIa and the other against cytosolic phospholipase A(2) IVa) (Group 4) increased th

83 tors rotenone and oligomycin, but not by the cytosolic phospholipase A(2) or xanthine oxidase inhibit

84 K1/2, the PI3K/Btk pathway does not regulate cytosolic phospholipase A(2) phosphorylation but rather

85 as added, suggesting that a Ca(2+)-dependent cytosolic phospholipase A(2) released the 20-HETE contai

86 d enzymes, namely COX-1, 5-lipoxygenase, and cytosolic phospholipase A(2) were not induced.

87 ke the C2 domain within protein kinase C and cytosolic phospholipase A(2) with unique determinants th

88 ating gene expression and enzyme activity of cytosolic phospholipase A(2), an enzyme that selectively

89 isoenzymes, secretory phospholipase A(2) and cytosolic phospholipase A(2), are overexpressed during s

90 that SCLC cell lines expressed little or no cytosolic phospholipase A(2), COX-1, or COX-2, sulindac

91 IL-13 increases the levels of mRNA encoding cytosolic phospholipase A(2), LTA(4) hydrolase, and 5-LO

92 ar proliferation and survival, activation of cytosolic phospholipase A(2), mast cell degranulation, a

93 following the ERK1/2-dependent activation of cytosolic phospholipase A(2), thus liberating arachidoni

94 positive cooperativity for the C2 domain of cytosolic phospholipase A(2), which binds two Ca(2+) ion

95 ors and with small interfering RNA show that cytosolic phospholipase A(2)-alpha and group IIA secrete

96 mRNA and protein levels), and the action of cytosolic phospholipase A(2)-alpha is required for this

97 he calcium-binding loops of the C2 domain of cytosolic phospholipase A(2).

98 a calcium ionophore, it can be acted upon by cytosolic phospholipase A(2).

99 ylation of p44/42(ERK1/2) or inactivation of cytosolic phospholipase A(2)alpha (cPLA(2)alpha) complet

100 provide the first direct evidence that host cytosolic phospholipase A(2)alpha (cPLA(2)alpha) contrib

101 We have previously shown that host cytosolic phospholipase A(2)alpha (cPLA(2)alpha) contrib

102 Cytosolic phospholipase A(2)alpha (cPLA(2)alpha) is acti

103 Cytosolic phospholipase A(2)alpha (cPLA(2)alpha) is the

104 Cytosolic phospholipase A(2)alpha (cPLA(2)alpha) is the

105 a potent and specific activator of group IV cytosolic phospholipase A(2)alpha (cPLA(2)alpha) via int

106 reatment also induced the phosphorylation of cytosolic phospholipase A(2)alpha (cPLA(2)alpha), a key

107 nt activation of Smad and phosphorylation of cytosolic phospholipase A(2)alpha (cPLA(2)alpha), a rate

108 noid synthesis proximal to the activation of cytosolic phospholipase A(2)alpha (cPLA(2)alpha), the in

109 7LR), and host signaling molecules including cytosolic phospholipase A(2)alpha (cPLA(2)alpha).

110 synthesis in concert with 5-lipoxygenase and cytosolic phospholipase A(2)alpha activation.

111 entify the principal splice variant of human cytosolic phospholipase A(2)beta (cPLA(2)beta) (also kno

112 Cytosolic phospholipase A(2)gamma (cPLA(2)gamma) is a ca

113 The enzymatic properties of cytosolic phospholipase A(2)gamma (cPLA(2)gamma), an iso

114 human corneal epithelial (HCE) cells via the cytosolic phospholipase A(2alpha) (cPLA(2alpha)) pathway

115 We recently identified a cytosolic phospholipase A1 activity in bovine brain and

116 We previously purified a cytosolic phospholipase A1 that could catalyze the prefe

117 The C2 domain of cytosolic phospholipase A2 (C2cPLA2) plays an important

118 F. tularensis-infected macrophages requires cytosolic phospholipase A2 (cPLA(2)), cyclooxygenase 2 (

119 ive of this study was to investigate whether cytosolic phospholipase A2 (cPLA2 ), an important isofor

120 high levels of MYC, we found an increase in cytosolic phospholipase A2 (cPLA2) activity with a prefe

121 on specifically inhibited receptor-dependent cytosolic phospholipase A2 (cPLA2) activity, whereas thi

122 on in VWF/GPIb-IX-induced phosphorylation of cytosolic phospholipase A2 (cPLA2) and consequent thromb

123 cells have constitutively high expression of cytosolic phospholipase A2 (cPLA2) and cyclooxygenase (C

124 by constitutively high expression of 85-kDa cytosolic phospholipase A2 (cPLA2) and cyclooxygenase 2

125 In contrast, the kinetics of cytosolic phospholipase A2 (cPLA2) and extracellular sig

126 ing findings exist regarding the function of cytosolic phospholipase A2 (cPLA2) and its role in membr

127 rapidly activates the enzymatic activity of cytosolic phospholipase A2 (cPLA2) as at-tested to by ar

128 NE enhanced release of AA via activation of cytosolic phospholipase A2 (cPLA2) but not secretory PLA

129 Cytosolic phospholipase A2 (cPLA2) catalyzes release of

130 The 85-kDa Group IV calcium-dependent cytosolic phospholipase A2 (cPLA2) catalyzes the hydroly

131 Cytosolic phospholipase A2 (cPLA2) catalyzes the selecti

132 Cytosolic phospholipase A2 (cPLA2) catalyzes the selecti

133 This study demonstrates that host cell cytosolic phospholipase A2 (cPLA2) contributes to E. col

134 Cytosolic phospholipase A2 (cPLA2) controls AA generatio

135 We examined the role of cytosolic phospholipase A2 (cPLA2) during human eosinoph

136 The group IV cytosolic phospholipase A2 (cPLA2) exhibits a potent and

137 ase-1 (COX-1), cyclooxygenase-2 (COX-2), and cytosolic phospholipase A2 (cPLA2) expression, the rate-

138 We have used mice in which the gene for cytosolic phospholipase A2 (cPLA2) has been disrupted to

139 Group IVA cytosolic phospholipase A2 (cPLA2) has been shown to pla

140 Cytosolic phospholipase A2 (cPLA2) hydrolyzes the sn-2-a

141 port we examine the phosphorylation state of cytosolic phospholipase A2 (cPLA2) in C3HA fibroblasts t

142 be due to the relatively lower expression of cytosolic phospholipase A2 (cPLA2) in H596 cells than th

143 fies the phosphorylation sites of the 85-kDa cytosolic phospholipase A2 (cPLA2) in human platelets an

144 mediating phosphorylation and activation of cytosolic phospholipase A2 (cPLA2) in intact cells remai

145 rol expression of the arachidonyl-selective, cytosolic phospholipase A2 (cPLA2) in intestinal cells.

146 To investigate the role of cytosolic phospholipase A2 (cPLA2) in regulating the dif

147 The role of cytosolic phospholipase A2 (cPLA2) in the regulation of

148 Cytosolic phospholipase A2 (cPLA2) is a Ca2+-dependent e

149 dependent lipid binding domain of the 85-kDa cytosolic phospholipase A2 (cPLA2) is a homolog of C2 do

150 We have shown previously that cytosolic phospholipase A2 (cPLA2) is able to activate g

151 The C2 domain of cytosolic phospholipase A2 (cPLA2) is involved in the Ca

152 have reported recently that the activity of cytosolic phospholipase A2 (cPLA2) is necessary for the

153 The Ca2+-sensitive 85-kDa cytosolic phospholipase A2 (cPLA2) is responsible for th

154 TNF activation of the 85-kDa cytosolic phospholipase A2 (cPLA2) is thought to be esse

155 erest to know whether arachidonate-releasing cytosolic phospholipase A2 (cPLA2) localizes at lipid bo

156 Cytosolic phospholipase A2 (cPLA2) mediates agonist-indu

157 yotic signal-transducing proteins, including cytosolic phospholipase A2 (cPLA2) of the vertebrate inf

158 No changes in the level of cytosolic phospholipase A2 (cPLA2) or COX-1 were observe

159 GF, but not IGF-I, stimulated MAPK activity, cytosolic phospholipase A2 (cPLA2) phosphorylation, and

160 ticularly the potential contributions of the cytosolic phospholipase A2 (cPLA2) signaling pathway.

161 Translocation of cytosolic phospholipase A2 (cPLA2) to Golgi and ER in re

162 Full-length cytosolic phospholipase A2 (cPLA2) was cloned from U937

163 AA) release and on protein levels of p11 and cytosolic phospholipase A2 (cPLA2) was studied in two ep

164 thway (Ras/Raf/MEK/ERK) and Ca(2+)-dependent cytosolic phospholipase A2 (cPLA2) were activated in chl

165 e phosphorylation sites on the human, 85-kDa cytosolic phospholipase A2 (cPLA2) were identified using

166 e gel electrophoresis immunoblot signals for cytosolic phospholipase A2 (cPLA2), 5-lipoxygenase (5-LO

167 e, both basal and IL-1-induced expression of cytosolic phospholipase A2 (cPLA2), a key enzyme-regulat

168 on increased phosphorylation and activity of cytosolic phospholipase A2 (cPLA2), an enzyme causing AA

169 g (1) inhibition of nuclear translocation of cytosolic phospholipase A2 (cPLA2), and (2) blockade of

170 rylation of ERKs, whereas phosphorylation of cytosolic phospholipase A2 (cPLA2), and arachidonic acid

171 (Ad5) affects the expression and activity of cytosolic phospholipase A2 (cPLA2), cyclooxygenase-2 (CO

172 Tissue damage activates cytosolic phospholipase A2 (cPLA2), releasing arachidoni

173 mitogen-activated protein kinase (MAPK) and cytosolic phospholipase A2 (cPLA2), resulting in release

174 quires protease-activated receptors 1 and 4, cytosolic phospholipase A2 (cPLA2), Src tyrosine kinases

175 ism of calcium-dependent membrane binding of cytosolic phospholipase A2 (cPLA2), we measured the inte

176 ed protein (MAP) kinase in the regulation of cytosolic phospholipase A2 (cPLA2)-mediated AA release b

177 ndent signal involves activation of group IV cytosolic phospholipase A2 (cPLA2).

178 ed human cDNAs encode paralogs of the 85-kDa cytosolic phospholipase A2 (cPLA2).

179 Lysolecithin also activated cytosolic phospholipase A2 (cPLA2).

180 , zymosan, and correlates with activation of cytosolic phospholipase A2 (cPLA2).

181 ghly dependent on previous activation of the cytosolic phospholipase A2 (cPLA2).

182 racts with the carboxyl region of the 85-kDa cytosolic phospholipase A2 (cPLA2).

183 nic acid (AA) from membrane phospholipids by cytosolic phospholipase A2 (cPLA2).

184 ught to require TNF-activation of the 85-kDa cytosolic phospholipase A2 (cPLA2).

185 mitogen-activated protein kinase (MAPK) and cytosolic phospholipase A2 (cPLA2).

186 pha caused phosphorylation and activation of cytosolic phospholipase A2 (cPLA2).

187 rachidonic acid by phospholipase A2, and the cytosolic phospholipase A2 (cPLA2)alpha isoform has been

188 ular dynamics simulation of the C2 domain of cytosolic phospholipase A2 (cPLA2-C2) in a 1-palmitoyl-2

189 amino-terminal, 138 amino acid C2 domain of cytosolic phospholipase A2 (cPLA2-C2) mediates an initia

190 The role of Group IVA cytosolic phospholipase A2 (cPLA2alpha) activation in re

191 Group IVA cytosolic phospholipase A2 (cPLA2alpha) acts as a bridge

192 sion was shown to require activation of host cytosolic phospholipase A2 (cPLA2alpha) by Loops1 and 2

193 There is compelling evidence that group IVA cytosolic phospholipase A2 (cPLA2alpha) targets arachido

194 ygous loss-of-function mutation in group IVA cytosolic phospholipase A2 (cPLA2alpha).

195 macrophages through activation of group IVA cytosolic phospholipase A2 (cPLA2alpha).

196 ptotagmin I (SytIC2A) and the C2 domain from cytosolic phospholipase A2 (cPLA2C2) are among the best

197 The Group IVA cytosolic phospholipase A2 (GIVA cPLA2) is a key provide

198 Cytosolic phospholipase A2 (GIVA cPLA2) is the only PLA2

199 Group IVA cytosolic phospholipase A2 (GIVA cPLA2) is the rate-limi

200 Phosphorylation and activation of cytosolic phospholipase A2 (PLA2) can occur independentl

201 achidonic acid by the ubiquitously expressed cytosolic phospholipase A2 (PLA2) has a fundamental role

202 activation were observed, whereas ERK1/2 and cytosolic phospholipase A2 (S505) phosphorylation was no

203 Reduced Ca(2+)-dependent cytosolic phospholipase A2 activation and oxidative meta

204 cells, PDGF-induced MAPK activation leads to cytosolic phospholipase A2 activation, PGE2 release, and

205 included measurement of prostaglandin E2 and cytosolic phospholipase A2 activity in membrane fraction

206 We further show that MIF regulates cytosolic phospholipase A2 activity via a protein kinase

207 ression of key enzymes in NPD1 biosynthesis, cytosolic phospholipase A2 and 15-lipoxygenase, was alte

208 Similarly, PGF2alpha causes translocation of cytosolic phospholipase A2 and also results in a 7-fold

209 Enhancement was blocked by inhibitors of cytosolic phospholipase A2 and cytochrome P450 epoxygena

210 arachidonic acid from phospholipid stores by cytosolic phospholipase A2 and cytochrome P450 metabolis

211 which is due to a constitutively stimulated cytosolic phospholipase A2 and enhanced basal expression

212 osphorylation and activation of the Group IV cytosolic phospholipase A2 and of the extracellular-sign

213 ll as beta-arrestin1-dependent activation of cytosolic phospholipase A2 and release of arachidonate,

214 ar relevance to studies on the regulation of cytosolic phospholipase A2 as these two MAPKs are capabl

215 d the binding of beta-arrestin1 to activated cytosolic phospholipase A2 as well as beta-arrestin1-dep

216 es upon cell stimulation, and cooperate with cytosolic phospholipase A2 at the membrane surface to ge

217 s NF-kappaBp50/p105, IL-1beta precursor, and cytosolic phospholipase A2 genes.

218 Eicosanoids, derived from the cytosolic phospholipase A2 group IVA (cPLA2alpha) activa

219 ed that an A-->G variant (rs12746200) of the cytosolic phospholipase A2 group IVA gene (PLA2G4A), whi

220 xercised in using AACOCF3 as an inhibitor of cytosolic phospholipase A2 in whole cell assays because

221 Pretreatment of DARas with antioxidants or a cytosolic phospholipase A2 inhibitor also restores the w

222 We also demonstrate that the cytosolic phospholipase A2 inhibitor arachidonyl trifluo

223 In contrast, a specific cytosolic phospholipase A2 inhibitor blocked the oxidant

224 determine the effects of a putative specific cytosolic phospholipase A2 inhibitor, arachidonyl triflu

225 Cells treated with the cytosolic phospholipase A2 inhibitor, cPLA2alpha, had no

226 d (AA) by exposure to fatty acid-free BSA or cytosolic phospholipase A2 inhibitors.

227 Cytosolic phospholipase A2 initiates the biosynthesis of

228 Cytosolic phospholipase A2 is involved in several signal

229 cells that express tau, receptors coupled to cytosolic phospholipase A2 may activate PLC-gamma isozym

230 Finally, we propose that cytosolic phospholipase A2 may be a potential source of

231 arthritis correlated with altered COX-2 and cytosolic phospholipase A2 messenger RNA levels in the j

232 alpha preferentially activates the MEK-Erk2- cytosolic phospholipase A2 pathway.

233 ed extracellular signal-regulated kinase and cytosolic phospholipase A2 phosphorylation, consistent w

234 ein's ability to induce prostaglandin E2 and cytosolic phospholipase A2 synthesis in patients' fibrob

235 Cytosolic phospholipase A2 translocates from the cytopla

236 pholipase A2 (sPLA2) amplifies the action of cytosolic phospholipase A2(cPLA2) alpha in regulating ei

237 itoneal macrophages, activation of group IVA cytosolic phospholipase A2(cPLA2alpha) by calcium- and m

238 as novel therapeutic targets in cancer (eg, cytosolic phospholipase A2, an upstream target of the cy

239 age-dependent alpha1G subtype Ca2+ channels, cytosolic phospholipase A2, and epoxyeicosatrienoic acid

240 ETE from membrane phospholipids by group IVA cytosolic phospholipase A2, and its conversion to bioact

241 phosphorylation of Raf1, MEK1, p42mapk, and cytosolic phospholipase A2, as well as the associated in

242 AAOCF3, which inhibits cytosolic phospholipase A2, blocked thapsigargin-stimula

243 ether the RvD1 biosynthetic machinery (e.g., cytosolic phospholipase A2, calcium-independent phosphol

244 tracellular Ca2+ concentration and activates cytosolic phospholipase A2, followed by lipoxygenase-cat

245 ion of this Ras-MAP kinase pathway activated cytosolic phospholipase A2, leading to the release of ar

246 Finally, inhibition of cytosolic phospholipase A2, one of the key enzymes invol

247 the Ca2+-dependent lipid-binding domains of cytosolic phospholipase A2, protein kinase C, Rabphilin-

248 utocrine loop by which LPI is synthesized by cytosolic phospholipase A2, pumped out of the cell by th

249 noid synthesis proximal to the activation of cytosolic phospholipase A2, the initial rate-limiting st

250 ese two MAPKs are capable of phosphorylating cytosolic phospholipase A2, thereby increasing its intri

251 decrease in expression of MEK1, p42mapk, and cytosolic phospholipase A2, which may contribute further

252 (2+)- and kinase-dependent activation of the cytosolic phospholipase A2, which releases arachidonic a

253 ssion of cyclooxygenase-2 and phosphorylated cytosolic phospholipase A2, which was reflected in prost

254 Cytosolic phospholipase A2-alpha (cPLA2-alpha) is a calc

255 ee functionally distinct signaling proteins: cytosolic phospholipase A2-alpha (cPLA2-alpha), protein

256 iglyceride and free fatty acid content and a cytosolic phospholipase A2-dependent increase in formati

257 FP, but by inhibitors of either secretory or cytosolic phospholipase A2.

258 ctivated by protein kinase C lambda/iota and cytosolic phospholipase A2.

259 P kinases and induces the phosphorylation of cytosolic phospholipase A2.

260 rifluoromethyl ketone, a potent inhibitor of cytosolic phospholipase A2.

261 staglandin E2 (PGE2) via a calcium-dependent cytosolic phospholipase A2/cyclooxygenase-mediated mecha

262 l proliferation; to induce the activation of cytosolic phospholipase A2; and to inhibit Na+-K+-ATPase

263 Cytosolic phospholipases A2 (cPLA2s) consist of a family

264 Secretory and cytosolic phospholipases A2 (sPLA2 and cPLA2) may contri

265 Cytosolic phospholipase A2alpha (cPLA2alpha) affects mem

266 Cytosolic phospholipase A2alpha (cPLA2alpha) hydrolyzes

267 We here studied possible involvement of cytosolic phospholipase A2alpha (cPLA2alpha) in this mec

268 ulin resistance and to determine the role of cytosolic phospholipase A2alpha (cPLA2alpha) in this pro

269 Cytosolic phospholipase A2alpha (cPLA2alpha) is a major

270 arachidonic acid release but did not involve cytosolic phospholipase A2alpha (cPLA2alpha) or calcium-

271 GE2 treatment induced the phosphorylation of cytosolic phospholipase A2alpha (cPLA2alpha), a key enzy

272 ains of protein kinase Calpha (PKCalpha) and cytosolic phospholipase A2alpha (cPLA2alpha), for exampl

273 ceramide kinase is an activator of group IVA cytosolic phospholipase A2alpha (cPLA2alpha), the rate-l

274 Cytosolic phospholipase A2alpha (cPLA2alpha), which init

275 whether there is an association between the cytosolic phospholipase A2alpha (cPLA2alpha)-controlled

276 Group IVA phospholipase A2 [cytosolic phospholipase A2alpha (cPLA2alpha)] is a key m

277 tionship of a series of indole inhibitors of cytosolic phospholipase A2alpha (cPLA2alpha, type IVA ph

278 Generation requires the participation of cytosolic phospholipase A2alpha and CoA-dependent acyltr

279 Moreover, blocking cytosolic phospholipase A2alpha by its inhibitor or smal

280 We propose that cytosolic phospholipase A2alpha, COX-2, and mPGES-1 in t

281 Cytosolic phospholipase A2alpha, which mobilizes arachid

282 of the promoter of its biosynthetic enzyme, cytosolic phospholipase A2alpha.

283 uct was approximately 56% identical to human cytosolic phospholipase A2gamma (cPLA2gamma).

284 quence homology, we named the molecule mouse cytosolic phospholipase A2gamma (cPLA2gamma).

285 Cytosolic phospholipase (cPLA(2))-initiated proinflammat

286 -independent phospholipase (iPLA(2)beta) and cytosolic phospholipase (cPLA(2)alpha), and substantiate

287 Activated cytosolic phospholipase (cPLA2) catalyzes the production

288 Whereas the subcellular locations of cytosolic phospholipase (PL) A(2) and each of the pathwa