ライフサイエンスコーパス: cytostatic

1 ing, rapamycin becomes cytotoxic rather than cytostatic.

2 totoxic, whereas two dimethyl analogues were cytostatic.

3 client proteins in the absence of UBQLN1 is cytostatic.

4 important beta-hydroxylated antibiotics and cytostatics.

5 debilitating side effect of many widely used cytostatics.

6 chemotaxis, and (c) increased resistance to cytostatics.

7 Clinically, the cytostatic ability of CDO could improve and enhance the

8 rs, breast cancer cells frequently evade the cytostatic action of TGF-beta while retaining Smad funct

9 The cytostatic action of the NO donor agents as well as alph

10 ly, discriminate between the targets of GR's cytostatic action, the cyclin-dependent kinase inhibitor

11 ted low micromolar or submicromolar in vitro cytostatic activities against a broad panel of cancer an

12 The 4-N-alkanoylgemcitabines showed potent cytostatic activities in the low nanomolar range against

13 tions: antitumoral through pro-apoptotic and cytostatic activities, and pro-tumoral promoting growth

14 ds to macrophage-mediated, nitrite-dependent cytostatic activity against nontransduced tumor cells.

15 eric final product mixture shows a different cytostatic activity for the two diastereoisomers.

16 ne phosphoramidate prodrugs and screened for cytostatic activity in a range of different tumor cell l

17 sh targeted therapy combinations with robust cytostatic activity in p16(INK4A)-deficient PDAC cells a

18 tect against free-radical damage and possess cytostatic activity in vascular endothelial cells.

19 The cytostatic activity of 3-fluoro-3-deazauridine (CC(50) =

20 xanthine and adenine markedly potentiate the cytostatic activity of 3F-3DUrd.

21 demonstrate that C/EBPgamma neutralizes the cytostatic activity of C/EBPbeta through heterodimerizat

22 3'UTR sequences inhibited Ras-induced cytostatic activity of C/EBPbeta, DNA binding, transacti

23 emonstrated an approximately 10-fold loss of cytostatic activity of cladribine in MCF-7.Hyor cells an

24 The markedly lower anabolism and related cytostatic activity of dFdC in mycoplasma-infected tumor

25 Consequently, no effect on the cytostatic activity of dFdC was observed in tumor cell c

26 Indeed, the cytostatic activity of gemcitabine could be restored by

27 In contrast, the cytostatic activity of nucleoside analogs carrying a hig

28 ng RNA-mediated TAK1 deficiency restored the cytostatic activity of TGF-beta in MCF10A-CA1a cells.

29 The intracellular metabolism and cytostatic activity of the anticancer drug gemcitabine (

30 n of PNPHyor by a PNP inhibitor restored the cytostatic activity of the purine-based nucleoside drugs

31 nd p21(CIP/WAF-/-) mice are resistant to the cytostatic activity of TNP-470.

32 eing explored as cancer therapeutics exhibit cytostatic activity rather than cytotoxic activity, whic

33 olo[1,2-a]indole-based quinones exhibit more cytostatic activity than the pyrido[1,2-a]indole analogu

34 The minimal region of Emi2 required for its cytostatic activity was mapped to a region containing th

35 lysis, and a markedly decreased or increased cytostatic activity was observed in Mycoplasma hyorhinis

36 he compounds displayed minimal antiviral and cytostatic activity, except for 6, against vaccinia viru

37 ant for Ras-induced C/EBPbeta activation and cytostatic activity.

38 still activated by anti-CD40 mAb to mediate cytostatic activity.

39 cient for LMP-1's lipid raft association and cytostatic activity.

40 B activation, rodent cell transformation and cytostatic activity.

41 ane spanning segments, alone can mediate its cytostatic activity.

42 ereas higher doses showed both cytotoxic and cytostatic activity.

43 deletion and overexpression of Prl-3 can be cytostatic, adding to a growing list of genes whose expr

44 etagal-treated vessels (P<0.05), whereas the cytostatic agent Ad-p21 decreased lesion size by 58% (P<

45 e progression) to evaluate the efficacy of a cytostatic agent in a phase II trial is more relevant th

46 ongly suggest that the use of rapamycin as a cytostatic agent may be an efficient tool for the treatm

47 esign to evaluate the activity of a putative cytostatic agent, acknowledging heterogeneity of tumor g

48 al trials suggested that sorafenib acts as a cytostatic agent, as many patients experienced prolonged

49 ory nerve action potential amplitude for all cytostatic agents and a moderate reduction of nerve cond

50 onged by subsequent treatment with the three cytostatic agents in all HCCs may be of clinical importa

51 is a growth suppressive program activated by cytostatic agents in some cancer cells.

52 intenance strategies with both cytotoxic and cytostatic agents in women who achieve a secondary respo

53 As known and described in detail, the three cytostatic agents inhibit different processes necessary

54 Such cytostatic agents may offer clinical benefits for patien

55 n colon carcinoma (HCC) cells, the effect of cytostatic agents reported to inhibit HCC growth [IFN-al

56 Over 300 cytostatic agents selected from the National Cancer Inst

57 erties have been reported previously for the cytostatic agents shown here to up-regulate beta-chemoki

58 These results suggest that novel cytostatic agents with efficacy against human prostate c

59 Although mTOR inhibitors are cytostatic agents, best used in combination therapy, we

60 sintercalators (8, 9, 12, and 13) behaved as cytostatic agents, while the monosubstituted acridine an

61 s in the early development stage of targeted cytostatic agents.

62 ns for the early development of target-based cytostatic agents.

63 models for the treatment effect of targeted cytostatic agents.

64 II trials may not be appropriate for testing cytostatic agents.

65 dependent manner) may not be appropriate for cytostatic agents.

66 s for modifying trial designs to accommodate cytostatic agents.

67 onse to a broad range of cell cycle specific cytostatic agents.

68 regions of a tumor and release cytotoxic or cytostatic agents; several of these HAPs are currently i

69 uamous cell carcinoma cells treated with the cytostatic all-trans-retinoic acid or with the proapopto

70 tic cells with cytotoxic analogues than with cytostatic analogues.

71 nase (MMP) inhibitors have been developed as cytostatic and anti-angiogenic agents and are currently

72 the development of derivatives with improved cytostatic and antiviral properties.

73 he overall drug effect (i.e., combination of cytostatic and apoptotic effects) was determined by the

74 to respond to stress-induced, p53-dependent cytostatic and apoptotic signals that would otherwise be

75 wth inhibition of five cancer cell lines are cytostatic and approximately 100 times more potent than

76 In addition, cytostatic and cytocidal activities of series 3, but not

77 d chlorine substitution at C3 increased both cytostatic and cytocidal activities.

78 It is now clear that these cytostatic and cytocidal CQR phenotypes are not equivale

79 lly penetrates human cancer cells and exerts cytostatic and cytotoxic (apoptotic) effects with no app

80 nines to the PBI results in highly selective cytostatic and cytotoxic activity against melanoma, alth

81 While some DNA alkylation was required for cytostatic and cytotoxic activity by series 1-9, too muc

82 nyl quinone formation and fate as well as on cytostatic and cytotoxic activity.

83 that DNA alkyation was not necessary for PBI cytostatic and cytotoxic activity.

84 e sought to investigate mensacarcin's unique cytostatic and cytotoxic effects and its mode of action.

85 ry effects were clearly distinguishable from cytostatic and cytotoxic effects at higher drug concentr

86 criptional activator or repressor, to elicit cytostatic and cytotoxic effects in a variety of cells.

87 These compounds exert cytostatic and cytotoxic effects on a variety of cancer

88 -activated Rep gene expression, which exerts cytostatic and cytotoxic effects on the host cells.

89 Tamoxifen (TAM) has both cytostatic and cytotoxic properties for breast cancer.

90 ide chain rings (indole and phenol), display cytostatic and cytotoxic properties similar to that of t

91 Orlistat, an antiobesity drug, is cytostatic and cytotoxic to tumor cells.

92 ue homeostasis in mammals relies on powerful cytostatic and differentiation signals delivered by the

93 3 can render tumor cells insensitive to both cytostatic and genotoxic drugs.

94 Interferons (IFNs) can exert cytostatic and immunomodulatory effects on carcinoma cel

95 Here, we report that AICAR induces profound cytostatic and metabolic effects on 1CT+7 cells, but not

96 Treatment with PD98059 is cytostatic and not cytotoxic, as treated cells regain th

97 n process underlying the association between cytostatic and polyphenols occurs in the ground state.

98 pathway that is p53-independent and (ii) the cytostatic and pro-apoptotic effects of type I IFNs empl

99 design for determining activity of possibly cytostatic anticancer agents.

100 he network response to certain genotoxic and cytostatic anticancer drugs.

101 In general, CDK4/6 inhibitors are cytostatic as monotherapy but demonstrate favorable tole

102 cellular ATP at higher concentrations exerts cytostatic as well as cytotoxic effects in a variety of

103 the tumor burden process, being sensitive to cytostatic as well as cytotoxic mechanisms of interventi

104 signaling pathway alone might tend to have a cytostatic, as opposed to a cytotoxic, effect on pancrea

105 oxic at a concentration > or =6.7 microM and cytostatic at > or =11 microM, while dienoic esters 16a,

106 se with cytototoxic autophagy, inhibition of cytostatic autophagy protects the tumor cell from the ag

107 Thus, regimens that incorporate cytostatic bacterial enterotoxins and inhibitors of cGMP

108 atment with ROCK inhibitors is cytotoxic and cytostatic based on bromodeoxyuridine (BrdU) assay, prop

109 egulation of HER2/neu expression is not only cytostatic, but it also results in the activation of apo

110 Single drug treatments were cytostatic, but only DDP and PTX were also cytotoxic.

111 orders and preserve neural stem cells during cytostatic cancer therapies.

112 y distinguishes between (1) cytotoxic versus cytostatic cellular responses; and (2) changes in morpho

113 parental (Adriamycin-sensitive) cells, using cytostatic concentrations of Adriamycin.

114 ctions indicated that, after incubation with cytostatic concentrations of CNDAC, cell cycle progressi

115 man myeloid leukemia ML-1 cells responded to cytostatic concentrations of fludarabine nucleoside (F-a

116 l proliferation in the presence of otherwise cytostatic concentrations of galactose.

117 lation accumulated in S-phase in response to cytostatic conditions.

118 me in the ribonuclease A superfamily, exerts cytostatic, cytotoxic, and antiviral activity when added

119 Both embellicines (1 and 2) are cytostatic, cytotoxic, and inhibit NF-kappaB transcripti

120 ubstrate activity, DNA reductive alkylation, cytostatic/cytotoxic activity, and in vivo activity.

121 nated X-ray contrast media, antiinflamatory, cytostatics, diuretics, beta blockers, anesthetics, anal

122 We found that continuous exposure to cytostatic doses of CAI and LM-1685, a celecoxib analogu

123 uced cytotoxicity, and (b) pretreatment with cytostatic doses of DNA-damaging drugs before treatment

124 A cytostatic drug (5-fluorouracil) was introduced into the

125 failed to distinguish between cytotoxic and cytostatic drug effects whereas the MZOnano-QCM was able

126 roliferative activity in the presence of the cytostatic drug paclitaxel, and causes resistance to apo

127 heir current usage as a 5-HT1B/1D agonist or cytostatic drug to act as mimetics for PSA to stimulate

128 n as serotonin receptor 5-HT1B/1D agonist or cytostatic drug, respectively.

129 eptibility of Ras-transformed fibroblasts to cytostatic drug-induced apoptosis.

130 We tested a number of cytostatic drugs (camptothecin, etoposide, daunorubicin,

131 conventional pharmacology, external sheaths, cytostatic drugs and gene transfer.

132 c (REF/Myc) from genotoxic and non-genotoxic cytostatic drugs and identify cyclin D1 as a downstream

133 n addition, BCR/ABL can induce resistance to cytostatic drugs and irradiation by modulation of DNA re

134 y which SP cells could escape the effects of cytostatic drugs and might eventually contribute to leuk

135 e earlier use of potent immunosuppressive or cytostatic drugs and the recent emergence of biologicals

136 cells displayed drug resistance against the cytostatic drugs cisplatin and mitomycin C.

137 the lymphocyte cell cycle by treatment with cytostatic drugs may help to control the replication of

138 1) phase of the cell cycle by treatment with cytostatic drugs results in increased levels of the thre

139 Conventional cytostatic drugs such as the anthracycline doxorubicin c

140 I571 was recently combined with the standard cytostatic drugs to achieve better therapeutic results a

141 These data directly link eIF4E rescue from cytostatic drugs to cyclin D1.

142 by itself, (b) be combined with cytotoxic or cytostatic drugs, and (c) serve to initiate radiation-in

143 ne-suppressive and immune-modulatory agents, cytostatic drugs, and biological response modifiers.

144 to distinguish this class from conventional cytostatic drugs, which are mainly directed against cell

145 ion, such as antiangiogenic, immunologic, or cytostatic drugs.

146 = 3.03 muM) coupled with the absence of any cytostatic effect (CC50 > 163 muM; SI > 54) in Huh 9-13

147 GSNO also caused a rapid, GGT-dependent cytostatic effect in Hut-78, a human T cell lymphoma, as

148 Together, these findings show a reversible cytostatic effect of corticosterone via perturbations in

149 The cytostatic effect of CpdA is receptor dependent: down-re

150 Interestingly, the cytostatic effect of glucocorticoids in SAOS2 cells invo

151 The cytostatic effect of mTORC2 down-regulation in prolifera

152 The cytostatic effect of NO and DFMO was prevented by the MA

153 uinoxalin-1-one nor zaprinast influenced the cytostatic effect of NO or DFMO or their ability to acti

154 The cytostatic effect of p53 is mediated by transcriptional

155 t determinant of cellular sensitivity to the cytostatic effect of rapamycin.

156 fi-1 influences the response of cells to the cytostatic effect of TGFbeta.

157 This cytostatic effect of the NO donor was associated with th

158 While most antimetabolites caused a cytostatic effect on cell growth, only inhibitors of the

159 NO has a cytostatic effect on EG7 growth in vitro, and NO is impo

160 Tamoxifen (TAM) is thought to exert a cytostatic effect on hormone-sensitive breast cancer cel

161 This response may involve a cytostatic effect or the induction of apoptosis dependin

162 Furthermore, this cytostatic effect was protracted and associated with an

163 tiangiogenic agents often exert an indirect, cytostatic effect, many are being evaluated in combinati

164 ts in metabolic dormancy and a predominantly cytostatic effect.

165 vidually, all gold-bearing compounds display cytostatic effects against leukemia and adherent cancer

166 hput in silico screen of this pocket exhibit cytostatic effects and act by reducing the apparent prot

167 ive metastatic breast cancer, although their cytostatic effects are limited by primary and acquired r

168 macological blockade of GDH elicited largely cytostatic effects in culture, but these effects became

169 also primed macrophages in vitro to mediate cytostatic effects in the presence of LPS.

170 topic expression of decorin induces profound cytostatic effects in transformed cells with diverse his

171 NMT1 resulted in increased resistance to the cytostatic effects of 5-Aza-dC, delayed onset of gamma-H

172 The cytostatic effects of both TPA and cathepsin B were supp

173 However, their responses to the cytostatic effects of fulvestrant varied greatly, and th

174 Both mutants were hypersensitive to the cytostatic effects of gamma radiation, suggesting that N

175 tive to both the toxic effects of UV and the cytostatic effects of gamma radiation.

176 The cytostatic effects of GC-C agonists were associated with

177 l role of this mechanism in transforming and cytostatic effects of LMP1 variants in cells and Epstein

178 somal protein L3 (RPL3), is resistant to the cytostatic effects of PAP.

179 The cytostatic effects of TAM have been attributed to the an

180 ng in multiple cell types and diminished the cytostatic effects of TGF-beta in mammary epithelial cel

181 rated faster and were less responsive to the cytostatic effects of TGF-beta than cells from an unaffe

182 NAs that prevent p57 up-regulation block the cytostatic effects of TGFbeta on human hematopoietic cel

183 inhibitors CA-074 or Z-FA-FMK suppressed the cytostatic effects of TPA and activation of pro-uPA.

184 esponse was associated with amplification of cytostatic effects of transforming growth factor-beta th

185 The use of CYP24A1 RNAi enhanced the cytostatic effects of vitamin D3 in human prostate cance

186 idence that beyond their direct cytotoxic or cytostatic effects on cancer cells, several conventional

187 ecular pathway by which TGFbeta mediates its cytostatic effects on human hematopoietic cells and sugg

188 f toxicity to normal cells, cytotoxic versus cytostatic effects on tumor cells, and the persistence a

189 These cytostatic effects were achieved with relatively low vir

190 rate, malonyl-CoA, after FAS inhibition, the cytostatic effects were independent of malonyl-CoA accum

191 Cytostatic effects, including genotoxicity, were cell- a

192 00E) using vemurafenib, independently of its cytostatic effects, suppresses metastasis by acting on t

193 activated CPA, it did not inhibit the drug's cytostatic effects.

194 d apoptosis, whereas MEK1 inhibition exerted cytostatic effects.

195 Since the discovery of cytostatic factor (CSF) 35 years ago, significant progre

196 Cytostatic factor (CSF) arrests vertebrate eggs in metap

197 special form of meiotic metaphase arrest by cytostatic factor (CSF) is mediated by MAPK activation o

198 are arrested at second meiotic metaphase by cytostatic factor (CSF) while awaiting fertilization.

199 s are arrested in metaphase of meiosis II by cytostatic factor (CSF), an activity that requires activ

200 osis II due to a cytoplasmic activity termed cytostatic factor (CSF), which appears not to be regulat

201 ertebrate eggs are arrested in meiosis II by cytostatic factor (CSF), which holds the anaphase-promot

202 protein kinase is an essential component of cytostatic factor (CSF), which is required for metaphase

203 tilized eggs are arrested in metaphase II by cytostatic factor (CSF), which is required to maintain m

204 eiotic arrest is achieved by the action of a cytostatic factor (CSF), which reduces cyclin B1 degrada

205 m metaphase is blocked by an activity called cytostatic factor (CSF), which stabilizes cyclin B by in

206 ows direct progression into MII, producing a cytostatic factor (CSF)-arrested egg.

207 roceed through meiosis I before undergoing a cytostatic factor (CSF)-mediated arrest at metaphase of

208 ms, including the spindle checkpoint and the cytostatic factor (CSF).

209 hase II of meiosis prior to fertilization by cytostatic factor (CSF).

210 n are arrested at metaphase of meiosis II by cytostatic factor (CSF).

211 iosis II is mediated by an activity known as cytostatic factor (CSF).

212 e exit is blocked in eggs by the activity of cytostatic factor (CSF).

213 is arrested by a biochemical activity called cytostatic factor (CSF).

214 B1, cyclin B2, and securin upon release from cytostatic factor arrest, whereas excess Xnf7 inhibited

215 Rsk appears to be essential for cytostatic factor arrest.

216 ically arrested at metaphase II (mII) by the cytostatic factor Emi2 until fertilization.

217 he polymerizing plus ends of microtubules in cytostatic factor extracts and uniformly along the lengt

218 The cytostatic factor Mos-MAPK promoted Emi2-dependent metap

219 kinase (p42 MAPK) during mitosis induces a "cytostatic factor" arrest, the arrest responsible for pr

220 lmodulin-activated kinase, which inactivates cytostatic factor, allowing the anaphase-promoting facto

221 c-Mos is a key component of an activity, cytostatic factor, required for metaphase II arrest of u

222 Immunodepletion of EB1 from cytostatic factor-arrested M-phase Xenopus egg extracts

223 tion of viral genes, such as LMP-1, which is cytostatic for B cells when overexpressed.

224 The other is what we now term the cytostatic form of autophagy in that its activation resu

225 ned for the apoptotic FTI BMS-214662 and the cytostatic FTI BMS-225975.

226 seful for evaluating the in vivo activity of cytostatic FTIs such as BMS-225975.

227 The potential cytostatic function of apolipoprotein (apo) E in vivo wa

228 netic and epigenetic events often negate the cytostatic function of transforming growth factor-beta (

229 use of 31 in combination with DFMO led to a cytostatic growth inhibition of a variety of cancer cell

230 s potent pro-apoptotic activity to otherwise cytostatic HER TKIs, re-affirming the oncogene-addicted

231 , regardless of P-gp status, with an average cytostatic IC50 of >60 microM.

232 to proapoptotic stimuli and was found to be cytostatic in melanoma cell lines.

233 in tumor cells lacking p53 function but only cytostatic in p53 wild-type tumor cells.

234 or 250 nM lovastatin + 50 nM 5c were highly cytostatic in STS-26T cell culture.

235 thereby demonstrating antagonism between the cytostatic influence of the CDK-inhibitor and cytotoxic

236 Carboxyamidotriazole (CAI) is a cytostatic inhibitor of nonvoltage-operated calcium chan

237 A cytostatic mechanism based on quantification of the numb

238 ng response to biologic agents, which have a cytostatic mechanism of action.

239 ers might inhibit proliferation of them by a cytostatic mechanism rather than by inducing cytotoxicit

240 ancer cell proliferation initially through a cytostatic mechanism.

241 Pronounced deamination of dFdC to its less cytostatic metabolite 2',2'-difluoro-2'-deoxyuridine was

242 Because mTORis are primarily cytostatic, not cytotoxic, the observed clinical efficac

243 lture growth inhibition by GSK461364A can be cytostatic or cytotoxic but leads to tumor regression in

244 mediates tumor-suppressive effects that are cytostatic or cytotoxic depending on the Rb status.

245 Apo2L exerted cytostatic or cytotoxic effects in vitro on 32 of 39 cel

246 Our experiments demonstrated dose-dependent cytostatic or cytotoxic effects of laser irradiation.

247 ceptor surfaces are used to evoke either the cytostatic or cytotoxic response to glucocorticoids.

248 ive overall response rate (ORR) of 19% and a cytostatic ORR of 33%.

249 comas and chondrosarcomas, for which OSM was cytostatic, OSM induced proliferation of ES cell lines.

250 Thus, the cytotoxic versus cytostatic outcome of glucocorticoid treatment is cell c

251 The cytostatic p21-activated protein kinase 2 (Pak2)/gamma-P

252 activity against the TRAP1 network and high cytostatic potential in BRAF-mutated colorectal carcinom

253 irst to gemcitabine to display a significant cytostatic potential, whereas 4-N-alkyl derivatives atta

254 riptional control mechanisms of the TGF-beta cytostatic program could explain, in part, the resistanc

255 quired for the manifestation of the TGF-beta cytostatic program in specific cell types.

256 e responses that are central to the TGF-beta cytostatic program include activation of the cyclin-depe

257 and Id3) is a general feature of the TGFbeta cytostatic program.

258 It exhibits potent cytostatic properties (mean of 50% growth inhibition = 0

259 d protein kinase (PAK) family, gamma-PAK has cytostatic properties and is activated by cellular stres

260 21-activated protein kinases, gamma-PAK, has cytostatic properties and is activated during apoptosis

261 ported previously to bind to and inhibit the cytostatic properties of the c-Abl oncoprotein.

262 contribute mechanistically to its beneficial cytostatic properties.

263 The cytostatic property of TNFalpha is also shown by its abi

264 Several cytostatic purine nucleoside analogs proved to be suscep

265 combination of proapoptotic simvastatin and cytostatic rapamycin shows promise for combinational the

266 t the antiproliferative activity is due to a cytostatic rather than cytotoxic activity of the compoun

267 t affecting viability, suggesting that NO is cytostatic rather than cytotoxic for G. lamblia.

268 (NHE1), direct acidification was shown to be cytostatic rather than cytotoxic.

269 -dependent kinase inhibitors that generate a cytostatic reponse.

270 wever, RB-deficient cells failed to elicit a cytostatic response (compared with RB proficient isogeni

271 SRF causes resistance to the TGF-beta1 cytostatic response by directly repressing the Smad tran

272 se inhibitors in GBM tumor cells generates a cytostatic response characterized by a cell cycle arrest

273 actions and adaptive functions accompany the cytostatic response of keratinocytes to TGF-beta.

274 forcing G(1) cell cycle arrest, leading to a cytostatic response to rapamycin.

275 lete morphological reversion, restored their cytostatic response to TGF-beta, and blocked their secre

276 ed their growth in soft agar, restored their cytostatic response to TGF-beta, decreased their invasiv

277 TGF-beta as well as partially restored their cytostatic response to TGF-beta.

278 and TP53 SNP72) did not confer apoptotic or cytostatic responses in sarcoma tissue biopsies (n = 24)

279 f genetic backgrounds but often yielded only cytostatic responses.

280 previously, NN stimulated antineoplastic or cytostatic signaling and phenotype in cancer cells, wher

281 e TbetaRI degradation and attenuated TGFbeta cytostatic signaling, a consequence that could conceivab

282 ve Akt specifically activates TSC1-dependent cytostatic Smad signaling to induce growth arrest.

283 ndant LMP1 in 6TR cells yielded a relatively cytostatic state compared to the proliferative one produ

284 des show promising anticancer activity, with cytostatic studies on five different cancer cell lines i

285 immunosuppressants such as cyclosporine, and cytostatics such as bleomycin.

286 results show that retinal neurons produce a cytostatic TGF(beta) signal that maintains mitotic quies

287 ncogenic pathway is linked to suppression of cytostatic TGF-beta signaling and could potentially serv

288 kt because they may impair tumor-suppressive cytostatic TGF-beta signaling by inhibiting Akt- and TSC

289 therapy-limiting side effect of widely used cytostatics that is particularly difficult to treat.

290 hough doxorubicin is one of the most applied cytostatics, the molecular mechanisms of its immunomodul

291 Novel cytostatic therapies that require protracted drug admini

292 ryonal rhabdomyosarcoma-derived cell line is cytostatic, thereby suggesting a tumor suppressor-like r

293 As a result Myc switches, from cytostatic to apoptotic, the p53-dependent response of c

294 sis by converting mTOR inhibitor action from cytostatic to cytotoxic.

295 ression, a central component of the TGF-beta cytostatic transcriptional response previously observed

296 rendering medulloblastoma cells sensitive to cytostatic treatment.

297 rgeting cancer-cell membranes, especially of cytostatic tumors.

298 manized monoclonal antibody against HER2, is cytostatic when added alone and highly successful in cli

299 In cell culture assays, L82 was cytostatic whereas L67 and L189 were cytotoxic.

300 halocin R1 (strain GN101) preparations were cytostatic, while halocin A4 (strain TuA4) preparations