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1 ctivated by protein kinase C lambda/iota and cytosolic phospholipase A2.
2 P kinases and induces the phosphorylation of cytosolic phospholipase A2.
3 rifluoromethyl ketone, a potent inhibitor of cytosolic phospholipase A2.
4 FP, but by inhibitors of either secretory or cytosolic phospholipase A2.
6 cells, PDGF-induced MAPK activation leads to cytosolic phospholipase A2 activation, PGE2 release, and
7 included measurement of prostaglandin E2 and cytosolic phospholipase A2 activity in membrane fraction
10 ee functionally distinct signaling proteins: cytosolic phospholipase A2-alpha (cPLA2-alpha), protein
11 as novel therapeutic targets in cancer (eg, cytosolic phospholipase A2, an upstream target of the cy
12 ression of key enzymes in NPD1 biosynthesis, cytosolic phospholipase A2 and 15-lipoxygenase, was alte
13 Similarly, PGF2alpha causes translocation of cytosolic phospholipase A2 and also results in a 7-fold
14 Enhancement was blocked by inhibitors of cytosolic phospholipase A2 and cytochrome P450 epoxygena
15 arachidonic acid from phospholipid stores by cytosolic phospholipase A2 and cytochrome P450 metabolis
16 which is due to a constitutively stimulated cytosolic phospholipase A2 and enhanced basal expression
17 osphorylation and activation of the Group IV cytosolic phospholipase A2 and of the extracellular-sign
18 ll as beta-arrestin1-dependent activation of cytosolic phospholipase A2 and release of arachidonate,
19 age-dependent alpha1G subtype Ca2+ channels, cytosolic phospholipase A2, and epoxyeicosatrienoic acid
20 ETE from membrane phospholipids by group IVA cytosolic phospholipase A2, and its conversion to bioact
21 l proliferation; to induce the activation of cytosolic phospholipase A2; and to inhibit Na+-K+-ATPase
22 ar relevance to studies on the regulation of cytosolic phospholipase A2 as these two MAPKs are capabl
23 d the binding of beta-arrestin1 to activated cytosolic phospholipase A2 as well as beta-arrestin1-dep
24 phosphorylation of Raf1, MEK1, p42mapk, and cytosolic phospholipase A2, as well as the associated in
25 es upon cell stimulation, and cooperate with cytosolic phospholipase A2 at the membrane surface to ge
28 ether the RvD1 biosynthetic machinery (e.g., cytosolic phospholipase A2, calcium-independent phosphol
29 F. tularensis-infected macrophages requires cytosolic phospholipase A2 (cPLA(2)), cyclooxygenase 2 (
30 ive of this study was to investigate whether cytosolic phospholipase A2 (cPLA2 ), an important isofor
31 high levels of MYC, we found an increase in cytosolic phospholipase A2 (cPLA2) activity with a prefe
32 on specifically inhibited receptor-dependent cytosolic phospholipase A2 (cPLA2) activity, whereas thi
33 on in VWF/GPIb-IX-induced phosphorylation of cytosolic phospholipase A2 (cPLA2) and consequent thromb
34 cells have constitutively high expression of cytosolic phospholipase A2 (cPLA2) and cyclooxygenase (C
35 by constitutively high expression of 85-kDa cytosolic phospholipase A2 (cPLA2) and cyclooxygenase 2
37 ing findings exist regarding the function of cytosolic phospholipase A2 (cPLA2) and its role in membr
38 rapidly activates the enzymatic activity of cytosolic phospholipase A2 (cPLA2) as at-tested to by ar
39 NE enhanced release of AA via activation of cytosolic phospholipase A2 (cPLA2) but not secretory PLA
48 ase-1 (COX-1), cyclooxygenase-2 (COX-2), and cytosolic phospholipase A2 (cPLA2) expression, the rate-
52 port we examine the phosphorylation state of cytosolic phospholipase A2 (cPLA2) in C3HA fibroblasts t
53 be due to the relatively lower expression of cytosolic phospholipase A2 (cPLA2) in H596 cells than th
54 fies the phosphorylation sites of the 85-kDa cytosolic phospholipase A2 (cPLA2) in human platelets an
55 mediating phosphorylation and activation of cytosolic phospholipase A2 (cPLA2) in intact cells remai
56 rol expression of the arachidonyl-selective, cytosolic phospholipase A2 (cPLA2) in intestinal cells.
60 dependent lipid binding domain of the 85-kDa cytosolic phospholipase A2 (cPLA2) is a homolog of C2 do
63 have reported recently that the activity of cytosolic phospholipase A2 (cPLA2) is necessary for the
66 erest to know whether arachidonate-releasing cytosolic phospholipase A2 (cPLA2) localizes at lipid bo
68 yotic signal-transducing proteins, including cytosolic phospholipase A2 (cPLA2) of the vertebrate inf
70 GF, but not IGF-I, stimulated MAPK activity, cytosolic phospholipase A2 (cPLA2) phosphorylation, and
71 ticularly the potential contributions of the cytosolic phospholipase A2 (cPLA2) signaling pathway.
74 AA) release and on protein levels of p11 and cytosolic phospholipase A2 (cPLA2) was studied in two ep
75 thway (Ras/Raf/MEK/ERK) and Ca(2+)-dependent cytosolic phospholipase A2 (cPLA2) were activated in chl
76 e phosphorylation sites on the human, 85-kDa cytosolic phospholipase A2 (cPLA2) were identified using
77 e gel electrophoresis immunoblot signals for cytosolic phospholipase A2 (cPLA2), 5-lipoxygenase (5-LO
78 e, both basal and IL-1-induced expression of cytosolic phospholipase A2 (cPLA2), a key enzyme-regulat
79 on increased phosphorylation and activity of cytosolic phospholipase A2 (cPLA2), an enzyme causing AA
80 g (1) inhibition of nuclear translocation of cytosolic phospholipase A2 (cPLA2), and (2) blockade of
81 rylation of ERKs, whereas phosphorylation of cytosolic phospholipase A2 (cPLA2), and arachidonic acid
82 (Ad5) affects the expression and activity of cytosolic phospholipase A2 (cPLA2), cyclooxygenase-2 (CO
84 mitogen-activated protein kinase (MAPK) and cytosolic phospholipase A2 (cPLA2), resulting in release
85 quires protease-activated receptors 1 and 4, cytosolic phospholipase A2 (cPLA2), Src tyrosine kinases
86 ism of calcium-dependent membrane binding of cytosolic phospholipase A2 (cPLA2), we measured the inte
87 ed protein (MAP) kinase in the regulation of cytosolic phospholipase A2 (cPLA2)-mediated AA release b
98 rachidonic acid by phospholipase A2, and the cytosolic phospholipase A2 (cPLA2)alpha isoform has been
99 ular dynamics simulation of the C2 domain of cytosolic phospholipase A2 (cPLA2-C2) in a 1-palmitoyl-2
100 amino-terminal, 138 amino acid C2 domain of cytosolic phospholipase A2 (cPLA2-C2) mediates an initia
101 pholipase A2 (sPLA2) amplifies the action of cytosolic phospholipase A2(cPLA2) alpha in regulating ei
104 sion was shown to require activation of host cytosolic phospholipase A2 (cPLA2alpha) by Loops1 and 2
105 There is compelling evidence that group IVA cytosolic phospholipase A2 (cPLA2alpha) targets arachido
108 itoneal macrophages, activation of group IVA cytosolic phospholipase A2(cPLA2alpha) by calcium- and m
109 ptotagmin I (SytIC2A) and the C2 domain from cytosolic phospholipase A2 (cPLA2C2) are among the best
111 staglandin E2 (PGE2) via a calcium-dependent cytosolic phospholipase A2/cyclooxygenase-mediated mecha
112 iglyceride and free fatty acid content and a cytosolic phospholipase A2-dependent increase in formati
113 tracellular Ca2+ concentration and activates cytosolic phospholipase A2, followed by lipoxygenase-cat
119 ed that an A-->G variant (rs12746200) of the cytosolic phospholipase A2 group IVA gene (PLA2G4A), whi
120 xercised in using AACOCF3 as an inhibitor of cytosolic phospholipase A2 in whole cell assays because
121 Pretreatment of DARas with antioxidants or a cytosolic phospholipase A2 inhibitor also restores the w
124 determine the effects of a putative specific cytosolic phospholipase A2 inhibitor, arachidonyl triflu
129 ion of this Ras-MAP kinase pathway activated cytosolic phospholipase A2, leading to the release of ar
130 cells that express tau, receptors coupled to cytosolic phospholipase A2 may activate PLC-gamma isozym
132 arthritis correlated with altered COX-2 and cytosolic phospholipase A2 messenger RNA levels in the j
135 ed extracellular signal-regulated kinase and cytosolic phospholipase A2 phosphorylation, consistent w
137 achidonic acid by the ubiquitously expressed cytosolic phospholipase A2 (PLA2) has a fundamental role
138 the Ca2+-dependent lipid-binding domains of cytosolic phospholipase A2, protein kinase C, Rabphilin-
139 utocrine loop by which LPI is synthesized by cytosolic phospholipase A2, pumped out of the cell by th
140 activation were observed, whereas ERK1/2 and cytosolic phospholipase A2 (S505) phosphorylation was no
142 ein's ability to induce prostaglandin E2 and cytosolic phospholipase A2 synthesis in patients' fibrob
143 noid synthesis proximal to the activation of cytosolic phospholipase A2, the initial rate-limiting st
144 ese two MAPKs are capable of phosphorylating cytosolic phospholipase A2, thereby increasing its intri
146 decrease in expression of MEK1, p42mapk, and cytosolic phospholipase A2, which may contribute further
147 (2+)- and kinase-dependent activation of the cytosolic phospholipase A2, which releases arachidonic a
148 ssion of cyclooxygenase-2 and phosphorylated cytosolic phospholipase A2, which was reflected in prost
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