ライフサイエンスコーパス: cytotoxicity assay

1 etion system dependent Y. pseudotuberculosis cytotoxicity assay).

2 icrog/ml, as determined by a Vero cell-based cytotoxicity assay.

3 ssay results were confirmed by the Vero cell cytotoxicity assay.

4 NAs to induce cell death in an in vitro cell cytotoxicity assay.

5 assay, and antibody-dependent cell-mediated cytotoxicity assay.

6 sensitivities and specificities compared to cytotoxicity assay.

7 s conferring unusual potency in a tumor cell cytotoxicity assay.

8 oth mAbs in antibody-dependent cell-mediated cytotoxicity assay.

9 hat these variants are active in the cognate cytotoxicity assay.

10 44 lacks inhibitory capacity in a redirected cytotoxicity assay.

11 a simple anti-ganglioside antibody-mediated cytotoxicity assay.

12 le were identified by using a (51)Cr release cytotoxicity assay.

13 spot assay and the standard chromium release cytotoxicity assay.

14 n production was demonstrated by a HeLa cell cytotoxicity assay.

15 roduction as assessed by PCR and a HeLa cell cytotoxicity assay.

16 tolytic activity against leukemia cells in a cytotoxicity assay.

17 eir effects against rat P. carinii by an ATP cytotoxicity assay.

18 diagnosing FHL than hemophagocytosis and the cytotoxicity assay.

19 red the presence of high dose SEB during the cytotoxicity assay.

20 ermined serially with a complement-dependent cytotoxicity assay.

21 ically active TNF-alpha, using the L929 cell cytotoxicity assay.

22 gically active TNF-alpha using the L929 cell cytotoxicity assay.

23 ct receptor on cells as well as an apoptosis/cytotoxicity assay.

24 he activity of the preparation in a WEHI 164 cytotoxicity assay.

25 also exhibited by splenocytes in an in vitro cytotoxicity assay.

26 9 (0.5 microM) was removed 24 h prior to the cytotoxicity assay.

27 in B digital ELISA was 100% sensitive versus cytotoxicity assay.

28 the National Cancer Institute's 60 cell line cytotoxicity assay.

29 ant was cytotoxic to BHS PMNs in an in vitro cytotoxicity assay.

30 toxin and similar IC50 values in a Vero cell cytotoxicity assay.

31 as neutralize purified toxins in an in vitro cytotoxicity assay.

32 eliable, quantitative, and robust cell-based cytotoxicity assay.

33 ing assay to breast cancer cell lysate and a cytotoxicity assay.

34 bolished the inhibitory function of Ly49A in cytotoxicity assays.

35 7-aminoactinomycin D staining in flow-based cytotoxicity assays.

36 nstrated through fluorescence microscopy and cytotoxicity assays.

37 llular cytotoxicity and complement-dependent cytotoxicity assays.

38 found to be nontoxic in preliminary in vitro cytotoxicity assays.

39 acetate succinimidyl ester dye dilution) and cytotoxicity assays.

40 e variant epitopes were poorly recognized in cytotoxicity assays.

41 by tetramer binding, IFN-gamma ELISPOT, and cytotoxicity assays.

42 the normal hematopoietic cells in short-term cytotoxicity assays.

43 tectable by standard lymphoproliferation and cytotoxicity assays.

44 esponses, as detected by in vivo or in vitro cytotoxicity assays.

45 L39) and transfected into HCC cells for G207 cytotoxicity assays.

46 ormoxia (21% O2), and infected with G207 for cytotoxicity assays.

47 active as paclitaxel in tubulin assembly and cytotoxicity assays.

48 lytic function in both direct and redirected cytotoxicity assays.

49 ro, as determined by IFN-gamma secretion and cytotoxicity assays.

50 ts of E1A are easily measured in vitro using cytotoxicity assays.

51 EGF receptor, Flk-1, as measured by in vitro cytotoxicity assays.

52 ved as a model for xenograft target cells in cytotoxicity assays.

53 cells with different VHL status in TNFalpha cytotoxicity assays.

54 d HLA-class I- restricted manner in standard cytotoxicity assays.

55 ating alloantibody levels were determined by cytotoxicity assays.

56 e-linked immunospot (ELISPOT), tetramer, and cytotoxicity assays.

57 ions (XMLRs) and in natural killer (NK) cell cytotoxicity assays.

58 cells was evaluated in in vitro and in vivo cytotoxicity assays.

59 ften do not lyse HIV-infected targets in 4-h cytotoxicity assays.

60 , and potentiated the activity of CT-2584 in cytotoxicity assays.

61 ed in gamma-IFN enzyme-linked immunospot and cytotoxicity assays.

62 lpha RI as measured in Ab-dependent cellular cytotoxicity assays.

63 or frequency (limiting dilution assay [LDA]) cytotoxicity assays.

64 TAT ELISA system and by complement-dependent cytotoxicity assays.

65 s systems of infected mice in direct ex vivo cytotoxicity assays.

66 the MART-1(27-35) peptide, AAGIGILTV, in 4-h cytotoxicity assays.

67 and perforin-dependent killing in redirected cytotoxicity assays.

68 he presence or absence of AH in conventional cytotoxicity assays.

69 of chickenpox, by T lymphoproliferation and cytotoxicity assays.

70 c cytotoxic T cells (CTLs) in direct ex vivo cytotoxicity assays.

71 neral, tetramer binding correlated well with cytotoxicity assays.

72 toxicity was measured in 4-h and 16- to 18-h cytotoxicity assays.

73 in two different P. aeruginosa T3SS-mediated cytotoxicity assays.

74 ry, and enzyme-linked immunosorbent spot and cytotoxicity assays.

75 ive to CMV peptides in IFN-gamma release and cytotoxicity assays.

76 cellular injury was evaluated using the same cytotoxicity assays.

77 ility was assessed using TUNEL and viability/cytotoxicity assays.

78 were examined by flow cytometry and in vitro cytotoxicity assays.

79 nel formation, N-terminus translocation, and cytotoxicity assays.

80 analyses and to neutralize them in Vero cell cytotoxicity assays.

81 In cytotoxicity assays, 15N-TrkB cells were consistently 1.

82 In a Vero cell cytotoxicity assay, 24B11 was approximately two times mo

83 In 4-day cytotoxicity assays, ABCG2-mediated resistance to SN-38

84 ein endothelial cells (HUVECs) in redirected cytotoxicity assays after T-cell receptor triggering and

85 Moreover, in antibody-dependent cellular cytotoxicity assays against Raji target cells, chLym-1/I

86 KO/gld LAK cells were cytotoxic in long term cytotoxicity assays against TNF-sensitive tumor lines, a

87 nzyme-linked immunospot (ELISPOT) assay, and cytotoxicity assay all showed that the Ad-sig-TAA/ecdCD4

88 biological context is also demonstrated in a cytotoxicity assay and a cell internalization study with

89 e cell and to the lungs, as evidenced by the cytotoxicity assay and analyses of the injury markers in

90 ines and the results were validated by WST-1 cytotoxicity assay and annexin V-FITC/propidium iodide (

91 ositive B16 and CT26 tumor cells in vitro by cytotoxicity assay and antitumor activity in vivo using

92 MTT cytotoxicity assay and confocal microscopy images were c

93 s was predictive for rejection in an in vivo cytotoxicity assay and correlated with skin allograft re

94 noplexes in fibroblasts were evaluated using cytotoxicity assay and florescence microscopy, respectiv

95 ally active, as demonstrated by a cell-based cytotoxicity assay and inhibition of microglia activatio

96 MTS assay cytotoxicity assay and live-dead cell viability test wer

97 esence of Shiga toxin using both a Vero cell cytotoxicity assay and the Shiga Toxin Quik Chek test (S

98 In vitro cytotoxicity assay and tumor S-phase fraction can be use

99 cells were quantified by the standard YAC-1 cytotoxicity assay and were found to appear in the genit

100 nontoxigenic in the Vero cell tissue culture cytotoxicity assay and were therefore nontoxigenic for d

101 of higher avidity measured both by in vitro cytotoxicity assays and a new methodology that measures

102 ble alloreactivity in both proliferation and cytotoxicity assays and are able to proliferate and secr

103 e recognized AFP-transfected targets in both cytotoxicity assays and cytokine release assays.

104 th Flu-M1 and G9(280)-9V-specific T cells in cytotoxicity assays and IFN-gamma ELISPOT assays.

105 ing HLA-A*0201(+)/AFP(+) tumor cells in both cytotoxicity assays and IFN-gamma enzyme-linked immunosp

106 n, cytotoxicity, and antibody-dependent cell cytotoxicity assays and in vivo by human lymphoma xenogr

107 ndemic H1N1 strain, and influenza B virus in cytotoxicity assays and intracellular-cytokine-staining

108 icide gene therapy for neuroblastomas by GCV cytotoxicity assays and noninvasive bioluminescent imagi

109 e peptide KIF and HER-2-expressing tumors in cytotoxicity assays and secreted gamma interferon (IFN-g

110 ated by both inhibition studies and in vitro cytotoxicity assays and shows a correlated structure-act

111 In vivo cytotoxicity assays and various gene-deficient recipient

112 ntihuman-globulin-enhanced T cell and B cell cytotoxicity assays and/or flow cytometry.

113 radioimmunoassay (RIA), neuroblastoma (N2A) cytotoxicity assay, and liquid chromatography/mass spect

114 heir viability was assessed by a BCECF-based cytotoxicity assay, and their function was assessed by a

115 ng flow cytometry, [(125)I]IAAP binding, and cytotoxicity assays, and interaction was documented in 2

116 Toxin-specific enzyme immunoassays, cytotoxicity assays, and PCR were used to analyze 48 tox

117 etermined in both tubulin polymerization and cytotoxicity assays, and several analogues with enhanced

118 e antigen proteins were analyzed by cellular cytotoxicity assays, and their interactions with antibod

119 For this reason, ecotoxicity and cytotoxicity assays are of special interest in order to

120 Enzyme-linked immunospots, cytotoxicity assays as well as adoptive transfer in NOD/

121 (1) Proliferation and cytotoxicity assays, as well as skin graft survival, dem

122 a more traditional methyl tetrazolium (MTT) cytotoxicity assay at selected time points following app

123 ific CD8(+) T cells, using a flow-cytometric cytotoxicity assay based on caspase-3 activation in dyin

124 Cytotoxicity assays based on colony formation revealed t

125 ur IgA MAbs neutralized ricin in a Vero cell cytotoxicity assay, blocked toxin-induced interleukin-8

126 ytolytic properties, as measured in vitro by cytotoxicity assays, but differed markedly in their capa

127 darabine to bendamustine resulted in maximum cytotoxicity assayed by 3,3'-dihexyloxacarbocyanine iodi

128 ciency of peptide generation was measured in cytotoxicity assays by determining 1) the kinetics of pr

129 This simple cytotoxicity assay can potentially be used for screening

130 ibrils, and that the PC 12-based comparative cytotoxicity assay can provide insights into toxicity di

131 Natural killer (NK)-cell cytotoxicity assays can quickly screen for all of these

132 ate drug safety in a regime that the current cytotoxicity assays cannot cover and be generally applie

133 during a 3-month period using a cell culture cytotoxicity assay (CCCA).

134 As assessed by MTT cytotoxicity assay, CEM cells were also significantly mo

135 cence microscopy using a live-dead viability-cytotoxicity assay conducted by an observer uninformed o

136 Finally, in vitro dose-escalation cytotoxicity assays confirm the biocompatibility of the

137 In vitro cytotoxicity assays confirmed that mouse neutrophils lys

138 Cytotoxicity assays confirmed that the LF(N) mutations i

139 Cytotoxicity assays, confocal laser scanning microscopy,

140 Data derived from cytotoxicity assays, confocal laser scanning microscopy,

141 sensitization of target cells in an in vitro cytotoxicity assay, consistent with enhanced antigen pre

142 T cell proliferation assays and NK cytotoxicity assays demonstrate that this fusion protein

143 A Vero cell cytotoxicity assay demonstrated that 90% of the represen

144 sistent with chemistry observation, in vitro cytotoxicity assay demonstrated that these agents induce

145 Cytotoxicity assays demonstrated at least additivity in

146 Cytotoxicity assays demonstrated higher responses to don

147 Cr51 release cytotoxicity assays demonstrated less susceptibility to

148 In vitro cytotoxicity assays demonstrated that activity of an unt

149 However, cytotoxicity assays demonstrated that patients treated w

150 Cytotoxicity assays demonstrated the crucial role of the

151 Moreover, NK cell receptor blockade in cytotoxicity assays demonstrates that NCRs play a major

152 d (PKO/gld) were not cytolytic in short term cytotoxicity assays, demonstrating that perforin and Fas

153 s determined by LC/MS, the RBA, RIA, and N2A cytotoxicity assay detected 73, 83, and 51% of the total

154 e a mechanistic understanding of an in vitro cytotoxicity assay developed while he was a fellow with

155 Although cytotoxicity assays did not support differences between

156 and B by enzyme immunoassay and cell culture cytotoxicity assay (EIA/CCA).

157 In vitro cytotoxicity assays established that the mAb-MGB drug co

158 also were inactive in antiproliferative and cytotoxicity assays, except for 3-methyl-6-beta-D-ribofu

159 hiazol-2-yl)-2,5-diphenyltetrazolium bromide cytotoxicity assay, flow cytometric apoptosis quantifica

160 this work, we have developed a microfluidic cytotoxicity assay for a cell culture and detection plat

161 The CC50 value obtained in a cytotoxicity assay for compound 9 was >100 muM, correspo

162 ed bioactivity assays along with traditional cytotoxicity assays for in vitro screening.

163 om proteasomal breakdown and, as measured in cytotoxicity assays, from major histocompatibility compl

164 Cytotoxicity assays further confirmed that these melanom

165 ficile by anaerobic bacterial culture and/or cytotoxicity assays has been largely replaced by rapid e

166 In a 3-day cytotoxicity assay, human SPF45 overexpression conferred

167 HPLC, mass spectrometry, cytotoxicity assays, IFN-gamma ELISPOT, and human breast

168 pathway, we developed an indirect glycolate cytotoxicity assay in a 1,536-well plate format for high

169 e complexes were determined through in vitro cytotoxicity assay in human fibroblasts (MRC5) and two c

170 ted against the standard LIVE/DEAD Viability/Cytotoxicity Assay in small tumor spheroid cultures, sho

171 ctivity was established in an A2780 cellular cytotoxicity assay in which 21 showed an IC(50) = 95 nM.

172 logical activity in the complement-dependent cytotoxicity assay in which the wild-type IgG2 is inacti

173 say, along with in vitro phosphorylation and cytotoxicity assays in leukemia cells, we compared PKC41

174 malaria parasite was validated by performing cytotoxicity assays in red blood cells infected with Pla

175 Estimates have been obtained using in vivo cytotoxicity assays in which peptide-pulsed splenocytes

176 In cytotoxicity assays, incubation of 1 microM CPT-11 with

177 Viability/cytotoxicity assays indicate dose-dependent cytotoxic ef

178 In vitro cytotoxicity assays indicate that Ly49I recognizes H2(q)

179 In vitro cytotoxicity assays indicated that 27 was more potent th

180 In vitro cytotoxicity assays indicated that donor immunization in

181 Results of cytotoxicity assays indicated that the nonstructural pro

182 CD8 T cells in the spleen, as determined by cytotoxicity assays, intracellular staining for gamma in

183 Mouse or human ESCs were subjected to cytotoxicity assays involving their respective species-m

184 The commonly performed complement-dependent cytotoxicity assay is insensitive compared with newer me

185 In cytotoxicity assays, ISG15 was a potent inducer of cytol

186 primate and human subjects using traditional cytotoxicity assay methods.

187 cal, superoxide radical, hypochlorous acid), cytotoxicity assay (MTT) and quantification of TNF-alpha

188 From these preliminary cytotoxicity assays (MTT) we found that C8-propyl-catech

189 The cytotoxicity assay of nanoMgO particles, examined using

190 al blood mononuclear cells, and 51Cr release cytotoxicity assay of rNcSRS2-stimulated effector cells.

191 Competitive uptake and cytotoxicity assays of 2 were investigated and interacti

192 fluorescence microscope images and live/dead cytotoxicity assays of HeLa cancer cells suggested that

193 sitive or negative results from conventional cytotoxicity assays of nanomaterials (NMs) suggests that

194 ldin A are likely to be generated during the cytotoxicity assays of the sulfoxide derivatives.

195 etermined by use of the complement-dependent cytotoxicity assay, of 77+/-19% or with donor-specific a

196 tomy, sera were tested by flow cytometry and cytotoxicity assay on porcine peripheral blood mononucle

197 The cytotoxicity assay on RAW264.7 cells suggested that the

198 on linoleate uptake in vitro was measured by cytotoxicity assays on Caco-2 cells.

199 In vitro cytotoxicity assays performed on H2987 lung adenocarcino

200 ile isolates selected from 50 tissue culture cytotoxicity assay-positive clinical stool samples.

201 This rapid and efficient in vivo cytotoxicity assay recapitulated the specificity of NK c

202 and 3 h in sensitized recipients in in vivo cytotoxicity assay, reflecting Ab-mediated cytotoxicity.

203 125% as determined by the RBA, RIA, and N2A cytotoxicity assay, respectively.

204 osine triphosphatase (ATPase) and cell-based cytotoxicity assays, respectively.

205 iazol-2-yl]-2,5-diphenyltetrazolium bromide) cytotoxicity assay revealed that Sf9 cells expressing CY

206 Cytotoxicity assays revealed that LF was cytotoxic to WE

207 Cytotoxicity assays revealed that PZS was highly toxic.

208 Cytotoxicity assays revealed that the compounds inhibite

209 Cytotoxicity assays revealed that the TDN p53 cell lines

210 Cytotoxicity assays revealed that the two trophoblast ce

211 In addition, cytotoxicity assays show that the LLC-MDR1-3H cells are

212 A dye reduction cytotoxicity assay showed that IL-4 induced resistance t

213 Cytotoxicity assay showed that NK cells from HLA-C1 posi

214 In vitro cytotoxicity assays showed CD8+ T cell-mediated eliminat

215 is, reverse antibody-dependent cell-mediated cytotoxicity assays showed potent degranulation and cyto

216 Cytotoxicity assays showed that both nonfunctionalized a

217 onding to variant epitopes in direct ex vivo cytotoxicity assays showed that each mutation caused a l

218 Cytotoxicity assays showed that HFFs expressing HPV 16E6

219 In vitro cytotoxicity assays showed that T lymphocytes or CD8(+)

220 Cytotoxicity assays showed that the date extracts were a

221 T-cell cytotoxicity assays showed that TIV is processed and the

222 Cytotoxicity assays showed, however, that all four of th

223 tumors did not lyse 9L cells in 51Cr-release cytotoxicity assays, specific cytotoxicity was demonstra

224 Cytotoxicity assays suggest that toxicity is a property

225 The cytotoxicity assay suggested that the inhibition of PAM

226 -deficient and wild-type controls in in vivo cytotoxicity assays, suggesting donor-specific tolerance

227 Using specimens that were negative by cytotoxicity assay/TC/NAAT, clinical cutoffs were set at

228 of UV-irradiated AdLacZ adenovirus and in a cytotoxicity assay that appears to be the result of aber

229 virus-infected mice in vivo using an in vivo cytotoxicity assay that features class II-expressing B c

230 g a multilayered multiple myeloma cell-based cytotoxicity assay that modeled disease niche, normal li

231 e compounds were evaluated using an in vitro cytotoxicity assay that utilizes a hippocampal-derived c

232 Safety of drugs is regularly evaluated using cytotoxicity assays that measure cell death.

233 In the plaque reduction and cytotoxicity assays, the 5-bromo analogue (3) showed goo

234 ed in interferon-gamma Elispot assays and in cytotoxicity assays, these responses were of low frequen

235 to standard Hsp90alpha binding and cell line cytotoxicity assays, this study also highlights the firs

236 ected DCs also serve as effective targets in cytotoxicity assays, thus providing a general method for

237 In the cytotoxicity assay to correlate intracellular anthracycl

238 them in a murine fibroblast cell line (L929) cytotoxicity assay to investigate whether these mycobact

239 Compound 28 at 3 muM reduced resistance in cytotoxicity assay to paclitaxel in P-gp-expressing SW62

240 One of the transconjugants is shown by cytotoxicity assay to produce toxin B at a similar level

241 virus 68 (gammaHV68) in in vitro and in vivo cytotoxicity assays to show CD4-dependent killing of gam

242 ts" was further refined using cell viability-cytotoxicity assays to two 1,3,5-triaryl pyrazoline comp

243 mmunoassays are insufficiently sensitive and cytotoxicity assays too complex; assays that detect toxi

244 re investigated in a glutamate (Glu)-induced cytotoxicity assay using either primary rat cortical neu

245 blot and immunoprecipitation, as well as by cytotoxicity assay using Fas-expressing target cells.

246 sitive and negative signaling in an in vitro cytotoxicity assay using sorted NK cell subsets as effec

247 analogues proved to be highly active in the cytotoxicity assay using the human cervix carcinoma cell

248 Cytotoxicity assays using A549 and H596 lung cancer cell

249 In vitro cytotoxicity assays using hematopoietic cells and fibrob

250 In vitro cytotoxicity assays using multiple different cell lines

251 LA-DR molecules and in IFN-gamma ELISPOT and cytotoxicity assays using peripheral blood lymphocytes f

252 Antibody-dependent cellular cytotoxicity assays using purified peripheral blood mono

253 s by RT-PCR, Western blot analysis, IHC, and cytotoxicity assays using siRNA or transfection-modified

254 minor histocompatibility Ag, as detected by cytotoxicity assays using SMCY(311-319)-specific CTL.

255 ing results were confirmed functionally with cytotoxicity assays using sorted 129/J NK cells.

256 NK cell function was tested using a cytotoxicity assay versus YAC-1 target cells on day 14 o

257 Metformin cytotoxicity assay was performed using the MTS assay.

258 NK cells in a redirected, antibody-dependent cytotoxicity assay was triggered by a number of receptor

259 f lethal concentration derived from standard cytotoxicity assays was not.

260 Using in vivo cytotoxicity assays we demonstrated that early up-regula

261 analysis, mutagenesis, NMO-IgG binding, and cytotoxicity assay, we have disclosed the key role of as

262 Using an ultrasensitive cytotoxicity assay, we measured C. difficile toxin A (Tc

263 unoassays compared to the accepted standard, cytotoxicity assay, we studied three enzyme immunoassays

264 Using NK cell activation and NK cytotoxicity assays, we compared ADCC-mediating antibodi

265 is of intracellular IFN-gamma production and cytotoxicity assays, we determined that CD16(+) liver NK

266 Using in vivo cytotoxicity assays, we evaluated the effector systems m

267 ate dehydrogenase release and live/dead cell cytotoxicity assays, we found in different cell lines, a

268 ng with resistance/enzymatic, hemolytic, and cytotoxicity assays were also studied.

269 Complement-dependent cytotoxicity assays were performed to determine the cyto

270 cally, Affymetrix U133 Plus 2.0 GeneChip and cytotoxicity assays were performed to obtain basal mRNA

271 Cytotoxicity assays were performed using osteoblast and

272 ctin expression, induction of apoptosis, and cytotoxicity assays were performed.

273 ELISPOT and cytotoxicity assays were used to evaluate tumor-reactive

274 sponded to VP16 393-405 in proliferation and cytotoxicity assays when presented by DRB1*0402, DRB1*11

275 NM interactions compared to the conventional cytotoxicity assays where only one aspect of toxicity ca

276 SPOT), interferon (IFN)-gamma secretion, and cytotoxicity assays, whereas HCV-specific antibodies wer

277 toma cells and medulloblastoma cell lines in cytotoxicity assays, whereas HER2-negative tumor cells w

278 e standard Chinese hamster ovary (CHO)-based cytotoxicity assay, which took about 72 h to complete.

279 s of memory T cells was reflected by in vivo cytotoxicity assays, which showed decreased clearance of

280 In cytotoxicity assays, wild-type Chinese hamster ovary (CH

281 body-positive sera in a complement-dependent cytotoxicity assay with cultured melanoma cell lines.

282 A cytotoxicity assay with NCI/ADR-RES, a drug resistant ce

283 ue extracts, is even more active than QL9 in cytotoxicity assays with 2C CTL.

284 utralization of diphtheria toxin in in vitro cytotoxicity assays with a 50% effective concentration o

285 Candidates were characterized in cellular cytotoxicity assays with Chinese hamster ovary (CHO) cel

286 efficacy as hapalosin in antagonizing MRP in cytotoxicity assays with HL-60/ADR cells.

287 Cytotoxicity assays with human breast cancer cells showe

288 In vitro tumor cytotoxicity assays with lymph node effector cells revea

289 to be significant in the context of in vitro cytotoxicity assays with the cephalosporin-doxorubicin p

290 In vitro cancer cell cytotoxicity assays with the human colon carcinoma cell

291 particularly in localities where performing cytotoxicity assays would be problematic.