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1 LKB1 by ATM was involved in AZD1775-mediated cytotoxicity.
2 h an agonistic antibody enhanced CD4+ T cell cytotoxicity.
3 y, and increased antibody-dependent cellular cytotoxicity.
4 ll models, and can ameliorate FUS-associated cytotoxicity.
5 X with R1 and R2 significantly prolonged its cytotoxicity.
6 sed on the mechanisms underlying mutant SOD1 cytotoxicity.
7 DA-MB-468 TNBC cells without any significant cytotoxicity.
8 annels (Pico145) strongly inhibited Icat and cytotoxicity.
9 ntributes to the molecular basis of graphene cytotoxicity.
10 is efficiently internalized by cells without cytotoxicity.
11 cessfully decaged in live cells to reinstate cytotoxicity.
12 nd is even more intriguing in the absence of cytotoxicity.
13 to be the principle mechanism of IFN-induced cytotoxicity.
14 lasmic antibiotic concentration for enhanced cytotoxicity.
15 MMR-deficient cells, resulting in selective cytotoxicity.
16 g ThCTL that mediate MHC class II-restricted cytotoxicity.
17 gs with increased anti-clot activity and low cytotoxicity.
18 ells to investigate both cellular uptake and cytotoxicity.
19 o Jurkat T-cells and severely impaired their cytotoxicity.
20 re prepared, characterized and evaluated for cytotoxicity.
21 an increase antibody-dependent cell-mediated cytotoxicity.
22 anscriptional, including NK localization and cytotoxicity.
23 It is anticancer because of its cytotoxicity.
24 fected mice were polyfunctional and mediated cytotoxicity.
25 h phenotypic data on cellular cytostasis and cytotoxicity.
26 imal doses active in depleting DNMT1 without cytotoxicity.
27 HCV RNA replication through antigen-specific cytotoxicity.
28 increased inflammatory monocytes and reduced cytotoxicity.
29 rther sphingosine accumulation and, thereby, cytotoxicity.
30 edical applications by reducing the possible cytotoxicity.
31 including oligomerization, fibrillation, and cytotoxicity.
32 ability and confer resistance to indisulam's cytotoxicity.
33 ts is an effective strategy to enhance Taxol cytotoxicity.
34 of sAML cell growth, and enhancement of DNR cytotoxicity.
35 ducing mTORC1 signaling, thus evoking little cytotoxicity.
36 beta oligomerization, amyloid formation, and cytotoxicity.
37 ide-induced H2O2 accumulation and associated cytotoxicity.
38 ing was achieved in vitro with no detectable cytotoxicity.
39 1 depletion abrogates PARP-inhibitor-induced cytotoxicity.
40 secretion of effector proteins and HeLa cell cytotoxicity.
41 de the most accurate quantification of honey cytotoxicity.
42 vitro as well as apoE4 potentiation of Abeta cytotoxicity.
43 target cells, including complement-dependent cytotoxicity, Ab-dependent cellular cytotoxicity, and Ab
44 The boron compounds 3 and 4 have shown low cytotoxicity activity in cell line A-431 and low green s
45 cells, and had minimal complement-dependent cytotoxicity activity similar to that of the negative co
48 ies that mediate antibody-dependent cellular cytotoxicity (ADCC) against avian influenza virus subtyp
49 riments and antibody-dependent cell-mediated cytotoxicity (ADCC) assays indicate that this protection
50 Moreover, antibody-dependent cell-mediated cytotoxicity (ADCC) assays revealed that the cell surfac
54 est in utilizing antibody-dependent cellular cytotoxicity (ADCC) to eliminate infected cells followin
55 V1V2 responses, antibody-dependent cellular cytotoxicity (ADCC), and low-titer tier 1B and tier 2 ne
56 cantly decreases antibody-dependent cellular cytotoxicity (ADCC), whereas terminal alpha2,6-sialylati
60 ted, PTX+TET/iRGD LPNs presented the highest cytotoxicity against A2780/PTX cells and effectively pro
61 drugs, explaining their better 24 h in vitro cytotoxicity against human glioblastoma U87 cell line.
63 ies towards Hsp70 and Abl, and display lower cytotoxicity against leukemia cells compared to those of
65 cid LpxC inhibitors, exemplified by 1, where cytotoxicity against mammalian cell lines was reduced, s
69 ipt 1 (LLT1) interaction in NK cell-mediated cytotoxicity against normal human articular chondrocytes
70 ancer cell lines, while demonstrating little cytotoxicity against normal mobilized peripheral blood p
71 illoma virus (HPV) 16 E7 oncoprotein induces cytotoxicity against peptide-expressing targets in vivo,
72 (Pr20M) directed antibody-dependent cellular cytotoxicity against PRAME+HLA-A2+ leukemia cells and wa
73 has garnered attention due to their natural cytotoxicity against tumor cells and safety upon adoptiv
76 ule compounds called G4 ligands often causes cytotoxicity, although the potential medicinal impact of
79 in 21 (IL-21), which induces direct lymphoma cytotoxicity and activates immune effector cells, to the
80 drug concentrations, and biological effects (cytotoxicity and anti-migration) on drug-naive recipient
81 we demonstrate that DOCK8 regulates NK cell cytotoxicity and cytokine production in response to targ
82 tin-like receptor (CTLR) triggering cellular cytotoxicity and cytokine secretion upon high-affinity i
83 sed tumor-infiltrating T-cell activation and cytotoxicity and decreased the frequency of immunosuppre
84 e inhibitor (ouabain) potentiated EA-induced cytotoxicity and direct Na(+) loading by gramicidin-A ca
87 Moreover, gladiolin displayed low mammalian cytotoxicity and good activity against several M. tuberc
88 expose underlying mechanisms of nanomaterial cytotoxicity and guide the design of safer nanomedical t
89 h treatment with 100-1000nM PTX), and caused cytotoxicity and inhibited migration of Recipient cells.
90 regulates gene expression and stress-induced cytotoxicity and is required in early embryogenesis thro
91 Here the authors show NFATc1 controls the cytotoxicity and metabolic switching of activated CD8(+)
92 HSPCs produced T cells with antigen-specific cytotoxicity and near-complete lack of endogenous TCR Vb
93 Rpn11 upstream of 20S proteasome to enhance cytotoxicity and overcome proteasome inhibitor resistanc
95 lla meneghiniana as a test subject to assess cytotoxicity and pro-inflammatory reactions to diatom-bi
98 at replicated efficiently but exhibited less cytotoxicity and reduced antitranscriptional activities,
99 e, NK92mi, resulted in inhibition of NK cell cytotoxicity and reproduced other aspects of the CHS cel
100 n dispersed in phosphate-buffered saline for cytotoxicity and senescence-associated beta-galactosidas
101 Histones released during influenza induced cytotoxicity and showed strong binding to platelets with
102 Compounds 1 and 2 exhibited moderate to weak cytotoxicity and significant inhibitory activity against
103 e evidence that poly GA is a key mediator of cytotoxicity and that cross-talk between DPR proteins li
104 rginine availability is a determinant of GBS cytotoxicity and that the pathway between stringent resp
105 ted cells showed a protective effect against cytotoxicity and viral replication in HIV-1-infected mac
106 ependent cytotoxicity, Ab-dependent cellular cytotoxicity, and Ab-dependent cellular phagocytosis.
107 re assessed for their size, charge, in vitro cytotoxicity, and capacity to transfect human bone marro
109 uction of TNF and IFNgamma, elevated natural cytotoxicity, and increased antibody-dependent cellular
110 er inflammation and MAIT cell activation and cytotoxicity, and increased the MAIT cell frequency amon
111 dies mediate functions such as phagocytosis, cytotoxicity, and maintenance of immune homeostasis.
112 rrelations were observed among genotoxicity, cytotoxicity, and NAC thiol reactivity for all disinfect
113 nd proliferation, induction of apoptosis and cytotoxicity, and up-regulation of the type 1 interferon
114 CD4(+) T cells restrains Runx3 functions and cytotoxicity; and STAT3 restrained cytotoxic gene expres
118 e cell and to the lungs, as evidenced by the cytotoxicity assay and analyses of the injury markers in
119 iazol-2-yl]-2,5-diphenyltetrazolium bromide) cytotoxicity assay revealed that Sf9 cells expressing CY
122 ate drug safety in a regime that the current cytotoxicity assays cannot cover and be generally applie
134 constituent chemicals were tested for their cytotoxicity by colony formation assay in cells of diffe
135 hocytes and demonstrate that T1-IFN augments cytotoxicity by inducing rapid phosphorylation of STAT4,
137 LA2G16 as a host factor that is required for cytotoxicity by rhinoviruses, which cause the common col
138 luded those that investigated mammalian cell cytotoxicity, C. parvum proliferation inhibition in vitr
140 es tumor cell lysis via complement-dependent cytotoxicity (CDC) and attracts and activates cytotoxic
141 tibodies, complement-dependent cell-mediated cytotoxicity (CDCC) and complement-dependent cell-mediat
142 f DNA repair enzymes in trimethoprim-induced cytotoxicity clearly indicates that different amounts an
143 LCPM from PU-CNT shows significantly higher cytotoxicity compared to PU which could be attributed to
144 cells use different signaling mechanisms for cytotoxicity compared with other cytotoxic lymphocytes.
151 ariant-dependent intracellular K(+) loss and cytotoxicity does not drive kidney disease progression.
152 We report here the synthesis, assembly and cytotoxicity evaluation of self-assembling hybrid prodru
153 ndent cytotoxicity and Ab-dependent cellular cytotoxicity favored a membrane-proximal epitope, wherea
157 profile (including CCR2 and CCR5), profound cytotoxicity (Granzyme B and CD107A), resistance to apop
158 l linkers have shown a significant effect on cytotoxicity, growth and cytokine response, thus warrant
159 h high Top1 inhibitory activities and potent cytotoxicities in human cancer cell cultures and reduced
166 50 nm SiNPs did not induce acute significant cytotoxicity in corneal endothelial cells at concentrati
168 showed that all pectic samples reduced Stx2 cytotoxicity in HT29 cells, as measured by the reduction
171 ral-mediated ChR2 overexpression might cause cytotoxicity in NRVM cultures, which could be alleviated
175 s via heteromeric TRPC4/C1 channels to cause cytotoxicity in some types of cancer cell but not normal
177 Moreover, they did not show any significant cytotoxicity in the dark or under irradiation on nontumo
178 iferation, decreased apoptosis and increased cytotoxicity in the presence of immunosuppressive ascite
180 nstrated no antibody-dependent cell-mediated cytotoxicity in vitro against Daudi cells with cynomolgu
181 and accessible assays for measuring honey's cytotoxicity in vitro, we found honey is cytotoxic towar
184 ) T cells also resisted chemotherapy-induced cytotoxicity in vivo and underwent significant expansion
186 nding how decidual CD8(+) T cell (CD8(+) dT) cytotoxicity is regulated and how these cells integrate
187 y with thermal ablation or thermally-induced cytotoxicity, limited access of the drug to tumor loci i
190 to treat cancer and its subsequent impact on cytotoxicity measurements and assays have not been inves
191 lication on macrophage function, we assessed cytotoxicity, nitric oxide or reactive oxygen species pr
192 The in vitro determination of reactivity, cytotoxicity, NLRP3 ATPase inhibition, and antipyroptoti
193 n of nonprotein sulfhydryl and occurrence of cytotoxicity (observable by routine histology) in the OM
198 have been proposed to play a key role in the cytotoxicity of amyloid fibrils and the pathogenesis of
201 ction is dominated by signal blocking or the cytotoxicity of Fc-driven innate immune effector functio
202 bination of factors crucial for the enhanced cytotoxicity of GAELs opens new avenues to develop poten
204 gamma exposure during activation reduced the cytotoxicity of human-origin type 1 diabetes-relevant au
205 chemical profile, antioxidant activity, and cytotoxicity of hydroethanolic extracts of green Coffea
206 lar carcinoma), were used to investigate the cytotoxicity of indospicine and its metabolite 2-aminopi
209 s essential for efficient activation and for cytotoxicity of NK cells because it initiates the assemb
212 ptive NK-92 cell therapy block anti-leukemia cytotoxicity of NK-92 cells and other NK-92 cell functio
214 vated by this issue, we focused on screening cytotoxicity of polymers widely used for the layer-by-la
215 s, leading us to determine the structure and cytotoxicity of protein segments composing the amyloid s
216 of exosomes on intercellular drug transfer, cytotoxicity of PTX on Donor cells and cytotoxicity of P
217 sfer, cytotoxicity of PTX on Donor cells and cytotoxicity of PTX-containing exosomes on Recipient cel
218 ent nitrotyrosine formation and abrogate the cytotoxicity of RNS against phoQ Salmonella, presumably
219 echin gallate (EGCG) effectively reduces the cytotoxicity of the Alzheimer's disease beta-amyloid pep
221 structure changes during stability test and cytotoxicity of the extracts against Vero cells were eva
228 t the potential genotoxicity, as well as the cytotoxicity, of toxic species generated in cell culture
230 particles are investigated in terms of their cytotoxicity on suspension and adherent cells to prove t
232 Although all 3 mAbs potently neutralized cytotoxicity, only SA-15 and SA-17 significantly inhibit
233 vitro characteristics of growth, adherence, cytotoxicity, or serum resistance, though it profoundly
236 terial metabolism underpins fluoropyrimidine cytotoxicity, providing a paradigm for unraveling bacter
238 bserved that inducible IFN-gamma and natural cytotoxicity receptor (NCR) expression in a specific sub
240 neered bNAb variants, antibody-mediated cell cytotoxicity reporter assays, and Fcgamma receptor-defic
242 ted to tier 1 viruses and antibody-dependent cytotoxicity responses (ADCC) after DC-targeting boosts.
243 d high levels of antibody-dependent cellular cytotoxicity responses and HIV-1-neutralizing antibodies
244 growing evidence that an important aspect of cytotoxicity results from treatment-induced metabolic pe
245 Inducing differentiation of myeloblasts, not cytotoxicity, seems to drive the clinical efficacy of en
247 hus making them more prone to Ca(2+)-induced cytotoxicity.SIGNIFICANCE STATEMENT In the inner ear, se
248 matory (absent in S. bellinii mycelia) and a cytotoxicity similar (sometimes superior) to its fruitin
250 osomes (t-L) was assessed by cell uptake and cytotoxicity studies in the alphavbeta6 positive cells l
252 -alpha fibrillation of PSMalpha3 facilitated cytotoxicity, suggesting that this assembly mode underli
253 and spatial correlation between PrP(Sc) and cytotoxicity suggests the contribution of host factors.
255 sitive and no less specific compared with NK cytotoxicity testing for screening for genetic HLH and s
258 he liver had higher levels of activation and cytotoxicity than MAIT cells from blood (P < .0001).
259 pecific fractions showed reproducibly higher cytotoxicity than other fractions as well as the unsepar
261 wn to be selective for Cys181 and have lower cytotoxicity than the approved NNRTI drugs efavirenz and
263 notypic changes enhancing drug transport and cytotoxicity, thus providing a potential baseline for cl
264 were evaluated for transfection efficacy and cytotoxicity to a range of human HCC cells as well as he
265 over other anti-apoptotic proteins, possess cytotoxicity to cancer cell lines, and induce hallmarks
267 ted similarly effective complement-dependent cytotoxicity to GM2-expressing cancer cell line MCF-7.
268 c cancer cells (HGC27 and SGC7901), but less cytotoxicity to non-malignant gastric epithelial cells G
270 le formulation, while maintaining comparable cytotoxicity to those of Abraxane and solvent-dissolved
271 l effects on Candida albicans ATCC90028, the cytotoxicity toward human dental pulp cells (HDPCs), and
272 e show that Y3 exhibits selective and potent cytotoxicity toward human T-cell leukemia Jurkat cells c
274 le in many diseases, primarily through their cytotoxicity toward nucleated cells and their ability to
275 icity in living cells, exhibited substantial cytotoxicity towards HeLa cells, and was a highly sensit
277 iched for diverse immune functions including cytotoxicity, viral response, B cell, platelet, neutroph
284 conventional, but with the addition of DDP, cytotoxicity was similar and considerably less than expe
286 oteins such as PD-1 to evade immune-mediated cytotoxicity, we did a trial of the anti-PD-1 antibody n
287 rescribed to hybrubin A except for a lack of cytotoxicity, we further profiled this unique alkaloid a
288 To explore molecular mechanism of their cytotoxicity, we have designed and tested a number of ne
289 ch the stringent response leads to increased cytotoxicity, we performed transcriptome sequencing (RNA
290 f autophagy, rapamycin-induced apoptosis and cytotoxicity were blocked in STAT1-deficient cells but r
291 which bind the oligomers and neutralize the cytotoxicity were exclusively identified in the serum of
293 and NK cell-mediated antibody-dependent cell cytotoxicity were present in aleumtuzumab-treated CMV se
294 lity of cisplatin-resistant cells to NK cell cytotoxicity when neutralizing antibody of PD-1 or PD-L1
295 e weak inhibitors of the Icat and EA-induced cytotoxicity whereas a potent inhibitor of TRPC4/C1 chan
297 unction of IL-17A in promoting CD8(+) T cell cytotoxicity, which may have broad implications in other
298 ated over the last two decades express their cytotoxicity with a mechanism of action involving, among
299 mpounds induce tumour cell death and enhance cytotoxicity with chemotherapeutic agents and targeted c
300 promise in cancer treatment by coupling drug cytotoxicity with thermal ablation or thermally-induced
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