ライフサイエンスコーパス: damage checkpoint

1 agents, even in mutants defective in the DNA damage checkpoint.

2 uired for replisome assembly and for the DNA damage checkpoint.

3 repair before the execution of an intact DNA damage checkpoint.

4 otic response of the conserved pachytene DNA damage checkpoint.

5 but they are compromised for the G(2)/M DNA damage checkpoint.

6 plication and subsequently arrest at the DNA damage checkpoint.

7 l cycle because of the activation of the DNA damage checkpoint.

8 the G(2) phase, thereby attenuating the DNA damage checkpoint.

9 termines the activation threshold of the DNA damage checkpoint.

10 e-strand breaks (DSBs) that activate the DNA-damage checkpoint.

11 lex, but they maintain an intact S phase DNA damage checkpoint.

12 recovery or when the cells adapt to the DNA damage checkpoint.

13 A lesions and subsequent activation of a DNA-damage checkpoint.

14 that is the effector molecule in the G2 DNA damage checkpoint.

15 in gamma-H2AX induction, or an abrogated DNA damage checkpoint.

16 miR-106b overrides a doxorubicin-induced DNA damage checkpoint.

17 ks (DSBs), eukaryotic cells activate the DNA damage checkpoint.

18 as cells are unable to recover from the DNA damage checkpoint.

19 tion fork collapse that activates the G2 DNA damage checkpoint.

20 s a stable G2 arrest requiring an intact DNA damage checkpoint.

21 ell-established signal transducer in the DNA damage checkpoint.

22 sms to respond to DNA damage, termed the DNA damage checkpoint.

23 ation due to increased activation of the DNA damage checkpoint.

24 s that recapitulates key elements of the DNA damage checkpoint.

25 origins of replication, and inhibits the DNA damage checkpoint.

26 tinguished from DNA breaks that activate DNA damage checkpoint.

27 ation results in a defect in the S phase DNA damage checkpoint.

28 teins were found to be controlled by the DNA damage checkpoint.

29 s and also functions in the ATR-mediated DNA damage checkpoint.

30 tion of the metabolic checkpoint and the DNA damage checkpoint.

31 ated by cyclin-dependent kinases and the DNA damage checkpoint.

32 ucleosome dynamics is independent of the DNA damage checkpoint.

33 rt of the MBF core, is the target of the DNA damage checkpoint.

34 dimer is essential for establishing the DNA damage checkpoint.

35 le checkpoint but instead depends on the DNA damage checkpoint.

36 m DNA double-strand breaks that activate DNA damage checkpoints.

37 agents and play a role in activation of DNA damage checkpoints.

38 to facilitate repair by HR and regulate DNA damage checkpoints.

39 ate DNA damage and to activate host cell DNA damage checkpoints.

40 /Chk1 to promote efficient activation of DNA damage checkpoints.

41 are also important for the activation of DNA damage checkpoints.

42 double-strand breaks (DSBs) to regulate DNA damage checkpoints.

43 central anti-tumorigenic function of the DNA damage checkpoints.

44 equires interdependence with mediator of DNA damage checkpoint 1 (MDC1) and H2AFX.

45 duced gammaH2AX foci recruit mediator of DNA damage checkpoint 1 (MDC1) and p53 binding protein 1 (53

46 se (DDR) proteins, including mediator of DNA damage checkpoint 1 (Mdc1) and p53 binding protein 1 (53

47 eaks and associates with the mediator of DNA damage checkpoint 1 (MDC1) and the ataxia telangiectasia

48 omplex components (MCMs) and mediator of DNA damage checkpoint 1 (MDC1) expression.

49 We show that mediator of DNA damage checkpoint 1 (MDC1), a binding partner of phospho

50 together with recruitment of mediator of DNA damage checkpoint 1 (MDC1), and the Mre11-Rad50-Nbs1 (MR

51 ylated H2AX (gammaH2AX), and mediator of DNA damage checkpoint 1 (MDC1), as well as components of pre

52 damage factors such as NBS1, mediator of DNA damage checkpoint 1 (MDC1), RNF8, 53BP1, and BRCA1.

53 X, also known as H2AFX)- and mediator of DNA damage checkpoint 1 (MDC1)-dependent events.

54 cylation of histone H2AX and mediator of DNA damage checkpoint 1 (MDC1).

55 blocks recruitment of MDC1 (mediator of DNA damage checkpoint 1) and 53BP1 (p53 binding protein 1) t

56 by gamma-H2AX and by MDC-1 (mediator of DNA damage checkpoint 1), which binds to gamma-H2AX in chrom

57 phosphorylated histone 2AX, mediator of DNA-damage checkpoint 1, and p53 binding protein 1, at DSBs

58 rand breaks (DSBs) and activation of the DNA damage checkpoint [2-7].

59 ransformation by enabling cells to evade DNA damage checkpoints activated by oncogenic stimuli.

60 s error-prone in this context because of DNA damage checkpoint activation and base pair lesions and u

61 ese data demonstrate that L1CAM augments DNA damage checkpoint activation and radioresistance of GSCs

62 the recruitment of factors critical for DNA damage checkpoint activation and repair by homologous re

63 ing L1CAM by RNA interference attenuated DNA damage checkpoint activation and repair, and sensitized

64 s, we found that H3K14ac is critical for DNA damage checkpoint activation by directly regulating the

65 eoprotein aggregates form in response to DNA damage checkpoint activation in egg chambers of females

66 y passage primary MEFs is antagonized by DNA damage checkpoint activation, consistent with nuclear cy

67 ection, the generation of ssDNA, affects DNA damage checkpoint activation, DNA repair pathway choice,

68 ckdown is independent of p53 activation, DNA damage checkpoint activation, or changes in the AKT path

69 egulates RAD53 transcription to suppress DNA damage checkpoint activation.

70 result from Chk-2 (checkpoint kinase-2) DNA damage checkpoint activation.

71 ack loop to limit ssDNA accumulation and DNA damage checkpoint activation.

72 hTERT-RPE1 clones displayed evidence of DNA-damage checkpoint activation.

73 dependent on ATM-, but not ATR-mediated DNA damage checkpoint activation.

74 he metabolic conversion of ANI-7 induces DNA damage, checkpoint activation, S-phase cell cycle arrest

75 acetylation of the ATM kinase, promoting DNA-damage-checkpoint activation and cell survival.

76 s required for rapid inactivation of the DNA damage checkpoint after DSB repair.

77 chronic activation of the ATM-dependent DNA-damage checkpoint and accumulation of a discrete single-

78 r of Mre11 at DNA ends, shutting off the DNA damage checkpoint and allowing cell cycle progression.

79 Cs) display a preferential activation of DNA damage checkpoint and are relatively resistant to radiat

80 15 ablation potentiated induction of the DNA damage checkpoint and cancer cell death by 6-thioguanine

81 reak (DSB) is sufficient to activate the DNA damage checkpoint and cause Saccharomyces cells to arres

82 n ART-27 depletion include regulators of DNA damage checkpoint and cell cycle progression, suggesting

83 3 gene is dependent on activation of the DNA damage checkpoint and chromatin remodelling by SWI/SNF.

84 aling abrogates the activation of the G2 DNA damage checkpoint and confers specific sensitization of

85 tants were associated with activation of DNA damage checkpoint and depletion of dNTP concentrations t

86 that is essential for activation of the DNA damage checkpoint and DNA repair by homologous recombina

87 re involved in the maintenance of a G2/M DNA damage checkpoint and DNA repair mediated by the nonhomo

88 A damage by concurrently attenuating the DNA damage checkpoint and DNA repair, resulting in polyploid

89 ivation of these kinases from the G(2)/M DNA damage checkpoint and efficient checkpoint recovery.

90 at late activation of Notch triggers the DNA damage checkpoint and G2/M interphase arrest.

91 This sustains the DNA damage checkpoint and is suppressed by Rad53 phosphoryla

92 rol the activity of cyclin A at the G(1) DNA damage checkpoint and may thereby prevent S-phase entry

93 tein complex that impacts mammalian G2/M DNA damage checkpoint and NHEJ.

94 UmuD is implicated in a primitive DNA damage checkpoint and prevents DNA polymerase IV-depende

95 DNA damage checkpoint and recombinational repair are both im

96 s loading mechanism and association with DNA damage checkpoint and repair enzymes.

97 ex at DSBs occurs independently of known DNA damage checkpoint and repair proteins.

98 Mec1-Ddc2 (ATR-ATRIP) controls the DNA damage checkpoint and shows differential cell-cycle regu

99 ls that fail to launch a robust G2 phase DNA damage checkpoint and that this renders them sensitive t

100 A turnover through the activation of the DNA-damage checkpoint and the Aft1/Aft2-controlled iron regu

101 In budding yeast, both the DNA damage checkpoint and the spindle assembly checkpoint (S

102 n kinase Rad53 is a key regulator of the DNA damage checkpoint and uses its two FHA domains to intera

103 licase displayed increased activation of DNA damage checkpoints and genomic instability.

104 tect telomeres against activation of the DNA damage checkpoints and recombinational repair.

105 n essential factor for the initiation of DNA damage checkpoints and the maintenance of genomic stabil

106 ity to recruit telomerase, activates the DNA damage checkpoint, and loses heterochromatin at telomere

107 ific DSBs, fail to properly activate the DNA-damage checkpoint, and show genetic interactions with DS

108 rid mutant viability is dependent on the DNA damage checkpoint, and surprisingly Mrc1, a protein requ

109 lization of Claspin, an activator of the DNA-damage checkpoint, and Wee1, an inhibitor of cell-cycle

110 p21, which promotes cell-cycle arrest at DNA damage checkpoints, and Gadd45 and p53R2, with pivotal r

111 umulated oxidative DNA damage, activated DNA damage checkpoints, and showed G1-phase arrest at atmosp

112 B repair and the deoxyribonucleic acid (DNA) damage checkpoint are unclear.

113 Although DNA damage checkpoints are broadly activated in response to

114 ting in inefficient gene conversion and G2/M damage checkpoint arrest.

115 0 is required to allow the adaptation of DNA damage checkpoint-arrested cells with an unrepaired DSB

116 G2/M DNA damage checkpoint, ATM signaling, mitochondrial dysfunct

117 Obfc2b does not affect the initiation of DNA damage checkpoints, Atm activation, or the maintenance o

118 This process is regulated by the DNA damage checkpoint, because RFWD3 is phosphorylated by AT

119 t the requirements for recovery from the DNA damage checkpoint become more stringent with increased l

120 only on Mec1 and other components of the DNA damage checkpoint but also on the presence of the centro

121 hality that is dependent on the upstream DNA damage checkpoint but independent of the downstream core

122 process resulting from activation of the DNA damage checkpoint by an ATR-regulated pathway, which fun

123 r with UmuC, plays a role in a primitive DNA damage checkpoint by decreasing the rate of DNA synthesi

124 ere we review how impaired DNA-repair or DNA-damage checkpoints can lead to genetic instability and p

125 s of spindle-class females, an activated DNA damage checkpoint causes inefficient Grk translation and

126 ls compromised in DNA repair pathways or DNA damage checkpoints, cells reliant on homologous recombin

127 The DNA damage checkpoint clamp (the 9-1-1 complex) has been rep

128 The yeast DNA damage checkpoint clamp Ddc1-Mec3-Rad17 (human Rad9-Hus1

129 der, replication factor C (RFC), and the DNA damage checkpoint clamp loader, Rad24-RFC, using two sep

130 progression is reduced in the absence of DNA damage checkpoint components and nonhomologous end-joini

131 ncogenic transformation, and hyperactive DNA damage checkpoints, consistent with upregulated levels a

132 on down-regulation was associated with a DNA damage checkpoint consisting of p53, p21, and endothelia

133 The DNA damage checkpoint, consisting of an evolutionarily conse

134 microcephaly, plays an important role in DNA damage checkpoint control and mitotic entry.

135 ity of HPV-16 E7 involves attenuation of DNA damage checkpoint control by accelerating the proteolyti

136 we show that the CHK2 (CHEK2)-dependent DNA damage checkpoint culls not only recombination-defective

137 n cell-cycle progression enforced by the DNA-damage checkpoint (DDC) signalling pathway positively co

138 signal transduction cascade known as the DNA damage checkpoint (DDC).

139 Despite the underlying DNA damage checkpoint defects, increased DNA damage signalin

140 r of cells after they have experienced a DNA damage checkpoint delay is poorly characterized.

141 we define a role for MRN in the S-phase DNA damage checkpoint-dependent slowing of replication that

142 various cellular processes including the DNA damage checkpoint, DNA repair, and transcription.

143 rc1 experience chronic activation of the DNA damage checkpoint during chromosome replication and do n

144 Such pathways, along with DNA-damage checkpoints, ensure that either the damage is pro

145 streplication repair complex, downstream DNA-damage checkpoint factors (Rad53, Chk1, and Dun1), or th

146 rized genes, including mRNA splicing and DNA damage checkpoint factors.

147 ability that was associated with S-phase DNA damage checkpoint failure.

148 ve been known to be downregulated by the DNA damage checkpoint for many years.

149 homologous recombination repair and the DNA damage checkpoint for viability.

150 Aberrant regulation of DNA damage checkpoint function leads to genome instability t

151 We found that Dss1p and Rae1p have a DNA damage checkpoint function, and upon treatment with UV l

152 ork metabolism, are required for S-phase DNA damage checkpoint function.

153 7 in either activation or termination of DNA damage checkpoint function.

154 ed by disruption of either MEC1 or RAD53 DNA damage checkpoint genes, as well as the lethality seen w

155 es this phenotype because it can repress DNA damage checkpoint genes.

156 AFs), Asf1 and CAF-1, in turning off the DNA damage checkpoint in budding yeast.

157 imate lentiviruses, arrests cells at the DNA damage checkpoint in G2 phase of the cell cycle, but the

158 Finally, we suggest escaping this DNA damage checkpoint in maternal ageing may be one of the c

159 s display a significant defect in G(2)/M DNA damage checkpoint in response to ionizing radiation (IR)

160 Previous work on the DNA damage checkpoint in Saccharomyces cerevisiae has shown

161 d4(TopBP1) facilitates activation of the DNA damage checkpoint in Schizosaccharomyces pombe by physic

162 eatment, and the noted abrogation of the DNA damage checkpoint in the MTA1-depleted cells may be, at

163 in is also required for the integrity of DNA damage checkpoints in somatic cells, where cohesin loadi

164 initiation can lead to activation of the DNA damage checkpoint independent of the intra-S phase check

165 one example, a pathway-based screen for DNA damage checkpoint inhibitors identified a compound, MARP

166 The G2 DNA damage checkpoint inhibits Cdc2 and mitotic entry throug

167 d conditions and the DNA replication and DNA damage checkpoints into a single transcriptional complex

168 However, it remains unclear how the DNA damage checkpoint is activated by oxidative stress at th

169 This lack of an efficient DNA damage checkpoint is because oocytes fail to effectively

170 nt when a DSB is slowly repaired and the DNA damage checkpoint is fully activated.

171 t mechanism of how an ATR-Chk1-dependent DNA damage checkpoint is mediated by APE2 in the oxidative s

172 ng yeast (Saccharomyces cerevisiae), the DNA damage checkpoint is regulated by a signaling cascade of

173 aintains proliferation despite activated DNA damage checkpoints is incompletely understood.

174 Thus, SAC, much like the DNA damage checkpoint, is essential for genome stability.

175 t kinase 1 (Chk1), a component of the G2 DNA damage checkpoint, is important in the resistance of nor

176 ing agents is independent of the replication damage checkpoint kinase ataxia telangiectasia-mutated a

177 ed by mutations in the gene encoding the DNA damage checkpoint kinase ATM, is characterized by multis

178 oration causes DNA damage that activates the damage checkpoint kinase Chk1 and sensitizes cells to UV

179 ks the serine 345 phosphorylation of the DNA damage checkpoint kinase Chk1 by Rad3 (ATR) at broken re

180 sitive to single-agent inhibition of the DNA damage checkpoint kinase Chk1, leading us to examine dow

181 The DNA damage checkpoint kinase Mec1(ATR) is critical for maint

182 mour cells to clinical inhibitors of the DNA damage checkpoint kinase, ATR, both in vitro and in vivo

183 nuclear foci and activation of the Rad53 DNA damage checkpoint kinase, indicating that the toxicity i

184 r suppressor genes Egr1 and JunB and the DNA damage checkpoint kinase, polo-like kinase 2 (Plk2) as d

185 ei from syncytial blastoderm embryos via DNA damage checkpoint kinase-mediated retention of specific

186 we show that, in the absence of induced DNA damage, checkpoint kinase-1 (CHK1), an enzyme essential

187 the existing knowledge of the targets of DNA damage checkpoint kinases and provides insights into the

188 nse to DNA damage is orchestrated by the DNA damage checkpoint kinases ATAXIA TELANGIECTASIA MUTATED

189 core component of NHEJ, partnering with DNA-damage checkpoint kinases ataxia telangiectasia mutated

190 y in vivo kinase substrates of the yeast DNA damage checkpoint kinases Mec1, Tel1, and Rad53 (ortholo

191 In normal cells, p53 is activated by DNA damage checkpoint kinases to simultaneously control the

192 e phosphorylations were dependent on the DNA damage checkpoint kinases, Mec1/Tel1 and Rad53.

193 DK), Dbf4-dependent kinase (DDK) and the DNA damage checkpoint kinases.

194 The results suggest that defects in DNA damage checkpoints may be recognized in melanomas throug

195 ains with deletions of both ISC1 and the DNA damage checkpoint mediator gene RAD9 display reduced mor

196 In the S-phase DNA damage checkpoint, MRN acts both in activation of checkp

197 Novel targeted therapies against the DNA damage checkpoint or stem-cell maintenance pathways may

198 Recently, strategies aimed at targeting DNA damage checkpoints or DNA repair processes have demonstr

199 GR are not achieved by either activating DNA damage checkpoints or regulating the expression of the G

200 We propose that the DNA damage checkpoint pathway coordinates resection and nucl

201 We find the DNA damage checkpoint pathway facilitates HR, in part, by pr

202 The DNA damage checkpoint pathway governs how cells regulate cel

203 ear extensions, whereas inactivating the DNA damage checkpoint pathway in a DNA repair mutant reduced

204 Here we identify roles for the DNA damage checkpoint pathway in facilitating homologous rec

205 The DNA damage checkpoint pathway is activated in response to DN

206 he Chk2-mediated deoxyribonucleic acid (DNA) damage checkpoint pathway is important for mitochondrial

207 MTA1 also participates in the UV-induced DNA damage checkpoint pathway remains unknown.

208 etermine whether reduced activity in the DNA damage checkpoint pathway would cooperate with MMR defic

209 As a central component of the DNA damage checkpoint pathway, the conserved protein kinase

210 functions as a mediator in the ATR-Chk1 DNA damage checkpoint pathway.

211 ticipates in the UV-induced ATR-mediated DNA damage checkpoint pathway.

212 a cells and relieves the reliance on the DNA damage checkpoint pathway.

213 DNA damage checkpoint pathways operate to prevent cell-cycle

214 ion fork protection, and DNA replication/DNA damage checkpoint pathways.

215 (DSB) repair, meiotic recombination, and DNA damage checkpoint pathways.

216 cation upon Emi1 depletion activates the DNA damage checkpoint pathways.

217 Although the DNA damage checkpoint PI3-kinases ATM and ATR localize to te

218 The DNA damage checkpoint plays a crucial role in maintaining fu

219 Pds1p stabilization by the spindle or DNA damage checkpoints prevents sister-chromatid separation

220 pha mutant activated the ATM/R-dependent DNA damage checkpoint, probably due to reduced catalytic act

221 ere it plays a key role in advancing the DNA damage checkpoint process.

222 docking site to recruit the mediator of DNA damage checkpoint protein 1 (MDC1) and DNA repair protei

223 Mediator of DNA damage checkpoint protein 1 (MDC1) is an early and key c

224 interact with phosphorylated mediator of DNA damage checkpoint protein 1 (phospho-MDC1) or E3 ubiquit

225 le checkpoint proteins MDC1 (mediator of DNA damage checkpoint protein 1) and BRCA1 (breast cancer pr

226 he DDR factors because MDC1 (mediator of DNA damage checkpoint protein 1), which normally binds to ga

227 have found that TRF2 interacts with the DNA damage checkpoint protein Chk2.

228 shed that Cdc2 kinase phosphorylates the DNA damage checkpoint protein Crb2(53BP1) in mitosis, the fu

229 The DNA damage checkpoint protein Hus1 associates with Rad9 and

230 53BP1, first identified as a DNA damage checkpoint protein, and BRCA1, a well-known breas

231 rate that by fusing AtCRY2 to the TopBP1 DNA damage checkpoint protein, light-induced AtCRY2 PBs can

232 Mediator of DNA Damage Checkpoint protein, MDC1, and H2AX are chromatin

233 A, XPC, TFIIH, XPG, and XPF-ERCC1), core DNA damage checkpoint proteins (ATR-ATRIP, TopBP1, RPA), and

234 Here, we find that within minutes of DNA damage checkpoint proteins are assembled at the kinetoch

235 The requirement for specific DNA-damage checkpoint proteins suggests roles in recruiting

236 The molecular pathways linking DNA-damage checkpoint proteins to cell-cycle progression rem

237 omotes DSB processing and recruitment of DNA damage checkpoint proteins, thus implicating cohesin in

238 binding by homologous recombination and DNA damage checkpoint proteins.

239 In response to DNA damage, checkpoint proteins halt cell cycle progression

240 LK1 at threonine 210, a prerequisite for DNA damage checkpoint recovery, remained detectable followin

241 its degradation plays a critical role in DNA damage checkpoint recovery.

242 ogress has advanced our understanding of DNA damage checkpoint regulations, little is known as to how

243 chromatin remodeling complexes regulate DNA damage checkpoints remain unclear.

244 Activation of DNA damage checkpoints requires the rapid accumulation of nu

245 damage cause a metabolic checkpoint and DNA damage checkpoint, respectively.

246 berrant replication, and activation of a DNA damage checkpoint response (DDR), rendering therapeutic

247 and Rad5) and in the early steps of the DNA-damage checkpoint response (Rad17, Mec3, Ddc1, Mec1, and

248 itin-ligase CRL4 controls cell cycle and DNA damage checkpoint response and ensures genomic integrity

249 e signal that activates the ATR-mediated DNA damage checkpoint response and that the signal is enhanc

250 The DNA damage checkpoint response delays cell cycle progression

251 etic agent to analyze the basic steps of DNA damage checkpoint response in a biochemically defined sy

252 s genetically interact with genes in the DNA damage checkpoint response pathway and in the insulin si

253 es signaling through the Chk1 arm of the DNA damage checkpoint response via recruitment and stimulati

254 However, no deficiencies in DNA damage checkpoint response were detected in Cdc14b mutan

255 ion for IKK and NF-kappaB modulating the DNA-damage checkpoint response, allowing the cell to integra

256 hesin is involved in both DSB repair and the damage checkpoint response, although the relationship be

257 tide damage repair, mismatch repair, and DNA damage checkpoint response, but its function in DNA doub

258 se many activated oncoproteins trigger a DNA damage checkpoint response, which serves as a barrier to

259 cycle regulation is also observed in the DNA damage checkpoint response.

260 ssential set of factors for ATR-mediated DNA damage checkpoint response.

261 otein that coordinates activation of the DNA-damage-checkpoint response by coupling binding of the 9-

262 rigins become active despite an elevated DNA damage-checkpoint response.

263 Chk1 is a key regulator of DNA damage checkpoint responses and genome stability in euka

264 amage through preferential activation of DNA damage checkpoint responses and increased capacity for D

265 hat the HPV-16 E7 oncoprotein alleviates DNA damage checkpoint responses and promotes mitotic entry b

266 re, we show that L1CAM (CD171) regulates DNA damage checkpoint responses and radiosensitivity of GSCs

267 yclin D1b was not sufficient to abrogate DNA damage checkpoint responses, it did efficiently overcome

268 t L1CAM signals through NBS1 to regulate DNA damage checkpoint responses.

269 DNA repair processes, but does influence DNA damage checkpoint responses.

270 (MRN), thereby repressing ATM-dependent DNA damage checkpoint responses.

271 to dissect MRN's ATM-independent S-phase DNA damage checkpoint roles from its role in ATM activation.

272 s that are essential for the assembly of DNA damage checkpoint signaling and DNA repair protein compl

273 t replication intermediates to attenuate DNA damage checkpoint signaling and prevent pathological imm

274 tical feature of the human ATR-initiated DNA damage checkpoint signaling has not been demonstrated in

275 osphorylation of Rad53 when the upstream DNA damage checkpoint signaling is turned off.

276 form bulky lesions on DNA that activate DNA damage checkpoint signaling pathways in human cells.

277 Chk1 is widely known as a DNA damage checkpoint signaling protein.

278 In fission yeast, DNA damage checkpoint signaling requires Rad3, the homolog o

279 mutated and Rad3-related (Atr)-mediated DNA damage checkpoint signaling, including activation of the

280 s the processing and repair of DSBs with DNA damage checkpoint signalling, preserving genome integrit

281 In response to DNA damage, checkpoint signalling protects genome integrity

282 ein kinase is an important transducer of DNA damage checkpoint signals, and its mutation contributes

283 Here we show that the conserved DNA damage checkpoint sliding clamp (the 9-1-1 complex) play

284 The S-phase DNA damage checkpoint slows the rate of DNA synthesis in res

285 ch is required for the activation of the DNA damage checkpoint, suggesting that this checkpoint plays

286 Damage checkpoint systems cause cell cycle arrest, promo

287 o damaged DNA, leading to both premature DNA damage checkpoint termination and inhibition of DNA repa

288 tic genome integrity is maintained via a DNA damage checkpoint that recognizes DNA damage and halts t

289 ein kinase that is a key mediator of the DNA damage checkpoint that responds to DNA double-strand bre

290 nbroken chromosomes, suggesting that the DNA damage checkpoint through Eco1 provides genome-wide prot

291 ed and damaged DNA, these cells evade the G2 damage checkpoint to form ultrafine bridges, fragmented

292 processes that include activation of the DNA damage checkpoint, transient cell cycle arrest, DNA dama

293 hat loss of miRNA biogenesis activates a DNA damage checkpoint, up-regulates p19(Arf)-p53 signaling,

294 It seems that DNA damage checkpoints were not reactivated in cells that ov

295 ks (DSBs), eukaryotic cells activate the DNA damage checkpoint, which is orchestrated by the PI3 kina

296 was associated with activation of a G2/M DNA damage checkpoint, which prevented activation of the cyc

297 In Saccharomyces cerevisiae, the DNA damage checkpoint, which responds to lesions such as dou

298 -strand breaks (DSBs), and activation of DNA damage checkpoints, which in primary human cells leads t

299 DNA repair and DNA damage checkpoints work in concert to help maintain geno

300 , cells with DNA damage that override the G2 damage checkpoint would precociously enter mitosis and u