ライフサイエンスコーパス: damage in

1 r reversed glomerular and tubulointerstitial damage in 1,25-vitamin D3-deficient animals, thereby pre

2 sure of skin pattern (microtopography score) damage in 1,671 twin pairs and 1,745 singletons (N = 5,0

3 Overall, flood damage in 34 out of 48 investigated states can be predic

4 es (25%) and 5 eyes (31%) (P = .73), corneal damage in 8 eyes (29%) and 6 eyes (38%) (P = .34), and e

5 c damage, pneumolysin contributes to cardiac damage in a bacterial strain-specific manner, and pneumo

6 tes systemic inflammation and multiple organ damage in a clinically relevant model of sepsis.

7 riant are associated with liver fibrosis and damage in a large multicenter cohort of patients at risk

8 during the current study, to ameliorate lung damage in a murine VILI model.

9 nce in two species, prevents lung and kidney damage in a rat model of acute pancreatitis, and is prog

10 y generating localized telomere-specific DNA damage in a real-time fashion and a dose-dependent manne

11 luding their ability to induce target tissue damage in a unique in vitro human graft-versus-host dise

12 Twinkle helicase is inhibited by DNA damage in a unique manner that is dependent on the type

13 so phosphorylated by CDK2, in the absence of damage, in a cell cycle-dependent manner and we identify

14 In ischaemia myelin is damaged in a Ca(2+)-dependent manner, abolishing action

15 materials that when punctured, cut, shot or damaged in a variety of ways, are capable of autonomousl

16 immune diseases, and for preventing neuronal damage in acute neuronal injury and chronic neurodegener

17 ain, hyperglycemia aggravates ischemic brain damage in acute stroke.

18 In vitro, DNA damage in adipocytes increased the expression of chemoki

19 mage, suggesting poly(GR) contributes to DNA damage in aged C9ORF72 neurons.

20 The role of DNA damage in aging and age-related diseases is illustrated

21 rangement in exacerbating postburn end organ damage in alcohol-exposed mice.

22 demonstrated to influence histological liver damage in alcoholic liver disease, nonalcoholic fatty li

23 No single brain region was damaged in all cases.

24 evelop in two steps and may help to restrict damage in Alzheimer and related diseases.

25 abine in inducing DNA replication stress and damage in AML cell lines.

26 ochondrial elimination and increased cardiac damage in an animal model of heart attack.

27 meres and stabilizes TRF1 at telomeres after damage in an ATM activation-dependent manner.

28 zation protected mice from lethal intestinal damage in an IL-10-IL-10R-dependent manner.

29 which likely facilitates recognition of DNA damages in an RNA/DNA complementary strand-specific mann

30 motes glomerular neutrophil accumulation and damage in anti-glomerular basement membrane-induced (ant

31 The endothelial damage in atherosclerotic carotid arteries was assessed

32 e to the induction and perpetuation of liver damage in autoimmune hepatitis (AIH) and autoimmune scle

33 s an essential process for responding to DNA damage in bacteria.

34 tent of oxidative stress-induced periodontal damage in both CP and AgP.

35 dysfunction, possibly leading to excitotoxic damage in both EAE and MS diseases.

36 Sodium naproxen induced gastric damage in both groups.

37 These results suggest that DR induces damage in both KEs and PFs, and especially affects proxi

38 nt mice were more susceptible to acute liver damage in both models.

39 that ATM deficiency leads to persistent DNA damage in both precancerous lesions and primary tumors.

40 he corticospinal tract was most likely to be damaged in both subgroups.

41 es and Southeast England were the most badly damaged in both trial sites.

42 cit in the CM patients was best explained by damage in brain areas activated during handgrip.

43 nhibition, can increase chemotherapy-induced damage in BRCA-competent cells.

44 ies do not yet exist that can replicate this damage in bulk materials.

45 Mechanistically, doxorubicin-induced DNA damage in c-kit(+) cells resulted in expression of p53.

46 on of oxidative stress partially rescued DNA damage in C9ORF72 neurons and control neurons expressing

47 ors, and they produce significantly more DNA damage in cancer cells than in normal cells.

48 mtDNA damage in cardiac myocytes resulting from increased oxid

49 in the heart preceded visual signs of tissue damage in cardiac tissue sections stained with hematoxyl

50 d detrimental effects, including endothelial damage, in cardiac surgical patients with prolonged CPB

51 ase, MDMX depletion was synergistic with DNA damage in causing cell death, whereas in the second phas

52 lutants (POPs) in the induction of oxidative damage in cell structures, this issue has been poorly ad

53 ed restart of collapsed forks and led to DNA damage in cells experiencing DRS.

54 rtant factor contributing to increased flood damage in central US while urbanland exhibits positive a

55 iminating microbes but may cause host tissue damage in certain disease contexts, including sepsis.

56 ruzi infection have been used to study heart damage in Chagas disease.

57 ore-accurate non-invasive markers of mucosal damage in children and adults with celiac disease who ar

58 2 innate immunity for restricting UGT tissue damage in Chlamydia-infected mice, and in initial studie

59 n of hepatic CES2 causes liver steatosis and damage in chow- or Western diet-fed C57BL/6 mice.

60 o the discovery and efficient repair of base damage in chromatin.

61 easily accessible biomarker of early axonal damage in CIS and MS.

62 ential targets to dampen inflammatory tissue damage in clinical scenarios of severe systemic infectio

63 inflammation but the mechanisms causing BBB damage in CNS TB are uncharacterized.

64 n and prevents structural bone and cartilage damage in collagen antibody-induced arthritis.

65 s showed widespread superficial white matter damage in comparison to recovered patients and healthy c

66 ndervalue regional and spatially distributed damages in compensation algorithms.

67 e fatty acids as the cause for mitochondrial damage in consequence of peroxisome loss in Pex19 mutant

68 tion of the antenna complexes from oxidation damage in contaminated trees, providing an insight into

69 A considerable increase in flood damage in CONUS is recorded for the study period which i

70 ed cumulative characteristics of periodontal damage in CP.

71 a p53/PINCR/Matrin 3 axis in response to DNA damage in CRC cells.

72 Heart and kidney damage in CRS2 results predominantly from chronic stimul

73 The formation of stable radiation damage in crystalline solids often proceeds via complex

74 DAC1) was shown previously to precede axonal damage in culture, but the in vivo relevance of these fi

75 on and axonal growth, and increased neuronal damage in cultured rat cortical neurons.

76 ter (WM) macrostructural and microstructural damage in demented patients compared with controls.

77 health concern because of its link to brain damage in developing human fetuses.

78 mulate and promote inflammation and vascular damage in diabetes.

79 ntributed to increased myocardial structural damage in diabetic female rats.

80 ferences in the location and extent of brain damage in different patient groups.

81 immune defences, antioxidants and oxidative damage in different tissues vary along the urbanization

82 uring chromosome segregation, triggering DNA damage in diploid daughter cells and elevated ploidy.

83 their association with progressive glomeruli damage in disease states.

84 infection by restricting inflammation-driven damage in distant tissues.

85 sease (DKD), but their contribution to organ damage in DKD remains largely unknown.

86 y be important for the late onset of cardiac damage in DMD.

87 ouse model in which the mitochondrial DNA is damaged in dopaminergic neurons.

88 duction in the spinal cord and oxidative DNA damage in dorsal horn neurons.

89 s the repair of ultraviolet (UV)-induced DNA damage in E-cadherin-inhibited cells.

90 n of intervention strategies to prevent lung damage in early cystic fibrosis (CF) requires objective

91 viral cytopathology and immune-mediated cell damage in ebolavirus disease often result in severe comp

92 mutant (kinase dead) had no effect on mtDNA damage in either midbrain or cortical neuronal cultures.

93 ed on our results, chronic right ventricular damage in elite endurance master athletes with lifelong

94 induce p53-dependent senescence without DNA damage in endothelial cells.

95 Seizure-driven brain damage in epilepsy accumulates over time, especially in

96 aranase contributes to proteinuria and renal damage in experimental glomerulonephritis by decreasing

97 ngs highlight the significance of nonnuclear damage in FA injury and reveal a major role for immunopr

98 od and was paralleled by decreased oxidative damage in fat and liver.

99 that pancreatic enzymes contribute to tissue damage in fatal EVD, and suggest that Ebola virus infect

100 led a high predisposition to stretch-induced damage in fiber bundles of R349P mice.

101 activation does not occur in response to DNA damage in fully mature eggs during meiosis II, despite t

102 ation and accumulation of CFS-associated DNA damage in G1 cells.

103 The formation of radiation damage in Ge above room temperature is dominated by comp

104 e role of tau in retinal ganglion cell (RGC) damage in glaucoma.

105 purinergic signaling contributes to podocyte damage in GN.

106 VA combinations also cause extensive protein damage in HaCaT human keratinocytes.

107 s ex vivo.Repeated cell divisions induce DNA damage in haematopoietic stem cells (HSC) and telomeres

108 utant Htt-induced mitochondrial and synaptic damage in HD neurons, and these mitochondria-targeted mo

109 de protects against naproxen-induced gastric damage in healthy volunteers.

110 not protect against naproxen-induced gastric damage in healthy volunteers.

111 ed T-helper 1 cytokine-mediated inflammatory damage in heart.

112 is revealed that MMC treatment caused severe damage in highly replicating tissues of mice with partia

113 NK cell-targeted therapies to limit vascular damage in highly responsive sensitized patients.

114 njury in a model of severe antibody-mediated damage in highly sensitized recipients.

115 biomarkers of inflammation and neurological damage in HIV- subjects with CNS cryptococcosis may help

116 ART has reduced the severity of neurological damage in HIV-infected individuals, the likelihood of co

117 Formation and repair of UV-induced DNA damage in human cells are affected by cellular context.

118 Track structures and resulting DNA damage in human cells have been simulated for hydrogen,

119 suppressed ZIKV infection and reduced tissue damage in human cortical organoids and the embryonic bra

120 that could be harnessed to minimize hypoxic damage in human disease.

121 satinib therapy causes pulmonary endothelial damage in humans and rodents.

122 rther to prevent acute alcohol-induced liver damage in humans.

123 Our model is focused on the damage in hyaluronan (HA), which is the main structural

124 red for myeloid cell recruitment and tubular damage in I/R injury is unknown.

125 ls expressing IGF-1R, externally induced DNA damage in IGF-1R-negative cells caused G1 cell cycle arr

126 fibrils has been suggested to cause membrane damage in in vitro model phospholipid membrane systems a

127 fied markers strongly associated with canopy damage in infected trees.

128 ese results support a role for mitochondrial damage in inflammasome activation and CKD and suggest mi

129 natively, NET formation can result in tissue damage in inflammatory conditions and may perpetuate aut

130 The buildup of radiation damage in ion-irradiated crystals often depends on the s

131 face-to-volume ratio may alleviate radiation damage in irradiated metallic materials as free surface

132 TRPA1 block reduces myelin damage in ischaemia.

133 ction, and inactivation of EphA2 reduces BBB damage in ischemic stroke.

134 tochondrial ultrastructure and mitochondrial damage in ISCs/EBs.

135 The reduced oxidative damage in JAK2-deficient livers was linked to increased

136 m flux in cells that mediate coronary artery damage in KD suggests that this pathway may be a therape

137 gic analysis revealed that IR induced severe damage in kidneys from WT mice, whereas histologic chang

138 in apoptosis and a decrease in tubular cell damage in kidneys with nephrotoxic or IRI induced AKI.

139 emisphere language homologues compensate for damage in left hemisphere language areas, the current pr

140 its being a major cause of peripheral nerve damage in leprosy patients, the immunopathogenesis of EN

141 hages to M. leprae PGL-1 in initiating nerve damage in leprosy.

142 ffectively improves hepatic inflammation and damage in leptin-deficient ob/ob mice and in choline-def

143 regeneration give rise that ischemic muscle damage in limb transplantation might be reversible to a

144 reduced body size, high levels of oxidative damage in lipids and proteins, and a fragile juvenile pl

145 racterized as mediators of peripheral tissue damage in lupus, but it remains unclear whether they inf

146 iltrating CD8(+) T cells do not cause tissue damage in lupus-prone mice, as genetic ablation of these

147 In contrast, reduced epithelial damage in M-ILK-deficient mice is correlated with elevat

148 the basis of a mechanism analysis of neuron damage in manganism and may supply possible gene targets

149 gonist or effective drug for treating neuron damage in manganism.

150 apse is responsible for corrosion or surface damage in many mechanical devices.

151 (+) cells in the heart and increased cardiac damage in mdx mice.

152 with ocular lubricants in preventing corneal damage in mechanically ventilated and sedated critically

153 Small fibres in the skin are vulnerable to damage in metabolic or toxic conditions such as diabetes

154 cle radiations induce severe microstructural damage in metallic materials.

155 T cell activation did not worsen crypt damage in mice carrying either cell-specific deletion of

156 amage, we correlated diacetyl-induced airway damage in mice with immunofluorescence for markers of pr

157 bated renal dysfunction and promoted tubular damage in mice with IRI compared with vehicle-treated mi

158 ral transmission during pregnancy and testis damage in mice, as well as infection of nonhuman primate

159 ) and its impact on radiation-induced tissue damage in mice.

160 lasma adenosine to counteract hypoxic tissue damage in mice.

161 fects cannot explain the phenotypes of brain damage in most infected infants.

162 More important, we found signatures of damage in most sequencing data sets in widely used resou

163 ual dysfunction due to retinal ganglion cell damage in multiple sclerosis and experimental autoimmune

164 s significantly associated with target organ damage in multiple tissues but with minor effects in the

165 tivated T cells, protects cartilage and bone damage in murine models of inflammatory and rheumatoid a

166 h aerobic performance is linked to oxidative damage in muscles.

167 trict Nlrp3 inflammasome activity and tissue damage in myocardial IRI.

168 Many functions damaged in neurodegenerative diseases are regulated by c

169 and highly resolved view of oligodendrocyte damage in neuroinflammatory lesions.

170 ABC294640, an inhibitor of SK2, reduces DNA damage in neurons and increases survival in two neuron m

171 , prevents neuronal death, reduces oxidative damage in neurons, suppresses the decline of motor perfo

172 Ab induced stronger small intestinal mucosal damage in NOD2(-/-) mice compared with wild-type mice.

173 nd predisposes to the full spectrum of liver damage in nonalcoholic fatty liver disease (NAFLD).

174 increased risk of significant/advanced liver damage in nondiabetic subjects with NAFLD.

175 yr-24-containing peptide to evaluate protein damage in nonsmoking type 2 diabetes mellitus.

176 This study reveals that DNA damage in obese adipocytes could trigger p53-dependent s

177 ues, we aimed to characterize vascular brain damage in old ApoE(-/-) mice fed a high-cholesterol (HC)

178 Therefore, increased oxidative damage in older oocytes may be one of the factors that l

179 recently emerged, causing serious agronomic damage in one of the most important maize-growing region

180 ted optic nerve after optic neuritis nor the damage in optic radiations was associated with 1-year vi

181 his is unlikely to increase risk of freezing damage in P. strobus seedlings.

182 spermatogonia (GSG) following persistent DNA damage in p53R172H and p53-null mice.

183 omises mitochondrial function and causes DNA damage in part by increasing oxidative stress, revealing

184 defects in intron removal in SMA promote DNA damage in part through the formation of RNA:DNA hybrid s

185 ial fibrillation or perioperative myocardial damage in patients undergoing elective cardiac surgery.

186 ated with extensive superficial white matter damage in patients with incomplete recovery.

187 ay provide markers of central nervous system damage in patients with rare motor neuron disease.

188 oids and may account for increased oxidative damage in pericentral regions in NASH.

189 The extent of endogenous DNA damage in peripheral blood lymphocytes from dogs given t

190 Additionally, we found endothelial damage in peritubular capillaries and vasa recta.

191 uggests that Ga stress could cause oxidative damage in plants.

192 expect that clarifying the nature of myelin damage in preclinical AD may be informative on the disea

193 Expression of LRRK2 G2019S induced mtDNA damage in primary rat midbrain neurons, but not in corti

194 ss of FOXO3 leads to the accumulation of DNA damage in primitive hematopoietic stem and progenitor ce

195 the right side or the dominant side get more damaged in RA since the limited number of patients analy

196 we explore the mechanism of acute epidermal damage in radiation dermatitis.

197 junctions is pivotal for the acute epidermal damage in radiation dermatitis.

198 in response to acute notexin-induced muscle damage in rats.

199 ust and promising biomarkers of acute muscle damage in rats.

200 nical option for preventing tissue and organ damage in renal IRI.

201 2-deficient cancer cell line exacerbated DNA damage in response to chemotherapeutics.

202 kedly ameliorated albuminuria and glomerular damage in response to DOCA.

203 t chondrocyte death does not drive cartilage damage in response to injury.

204 l)), we show significantly diminished axonal damage in response to neurotoxic stimuli.

205 The selective attenuation of DNA damage in response to these agents is dependent on both

206 in cell death signaling secondary to axonal damage in retinal ganglion cells (RGCs) and other neuron

207 eration of synoviocytes contributes to joint damage in rheumatoid arthritis.

208 ble substrates but tend to induce mechanical damage in rigid ones.

209 f susceptibility to Parkinson's disease-like damage in rodent disease models and considered in clinic

210 nin/E-cadherin in vitro and ameliorated skin damage in rodent models.

211 and identifying a window for UV-irradiation damage in S phase.

212 cted telomeres and localized to sites of DNA damage in S phase.

213 attenuated sickling, inflammation and tissue damage in SCD chimeras.

214 sion of miR-96 significantly prevented brain damage in SE rats by inhibiting Atg7 and Atg16L1 express

215 wth of embryos after the accumulation of DNA damage in seeds.

216 uppressor mechanism, the accumulation of DNA damage in senescent cells is thought to cause genomic in

217 emic intravascular coagulation and end-organ damage in septic mice.

218 y of BP elevation and hypertensive end-organ damage in several animal models.

219 f the collision cascade density on radiation damage in SiC remain poorly understood.

220 associated with irreversible microstructural damage in single-crystal, coarse-grained, ultrafine-grai

221 pressure-volume relations, onset of cellular damage, in situ variation of water potential, and stomat

222 on failed to attenuate age-related oxidative damage in skeletal muscle of old mice or provide any pro

223 Upon inducing damage in slow- or fast-type muscle, we found that the d

224 icate at higher levels and cause more tissue damage in some animals.

225 free markers reflects the extent of protein damage in soybean samples and it suggests the possibilit

226 te to protect M. smegmatis against oxidative damage in stationary phase.

227 glutamatergic receptors contributes to brain damage in stroke.

228 eukocytes, perhaps preventing further tissue damage in such a sensitive organ.

229 renal failure 41%, bleeding 25%, neurologic damage in survivors 21%, sepsis/infections 21%, and leg

230 Conforming to predominantly left-lateralized damage in sv-PPA and accounts of interhemispheric inhibi

231 the MCM7/p-RB/gammaH2AX axis and induced DNA damage in TamR cells, especially when combined with tamo

232 y serve as a suitable biomarker for neuronal damage in TBI patients.

233 reversed mitochondrial impairment and liver damage in the acute stages of liver copper accumulation

234 otective effect of exercise on neurovascular damage in the ageing brain of ApoE(-/-) mice.

235 rect bilirubin (DBIL) with minimal bile duct damage in the ANIT treated rats.

236 -CEM cells documented significantly more DNA damage in the cancer cells vs normal cells.

237 translation apparatus or may cause oxidative damage in the cell.

238 effective in preventing inflammatory tissue damage in the central nervous system and none directly p

239 viral load, and a decrease in overall tissue damage in the CNS compared with isotype control-treated

240 Sam68 knockout mice suffer more severe damage in the colon and succumb more rapidly from acute

241 cytokine production, augmented pathological damage in the colon, and increased mortality.

242 ontribute to clinical autoimmunity and organ damage in the context of neonatal lupus (NL).

243 ve activity, markedly reduced diffuse axonal damage in the cortex and hippocampus, and improved memor

244 TASK channels can limit ischemia-reperfusion damage in the cortex, and postconditioning with volatile

245 However, while damage in the corticospinal tract was the best indicator

246 ndings strongly implicate widespread protein damage in the etiology of flavorings-related lung diseas

247 seq does not depend on repair/removal of the damage in the excised oligonucleotides, and thus it is a

248 V wavelengths in sunlight also introduce DNA damage in the form of cyclobutane pyrimidine dimers (CPD

249 or the efficient repair of AP sites and base damage in the genome.

250 ofunction to investigate the outcomes of DNA damage in the head and neck region.

251 +), WM-LL correlated with WM microstructural damage in the left peritrigonal WM (p<0.0001).

252 ietic cells controlled HSV-1 replication and damage in the livers of IFN-alphabetagammaR(-/-) mice.

253 nduced hearing loss and hair/supporting cell damage in the mammalian organ of Corti, and emphasize th

254 high rates of death as a result of end-organ damage in the months after recovery from pneumonia, and

255 ngs support a potential role for PNS hypoxic damage in the motor impairment that results from prematu

256 This review focuses on the etiology of DNA damage in the nervous system and the genome stability pa

257 Functional repair of damage in the nervous system requires re-establishment o

258 found that AIM2 senses radiation-induced DNA damage in the nucleus to mediate inflammasome activation

259 i in the germ line, indicating increased DNA damage in the ovary.

260 ighly dependent on the overall extent of DNA damage in the particular sample.

261 rize the SOS transcriptional response to DNA damage in the Patescibacteria superphylum.

262 fect of inhaled xenon on myocardial ischemic damage in the same study population.

263 kers of endothelial dysfunction and vascular damage in the serum of CML patients who were treated wit

264 sue-intrinsic programs that ameliorate organ damage in the setting of sterile immunopathology.

265 -strand breaks in the DNA, and (2) oxidative damage in the sperm DNA.

266 er for identifying and tracking inflammatory damage in the spinal cord after TAR in a mouse model.

267 es in the left testes, indicating reversible damage in the torsion group.

268 nd empirically derived estimates of economic damage in the United States from climate change.

269 HCC development depends on the mode of liver damage; in the case of HBsAg-driven hepatocarcinogenesis

270 ites to include areas that were consistently damaged in the patients with phonological impairments.

271 Thus, the overall effect of damages in the genome is primarily driven not by damage

272 We propose that structural damages in the thalamus and cortex are mostly responsibl

273 had rare variants that were predicted to be damaging in the replication cohort.

274 l (PAS) usage, and evidence of mitochondrial damage in these mice.

275 as a unique approach in preventing oxidative damage in these molecules, which had been linked to neur

276 ), and their implication in tissue and organ damage in this condition.

277 ights the clinical relevance of white matter damage in this disorder and warrants investigations of t

278 pathogen, but not the immune response, drove damage in this model.

279 ntial future therapeutic strategies to limit damage in various organs, including the heart, brain, ki

280 herapeutic target for treatment of secondary damage in various spinal cord pathologies.

281 d the causes, types, and consequences of DNA damage in vascular disease.

282 the most significant factor to reduce tissue damage in vascularized tissue transplantation.

283 t may contribute to progressive neurological damage in virally suppressed HIV-infected individuals.

284 of clbM attenuated pks+ E. coli-induced DNA damage in vitro and significantly decreased the DNA dama

285 ted neutrophils caused endothelial cell (EC) damage in vitro.

286 -dicarbonyl group in diacetyl causes protein damage in vitro.

287 ut inducing significant cutaneous GvH tissue damage in vitro.

288 ng intestinal cells against iron induced DNA damage in vitro.

289 monocyte/neutrophil production may limit LV damage in vivo.

290 ATP-dependent chromatin relaxation upon DNA damage in vivo.

291 levels of replication stress-associated DNA damage in vivo.

292 methods, does not induce extensive cellular damage in vivo.

293 Following retinal damage, in which MGPCs are known to form, mTor signaling

294 s pronounced as that caused by extensive DNA damage in wild-type cells but showed genetic dependencie

295 expression, similar to those induced by DNA damage in wild-type cells.

296 Structural changes induced by radiation damage in X-ray crystallography hinder the ability to un

297 The major source of transcription-associated damage in yeast is Topoisomerase I (Top1), an enzyme tha

298 nd in vivo after NMDA (N-methyl-d-aspartate) damage in young mice.

299 tor Ascl1 is upregulated in MG after retinal damage in zebrafish and is necessary for regeneration.

300 t Kim-1 expression results in chronic kidney damage in zebrafish through a mechanism involving mTOR.