コーパス検索結果 (1語後でソート)
通し番号をクリックするとPubMedの該当ページを表示します
1 enerated protein fragments (PGPFs)) that are cytotoxic.
2 e cytostatic, but only DDP and PTX were also cytotoxic.
3 quently, we demonstrate that 1l augments the cytotoxic action of sorafenib in murine hepatocellular c
4 provided substantial protection against the cytotoxic actions of chemotherapeutics, including reduct
5 ese results suggest that the degradative and cytotoxic activities exhibited by StmPr1 may contribute
7 activities, mutagenic/genotoxic activities, cytotoxic activities, further activities like neurotoxic
9 ng to proteolysis products also promoted the cytotoxic activity and binding of enterotoxin and beta t
12 CD16 expression and rituximab-dependent cell cytotoxic activity of peripheral NK cells in HT recipien
13 T-ALL cohorts, which correlated with similar cytotoxic activity of the SRC inhibitor KX2-391 and inhi
14 find that this mAb can enhance the in vitro cytotoxic activity of venetoclcax for CLL cells with hig
16 ed with M2 displayed lower degranulation and cytotoxic activity than NK cells cocultured with M1.
17 antigen presentation, chemokine expression, cytotoxic activity, and adaptive immune resistance, and
18 ts with P. aeruginosa pneumonia demonstrated cytotoxic activity, and lavage fluid contained amyloid m
19 t regulatory CD56(+)CD3(-) cells exhibit low cytotoxic activity, produce IL-22, and have an expressio
24 NX1 was upregulated posttranscriptionally by cytotoxic agents in C57BL/6 mice in vivo and hematopoiet
26 tibodies (MAbs) for their ability to deliver cytotoxic agents to infected or Env-transfected cells, w
28 able but insignificant case cohort use among cytotoxic agents was found for exposure to cyclophospham
29 arrangements in K28 can cause the release of cytotoxic alpha monomers, suggesting a toxin-intrinsic m
30 ruginosa induces production and release of a cytotoxic amyloid molecule with prion characteristics, i
33 CC-RCC treatment with ROCK inhibitors is cytotoxic and cytostatic based on bromodeoxyuridine (Brd
34 e OD600 method failed to distinguish between cytotoxic and cytostatic drug effects whereas the MZOnan
36 ical analysis indicates that GEBR-32a is not cytotoxic and genotoxic, and does not seem to possess em
38 to 20 mg/L), but not the OSPW-OF caused both cytotoxic and immunomodulatory changes in mouse macropha
39 d-modified PBAE gene delivery vector was not cytotoxic and maintained the viability of hepatocytes ab
40 Reactive oxygen species generate potentially cytotoxic and mutagenic lesions in DNA, both between and
41 ediated collagen contraction assay, was less cytotoxic, and a more potent inhibitor of alpha-smooth m
43 with trastuzumab or with the potent antibody-cytotoxic, anti-HER2 compound trastuzumab emtansine (T-D
46 p demonstrated less cytotoxic from Live/Dead cytotoxic assay and displayed higher cell attachment, pr
47 ing mitoxantrone with ionic liquid tags, and cytotoxic behavior of the designed conjugate was studied
49 on of toxic retinal lipofuscin deposits, and cytotoxic, by triggering lysosomal stress and cell death
51 rs of AH1-specific CD8(+) T cells exhibiting cytotoxic capacity were increased by F8-TNF plus doxorub
52 dysfunctional T cells that have a decreased cytotoxic capacity, 4-1BB ligation demonstrates a potent
53 thermore, these peptides prove to be broadly cytotoxic, causing cell death also in normal cells such
54 ntly effector memory cells and produced both cytotoxic (CD107a expression) and cytokine (macrophage i
55 ong isoforms were dispensable for generating cytotoxic CD8(+) effector T cells and maintaining memory
58 interleukin-10, and directly suppress liver cytotoxic CD8(+) T lymphocytes, which prevent emergence
60 o investigate the role of TILs, particularly cytotoxic CD8+ T cells, in the prediction of outcomes in
62 t unsaturated FAs, induced the production of cytotoxic ceramides (Cers) in macrophage cell lines.
63 ression of CD57 is associated with increased cytotoxic character and TNF and IFNgamma production upon
64 irect contact with cancer cells enhanced the cytotoxic character of NK92(CIRB) cells, which displayed
66 d as it evolves in the face of radiation and cytotoxic chemotherapy is just beginning to be understoo
67 GFR inhibitors, alone or in combination with cytotoxic chemotherapy, did not improve patient outcomes
73 ical boxes, two collections grouping 404 non-cytotoxic compounds with high antiparasitic potency, dru
79 Interstrand cross-links (ICLs) are highly cytotoxic DNA lesions that block DNA replication and tra
83 ggest modulation of ATP levels together with cytotoxic drugs could overcome drug-resistance in glycol
86 monoclonal antibodies with chemotherapeutic cytotoxic drugs provides clinical benefit to patients wi
91 into how we might measure the genotoxic and cytotoxic effect of plasma jet treatments (both indirect
92 in enhanced proteasome inhibition and robust cytotoxic effect on MM cells when BTZ was administered t
95 nnovative strategies to recruit and redirect cytotoxic effector cells to eliminate the HIV-1 latently
96 ation of infected CD4+ T cells by recruiting cytotoxic effector cells, such as natural killer cells,
97 coffee infusions at the highest dose without cytotoxic effects (500mug/mL) significantly prevented th
100 e persistent organic pollutants which elicit cytotoxic effects by inducing reactive oxygen species ge
102 ntrations in tissues, and exhibits selective cytotoxic effects in cancer cells through peroxide forma
103 of various fibril polymorphs with differing cytotoxic effects is essential for determining how the a
104 a protective mechanism against ROS-triggered cytotoxic effects of a cocktail of pollutants in Caco-2
105 otecting the photoreceptor cells against the cytotoxic effects of accumulated all-trans-retinal.
106 to 100 nM), prior to injury, attenuated the cytotoxic effects of BSI and preserved neurite length si
109 These findings provide insight into the cytotoxic effects of PARP inhibition, and point at combi
113 apsulated doxorubicin and paclitaxel exhibit cytotoxic effects on 4T1 and PC3-luc cells, respectively
115 PhIP and PhIP@OA did not show significant cytotoxic effects on SHSY5Y, MRC5, and human dermal fibr
116 unds (HMF and furfural F) and cytoprotective/cytotoxic effects upon Caco-2 cells (MTT, cell cycle and
118 /cytotoxicity assays indicate dose-dependent cytotoxic effects, which are inhibited by the nitric oxi
121 he PD-1/PD-L1 pathways and has antiviral and cytotoxic effects.IMPORTANCE We developed several novel
122 ture studies to probe for a possible role of cytotoxic extracellular histones in organ viability and
123 a transcriptional and proteomic program with cytotoxic features that is distinct from effector memory
129 scovered, innate-like subset of T cells with cytotoxic function, the role of which in lung immunity i
133 ression coordinately enforced acquisition of cytotoxic functions and protected the cytotoxic lineage
137 TA2 mutation displayed altered expression of cytotoxic granule constituents and produced interferon-g
142 dentify markers that reflect inflammatory or cytotoxic immune mechanisms contributing to its onset.
143 tumors show reduced expression of markers of cytotoxic infiltrating immune cells, especially CD8(+) T
145 We previously characterized alpha-helical cytotoxic islet amyloid polypeptide oligomers which inte
146 taT cells transition from early inflammatory cytotoxic killers to myeloid-like APC in response to inf
147 disconnection treatment using contralateral cytotoxic lesions of the PF and pDMS (Group CONTRA) or i
151 ion of cytotoxic functions and protected the cytotoxic lineage integrity by preventing TFH-lineage de
152 n resulted in a marked decrease in levels of cytotoxic lipid intermediates such as free fatty acids a
153 l models including a theory based on distant cytotoxic log-kill effects were unable to fit the data.
155 s DC population in Mgl2(DTR) hosts activated cytotoxic lymphocytes, reduced Tregs, and inhibited meta
159 d tropical disease, Buruli ulcer, produces a cytotoxic macrolide, mycolactone, whose function(s) in t
160 e for the stereoselective total synthesis of cytotoxic macrolides pestalotioprolides G and H has been
161 ty and TCR sensitivity, displaying increased cytotoxic markers and altered homing capabilities, and r
163 our results suggest that perforin-dependent cytotoxic mechanisms by CD8(+) T cells could impair the
164 We have examined the amyloidogenicity and cytotoxic mechanisms of this peptide by investigating mo
166 enera of fungi produce the antimicrobial and cytotoxic mellolide, protoilludane, and marasmane sesqui
169 spectrometry, we show that sphingosine, the cytotoxic metabolite accumulating in Gaucher cells throu
170 onsists of a small molecule or peptide-based cytotoxic moiety covalently linked, via lysine or cystei
174 LAM, T-bet, and Ly6C, had smaller amounts of cytotoxic molecules like granzyme B, and produced less i
175 g redox derivatives, such as thapsigargin, a cytotoxic natural product with potent antitumor activity
177 ties, we predicted and tested inhibitory and cytotoxic NK potential on the basis of KIR3DL1/HLA-B sub
181 luding direct tumor cell lysis, induction of cytotoxic or apoptosis-sensitizing cytokines and promoti
185 xosome biogenesis failed to suppress NK cell cytotoxic potential against tumor cells, as opposed to s
186 sets that are more mature and possess higher cytotoxic potential also show the highest activation of
189 ressing their production of pro-inflammatory/cytotoxic products while increasing their production of
190 by allowing expression of activators of the cytotoxic program, this inhibitory mechanism contributes
192 c liquids, including their antimicrobial and cytotoxic properties, are discussed in view of possible
193 strated that the DNF can deliver payloads of cytotoxic protein (i.e., RNase A) to the cells without a
194 ses, but its dependence on oxygen to produce cytotoxic reactive oxygen species (ROS) diminishes the t
197 ion data on hundreds of cell lines and their cytotoxic responses to a large compendium of drugs revea
200 Overall, our data provide evidence for a cytotoxic role of MAIT cells in the lung and highlight i
201 determine the corkscrew-like structure of a cytotoxic segment of superoxide dismutase 1 (SOD1) in it
202 d clinical trial, a low level of preexisting cytotoxic sTILs predicted the most benefit from an antib
204 t survive treatment still will have suffered cytotoxic stress and thereby enter a stem cell-like stat
205 first total synthesis of naturally occurring cytotoxic (+)-subincanadine E was also accomplished from
206 ill target cells by the regulated release of cytotoxic substances from granules at the immunological
207 ERK) antigen, the action of antigen-specific cytotoxic T cell (CTL) in vivo results in the emergence
208 h defective MHC class I expression, impaired cytotoxic T cell activation, and poor patient prognosis.
209 virotherapy with talimogene laherparepvec on cytotoxic T cell infiltration and therapeutic efficacy o
210 rsistent-latent virus that elicits different cytotoxic T cell responses characterized as acute resolv
213 11b+), increased dendritic cells (CD86+) and cytotoxic T cells (CD8+) in the p65 knockout (KO) mice.
215 d that AC-NPs induced an expansion of CD8(+) cytotoxic T cells and increased both CD4(+)T/Treg and CD
216 More importantly, PMVDS stimulated both cytotoxic T cells and natural killer cells of cell-media
218 cal proteins required for normal function of cytotoxic T cells and NK cells) or secondary (resulting
223 esented by Li et al shows that memory CD8(+) cytotoxic T cells mediate fibrosis via the secretion of
224 mine the mechanisms by which intraepithelial cytotoxic T cells mediate tissue destruction in celiac d
226 e cell types, while CD8(+) T cells (known as cytotoxic T cells) are major cells that provide immunity
227 ing cells increased over time exclusively on cytotoxic T cells, T-helper cells, and regulatory T cell
232 ortantly, rapamycin treatment did not impair cytotoxic T lymphocyte (CTL) recognition and killing of
235 only in tristetraprolin-deficient mice after cytotoxic T lymphocyte depletion, but also in WSX-1/tris
236 ate that NFATc1 is an important regulator of cytotoxic T lymphocyte effector functions.NFAT nuclear t
237 regulatory pathway for IL-27 expression and cytotoxic T lymphocyte function mediated by tristetrapro
238 human activated autoreactive CD8(+) T-cell (cytotoxic T lymphocyte) responses within the islets of p
239 ponsive beige-like anchor protein (LRBA) and cytotoxic T lymphocyte-associated antigen 4 (CTLA4) defi
240 las (TCGA) demonstrate reduced expression of cytotoxic T lymphocyte-associated genes and IFN-gamma-in
241 une checkpoint inhibitory antibodies against cytotoxic T lymphocyte-associated protein 4 (CTLA-4) and
242 1/programmed death ligand 1 (PD-1/PD-L1) and cytotoxic T lymphocyte-associated protein 4 (CTLA-4) res
243 These therapies are based on the idea that cytotoxic T lymphocytes (CTLs) directly recognize and re
245 apies that boost the anti-tumor responses of cytotoxic T lymphocytes (CTLs) have shown promise; howev
247 of producing clinical-grade BCR-ABL-specific cytotoxic T lymphocytes (CTLs), endowed with antileukemi
249 Here, we engineer human beta-cell-specific cytotoxic T lymphocytes and demonstrate that T1-IFN augm
251 mour regression that is dependent on neither cytotoxic T lymphocytes nor humoral immune response.
252 entiation of naive CD8 T cells into effector cytotoxic T lymphocytes upon antigen stimulation is nece
253 eradication is accomplishable by recruiting cytotoxic T lymphocytes, concomitant with downregulation
254 Here we show that CD8(+) T-cell (also called cytotoxic T lymphocytes, CTL) feedback activates the NLR
255 der characterized by unbridled activation of cytotoxic T lymphocytes, natural killer (NK) cells, and
256 d T-cell intracytoplasmic antigen 1-positive cytotoxic T lymphocytes, suggesting a robust adaptive cy
260 hese classes of therapeutics is dependent on cytotoxic T-cell activity and is associated with a reduc
264 te an important role for TNF-alpha-producing cytotoxic T-cells in mediating the anti-cancer effects o
265 thodology for stimulating strong CD8alpha(+) cytotoxic T-lymphocyte (CTL) responses remains lacking.
266 pression (programmed cell death 1 [PD-1] and cytotoxic T-lymphocyte antigen 4 [CTLA-4]) was similar t
268 bitor), alone or combined with ipilimumab (a cytotoxic T-lymphocyte antigen-4 checkpoint inhibitor),
269 nd 1 expression, BRAF status, and best prior cytotoxic T-lymphocyte antigen-4 therapy response, then
270 , such as programmed cell death 1 (PD-1) and cytotoxic T-lymphocyte associated protein 4 (CTLA4), dow
271 T lymphocytes, suggesting a robust adaptive cytotoxic T-lymphocyte response may, in part, confer res
272 nnate effector natural killer (NK) cells and cytotoxic T-lymphocyte responses to leukemia-associated
273 geted (BRAF or MEK) or an immune checkpoint (cytotoxic T-lymphocyte-associated antigen 4 [CTLA-4] or
274 tion of the autophagic machinery in DCs in a cytotoxic T-lymphocyte-associated protein 4-dependent (C
276 attenuates liver carcinogenesis and induces cytotoxic T-lymphocyte-mediated regression of establishe
277 checkpoint blockade using antibodies against cytotoxic-T-lymphocyte-associated protein 4 (CTLA4) or p
278 window to impede protective immunity through cytotoxic-T-lymphocyte-associated protein-4 (CTLA-4).
279 ndospicine and 2-aminopimelic acid were more cytotoxic than arginine, displaying the highest toxicity
280 nd phagocytosis of large aggregates was more cytotoxic than multiple small aggregates containing simi
282 Inclusion of an EZH2 inhibitor with standard cytotoxic therapies prevented emergence of acquired resi
286 A sound excitable drug (SED) that is non-cytotoxic to cells is developed to disrupt the plasma me
290 results suggest that diatom-biosilica is non-cytotoxic to J774.2 macrophage cells, and supports cell
294 and a novel putative binding site; is weakly cytotoxic towards human primary blood leukocytes or reti
295 y's cytotoxicity in vitro, we found honey is cytotoxic towards prostate cancer cells PC3 and DU145.
296 the functions but not the expression of the "cytotoxic" transcription factors T-bet and Eomesodermin.
297 n predicts the sensitivity of tumor cells to cytotoxic treatments can play an important role in indiv
298 Furthermore, higher doses of sunitinib were cytotoxic, triggered a decline in MCL-1 levels, and inhi
299 on, reduced cell viability, and was directly cytotoxic, whereas the exposure of cells to equivalent d
300 ZnO may be harmful because of the release of cytotoxic Zn(2+) ions during dissolution reactions.
WebLSDに未収録の専門用語(用法)は "新規対訳" から投稿できます。