ライフサイエンスコーパス: dapsone

1 mbination of antihistamines, colchicine, and dapsone.

2 ng a combination of glucocorticosteroids and dapsone.

3 vitro, and it possessed activity similar to dapsone.

4 ee antibiotics: rifampicin, clofazimine, and dapsone.

5 one and from 3.2 to 3.8 A in the presence of dapsone.

6 se in resistance to S/P or to chlorproguanil-dapsone.

7 tient is placed on a gluten-free diet and/or dapsone.

8 reased (decrease in K(S)) by the presence of dapsone.

9 en in the presence and absence of 100 microM dapsone.

10 ersensitivity caused by sulfamethoxazole and dapsone.

11 ing resistance to sulfamethoxazole (SMX) and dapsone.

12 rson-years; relative risk for atovaquone vs. dapsone, 0.85; 95 percent confidence interval, 0.67 to 1

13 ne (-6.7%, -45.9 to 22.0) nor chlorproguanil-dapsone (10.8%, -24.6 to 36.1) had a protective effect.

14 y atovaquone (1500-mg suspension) with daily dapsone (100 mg) for the prevention of P. carinii pneumo

15 smission sites), chlorproguanil (15 mg) plus dapsone (18.75 mg; n=317 and 285), mefloquine (125 mg; n

16 in distance from the heme in the presence of dapsone, 3.50 A, as compared to the absence of dapsone,

17 od is based on the diazotization reaction of dapsone (4,4'-diamino-diphenyl sulphone, DAP) and (napht

18 ials of antimalarial preparations containing dapsone (4,4'-diaminodiphenylsulfone; 2.5 mg/kg once dai

19 psone, 3.50 A, as compared to the absence of dapsone, 4.41 A.

20 nts was 3.78 for atovaquone as compared with dapsone (95 percent confidence interval, 2.37 to 6.01; P

21 ion of phenanthrene metabolism by CYP3A4 and dapsone activation of flurbiprofen and naproxen metaboli

22 g peroxidases and catalase) and 42 +/- 9% by dapsone (an inhibitor of lactoperoxidase).

23 Treating diabetic rats with dapsone, an agent known to inhibit neutrophil function,

24 ogic problems associated with drugs, such as dapsone and azathioprine, respectively.

25 Measures of dapsone and flurbiprofen metabolism were elevated throug

26 e ranged from 4.2 to 4.5 A in the absence of dapsone and from 3.2 to 3.8 A in the presence of dapsone

27 More infants died in the chlorproguanil-dapsone and mefloquine groups (18 and 15, respectively)

28 A treatment program including dapsone and other drugs completely resolved the oral les

29 p=0.05 for difference between chlorproguanil-dapsone and placebo).

30 the closed loop 1; (ii) the distribution of dapsone and sulfonamide resistance mutations; (iii) the

31 d by gluten-free diet (with poor adherence), dapsone, and conventional immune-suppressing agents resp

32 In this study, 20 commonly used NSAIDs, dapsone, and enantiomers of flurbiprofen were analyzed f

33 second-line therapies, including atovaquone, dapsone, and pentamide.

34 m-dependent toxicity of sulfamethoxazole and dapsone, and subsequent incubation of normal human epide

35 rimethoprim-sulfamethoxazole, atovaquone and dapsone are similarly effective for the prevention of P.

36 involving 872 participants who had received dapsone as part of multidrug therapy for leprosy (39 par

37 lticenter trials highlighted doxycycline and dapsone as valuable medications in the treatment of bull

38 to 6.01; P<0.001); among those not receiving dapsone at base line, it was 0.42 (95 percent confidence

39 Among the 546 patients who were receiving dapsone at base line, the relative risk of discontinuati

40 However, among those not receiving dapsone, atovaquone is better tolerated and may be the p

41 usly in the active site with the presence of dapsone causing flurbiprofen to be oriented more closely

42 assess the safety profile of chlorproguanil-dapsone (CD), and to compare the safety and efficacy of

43 e spread of drug-resistant strains; however, dapsone (DDS) resistance continues to be reported.

44 sulfadoxine-pyrimethamine or chlorproguanil-dapsone did.

45 ulfadoxine-pyrimethamine, and chlorproguanil-dapsone for the treatment of P vivax malaria was conduct

46 n-years), as compared with 135 of 521 in the dapsone group (18.4 cases per 100 person-years; relative

47 of 272 patients (9.9%) in the chlorproguanil-dapsone group.

48 Dapsone hydroxylamine also caused covalent adduct format

49 ts of sulfamethoxazole hydroxylamine but not dapsone hydroxylamine.

50 01 was confirmed to be a risk factor for the dapsone hypersensitivity syndrome (odds ratio, 20.53; P=

51 loci, was significantly associated with the dapsone hypersensitivity syndrome among patients with le

52 1 was associated with the development of the dapsone hypersensitivity syndrome among patients with le

53 Ps in an additional 31 participants with the dapsone hypersensitivity syndrome and 1089 controls and

54 dependent series of 37 participants with the dapsone hypersensitivity syndrome and 201 controls.

55 herapy for leprosy (39 participants with the dapsone hypersensitivity syndrome and 833 controls), usi

56 a specificity of 85.7% as a predictor of the dapsone hypersensitivity syndrome, and its absence was a

57 The dapsone hypersensitivity syndrome, which is associated w

58 sts are available to predict the risk of the dapsone hypersensitivity syndrome.

59 to be widely used for leprosy treatment was dapsone in the 1950s, which had to be taken over several

60 he relative orientations of flurbiprofen and dapsone in the active site of CYP2C9.

61 Dapsone is used in the treatment of infections and infla

62 systemic therapies, such as corticosteroids, dapsone, isotretinoin, and/or antibiotics.

63 o the heme iron of CYP2C9 in the presence of dapsone may play a role in activation.

64 sm by CYPs 2B6, 2C8, 2C9, and 3A5 as well as dapsone metabolism by CYP2C9.

65 enytoin (CYP-2C19), chlorzoxazone (CYP-2E1), dapsone (multiple CYP enzymes), and flurbiprofen (CYP-2C

66 ulcer margin; topical cromolyn sodium; oral dapsone, prednisone, cyclosporine, mycophenolate mofetil

67 Our results support the continuation of dapsone prophylaxis among patients who are already recei

68 Dapsone protons were less affected, being 4.40 A from th

69 ied primary drug resistance in 4 cases and a dapsone-resistant cluster caused by the same strain.

70 Of these, 2 had dapsone-resistant Mycobacterium leprae and 1 of these pa

71 ty (pamaquine, sitamaquine, tafenoquine, and dapsone) resulted in loss of G6PD-deficient huRBCs compa

72 ydroxylation is activated by the presence of dapsone resulting in reduction of the K(m) for flurbipro

73 DRDRs) of folP1, rpoB, and gyrA, targets for dapsone, rifampin, and fluoroquinolones, real-time PCR-H

74 Within 1 month after initiating dapsone therapy and increasing the dosage of prednisone,

75 ratinocytes metabolized sulfamethoxazole and dapsone to N-4-hydroxylamine and N-acetyl derivatives in

76 s of the prototypical CYP2C9 heteroactivator dapsone to validate a simple docking method that can be

77 reatment failure but not with chlorproguanil-dapsone treatment failure.

78 sulfadoxine-pyrimethamine and chlorproguanil-dapsone treatment for uncomplicated P. falciparum malari

79 methamine-sulfadoxine but not chlorproguanil-dapsone treatment, showing that a combination of these t

80 le typically managed by gluten-free diet and dapsone, treatment of DH refractory to standard treatmen

81 ced, and the relationship between TMP-SMX or dapsone use and gene mutations was analyzed.

82 pyrimethamine-sulfadoxine or chlorproguanil-dapsone was analyzed for variants of the genes coding fo

83 Chlorproguanil-dapsone was less effective than sulfadoxine-pyrimethamin

84 ration of a gluten-free diet with or without dapsone were observed.

85 eatment, a combination therapy consisting of dapsone with cimetidine and vitamin E to enhance drug ef