ライフサイエンスコーパス: daidzein

1 rgonidin), and isoflavones (e.g., genistein, daidzein).

2 y alcohol (eg, the isoflavones genistein and daidzein).

3 al kinase, was inhibited by equol but not by daidzein.

4 82,780, tamoxifen, raloxifene, genistein, or daidzein.

5 effects of the soy isoflavones genistein and daidzein.

6 3.2 h for free genistein and 4.2 h for free daidzein.

7 istribution were estimated for genistein and daidzein.

8 .2 h for total genistein and 8.2 h for total daidzein.

9 e methylation of the 4' position (B-ring) of daidzein.

10 addition of the isoflavonoids genistein and daidzein.

11 ical recovery was significantly inhibited by daidzein.

12 mmary tumors from mice that received dietary daidzein.

13 account for all of the loss of genistein and daidzein.

14 an IP injection of the caveolin-1 inhibitor, daidzein (0.4 mg/kg), every 24 h following reperfusion.

15 ary isoflavonoids were 0.72 (0.43, 0.96) for daidzein, 0.67 (0.43, 0.91) for genistein, and 0.72 (0.4

16 4(')-glucuronide, 13% monosulfates, 7% free daidzein, 0.9% sulfoglucuronides, 0.4% diglucuronide, an

17 Daidzein (1) is a natural estrogenic isoflavone.

18 Subjects excreted measurable amounts of daidzein (11.6-39.2 mg/day) and genistein (2.9-18.2 mg/d

19 nistein 1271+/-321 versus 425+/-104, P<0.05; daidzein 1304+/-352 versus 292+/-78, P<0.05).

20 0 mg per g of extract), genistin (3.7 mg/g), daidzein (2.6 mg/g), daidzein-4',7-diglucoside (1.2 mg/g

21 y contained an especially high proportion of daidzein (307gkg(-1)).

22 ), genistin (3.7 mg/g), daidzein (2.6 mg/g), daidzein-4',7-diglucoside (1.2 mg/g), genistein (0.2 mg/

23 y effect was not observed in the presence of daidzein (50 micromol/L), an analogue of genistein that

24 Twenty-five muM daidzein/50 muM genistein and 50 muM daidzein/50 muM gen

25 ive muM daidzein/50 muM genistein and 50 muM daidzein/50 muM genistein significantly increased the ap

26 Except 50 muM daidzein/50 muM genistein, all other combinations had no

27 rphostin A25 and controls, tyrphostin A1 and daidzein (a genistein congener), were inactive despite p

28 are products of gut bacterial metabolism of daidzein, a phytochemical found predominantly in soy.

29 Daidzein, a quercetin analogue that does not inhibit NF-

30 Daidzein, a soy isoflavone, is a clinically approved age

31 (7,3',4'-THIF) is one of the metabolites of daidzein, a well known soy isoflavone, but its chemoprev

32 n safety in humans, early and chronic use of daidzein aimed at augmenting ApoE may serve as a novel,

33 m estradiol, 3 microm genistein, or 3 microm daidzein all increased ERalpha expression, stimulated ce

34 Daidzein also elevated the cholesterol homeostasis genes

35 the flavonoids naringenin, eriodictyol, and daidzein also stimulated an increase in the DNA binding

36 Daidzein, an inactive analogue of genistein, fails to en

37 Transport was not affected by daidzein, an inactive genistein analog that does not inh

38 on of equol from the microbial metabolism of daidzein-an observation not yet documented in the US pop

39 ties of the resulting compounds, a series of daidzein analogues have been designed and synthesized.

40 Stable isotopically labeled [13C(3)]daidzein and [13C(3)]genistein were synthesized and used

41 ting the A-ring 7-hydroxyl of the isoflavone daidzein and a 4'-OMT methylating the B-ring 4'-hydroxyl

42 while increased the contents of daidzin and daidzein and decreased the content of genistein in the u

43 With maturation, the concentrations of daidzein and equol were unaffected, while the glycitein

44 their bioactive compounds, namely genistein, daidzein and equol, on the inflammatory responses induce

45 Daidzein and formononetin degraded primarily by direct p

46 ments using estradiol and the phytoestrogens daidzein and genistein (compounds known to bind ER-beta)

47 Mean daily serum levels of daidzein and genistein (free and conjugated forms) 15 h

48 es in soymilk at 97 degrees C for 25min, the daidzein and genistein aglycone contents were maintained

49 Daidzein and genistein are isoflavones found in soybean.

50 The amounts of daidzein and genistein in the SSF decreased to 8.6 +/- 1

51 The isoflavones daidzein and genistein occur naturally in most soyfoods,

52 Daidzein and genistein showed a synergistic effect on in

53 isoflavone combination with lower levels of daidzein and genistein to be a more efficacious and safe

54 The addition of 0.9% PGA caused 7S, 11S, daidzein and genistein to coacervate following a 1h incu

55 In addition, isoflavones including daidzein and genistein were also coacervated from the SS

56 HPLC analysis suggested that daidzein and genistein were bound to the 7S and 11S prot

57 These results suggested that daidzein and genistein were co-precipitated with the 7S

58 Total hydrolyzed daidzein and genistein were measured against quality ass

59 protein and flaxseed are due to isoflavones (daidzein and genistein), lignans (matairesinol and secoi

60 The anticancer effects of daidzein and genistein, and their combinations on early-

61 ts, and major soy isoflavones, in particular daidzein and genistein, are thought to be the source of

62 th previous findings for the soy isoflavones daidzein and genistein, both of which have relatively po

63 tain a significant amount of the isoflavones daidzein and genistein, which are weak estrogens.

64 possibly in part because of the isoflavones daidzein and genistein, which are weakly estrogenic.

65 t coagulant for the coacervation of 7S, 11S, daidzein and genistein.

66 rmentation caused significant changes in the daidzein and glycitein concentrations.

67 chalcone reductase led to very low levels of daidzein and increased levels of genistein, but did not

68 The mean sum of daidzein and its conjugates was within 20% of the hydrol

69 both milk and yogurt samples, the amounts of daidzein and its metabolite equol were significantly hig

70 hanisms of the chemopreventive activities of daidzein and its metabolite, equol, are not understood.

71 citein bioavailability is similar to that of daidzein and its urinary excretion is significantly high

72 These results suggest that dietary daidzein and legumes may contribute to urinary daidzein,

73 thase, thereby preventing its dehydration to daidzein and subsequent A-ring methylation by free IOMT.

74 d tyrphostin 23 and their inactive analogues daidzein and tyrphostin A1, respectively.

75 equol, O-desmethylangolensin, genistein, and daidzein) and lignan (enterodiol and enterolactone) cont

76 er accumulation of formononetin (4'-O-methyl daidzein) and medicarpin in the leaves than does elicita

77 n A was composed of 90 +/- 5% genistein, 10% daidzein, and 1% glycitein.

78 ulation B was composed of 43% genistein, 21% daidzein, and 2% glycitein.

79 Pure soy isoflavones (genistein, genistin, daidzein, and biochanin A) and soy phytochemical concent

80 In contrast, soybean isoflavones (genistein, daidzein, and biochanin A) are ERbeta-selective agonists

81 soy isoflavone phytoestrogens, genistein and daidzein, and equol (a daidzein metabolite produced by i

82 The elimination rates (k(e)) for genistein, daidzein, and equol were 0.1, 0.16, and 0.08 h(-1), resp

83 Recoveries of conjugates of genistein, daidzein, and equol were 24%, 66%, and 28% of the amount

84 hanisms by which soy isoflavones (genistein, daidzein, and equol) afford protection against oxidative

85 rminal plasma half-lives for free genistein, daidzein, and glycitein averaged 3.8, 7.7, and 3.4 h, re

86 soflavone preparations containing genistein, daidzein, and glycitein in postmenopausal women.

87 105.23 mg total isoflavones/d as genistein, daidzein, and glycitein in their natural ratios and incr

88 zein or combined soy isoflavones (genistein, daidzein, and glycitein) increased primary mammary tumor

89 studies of purified unconjugated genistein, daidzein, and glycitein, and defined pharmacokinetic par

90 isoflavone mixture consisting of genistein, daidzein, and glycitein.

91 ze S-equol from the precursor soy isoflavone daidzein, and it is significant that, unlike R-equol, th

92 -2-aminopropane (DOI), SRT1720, resveratrol, daidzein, and metformin produced mitochondrial biogenesi

93 d the plasma concentrations of genistein and daidzein, and the intestinally derived metabolite, equol

94 contained mainly glycosides of genistein and daidzein, and the total isoflavone content was similar a

95 The isoflavones genistein, daidzein, and their glycosides, found in high concentrat

96 Daidzein, another phytoestrogen, was ineffective, but eq

97 Indeed, daidzein appears to be safe as it has been widely consum

98 Puerarin, daidzin, and daidzein are 3 major isoflavonoid compounds isolated fro

99 Genistein and daidzein are biologically active isoflavones that are es

100 stinal absorption, circulating genistein and daidzein are eliminated primarily by the kidneys.

101 The soy isoflavones genistein and daidzein are found in blood and tissues as aglycones, gl

102 Genistein and daidzein are two estrogenic compounds derived from plant

103 This screen identified daidzein as a transcriptional inducer of Arg1.

104 Daidzein, at 10 degrees C, rose significantly from about

105 ansformation was inhibited by equol, but not daidzein, at noncytotoxic concentrations in a dose-depen

106 henol metabolites: enterolactone, genistein, daidzein, benzophenone-3, bisphenol A, the sum of parabe

107 ncreased the amount of daidzin, genistin and daidzein, but decreased that of genistein.

108 n, genistein was always better taken up than daidzein by both LNCaP and C4-2B cells.

109 In contrast, a compound (daidzein) chemically unrelated to PD 098059 had little e

110 Genistein and daidzein concentrations (0.03mg/100g) were similar in bo

111 e accuracy of the quantitation of the intact daidzein conjugates.

112 at received the basal diet, as the precursor daidzein contributed to the increased equol concentratio

113 on of activator protein-1 and c-fos, whereas daidzein did not exert any effect when tested at the sam

114 F expression in tumor extracts of mice after daidzein diets is associated with protein expression of

115 y-induced synaptic remodeling, we found that daidzein enhanced the cholesterol homeostasis genetic pr

116 However, the daidzein-enhanced functional benefits and synaptophysin

117 We examined the interactions of genistein, daidzein, equol, and liquiritigenin with estrogen recept

118 e photochemical behaviors of the isoflavones daidzein, formononetin, biochanin A, genistein, and equo

119 Genistein and daidzein (free and total) were rapidly cleared from plas

120 tural requirements for the transformation of daidzein from an ER agonist to an antagonist.

121 labilities of both total genistein and total daidzein from each of the 2 formulations were not signif

122 were treated with varying concentrations of daidzein, genistein (25-200 muM) or their combinations (

123 ng each soya diet period for the analysis of daidzein, genistein, and 2- and 16alpha-hydroxyestrone.

124 ndicative of a soy-based diet, particularly, daidzein, genistein, and equol.

125 roxydeoxybenzoin, and the external standards daidzein, genistein, and genistin.

126 tions of 12 isoflavone isomers, 3 aglycones (daidzein, genistein, and glycitein), and 9 glucosides (d

127 idzein and legumes may contribute to urinary daidzein, genistein, and ODMA concentrations in this low

128 ts, and seeds were significant correlates of daidzein, genistein, and ODMA concentrations; and soy le

129 0.48 (0.29, 0.61), and 0.50 (0.32, 0.64) for daidzein, genistein, and TIFLs, respectively.

130 n from 24-h recalls and urinary excretion of daidzein, genistein, and TIFLs.

131 mpounds, three of which are aglycons, namely daidzein, genistein, biochanin A, and two of which, daid

132 ontrols were analyzed for isoflavonoids (ie, daidzein, genistein, equol, and O-desmethylangolensin) a

133 the predominant phytoestrogen species, with daidzein, genistein, formononetin, and coumestrol presen

134 ment for several covariates, high intakes of daidzein, genistein, glycetin, secoisolariciresinol, tot

135 We monitored the isoflavones daidzein, genistein, glycitein, formononetin, and biocha

136 Daidzein, genistein, kaempferol, and coumestrol (group 2

137 peated 24-h recalls and urinary excretion of daidzein, genistein, total isoflavonoids (TIFLs), and eq

138 For daidzein sulfate, genistein sulfate, daidzein glucuronide, and genistein glucuronide, the tim

139 neous determination of isoflavone aglycones (daidzein, glycitein and genistein), their corresponding

140 ds were analyzed for isoflavones (genistein, daidzein, glycitein, biochanin A, and formononetin), lig

141 40% soybean isoflavones, on the contents of daidzein, glycitein, genistein, and equol in milk as wel

142 leation, with the effects of estrogen > or = daidzein > genistein.

143 +/- SEM) of isoflavonoid excretion in urine (daidzein > glycitein > genistein) and the quantity of is

144 Despite the absence of neuroprotection, daidzein improved motor/gait function in chronic stroke

145 covered that an FDA-approved soy isoflavone, daidzein, improved stroke-induced behavioral deficits vi

146 nide and sulfate conjugates of genistein and daidzein in humans after the consumption of a drink made

147 en to assess the metabolism of genistein and daidzein in patients with end-stage renal disease (ESRD)

148 The percentages of sulfates of genistein and daidzein in plasma (8% and 26%, respectively) were 2- to

149 udo half-lives for total genistein and total daidzein in plasma averaged 10.1 and 10.8 h, respectivel

150 mation of the concentration of genistein and daidzein in sunlit surface waters, which will allow for

151 (SD) plasma concentrations of genistein and daidzein in the seven infants fed soy-based formulas wer

152 FS resulting in production of the isoflavone daidzein in this system.

153 s, methylates the A-ring 7-hydroxyl group of daidzein in vitro, a reaction that probably does not occ

154 cell lines show that some of the effects of daidzein in vivo can be recapitulated by the daidzein me

155 onal isoflavones, including formononetin and daidzein, in response to UV-B or Phoma medicaginis, wher

156 In contrast to canonical Arg1 activators, daidzein increases Arg1 without increasing CREB phosphor

157 For daidzein, individual ORs were 5-38% lower.

158 knock-out mice, suggesting the importance of daidzein-induced ApoE upregulation in fostering stroke r

159 Dissociation between daidzein-induced functional benefits and the absence of

160 rimed in vivo by intrathecal or subcutaneous daidzein infusion.

161 None of the tyrphostins, including A47, nor daidzein inhibited resorption to >20 micromol/L.

162 Agricultural herbicides and daidzein inputs were primarily via upstream routes with

163 ly correlated (P for trend < 0.001) than was daidzein intake (P = 0.011).

164 Daidzein intake and consumption frequency of grain produ

165 he question of the relative contributions of daidzein intake and gut metabolism to equol and of equol

166 Milk and milk product consumption and daidzein intake, but not legumes, were significant corre

167 Genistein and daidzein intakes were highly correlated (r = 0.98); ther

168 The soy isoflavone daidzein is metabolized to equol and O-desmethylangolens

169 nd isotope dilution studies now confirm that daidzein is not an intermediate in isoflavonoid phytoale

170 rs and sensitizers, and results suggest that daidzein is transformed mainly via direct photolysis and

171 nverts the isoflavone daidzein to 7-O-methyl daidzein (isoformononetin) in vitro as well as in vivo i

172 Finally, genistein and daidzein levels were measured before and after dialysis

173 Glucuronides of genistein and daidzein made up a significantly lower percentage (P < 0

174 weakly estrogenic isoflavones genistein and daidzein may alter the metabolism of 17beta-estradiol to

175 at equol, a metabolite of the soy isoflavone daidzein, may advance breast cancer potential via up-reg

176 ietary food groups to urinary isoflavone and daidzein metabolite concentrations in a representative s

177 daidzein in vivo can be recapitulated by the daidzein metabolite equol.

178 rogens, genistein and daidzein, and equol (a daidzein metabolite produced by intestinal microflora) a

179 The predominant daidzein metabolites produced by human intestinal bacter

180 We evaluated relations between daidzein-metabolizing phenotypes and demographic, anthro

181 hromatography-mass spectrometry to determine daidzein-metabolizing phenotypes.

182 onnaire or food record, were associated with daidzein-metabolizing phenotypes.

183 st beneficial health effects associated with daidzein-metabolizing phenotypes; thus, assessing their

184 of hydrolysis of five isoflavone conjugates (daidzein, O-desmethylangolensin, equol, genistein, and g

185 eloped for the analysis of five isoflavones (daidzein, O-desmethylangolensin, equol, genistein, and g

186 e current study investigates the efficacy of daidzein on neuroprotection and functional recovery in a

187 We recently demonstrated that dietary daidzein or combined soy isoflavones (genistein, daidzei

188 of either of the major soybean isoflavones, daidzein or genistein, failed to restore normal nodulati

189 Equol, unlike the soy isoflavones daidzein or genistein, has a chiral center and therefore

190 oth CNS and PNS neurons primed in vitro with daidzein overcame neurite outgrowth inhibition from myel

191 Isoflavone-enriched (genistein-to-daidzein ratio of 2:1; 50 mg/d) or placebo cereal bars w

192 Isoflavone-enriched (genistein-to-daidzein ratio of 2:1; 50 mg/d) or placebo cereal bars w

193 Inhibition of ALDH by daidzein reduced the formation of DOPAC and increased th

194 Mechanistically, daidzein requires transcription and induction of Arg1 ac

195 Genistein, daidzein, rutin, quercetin and trans-resveratrol were al

196 y suggests that the early and chronic use of daidzein serves as a potential strategy to promote funct

197 Daidzin and daidzein shortened alcohol-induced sleep time (loss of r

198 ever, this inhibitory effect was mimicked by daidzein, suggesting that inhibition of tyrosine kinase

199 For daidzein sulfate, genistein sulfate, daidzein glucuronid

200 Daidzein, the other major isoflavone component of soybea

201 for methylation of the A-ring 7-hydroxyl of daidzein, the presumed substrate for O-methylation, in v

202 Except for kaempferol and daidzein, there were no significant associations between

203 (IOMT) from alfalfa converts the isoflavone daidzein to 7-O-methyl daidzein (isoformononetin) in vit

204 ra were cultured in vitro and incubated with daidzein to ascertain the stereospecificity of the bacte

205 subjects consuming both diets could convert daidzein to equol ex vivo.

206 ere prescreened for their ability to convert daidzein to equol.

207 interindividual differences in conversion of daidzein to equol.

208 nction, and thyroid economy of genistein and daidzein, two isoflavones in soy infant formula, and exi

209 In vitro, equol, but not daidzein, up-regulated eIF4G without affecting eIF4E or

210 Approximately 30% of the total genistein or daidzein was comprised of mixed conjugates (one glucuron

211 Further, daidzein was effective in promoting axonal regeneration

212 crease in urinary excretion of genistein and daidzein was observed in women but not in men during the

213 Genistein and daidzein were eliminated within 2 d in the healthy subje

214 early morning blood levels of genistein and daidzein were higher in seven dialysis patients than in

215 glycons of up to 22% of genistein and 18% of daidzein were observed.

216 ectively than the nonselective phytoestrogen daidzein, which effectively reproduced effects of estrog

217 crobial-derived metabolite of the isoflavone daidzein, which is produced in the large intestine after

218 lood levels of the isoflavones genistein and daidzein, while the remaining two-thirds have undetectab

219 ffected by the interaction of the intakes of daidzein with energy or with fiber.