ライフサイエンスコーパス: cytosolic tail

1 omain containing the fifth TMH (TMH-V) and a cytosolic tail.

2 -like domains, a transmembrane domain, and a cytosolic tail.

3 omain and the adjacent 28 amino acids of the cytosolic tail.

4 plasmalemma domains and deletion of PECAM-1 cytosolic tail.

5 putative polarized targeting signals in the cytosolic tail.

6 ts were isolated using antibodies to the CPD cytosolic tail.

7 tion are independent of the Kex2p C-terminal cytosolic tail.

8 ot deletions of the TLS or entire C-terminal cytosolic tail.

9 ization signal (TLS) in the Kex2p C-terminal cytosolic tail.

10 eolyzed form of Drs2p lacking the C-terminal cytosolic tail.

11 l fragment containing the channel domain and cytosolic tail.

12 ine located in a YxxL sequence in the CLEC-2 cytosolic tail.

13 nserved hydrophobic domain in the C-terminal cytosolic tail.

14 ptor tyrosine-based inhibitory motifs in its cytosolic tail.

15 tyrosine Lck kinase binding site in the CD28 cytosolic tail.

16 the removal of the transmembrane domain and cytosolic tail.

17 -inducible T cell kinase binding to the CD28 cytosolic tail.

18 twork (TGN) localization signal in the Kex2p cytosolic tail.

19 e substrate using antibody against the Kex2p cytosolic tail.

20 ated with the carboxyl terminus of the beta3 cytosolic tail.

21 res PIP2 binding to and rearrangement of the cytosolic tails.

22 e of tyrosine-based sorting signals in their cytosolic tails.

23 an ART sorting signal in the Mup1 N-terminal cytosolic tail: 1) an extended acidic patch, 2) in close

24 hrough the TSYT(346-349) region of the CXCR1 cytosolic tail, a region divergent from the CXCR2 cytoso

25 To explore the role of the TEM8 cytosolic tail, a series of truncated TEM8 mutants was t

26 resented that caspase cleavage of APP at its cytosolic tail affects its processing such that it is re

27 de evidence that Alg14 contains a C-terminal cytosolic tail and an N terminus that resides within the

28 in the absence of interactions between CD1d cytosolic tail and the actin cytoskeleton and correlates

29 n between a PPAY motif within its C-terminal cytosolic tail and the WW domains of Rsp5p.

30 d catenins, binds directly to the E-cadherin cytosolic tail and thereby localizes at cell-cell adhesi

31 individually and simultaneously altering the cytosolic tail and transmembrane region of the STcys iso

32 via mechanisms independently mediated by its cytosolic tail and transmembrane region.

33 -like domains, a transmembrane domain, and a cytosolic tail and which functions in the processing of

34 n Siglec-10 in its extracellular domain, the cytosolic tail appears only distantly related.

35 table, while proteins lacking the N-terminal cytosolic tail are stable and multimerize efficiently, b

36 sis defined the COOH-terminal residue of the cytosolic tail as critical in governing the distribution

37 lving p56(lck) and its binding motif on CD28 cytosolic tail, as well as the lipid rafts.

38 tein tyrosine kinase Lck binding to the CD28 cytosolic tail, because point mutations in C-terminal pr

39 Sst2 docks to the Ste2 cytosolic tail, but only its unphosphorylated state, all

40 compartments is regulated by signals in the cytosolic tail, but the exact pathway is controversial.

41 A Kex2p chimera containing the cytosolic tail (C-tail) of the vacuolar protein sorting

42 e to the TGN requires a signal (TLS1) in its cytosolic tail (C-tail).

43 ly to acidic dileucine sorting motifs in the cytosolic tails (C-tails) of intracellular receptors.

44 .1/ezrin/radixin/moesin) domain to the beta3 cytosolic tail causes activation of the integrin alphaII

45 rthermore, simulations of the ARM/E-cadherin cytosolic tail complex emulating the most probable stres

46 ressing an inducible polycystin-1 C-terminal cytosolic tail construct were shown to exhibit a cAMP gr

47 racellular immunoglobulin-like domains and a cytosolic tail containing two tyrosines, one within a ty

48 ; and 3) a type I transmembrane domain whose cytosolic tail controls protease trafficking and signali

49 in mice bearing a transgene encoding a RAGE cytosolic tail-deletion mutant, specifically in smooth m

50 became a pseudogene) and a transmembrane and cytosolic tail derived from another ancestral Siglec.

51 mpassing the N terminus to S6 with the mslo3 cytosolic tail domain (CTD).

52 eptors in which the 40-amino acid C-terminal cytosolic tail domains were swapped and site mutants of

53 of the MT1-MMP hemopexin, transmembrane, and cytosolic tail domains.

54 transmembrane domain, and 40 residues of the cytosolic tail (E3-M7-24-T40) was biosynthesized fused t

55 ncation of the C-terminal 56 residues of the cytosolic tail eliminates the enrichment in the TGN and

56 We conclude that the beta8 cytosolic tail in mesangial cells organizes a signaling

57 thway to the vacuole is contained within its cytosolic tail, in the 13 residues adjacent to the trans

58 ZnT3 cytosolic tail interacted selectively with AP-3 in cell-

59 rallel coiled coil conformation, whereas its cytosolic tail is flexible and exposed to the cytosol.

60 A Ctr1 mutant lacking the entire C-terminal cytosolic tail is functional in high affinity copper upt

61 tion, a variant Ctr1p with a deletion in the cytosolic tail is not internalized upon exposure of cell

62 ine overexpressing a wild-type ERGIC-53 or a cytosolic tail mutant of ERGIC-53 (KKAA) that is unable

63 tes of this proteolytic pathway bound to the cytosolic tail of a 96-kilodalton lysosomal membrane pro

64 Mutation of phenylalanine residues in the cytosolic tail of Arn1p also lead to missorting, but wit

65 is necessary for forming a complex with the cytosolic tail of BACE1 in co-immunoprecipitation assays

66 interact with specific signals found in the cytosolic tail of cargo proteins to incorporate them int

67 immunological synapse, as truncation of the cytosolic tail of CD28 disrupts synapse localization wit

68 mutation of the PI3K interaction site in the cytosolic tail of CD28 site disrupts the ability of CD28

69 to membranes as bound to Nef, such that the cytosolic tail of CD4 is situated to interact with its b

70 at Nef induces downregulation by linking the cytosolic tail of CD4 to components of the host-cell pro

71 Nef is believed to act by linking the cytosolic tail of CD4 to the endocytic machinery, thereb

72 e found that multiple lysine residues in the cytosolic tail of CD86 could support ubiquitination cons

73 Surprisingly, although the cytosolic tail of class I is required for rapid mK3-medi

74 Four putative splice variants (A-D) of the cytosolic tail of densin-180 are shown to be differentia

75 spindle orientation machinery that binds the cytosolic tail of E-cadherin.

76 protein-tyrosine phosphatase that binds the cytosolic tail of Fas (Apo1, CD95), presumably regulatin

77 Mutation of an IXTPK sequence in the cytosolic tail of Fus1p abolishes its physical interacti

78 e) in lysates of infected cells and with the cytosolic tail of gD fused to glutathione S-transferase

79 Ubiquitination of the cytosolic tail of heavy chain is not required for its di

80 MHC molecule, replacement of lysines in the cytosolic tail of heavy chains with arginine does not pr

81 localization signal (TLS) in the C-terminal cytosolic tail of Kex2p consisting of Tyr-713 and contex

82 This cytosolic tail of LAMP-2A interacts with chaperone Hsc70

83 -hand protein ALG-2 binds to the NH-terminal cytosolic tail of MCOLN1.

84 ese interactions can be reconstituted on the cytosolic tail of neurexins.

85 Here, we show that residues 1290-1309 in the cytosolic tail of NR2B are critical for CaMKII binding a

86 Remarkably, TCRalpha has a cytosolic tail of only five amino acid residues (i.e. RL

87 brane-proximal, polybasic motif (PBM) in the cytosolic tail of p14 is essential for efficient export

88 The cytosolic tail of PAM interacts with proteins that can a

89 a, in which the transmembrane domain and the cytosolic tail of PC7 were replaced by that of the conve

90 demonstrated previously that the C-terminal cytosolic tail of polycystin-1 binds and activates heter

91 reported that a polybasic motif (PBM) in the cytosolic tail of reptilian reovirus p14 FAST protein fu

92 that an amphipathic helix in the C-terminal cytosolic tail of RHD3 has a membrane anchoring ability

93 h the tyrosine-based inhibitory motif in the cytosolic tail of Siglec-F, the data suggested a negativ

94 tion of two conserved serine residues in the cytosolic tail of TCRalpha to alanine decreased ubiquiti

95 he interaction of an YKFFE sequence from the cytosolic tail of the Alzheimer's disease amyloid precur

96 hough ubiquitin conjugation may occur on the cytosolic tail of the class I MHC molecule, replacement

97 The data suggest that the cytosolic tail of the endothelin B receptor is involved

98 n neurons by binding to the C0 region in the cytosolic tail of the NR1 subunit.

99 s largely mediated by sorting signals in the cytosolic tail of the protein, we show here that targeti

100 We found that part of the N-terminal cytosolic tail of the V-ATPase a2-subunit (a2N), corresp

101 MIR1 and MIR2 leads to ubiquitination of the cytosolic tail of their target proteins and that ubiquit

102 The cytosolic tail of US2 and certain US2 lumenal sequences,

103 e propose that conformational changes in the cytosolic tail of yeast Ctr1 by copper sensing within th

104 The cytosolic tails of both receptors contain acidic-cluster

105 on that makes contacts with the membrane and cytosolic tails of cargo proteins.

106 hat functions by direct interaction with the cytosolic tails of certain TGN membrane proteins during

107 To analyze this finding, the cytosolic tails of DEC-205 and MMR were fused to the ext

108 ced green fluorescent fusion proteins of the cytosolic tails of mENaC subunits were consistent with r

109 tudy, we have tested the hypothesis that the cytosolic tails of sClC3 bind to actin directly and that

110 well as with a binding motif present in the cytosolic tails of some mannosyltransferases.

111 The structural and dynamic properties of the cytosolic tails of the adhesion receptor integrin alphaI

112 hrough recognition of sorting signals in the cytosolic tails of the cargos by adaptor proteins, leadi

113 activation can drive a reorientation of the cytosolic tails of the CD28 dimer.

114 taTrCP, CHIP interacts specifically with the cytosolic tails of the dimeric GHR, identifying both Ubc

115 tation screen to identify regions within the cytosolic tails of the mouse alpha, beta, and gamma epit

116 osomes is mediated by signals present in the cytosolic tails of the proteins.

117 hion and to recognize sorting signals in the cytosolic tails of the transmembrane cargo.

118 e sequence Yxx(L/I)x(6-12)Yxx(L/I), in their cytosolic tails or associated receptor chains.

119 As the cytosolic tail participates in down-regulation of Ste2p,

120 chimeric protein (K-V), in which the Vps10p cytosolic tail replaces the Kex2p tail.

121 ted nor were the conserved lysines in the mu cytosolic tail required for trafficking to late endosome

122 Nevertheless, mutants lacking just the cytosolic tail (residues 187 to 199) were unable to caus

123 al change unveils a region of the N-terminal cytosolic tail targeted by the Art1 alpha-arrestin, whic

124 th the length of the stretch of the cadherin cytosolic tail that is in contact with the ARM region.

125 that bears wild-type or mutated CD28 in its cytosolic tail that is incapable of binding to Lck, phos

126 les with various point mutations in the CD28 cytosolic tail, the present study documents that in vivo

127 peting LC-CoAs disrupted binding of the NHE1 cytosolic tail to PI(4,5)P2.

128 Interestingly, all of the cytosolic tail truncated TEM8 mutants functioned as PA r

129 hermore, a single point mutation in the CD28 cytosolic tail (tyrosine 188) interferes with the abilit

130 eported to be tyrosine phosphorylated in the cytosolic tails under specific stimulation conditions.

131 HC I HC lacking its transmembrane domain and cytosolic tail uses the same ERAD components and is degr

132 lass I mutant lacking lysine residues in its cytosolic tail was ubiquitinated and degraded in the pre

133 olic tail, a region divergent from the CXCR2 cytosolic tail, was essential for IL-8 to induce Pi upta

134 nged when either the core amino acids of the cytosolic tail were deleted or the sequence and length o

135 Both proteins were tagged at their cytosolic tails with RRR and KKXX motifs, respectively,