ライフサイエンスコーパス: daidzin

1 bited by ALDH inhibitors chloral hydrate and daidzin.

2 ochondria as the potential site of action of daidzin.

3 (DOPAL) which accumulate in the presence of daidzin.

4 s well, which accumulates in the presence of daidzin.

5 s and mediates the antidipsotropic effect of daidzin.

6 a series of synthetic structural analogs of daidzin.

7 Daidzin, a major active principle of an ancient Chinese

8 Synthetic daidzin added to the RP extract acquires the bioavailabi

9 The structure of daidzin/ALDH2 in complex at 2.4 A resolution shows the i

10 finding that it is bacterially derived from daidzin, an isoflavone abundant in soy foods, led to the

11 Daidzin analogs that suppress hamster ethanol intake als

12 Daidzin analogues that potently inhibit ALDH-2 but have

13 Daidzin analogues that potently inhibit ALDH-2 but have

14 +/-0.02 min(-1), 4.54+/-0.32 min, 60 min for daidzin and 0.16+/-0.02 min(-1), 2.28+/-0.11 min, 60 min

15 oked sample, while increased the contents of daidzin and daidzein and decreased the content of genist

16 Daidzin and daidzein shortened alcohol-induced sleep tim

17 ALDH-2 and MAO, we prepared 44 analogues of daidzin and determined their potencies for ALDH-2 and MA

18 ization mass spectrometry was used to detect daidzin and genistin after solid-phase extraction of the

19 on process significantly lowered contents of daidzin and genistin in 60min cooked sample, while incre

20 n, genistein, biochanin A, and two of which, daidzin and genistin, are glycosilated, in lentils and o

21 earity ranging from 0.1 to 5mg/L, except for daidzin and genistin, for which it ranged from 0.1 to 10

22 Daidzin and its active analogs, at concentrations that s

23 s possibility, we have studied the effect of daidzin and its analogs on 5-HT and DA metabolism in iso

24 Effects of daidzin and its structural analogues on the activities o

25 rom the graded dose-response curves for pure daidzin and RP extract daidzin are 23 and 2.3 mg per ham

26 we synthesized more structural analogues of daidzin and tested and compared their antidipsotropic ac

27 Puerarin, daidzin, and daidzein are 3 major isoflavonoid compounds

28 gh 48 h for compounds such as medicarpin and daidzin; and a lesser delayed and protracted response st

29 ponse curves for pure daidzin and RP extract daidzin are 23 and 2.3 mg per hamster per day, respectiv

30 A resolution shows the isoflavone moiety of daidzin binding close to the aldehyde substrate-binding

31 nts for the fact we previously observed that daidzin can suppress ethanol intake of this species with

32 Plasma daidzin concentration-time curves determined in hamsters

33 den hamsters was compared with that of crude daidzin contained in a methanol extract of Radix puerari

34 xtract cannot be accounted for solely by its daidzin content (22 mg/g).

35 This, together with the finding that daidzin does not affect the rates of mitochondria-cataly

36 d ALDH-2 inhibition by structural analogs of daidzin established a link between these two activities

37 DH2 and compared them to the ALDH2 inhibitor daidzin for selectivity against five ALDH1/2 isoenzymes.

38 procedure generally increased the amount of daidzin, genistin and daidzein, but decreased that of ge

39 quadratic on the length, moisture and on the daidzin, genistin and genistein content; linear on the f

40 genistein, and glycitein), and 9 glucosides (daidzin, genistin, glycitin, acetyldaidzin, acetylgenist

41 stein), their corresponding glycoside forms (daidzin, glycitin and genistin), and acetyl and malonyl

42 .p.injection indicate that the crude extract daidzin has approximately 10 times greater bioavailabili

43 ion for both the specificity and affinity of daidzin (IC50 =80 nM) and the affinity of analogues with

44 the methanol extract of RP assist uptake of daidzin in golden hamsters.

45 cytosolic isozyme is completely resistant to daidzin inhibition.

46 Daidzin is also a potent and selective inhibitor of huma

47 t appears that the antidipsotropic action of daidzin is not mediated by 5-HT (or DA) but rather by it

48 take-suppressive (antidipsotropic) action of daidzin is not mediated by the monoamines but rather by

49 Daidzin is the active principle in a herbal remedy for "

50 Daidzin is the major active principle in extracts of rad

51 These results show that (i) daidzin is the major active principle in methanol extrac

52 l product 7-O-glucosyl-4'-hydroxyisoflavone (daidzin), isolated from the kudzu vine ( Peruraria lobat

53 Thus, daidzin may act by inhibiting 5-HT and DA metabolism.

54 ive, are consistent with the hypothesis that daidzin may act via the mitochondrial MAO/ALDH pathway a

55 ween these two activities and suggested that daidzin may suppress ethanol intake by inhibiting ALDH-2

56 e suppression and raise the possibility that daidzin may, in fact, suppress ethanol intake of golden

57 The dose effect of pure daidzin on the suppression of ethanol intake in Syrian g

58 spectrometry failed to detect even traces of daidzin or genistin in plasma collected 1, 2, and 8 h af

59 mg of one of the isoflavone beta-glycosides (daidzin or genistin) or 250 mL soymilk containing mainly

60 hamsters administered various doses of pure daidzin or RP extract by i.p.injection indicate that the

61 Daidzin potently inhibits the formation of 5-hydroxyindo

62 or pure and crude daidzin using bioavailable daidzin rather than administered dose gives a single cur

63 In addition to daidzin, six other isoflavones were identified in the RP

64 AC) formation by six structural analogues of daidzin suggested a potential link between these two act

65 Recent studies showed that daidzin suppresses ethanol intake in ethanol-preferring

66 Thus, the mechanism by which daidzin suppresses ethanol intake in golden hamsters cle

67 quires the bioavailability of the endogenous daidzin that exists naturally in the extract.

68 Recently we have shown that daidzin, the major active principle of an ancient herbal

69 the dose-response effects for pure and crude daidzin using bioavailable daidzin rather than administe

70 indicated that the suppression of the BAC by daidzin was due mainly to delay of stomach emptying.

71 At least 10% of ingested daidzin was excreted in urine as equol conjugate in one

72 BACs also receded more slowly if daidzin was fed to the animals.

73 When daidzin was given to animals intragastrically with the e

74 Genistin and Daidzin were the major isoflavones in all samples.