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1 somehow escape endocytic vesicles to contact cytosolic protein.
2 nding interactions with a folded or unfolded cytosolic protein.
3 emonstrated a dose-dependent increase in Ras cytosolic protein.
4 ing frame of unknown function that encodes a cytosolic protein.
5 mutations in the RKRK motif resulted in the cytosolic protein.
6 TRAP_Cy3) to trap and visualize dithiols in cytosolic proteins.
7 causes the loss of solubility intracellular cytosolic proteins.
8 s may result from more widespread effects on cytosolic proteins.
9 o efficient in preventing the aggregation of cytosolic proteins.
10 down IRF5 from a mixture of endothelial cell cytosolic proteins.
11 lucosamine (O-GlcNAc) to various nuclear and cytosolic proteins.
12 the less hydrophobic amino acid segments in cytosolic proteins.
13 le in unconventional secretion of leaderless cytosolic proteins.
14 domains that distinguish MLPs from potential cytosolic proteins.
15 re was little impact on Ag presentation from cytosolic proteins.
16 a more restricted role in the processing of cytosolic proteins.
17 lational modification of diverse nuclear and cytosolic proteins.
18 interaction and docking targets for various cytosolic proteins.
19 ity of the cytosolic domain to interact with cytosolic proteins.
20 of protein methylation in the regulation of cytosolic proteins.
21 ell might also be facilitated by target cell cytosolic proteins.
22 ctive lysosomal mechanism for degradation of cytosolic proteins.
23 partments for the sequestration of misfolded cytosolic proteins.
24 es, which may recognize membrane, nuclear or cytosolic proteins.
25 to serine/threonine residues of nuclear and cytosolic proteins.
26 protein fractions compared with cell wall or cytosolic proteins.
27 brane proteins or diffusional entry of small cytosolic proteins.
28 belong to a small family of multifunctional cytosolic proteins.
30 OR], 2.54; P = 1.20 x 10(-6)) and lymphocyte cytosolic protein-1 (LCP1) (OR, 3.29; P = 2.96 x 10(-6))
32 tical for the capture of heat stress-induced cytosolic protein aggregates and their retention in the
35 eed by coupling an active transport model of cytosolic proteins along a two-dimensional microtubule (
37 focused on understanding the function of the cytosolic protein, alpha-synuclein, and its contribution
38 atially distinguishable transport routes for cytosolic proteins: an IFT-dependent path along the axon
40 D66 encodes an approximately 30-kDa soluble, cytosolic protein and that the chymotrypsin-like activit
41 ded with the impaired turnover of long-lived cytosolic proteins and accumulation of autophagosomes.
43 tions manifest themselves via scaffolding of cytosolic proteins and cytoskeletal networks to specific
44 ophagy (autophagy) is a process wherein bulk cytosolic proteins and damaged organelles are sequestere
45 ification is present on numerous nuclear and cytosolic proteins and has been implicated in essential
46 ophagy controls the degradation of selective cytosolic proteins and may protect neurons against degen
48 tabolic process, leads to the degradation of cytosolic proteins and organelles in the vacuole/lysosom
49 otes that utilizes small vesicles to traffic cytosolic proteins and organelles to the vacuole for bre
53 ise to nuclear chromosomal genes that encode cytosolic proteins and precursor proteins that are synth
54 e system by binding to peptides derived from cytosolic proteins and presenting them on the cell surfa
55 densed chromatin decorated with granular and cytosolic proteins and they can trap extracellular patho
56 n be sensed by a growing number of host cell cytosolic proteins and TLR3, which contribute to the ind
57 lling, (vi) degradation of Mo and fibroblast cytosolic proteins, and (vii) promotion of survival of i
63 e role of macroautophagy, a process in which cytosolic proteins are delivered to the lysosome by de n
66 ittle is currently known about how misfolded cytosolic proteins are recognized by protein quality con
68 elective type of autophagy by which specific cytosolic proteins are sent to lysosomes for degradation
73 Our observations establish misfolding of cytosolic proteins as an effect of aminoglycoside action
75 directly interacts with several membrane and cytosolic proteins at neuronal plasma membranes, leading
76 mics, electrical signaling, and diffusion of cytosolic proteins at unprecedented spatial resolution.
82 ation of NUP62 attenuated the gated entry of cytosolic proteins but did not affect entry of membrane
83 osttranslational modification of nuclear and cytosolic proteins but is present also in mitochondria.
85 osttranslational modification of nuclear and cytosolic proteins by O-linked beta-N-acetylglucosamine
86 either purified rhodanese or skeletal muscle cytosolic proteins by urea-induced unfolding or in respo
87 chanism whereby overexpression of a specific cytosolic protein bypasses the essentiality of an inner
89 first demonstration that large fragments of cytosolic proteins can be accumulated in prematurely sen
94 n induces pyroptosis, which is mediated by a cytosolic protein complex called the inflammasome that s
96 LRP3) inflammasome is a caspase-1-containing cytosolic protein complex that is essential for processi
97 uries trigger the assembly of inflammasomes, cytosolic protein complexes that activate caspase-1, lea
106 llular sensors is a protein known as Nod2, a cytosolic protein containing a leucine-rich repeat domai
108 -ribosylates and affects the function of the cytosolic protein, CpA, with the predominant functional
109 a strategy for analyzing axonal transport of cytosolic proteins (CPs) using photoactivatable GFP-PAGF
112 easome inhibition enhanced activation of the cytosolic protein damage sensor HSF1, elevated levels of
113 that distinct autophagic mechanisms control cytosolic protein delivery to late endosomes and identif
114 cytosol (yHsp60c) inhibits degradation of a cytosolic protein DeltaMTS-Aco1 tagged with the degron S
115 -10) cm(2) s(-1)) but increased with time as cytosolic protein density, which was initially high, dec
118 om glutamatergic AMPA and NMDA receptors and cytosolic proteins directly and differentially bind spin
119 ave indicated that mammalian cells contain a cytosolic protein disaggregation machinery comprised of
122 is work, we investigated the function of the cytosolic protein EspG(5), which is essential for ESX-5-
123 Bassoon and Piccolo are active zone specific cytosolic proteins essential for active zone assembly in
124 ultisite membrane-anchored proteins, but not cytosolic proteins, even when enzymes are in excess.
125 tes, about one-third of the Escherichia coli cytosolic proteins exhibit cotranslational folding, with
129 termine whether there is evidence of altered cytosolic protein folding by assessing whether amyloid d
130 fy new mechanisms for selection of misfolded cytosolic proteins for degradation via defining function
131 ng a genetic screen, we identified two novel cytosolic proteins, Fra1 and Fra2, that are part of a co
133 sion data were obtained for 874 membrane and cytosolic proteins from the M. avium subsp. paratubercul
137 et nuclear proteins and, to a lesser extent, cytosolic proteins, hardly anything is known about the S
138 O-Linked GlcNAc modification of nuclear and cytosolic proteins has been shown to regulate the functi
139 tants to establish that the levels of ZTL, a cytosolic protein, help govern the abundance and distrib
142 ith a short cytoplasmic domain can recruit a cytosolic protein in a phospholipid and Ca(2+)-specific
143 loid-related protein 14 (MRP14), an abundant cytosolic protein in myeloid cells, acts as an endogenou
144 our application of STICS to freely diffusing cytosolic protein in small cells extends the utility of
146 role for ERalpha-interacting membranous and cytosolic proteins in ERalpha action, but our understand
149 a selective mechanism for the degradation of cytosolic proteins in lysosomes that contributes to cell
150 gy (CMA), a selective form of degradation of cytosolic proteins in lysosomes, contributes to maintena
151 A), a selective mechanism for degradation of cytosolic proteins in lysosomes, contributes to the remo
158 al locations of transport routes for various cytosolic proteins in the 250-nm-wide shaft of live prim
160 the external medium requires the addition of cytosolic proteins including coatomer protein complex I
162 selected peptide-bound glutamine residues of cytosolic proteins (including actin and tubulin), while
163 d by a variety of receptor interactions with cytosolic proteins, including those that may be previous
164 er transcript, responsible for producing the cytosolic protein increases rapidly and specifically dur
165 osis inhibitory molecule (FAIM) is a soluble cytosolic protein inhibitor of programmed cell death and
166 Ric-8A) is a highly evolutionarily conserved cytosolic protein initially identified in Caenorhabditis
167 propose a model in which active transport of cytosolic proteins into both nuclear and ciliary compart
168 el where Hsc70 activity dynamically clusters cytosolic proteins into cargo complexes, allowing transp
169 t leads to enhanced turnover of non-critical cytosolic proteins into sources of energy or clearance o
170 ays for proteasomal degradation of misfolded cytosolic proteins involve functional interplay between
172 alpha-Synuclein (alpha-Syn) is an abundant cytosolic protein involved in the release of neurotransm
173 or proteins 5 (CRMP5) belongs to a family of cytosolic proteins involved in axon guidance and neurite
174 m the ER membrane not only YOD1 and p97, two cytosolic proteins involved in the extraction of ER tran
176 errupting locus (SIL), a vertebrate-specific cytosolic protein, is necessary for proper mitotic spind
177 nd its "constitutive" interactions with some cytosolic proteins, it nevertheless is a prerequisite bo
178 Nrf2 activity is controlled, in part, by the cytosolic protein Keap1, but the nature of this pathway
181 Dimeric tubulin, an abundant water-soluble cytosolic protein known primarily for its role in the cy
182 ile acid binding protein (IBABP) is the only cytosolic protein known to bind and transport bile acids
184 Unlike classical calpains, CAPN5 is a non-cytosolic protein localized to the nucleus and extra-nuc
185 implicate the periplasmic protein LptA, the cytosolic protein LptB, and the IM proteins LptC, LptF,
186 Here, we show that aminoglycosides cause cytosolic protein misfolding and that chaperonin GroEL/G
188 Liver fatty acid binding protein (L-FABP), a cytosolic protein most abundant in liver, is associated
189 Here, we identify and characterize a 34-kDa cytosolic protein, MSP polymerization-activating kinase
190 he ER membrane-associated E3 ligase mAMFR, a cytosolic protein mY33K, containing both UBA and UBX dom
191 otherwise rapid UPS-mediated turnover of the cytosolic proteins myoD and GFPu, but not the degradatio
192 serine and threonine residues of nuclear and cytosolic proteins (O-GlcNAc) is a posttranslational mod
196 s a catabolic pathway for the degradation of cytosolic proteins or organelles and is conserved among
197 neral homeostatic process for degradation of cytosolic proteins or organelles, has been reported to m
198 to the accumulation of damaged or aggregated cytosolic proteins, or membranes, and rely on autophagy
203 ntify SBP-AR and associated ligand-sensitive cytosolic proteins/protein complexes linked to AR activa
204 nappreciated regulatory pathway coordinating cytosolic protein quality control and mTORC1 signaling.
205 In conclusion, our results suggest that a cytosolic protein quality control pathway monitors foldi
206 e that ubiquitin chain editing is key to the cytosolic protein quality control under stress condition
207 his protein family, ZFP36L3 is a "full-time" cytosolic protein, rather than a nucleocytoplasmic shutt
208 no spurious signal even with highly abundant cytosolic proteins readily accessible to the bud neck (i
214 Myeloid-related proteins (MRPs) 8 and 14 are cytosolic proteins secreted from myeloid cells as proinf
216 n of these degradative compartments requires cytosolic proteins, some of which are autophagy specific
218 CP1 and CCP2-6 function in the processing of cytosolic proteins such as alpha-tubulin, which is known
219 intracellular inclusion pathology formed by cytosolic proteins such as Tau, alpha-synuclein and TDP-
221 ajority of the identified proteins were host cytosolic proteins, suggesting that S. aureus was rapidl
222 osterically through binding to a site on the cytosolic protein surface, which is different from the e
223 Stromule induction by ABA was dependent on cytosolic protein synthesis, but not plastid protein syn
224 of nascent chain length for Escherichia coli cytosolic proteins synthesized on both arrested and cont
225 found that in cultured axons, populations of cytosolic proteins tagged to photoactivatable GFP (PAGFP
227 lexin, also known as synaphin, is a neuronal cytosolic protein that acts as a major regulator of syna
230 quitinated proteins and that it is a soluble cytosolic protein that can be induced by interferons and
232 sicle-trafficking proteins, and for DHAR1, a cytosolic protein that facilitates the scavenging of rea
233 tage-dependent potassium channels (Kv1) is a cytosolic protein that forms a permanent complex with th
235 ors of Cholinesterase A (Ric-8A) is a 60-kDa cytosolic protein that has chaperone and guanine nucleot
237 ype fatty acid binding protein (H-FABP) is a cytosolic protein that is released rapidly from the card
239 y acid-binding protein (L-Fabp), an abundant cytosolic protein that modulates fatty acid (FA) metabol
240 clear prelamin A recognition factor-like), a cytosolic protein that plays a role in the cytosolic iro
241 Rhesus TRIM5alpha (TRIM5alpha(rh)) is a cytosolic protein that potently restricts HIV-1 at an ea
245 t, an integral membrane protein but rather a cytosolic protein that tightly associates with cellular
246 OXO1beta [NOXO1 (Nox organizer 1) beta] is a cytosolic protein that, in conjunction with NOXA1 (Nox a
248 on chromatography, we identified hundreds of cytosolic proteins that appeared to exist as components
249 exins, found in most eukaryotic species, are cytosolic proteins that are able to bind negatively-char
250 tTPK1 and AtTPK2 are biochemically redundant cytosolic proteins that are similarly expressed througho
251 embrane proteins, cytoskeletal proteins, and cytosolic proteins that are strongly associated with the
253 somes containing kidney-derived membrane and cytosolic proteins that can be used to probe the proteom
254 he interleukin-1 (IL-1) family cytokines are cytosolic proteins that exhibit inflammatory activity up
256 of 30 yeast strains with single deletions of cytosolic proteins that have known or hypothesized chape
257 liary subunits KCTD8, -12, -12b, and -16 are cytosolic proteins that influence agonist potency and G-
258 UBX-containing protein, UBXD4, as one of the cytosolic proteins that interact directly with the alpha
259 the basis for NO inhibition and to identify cytosolic proteins that may be involved, using inducible
261 rotein 5 (CRMP5) belongs to a family of five cytosolic proteins that play a major role in nervous sys
263 proteomic approaches, we identified numerous cytosolic proteins that show specific losses in solubili
265 7) are an evolutionarily conserved family of cytosolic proteins that transiently assembles into helic
268 h fluorescence-quenching agents and selected cytosolic proteins, the rate of substrate efflux was mon
270 Orai with the carboxy terminus of Stim as a cytosolic protein to activate the Orai channel without i
271 e demonstrate light-induced recruitment of a cytosolic protein to individual centromeres, kinetochore
273 ed specific ribosomal and bulk ubiquitinated cytosolic proteins to autolysosomes where they were prot
274 , our results suggest that routing misfolded cytosolic proteins to ER may be an effective strategy fo
275 -mediated autophagy involved in transport of cytosolic proteins to the lysosome for degradation.
276 To address this issue, we have targeted cytosolic proteins to the mitochondrion, a poly(A) speci
277 autophagy-like process that delivers soluble cytosolic proteins to the vesicles of late endosomes/mul
278 idic clusters, which interact with PACS-1, a cytosolic protein, to mediate retrograde transport from
279 r bound of about 7 to 16% on the fraction of cytosolic protein translation carried out by ribosomes a
281 axonal transport via motor-driven vesicles, cytosolic proteins travel in slow axonal transport via m
282 ane adapter protein PAG1, which recruits the cytosolic protein tyrosine kinase Csk to the plasma memb
283 ollows: BCR, Lyn, Fyn, Csk, PAG1, and Syk, a cytosolic protein tyrosine kinase that is activated as a
284 gle DHCH1 and FTL genes encoding exclusively cytosolic proteins, unlike other organisms where isoform
286 regulation involves assembly of an ISC on a cytosolic protein using Fecyt and a sulfur species gener
288 c) availability, and lead to modification of cytosolic proteins via O-linked attachment of the monosa
292 urred during evolution, whenever ancestrally cytosolic proteins were recruited to the secretory pathw
295 l TDP-43 increased the levels of nuclear and cytosolic protein, whereas Parkin co-expression mediated
296 ding to tyrosine-phosphorylated receptors or cytosolic proteins, which leads to the formation of larg
297 ha- and gamma-adaptin-binding protein p34, a cytosolic protein with a Rab-like GTPase domain, was sho
300 with only protein disulfide isomerase or all cytosolic proteins with only PA700, the 19S regulatory p
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