ライフサイエンスコーパス: cytotoxic

1 enerated protein fragments (PGPFs)) that are cytotoxic.

2 e cytostatic, but only DDP and PTX were also cytotoxic.

3 quently, we demonstrate that 1l augments the cytotoxic action of sorafenib in murine hepatocellular c

4 provided substantial protection against the cytotoxic actions of chemotherapeutics, including reduct

5 ese results suggest that the degradative and cytotoxic activities exhibited by StmPr1 may contribute

6 Antioxidant and cytotoxic activities of digestates were also measured us

7 activities, mutagenic/genotoxic activities, cytotoxic activities, further activities like neurotoxic

8 Two R. sempervirens extracts exerted cytotoxic activity against HeLa and HT-29 cell lines, bu

9 ng to proteolysis products also promoted the cytotoxic activity and binding of enterotoxin and beta t

10 fferent dynamics of numerical alteration and cytotoxic activity in HIV-infected patients.

11 These species have little or no cytotoxic activity in several bioassays.

12 CD16 expression and rituximab-dependent cell cytotoxic activity of peripheral NK cells in HT recipien

13 T-ALL cohorts, which correlated with similar cytotoxic activity of the SRC inhibitor KX2-391 and inhi

14 find that this mAb can enhance the in vitro cytotoxic activity of venetoclcax for CLL cells with hig

15 nsport abilities in artificial liposomes and cytotoxic activity on human cancer cell lines.

16 ed with M2 displayed lower degranulation and cytotoxic activity than NK cells cocultured with M1.

17 antigen presentation, chemokine expression, cytotoxic activity, and adaptive immune resistance, and

18 ts with P. aeruginosa pneumonia demonstrated cytotoxic activity, and lavage fluid contained amyloid m

19 t regulatory CD56(+)CD3(-) cells exhibit low cytotoxic activity, produce IL-22, and have an expressio

20 in the presence of HLA-A2, without eliciting cytotoxic activity.

21 and they mediate influenza A virus-specific cytotoxic activity.

22 Demonstration of long-lived cytotoxic agents after Pseudomonas infection may establi

23 lta), or both (dph3Delta) for sensitivity to cytotoxic agents and thermal stress.

24 NX1 was upregulated posttranscriptionally by cytotoxic agents in C57BL/6 mice in vivo and hematopoiet

25 agents might potentially replace traditional cytotoxic agents in lymphoma.

26 tibodies (MAbs) for their ability to deliver cytotoxic agents to infected or Env-transfected cells, w

27 Conjugation of cytotoxic agents to these nnAAs, yields homogeneous anti

28 able but insignificant case cohort use among cytotoxic agents was found for exposure to cyclophospham

29 arrangements in K28 can cause the release of cytotoxic alpha monomers, suggesting a toxin-intrinsic m

30 ruginosa induces production and release of a cytotoxic amyloid molecule with prion characteristics, i

31 The most cytotoxic analog (SM15) was shown to produce chromosome

32 ocyanates were tested for their spasmolytic, cytotoxic and antimicrobial activities.

33 CC-RCC treatment with ROCK inhibitors is cytotoxic and cytostatic based on bromodeoxyuridine (Brd

34 e OD600 method failed to distinguish between cytotoxic and cytostatic drug effects whereas the MZOnan

35 Importantly, the MIPs were not cytotoxic and did not affect cell viability; neither was

36 ical analysis indicates that GEBR-32a is not cytotoxic and genotoxic, and does not seem to possess em

37 The cytotoxic and hemolytic activities of the AMPs against h

38 to 20 mg/L), but not the OSPW-OF caused both cytotoxic and immunomodulatory changes in mouse macropha

39 d-modified PBAE gene delivery vector was not cytotoxic and maintained the viability of hepatocytes ab

40 Reactive oxygen species generate potentially cytotoxic and mutagenic lesions in DNA, both between and

41 ediated collagen contraction assay, was less cytotoxic, and a more potent inhibitor of alpha-smooth m

42 2 cell line, NK92(CIRB) were more activated, cytotoxic, and resistant to growth inhibition.

43 with trastuzumab or with the potent antibody-cytotoxic, anti-HER2 compound trastuzumab emtansine (T-D

44 To query the association of cytotoxic, anti-inflammatory, and immunomodulating agent

45 Following cytotoxic anticancer treatment, tumor-derived DAMPs (dam

46 p demonstrated less cytotoxic from Live/Dead cytotoxic assay and displayed higher cell attachment, pr

47 ing mitoxantrone with ionic liquid tags, and cytotoxic behavior of the designed conjugate was studied

48 The gallbladder excretes cytotoxic bile acids into the duodenum through the cysti

49 on of toxic retinal lipofuscin deposits, and cytotoxic, by triggering lysosomal stress and cell death

50 a new therapeutic target that may complement cytotoxic cancer therapies.

51 rs of AH1-specific CD8(+) T cells exhibiting cytotoxic capacity were increased by F8-TNF plus doxorub

52 dysfunctional T cells that have a decreased cytotoxic capacity, 4-1BB ligation demonstrates a potent

53 thermore, these peptides prove to be broadly cytotoxic, causing cell death also in normal cells such

54 ntly effector memory cells and produced both cytotoxic (CD107a expression) and cytokine (macrophage i

55 ong isoforms were dispensable for generating cytotoxic CD8(+) effector T cells and maintaining memory

56 while suppressing Th1 cell polarization and cytotoxic CD8(+) T cell activation.

57 used by immune destruction of melanocytes by cytotoxic CD8(+) T cells.

58 interleukin-10, and directly suppress liver cytotoxic CD8(+) T lymphocytes, which prevent emergence

59 CD4+ helper T cells and cytotoxic CD8+ T cells are key players for adaptive immu

60 o investigate the role of TILs, particularly cytotoxic CD8+ T cells, in the prediction of outcomes in

61 ytotoxicity (CDC) and attracts and activates cytotoxic cells.

62 t unsaturated FAs, induced the production of cytotoxic ceramides (Cers) in macrophage cell lines.

63 ression of CD57 is associated with increased cytotoxic character and TNF and IFNgamma production upon

64 irect contact with cancer cells enhanced the cytotoxic character of NK92(CIRB) cells, which displayed

65 signaling, leading to cellular resistance to cytotoxic chemotherapies and ionizing radiation.

66 d as it evolves in the face of radiation and cytotoxic chemotherapy is just beginning to be understoo

67 GFR inhibitors, alone or in combination with cytotoxic chemotherapy, did not improve patient outcomes

68 cytotoxic chemotherapy, ionizing radiation).

69 ific CT images, not seen during conventional cytotoxic chemotherapy, were observed.

70 understood and that is largely resistant to cytotoxic chemotherapy.

71 impaired DDR, blunting apoptosis induced by cytotoxic chemotherapy.

72 tem cell phenotype in response to hypoxia or cytotoxic chemotherapy.

73 ical boxes, two collections grouping 404 non-cytotoxic compounds with high antiparasitic potency, dru

74 x values were 4- to 15-fold lower than their cytotoxic concentrations observed in MT-2 cells.

75 inhibiting embryonic implantation within non-cytotoxic concentrations.

76 ental studies obscured the interpretation of cytotoxic contributions of nanosheet edges.

77 and interleukin-2 production and CD107(a/b) cytotoxic degranulation.

78 composition of the hydroperoxide products to cytotoxic derivatives are discussed.

79 Interstrand cross-links (ICLs) are highly cytotoxic DNA lesions that block DNA replication and tra

80 As expected with non-cytotoxic DNMT1-depletion, platelets increased and neutr

81 aride, a fluorophore, and an analogue of the cytotoxic drug duocarmycin.

82 n the therapeutic window of a nanoformulated cytotoxic drug.

83 ggest modulation of ATP levels together with cytotoxic drugs could overcome drug-resistance in glycol

84 nce to tyrosine kinase inhibitors (TKIs) and cytotoxic drugs in AML.

85 Upon exposure to standard-of-care cytotoxic drugs or epigenetic modifiers, NE and ML cell

86 monoclonal antibodies with chemotherapeutic cytotoxic drugs provides clinical benefit to patients wi

87 oxic moieties, including recombinant toxins, cytotoxic drugs, and tubulin inhibitors.

88 transplantation, cancer, infection, certain cytotoxic drugs, or pregnancy.

89 sing LPP-targeting siRNA in combination with cytotoxic drugs.

90 management of cancer beyond the conventional cytotoxic drugs.

91 into how we might measure the genotoxic and cytotoxic effect of plasma jet treatments (both indirect

92 in enhanced proteasome inhibition and robust cytotoxic effect on MM cells when BTZ was administered t

93 depend on the presence of oxygen to elicit a cytotoxic effect.

94 r T-bet, a driver of Th1 differentiation and cytotoxic effector cell maturation.

95 nnovative strategies to recruit and redirect cytotoxic effector cells to eliminate the HIV-1 latently

96 ation of infected CD4+ T cells by recruiting cytotoxic effector cells, such as natural killer cells,

97 coffee infusions at the highest dose without cytotoxic effects (500mug/mL) significantly prevented th

98 Moreover, they have shown strong cytotoxic effects against cancer cell lines.

99 estigate mensacarcin's unique cytostatic and cytotoxic effects and its mode of action.

100 e persistent organic pollutants which elicit cytotoxic effects by inducing reactive oxygen species ge

101 The cytotoxic effects depend directly on the drug's ability

102 ntrations in tissues, and exhibits selective cytotoxic effects in cancer cells through peroxide forma

103 of various fibril polymorphs with differing cytotoxic effects is essential for determining how the a

104 a protective mechanism against ROS-triggered cytotoxic effects of a cocktail of pollutants in Caco-2

105 otecting the photoreceptor cells against the cytotoxic effects of accumulated all-trans-retinal.

106 to 100 nM), prior to injury, attenuated the cytotoxic effects of BSI and preserved neurite length si

107 omologous DNA repair efficiency and enhanced cytotoxic effects of cisplatin in NSCLC cells.

108 HSP72 by minimizing the cell death caused by cytotoxic effects of heat.

109 These findings provide insight into the cytotoxic effects of PARP inhibition, and point at combi

110 ttle research on the potential genotoxic and cytotoxic effects of plasma jet treatment.

111 mechanisms that enable cells to tolerate the cytotoxic effects of sunitinib.

112 Cytotoxic effects of the PB cocktail occurred at lower c

113 apsulated doxorubicin and paclitaxel exhibit cytotoxic effects on 4T1 and PC3-luc cells, respectively

114 ey are biocompatible and show no evidence of cytotoxic effects on hMSCs.

115 PhIP and PhIP@OA did not show significant cytotoxic effects on SHSY5Y, MRC5, and human dermal fibr

116 unds (HMF and furfural F) and cytoprotective/cytotoxic effects upon Caco-2 cells (MTT, cell cycle and

117 eeding polyglutamine aggregation and exhibit cytotoxic effects when applied to neuronal cells.

118 /cytotoxicity assays indicate dose-dependent cytotoxic effects, which are inhibited by the nitric oxi

119 il extracellular traps and are known to have cytotoxic effects.

120 Accumulation of NO may cause cytotoxic effects.

121 he PD-1/PD-L1 pathways and has antiviral and cytotoxic effects.IMPORTANCE We developed several novel

122 ture studies to probe for a possible role of cytotoxic extracellular histones in organ viability and

123 a transcriptional and proteomic program with cytotoxic features that is distinct from effector memory

124 IHSF115 is cytotoxic for a variety of human cancer cell lines, mult

125 The inhibitors are far more cytotoxic for myeloma and lymphoma cell lines than for h

126 o Abeta(1-42) rather than Abeta(1-40) as the cytotoxic form.

127 Selectively targeting these small, cytotoxic forms should be therapeutically beneficial.

128 HCCS-PDA group demonstrated less cytotoxic from Live/Dead cytotoxic assay and displayed h

129 scovered, innate-like subset of T cells with cytotoxic function, the role of which in lung immunity i

130 dim) NK cells and partially restored NK cell cytotoxic function.

131 f CD7 CAR T cells without compromising their cytotoxic function.

132 ) perforin(+) response, suggesting increased cytotoxic functionality.

133 ression coordinately enforced acquisition of cytotoxic functions and protected the cytotoxic lineage

134 targeted MPO exerts both cell-protective and cytotoxic functions.

135 STAT3-induced RORgammat represses cytotoxic genes by inhibiting the functions but not the

136 lls (Tc17) produce IL-17 and fail to express cytotoxic genes.

137 TA2 mutation displayed altered expression of cytotoxic granule constituents and produced interferon-g

138 fector functions are closely linked to their cytotoxic granule proteins.

139 Ls use endocytosis of membrane components of cytotoxic granules.

140 These studies demonstrate that cytotoxic ICs can target virus-infected cells in vivo bu

141 ess perforin after degranulation and reduced cytotoxic immune function.

142 dentify markers that reflect inflammatory or cytotoxic immune mechanisms contributing to its onset.

143 tumors show reduced expression of markers of cytotoxic infiltrating immune cells, especially CD8(+) T

144 ped herein can be useful for assessing other cytotoxic insults on cultures of hESC.

145 We previously characterized alpha-helical cytotoxic islet amyloid polypeptide oligomers which inte

146 taT cells transition from early inflammatory cytotoxic killers to myeloid-like APC in response to inf

147 disconnection treatment using contralateral cytotoxic lesions of the PF and pDMS (Group CONTRA) or i

148 Fc receptor-dependent way in the absence of cytotoxic leukocytes or complement.

149 nd CHIKV isolates but also exhibited limited cytotoxic liability (CC50 > 100 muM).

150 3, central regulators for the CD4-helper/CD8-cytotoxic lineage choice.

151 ion of cytotoxic functions and protected the cytotoxic lineage integrity by preventing TFH-lineage de

152 n resulted in a marked decrease in levels of cytotoxic lipid intermediates such as free fatty acids a

153 l models including a theory based on distant cytotoxic log-kill effects were unable to fit the data.

154 Human cytotoxic lymphocytes kill intracellular microbes.

155 s DC population in Mgl2(DTR) hosts activated cytotoxic lymphocytes, reduced Tregs, and inhibited meta

156 hanisms for cytotoxicity compared with other cytotoxic lymphocytes.

157 LFA-1 is also needed to polarize the cytotoxic machinery of the NK cell toward the target cel

158 A formal total synthesis of the cytotoxic macrolide amphidinolide E is reported.

159 d tropical disease, Buruli ulcer, produces a cytotoxic macrolide, mycolactone, whose function(s) in t

160 e for the stereoselective total synthesis of cytotoxic macrolides pestalotioprolides G and H has been

161 ty and TCR sensitivity, displaying increased cytotoxic markers and altered homing capabilities, and r

162 t this need, because it does not rely on the cytotoxic mechanism of conventional therapies.

163 our results suggest that perforin-dependent cytotoxic mechanisms by CD8(+) T cells could impair the

164 We have examined the amyloidogenicity and cytotoxic mechanisms of this peptide by investigating mo

165 Intracellular cytotoxic mediators (perforin/granzyme B), proinflammato

166 enera of fungi produce the antimicrobial and cytotoxic mellolide, protoilludane, and marasmane sesqui

167 Allospecific CD154+T-cytotoxic memory cells (CD154+TcM) predict acute cellula

168 Allospecific CD154+T-cytotoxic memory cells predict acute cellular rejection

169 spectrometry, we show that sphingosine, the cytotoxic metabolite accumulating in Gaucher cells throu

170 onsists of a small molecule or peptide-based cytotoxic moiety covalently linked, via lysine or cystei

171 MG was initially considered a highly cytotoxic molecule with potential anti-cancer value.

172 XVX was the most cytotoxic molecule, but the combination of XVX with R1 a

173 lonal expansion and impaired upregulation of cytotoxic molecules in TEFF cells.

174 LAM, T-bet, and Ly6C, had smaller amounts of cytotoxic molecules like granzyme B, and produced less i

175 g redox derivatives, such as thapsigargin, a cytotoxic natural product with potent antitumor activity

176 Further, proportions of activated cytotoxic NK cells and CD8+ T cells increased significan

177 ties, we predicted and tested inhibitory and cytotoxic NK potential on the basis of KIR3DL1/HLA-B sub

178 ly in the 1980s and consist of predominantly cytotoxic, nontargeted approaches.

179 to 49.63 +/- 3.59 microM, but they are less cytotoxic on normal cells (IC50 > 100 microM).

180 A total of 57 of 86 cases (66.3%) received a cytotoxic or an immunomodulating agent.

181 luding direct tumor cell lysis, induction of cytotoxic or apoptosis-sensitizing cytokines and promoti

182 DNA repair is essential to prevent the cytotoxic or mutagenic effects of various types of DNA l

183 nctionality and monomethyl auristatin E as a cytotoxic payload.

184 PAIB-SOs are N-dealkylated into cytotoxic phenyl 4-(2-oxo-3-imidazolidin-1-yl)benzenesul

185 xosome biogenesis failed to suppress NK cell cytotoxic potential against tumor cells, as opposed to s

186 sets that are more mature and possess higher cytotoxic potential also show the highest activation of

187 tivated antigen-specific CD8(+) T cells with cytotoxic potential.

188 eruginosa infection liberates transmissible, cytotoxic prion amyloids.

189 ressing their production of pro-inflammatory/cytotoxic products while increasing their production of

190 by allowing expression of activators of the cytotoxic program, this inhibitory mechanism contributes

191 BOS is associated with increased cytotoxic/proinflammatory CD8+ T, NKT-like, and NK cells

192 c liquids, including their antimicrobial and cytotoxic properties, are discussed in view of possible

193 strated that the DNF can deliver payloads of cytotoxic protein (i.e., RNase A) to the cells without a

194 ses, but its dependence on oxygen to produce cytotoxic reactive oxygen species (ROS) diminishes the t

195 nfiltrate and resident immune cells generate cytotoxic reactive oxygen species.

196 Cytotoxic responses of T-cell subsets were measured by u

197 ion data on hundreds of cell lines and their cytotoxic responses to a large compendium of drugs revea

198 sms behind conventional T-cell and MAIT cell cytotoxic responses to NTHi.

199 We show that MAIT cell cytotoxic responses were upregulated by a combination of

200 Overall, our data provide evidence for a cytotoxic role of MAIT cells in the lung and highlight i

201 determine the corkscrew-like structure of a cytotoxic segment of superoxide dismutase 1 (SOD1) in it

202 d clinical trial, a low level of preexisting cytotoxic sTILs predicted the most benefit from an antib

203 a(2+)]i, resulting in greater sensitivity to cytotoxic stimuli.

204 t survive treatment still will have suffered cytotoxic stress and thereby enter a stem cell-like stat

205 first total synthesis of naturally occurring cytotoxic (+)-subincanadine E was also accomplished from

206 ill target cells by the regulated release of cytotoxic substances from granules at the immunological

207 ERK) antigen, the action of antigen-specific cytotoxic T cell (CTL) in vivo results in the emergence

208 h defective MHC class I expression, impaired cytotoxic T cell activation, and poor patient prognosis.

209 virotherapy with talimogene laherparepvec on cytotoxic T cell infiltration and therapeutic efficacy o

210 rsistent-latent virus that elicits different cytotoxic T cell responses characterized as acute resolv

211 geting immunomodulatory receptors to promote cytotoxic T cell responses.

212 ain source of alloantigen that drives CD8(+) cytotoxic T cell responses.

213 11b+), increased dendritic cells (CD86+) and cytotoxic T cells (CD8+) in the p65 knockout (KO) mice.

214 led more efficient expansion of E75-specific cytotoxic T cells (E75-CTL).

215 d that AC-NPs induced an expansion of CD8(+) cytotoxic T cells and increased both CD4(+)T/Treg and CD

216 More importantly, PMVDS stimulated both cytotoxic T cells and natural killer cells of cell-media

217 imicrobial peptide (AMP) that is produced by cytotoxic T cells and natural killer cells.

218 cal proteins required for normal function of cytotoxic T cells and NK cells) or secondary (resulting

219 sponse in advanced thyroid cancers linked to cytotoxic T cells and NK cells.

220 Cytotoxic T cells are of central importance in the immun

221 uccess; the use of autologous virus-specific cytotoxic T cells has proved effective as well.

222 Cytotoxic T cells infiltrating tumors are thought to uti

223 esented by Li et al shows that memory CD8(+) cytotoxic T cells mediate fibrosis via the secretion of

224 mine the mechanisms by which intraepithelial cytotoxic T cells mediate tissue destruction in celiac d

225 A failure of cytotoxic T cells to limit or contract inflammatory resp

226 e cell types, while CD8(+) T cells (known as cytotoxic T cells) are major cells that provide immunity

227 ing cells increased over time exclusively on cytotoxic T cells, T-helper cells, and regulatory T cell

228 of TNFalpha and YAP1 and low infiltration of cytotoxic T cells.

229 recognition by the T cell receptor (TCR) of cytotoxic T cells.

230 tly, susceptibility to lysis by PR1-specific cytotoxic T cells.

231 nced antigen-specific cross-presentation and cytotoxic T lymphocyte (CTL) activity.

232 ortantly, rapamycin treatment did not impair cytotoxic T lymphocyte (CTL) recognition and killing of

233 An effective cytotoxic T lymphocyte (CTL) response against intracellu

234 Cytotoxic T lymphocyte (CTL)-mediated killing involves t

235 only in tristetraprolin-deficient mice after cytotoxic T lymphocyte depletion, but also in WSX-1/tris

236 ate that NFATc1 is an important regulator of cytotoxic T lymphocyte effector functions.NFAT nuclear t

237 regulatory pathway for IL-27 expression and cytotoxic T lymphocyte function mediated by tristetrapro

238 human activated autoreactive CD8(+) T-cell (cytotoxic T lymphocyte) responses within the islets of p

239 ponsive beige-like anchor protein (LRBA) and cytotoxic T lymphocyte-associated antigen 4 (CTLA4) defi

240 las (TCGA) demonstrate reduced expression of cytotoxic T lymphocyte-associated genes and IFN-gamma-in

241 une checkpoint inhibitory antibodies against cytotoxic T lymphocyte-associated protein 4 (CTLA-4) and

242 1/programmed death ligand 1 (PD-1/PD-L1) and cytotoxic T lymphocyte-associated protein 4 (CTLA-4) res

243 These therapies are based on the idea that cytotoxic T lymphocytes (CTLs) directly recognize and re

244 CD8(+) cytotoxic T lymphocytes (CTLs) eliminate virally infecte

245 apies that boost the anti-tumor responses of cytotoxic T lymphocytes (CTLs) have shown promise; howev

246 Cytotoxic T lymphocytes (CTLs) kill target cells by the

247 of producing clinical-grade BCR-ABL-specific cytotoxic T lymphocytes (CTLs), endowed with antileukemi

248 oviruses can be recognized by HIV-1-specific cytotoxic T lymphocytes (CTLs).

249 Here, we engineer human beta-cell-specific cytotoxic T lymphocytes and demonstrate that T1-IFN augm

250 Cytotoxic T lymphocytes are effector CD8(+) T cells that

251 mour regression that is dependent on neither cytotoxic T lymphocytes nor humoral immune response.

252 entiation of naive CD8 T cells into effector cytotoxic T lymphocytes upon antigen stimulation is nece

253 eradication is accomplishable by recruiting cytotoxic T lymphocytes, concomitant with downregulation

254 Here we show that CD8(+) T-cell (also called cytotoxic T lymphocytes, CTL) feedback activates the NLR

255 der characterized by unbridled activation of cytotoxic T lymphocytes, natural killer (NK) cells, and

256 d T-cell intracytoplasmic antigen 1-positive cytotoxic T lymphocytes, suggesting a robust adaptive cy

257 substantial reduction in the number of tumor cytotoxic T lymphocytes.

258 nding and presenting immunogenic peptides to cytotoxic T lymphocytes.

259 or NFATc1 controls the cytotoxicity of mouse cytotoxic T lymphocytes.

260 hese classes of therapeutics is dependent on cytotoxic T-cell activity and is associated with a reduc

261 d-derived suppressor cells and inhibition of cytotoxic T-cell infiltration.

262 genes associated with acute inflammatory or cytotoxic T-cell responses.

263 Ultimately, these events promote cytotoxic T-cell-mediated clearance of tumour cells, whi

264 te an important role for TNF-alpha-producing cytotoxic T-cells in mediating the anti-cancer effects o

265 thodology for stimulating strong CD8alpha(+) cytotoxic T-lymphocyte (CTL) responses remains lacking.

266 pression (programmed cell death 1 [PD-1] and cytotoxic T-lymphocyte antigen 4 [CTLA-4]) was similar t

267 ses antitumor T-cell responses by binding to cytotoxic T-lymphocyte antigen 4.

268 bitor), alone or combined with ipilimumab (a cytotoxic T-lymphocyte antigen-4 checkpoint inhibitor),

269 nd 1 expression, BRAF status, and best prior cytotoxic T-lymphocyte antigen-4 therapy response, then

270 , such as programmed cell death 1 (PD-1) and cytotoxic T-lymphocyte associated protein 4 (CTLA4), dow

271 T lymphocytes, suggesting a robust adaptive cytotoxic T-lymphocyte response may, in part, confer res

272 nnate effector natural killer (NK) cells and cytotoxic T-lymphocyte responses to leukemia-associated

273 geted (BRAF or MEK) or an immune checkpoint (cytotoxic T-lymphocyte-associated antigen 4 [CTLA-4] or

274 tion of the autophagic machinery in DCs in a cytotoxic T-lymphocyte-associated protein 4-dependent (C

275 These data suggest that cytotoxic T-lymphocyte-associated protein 4-Ig should be

276 attenuates liver carcinogenesis and induces cytotoxic T-lymphocyte-mediated regression of establishe

277 checkpoint blockade using antibodies against cytotoxic-T-lymphocyte-associated protein 4 (CTLA4) or p

278 window to impede protective immunity through cytotoxic-T-lymphocyte-associated protein-4 (CTLA-4).

279 ndospicine and 2-aminopimelic acid were more cytotoxic than arginine, displaying the highest toxicity

280 nd phagocytosis of large aggregates was more cytotoxic than multiple small aggregates containing simi

281 , the VC(S)-PBD ADC is at least 20-fold more cytotoxic than the VC(R)-PBD ADC.

282 Inclusion of an EZH2 inhibitor with standard cytotoxic therapies prevented emergence of acquired resi

283 ent, including cross-sensitivity to standard cytotoxic therapies, as well as Hsp90 inhibitors.

284 ndering cells vulnerable to standard-of-care cytotoxic therapies.

285 2 is nontoxic to cells, but potently cytotoxic to cancer cells upon brief irradiation with lo

286 A sound excitable drug (SED) that is non-cytotoxic to cells is developed to disrupt the plasma me

287 Here we observe that hIAPP fibrils are cytotoxic to cultured pancreatic beta-cells, leading us

288 ted antibody-drug conjugate that is potently cytotoxic to GPC2-expressing neuroblastoma cells.

289 and was shown to be both antimetastatic and cytotoxic to human L3.6pl pancreatic cancer cells.

290 results suggest that diatom-biosilica is non-cytotoxic to J774.2 macrophage cells, and supports cell

291 with high specificity and are preferentially cytotoxic to MMR-deficient cells.

292 The 7-azaindenoisoquinolines are cytotoxic topoisomerase I (Top1) inhibitors.

293 Also 4a was found to be less cytotoxic toward normal cell lines as compared to cancer

294 and a novel putative binding site; is weakly cytotoxic towards human primary blood leukocytes or reti

295 y's cytotoxicity in vitro, we found honey is cytotoxic towards prostate cancer cells PC3 and DU145.

296 the functions but not the expression of the "cytotoxic" transcription factors T-bet and Eomesodermin.

297 n predicts the sensitivity of tumor cells to cytotoxic treatments can play an important role in indiv

298 Furthermore, higher doses of sunitinib were cytotoxic, triggered a decline in MCL-1 levels, and inhi

299 on, reduced cell viability, and was directly cytotoxic, whereas the exposure of cells to equivalent d

300 ZnO may be harmful because of the release of cytotoxic Zn(2+) ions during dissolution reactions.