ライフサイエンスコーパス: data bank

1 n from F1 structures 2HLD1 and 1H8E (Protein Data Bank).

2 sion), and structural data from PDB (Protein Data Bank).

3 ctures of epigenome readers from the Protein Data Bank.

4 ty rates using data from the National Trauma Data Bank.

5 torial analyses of each entry in the Protein Data Bank.

6 resolution ribozyme structure in the Protein Data Bank.

7 homologous structure families in the Protein Data Bank.

8 centers participating in the National Trauma Data Bank.

9 mistic thin filament models from the Protein Data Bank.

10 ives provided by the National Practitioner's Data Bank.

11 1 structure has no equivalent in the Protein Data Bank.

12 American College of Surgeons National Trauma Data Bank.

13 2707 different ligand types from the Protein Data Bank.

14 lergens and proteins reported in the Protein Data Bank.

15 t as well as structure data from the Protein Data Bank.

16 tem, and mirrors the contents of the Protein Data Bank.

17 -antigen cocrystal structures in the Protein Data Bank.

18 , and a bioinformatics screen of the Protein Data Bank.

19 ed in the structural database of the Protein Data Bank.

20 in spectra in the Protein Circular Dichroism Data Bank.

21 res, designated 2JMH and 2JRK in the Protein Data Bank.

22 taining molecules deposited into the Protein Data Bank.

23 tribute complications to the National Trauma Data Bank.

24 t study of patients from the National Trauma Data Bank.

25 that are made available through the Protein Data Bank.

26 all known protein structures in the Protein Data Bank.

27 ed from 99 polypeptide chains in the Protein Data Bank.

28 for at least one member exist in the Protein Data Bank.

29 tinct GroEL crystal structure in the Protein Data Bank.

30 h of structures now available in the Protein Data Bank.

31 ligands--currently available in the Protein Data Bank.

32 pockets in >26,000 structures in the Protein Data Bank.

33 tients were entered into the National Trauma Data Bank.

34 crystal and NMR structures from the Protein Data Bank.

35 ion intermediate structures from the Protein Data Bank.

36 37 have folds not represented in the Protein Data Bank.

37 in unique antibody structures in the Protein Data Bank.

38 ds from similar binding sites in the Protein Data Bank.

39 a Bank and map-derived models in the Protein Data Bank.

40 aptured by hundreds of structures in Protein Data Bank.

41 ures determined and deposited to the Protein Data Bank.

42 ycine amino acids in proteins in the protein data bank.

43 extracted from the 2007-2012 National Trauma Data Bank.

44 eir sources: DrugBank, BindingDB and Protein Data Bank.

45 the prospectively maintained National Trauma Data Bank.

46 ndly and is integrated into the RCSB Protein Data Bank.

47 ay structures of DNA duplexes in the Protein Data Bank.

48 e Control and Prevention and National Trauma Data Bank.

49 itor, acetazolamide, is available in Protein Data Bank.

50 Informatisees et Validees en Transplantation data bank.

51 structures of human proteins in the Protein Data Bank.

52 ther proteins and mRNAs are described in the data banks.

53 ESV proteins found no matches in the protein data banks.

54 ich an x-ray structure is available (Protein Data Bank 1nkn).

55 vel I/II TCs included in the National Trauma Data Bank 2007-2010.

56 matching substructures in the entire Protein Data Bank, along with a statistical significance estimat

57 tructures, and databases such as the Protein Data Bank, also implies large scale structural similarit

58 most frequently observed PTMs in the Protein Data Bank and all types of phosphorylation.

59 able PPI structures deposited in the Protein Data Bank and allows users to upload their own custom st

60 onto TM helix dimers parsed from the Protein Data Bank and by selecting conformations based on their

61 protein complexes retrieved from the Protein Data Bank and created the DNAproDB database to store thi

62 We search through the entire Protein Data Bank and identify several sequentially nonhomologou

63 ural data archives, which include maps in EM Data Bank and map-derived models in the Protein Data Ban

64 s who were registered in the National Trauma Data Bank and met inclusion criteria.

65 I who were registered in the National Trauma Data Bank and met the inclusion criteria.

66 on is needed to mine a large transcriptional data bank and properties of microarray data.

67 helices across RNA junctions in the Protein Data Bank and rationalized our findings with modeling an

68 0 crystal data sets deposited in the Protein Data Bank and show that sharpening improves the electron

69 nst the RNA structures in the entire Protein Data Bank and the abundances of them are estimated.

70 lly from the current releases of the Protein Data Bank and the Uniprot Knowledgebase; this core is co

71 whose structure is available in the Protein Data Bank and which exhibits one or more helices at the

72 ures in test sets extracted from the Protein Data Bank and would be useful starting points in modelin

73 main protein structures found in the Protein Data Bank) and ART structures and pockets, the widesprea

74 olecular structures available in the Protein Data Bank archive and the tools that are available at th

75 ximately 2% of the structures in the Protein Data Bank are from eukaryotic parasites and less than 0.

76 protein structures deposited in the Protein Data Bank are of membrane proteins.

77 s in the protein simulations and the Protein Data Bank are very similar and often distinct from those

78 structures have been archived in the Protein Data Bank as compared to the more than 100 000 structure

79 uncertainty for both SN within the Emissions Data Bank as well as nvPM mass within the new regulatory

80 me, GTK/KAT I, is listed in mammalian genome data banks as CCBL1 (cysteine conjugate beta-lyase 1).

81 ns < or =200 residues that cover the Protein Data Bank at 35% pairwise sequence identity.

82 ved from structures deposited in the Protein Data Bank, based on sequence similarly, fit of stem atom

83 nificant result that agrees with our Protein Data Bank-based backbone sampling and all-atom simulatio

84 to many such situations and combines Protein Data Bank-based torsional optimization with real-space r

85 I who were registered in the National Trauma Data Bank between 2009 and 2011.

86 s who were registered in the National Trauma Data Bank between 2009 and 2011.

87 The Biological Magnetic Resonance Data Bank (BMRB) is a public repository of Nuclear Magne

88 results of analysing proteins in the Protein Data Bank by this new scheme, recovering and extending p

89 Here using a large whole-genome sequencing data bank, cancer registry and colorectal tumour bank we

90 The conformational dynamics data bank (CDDB) is a database that aims to provide comp

91 ydroxy-3,5-dimethylphenyl)methanone (Protein Data Bank chemical component 0XV) was determined to 2.87

92 abundant and underrepresented in the Protein Data Bank class of 2-4 TM crossers and demonstrate the e

93 he peptide contained residues 20-45 (Protein Data Bank code 1BEA), and a C29D substitution was includ

94 ed for the P450 2D6 Met-374 variant (Protein Data Bank code 2F9Q).

95 small molecule effector salicylate (Protein Data Bank code 3DEU), reveal that, unlike many other Mar

96 toms in the initial vSGLT structure (Protein Data Bank code 3DH4).

97 erichia coli isoprenoid synthesis H (Protein Data Bank code 3F7T) as a template for homology modeling

98 catalytic domain crystal structure (Protein Data Bank code 3IR2); however, atomic force microscopy a

99 -yl)-2-(pyridin- 3-yl)ethanone (UDO; Protein Data Bank code 3ZG2) and N-[4-(trifluoromethyl)phenyl]-N

100 -4-piperi-dyl]p yridin-3-amine (UDD; Protein Data Bank code 3ZG3).

101 s 2C8 and 2C9, the atomic structure (Protein Data Bank code 4GQS) of cytochrome P450 2C19 complexed w

102 n all nucleic acid structures in the Protein Data Bank confirm the efficiency and robustness of the s

103 rvey of two-way RNA junctions in the protein data bank confirms that junction residues have a strong

104 Whereas the Protein Data Bank contains some 100,000 globular protein and 3,0

105 DRoP reads and superimposes multiple Protein Data Bank coordinates, transfers symmetry-related water

106 Protein Data Bank data mining using the HippDB database indicate

107 onding drug-target structures in the Protein Data Bank database, and 15 out of the 18 had been proved

108 ble in the Nucleic Acid Database and Protein Data Bank databases.

109 of protein-protein complexes in the Protein Data Bank, docking templates can be found for complexes

110 essors either as single files or as complete data bank downloads.

111 ives containing EM-based structural data: EM Data Bank (EMDB) and Protein Data Bank (PDB), and facili

112 tructures present in the electron microscopy data bank (EMDB).

113 iously reported structures of ba(3) (Protein Data Bank entries 1EHK and 1XME ), having a crystallogra

114 of D12A BsPFK have been determined (Protein Data Bank entries 4I36 and 4I7E , respectively), and bot

115 SCOPe 2.06 contains 77,439 Protein Data Bank entries, double the 38,221 structures classifi

116 ms that represent approximately 3800 Protein Data Bank entries.

117 rotein structure (residues 15 to 41; Protein Data Bank entry 1CWX) indicated that the residues G33 an

118 the crystal structure of rhodopsin (Protein Data Bank entry 1GZM), the experimentally measured dista

119 solved structure of MMP-3cd.TIMP-1 (Protein Data Bank entry 1UEA), we see substantial differences at

120 P450 3A4 (CYP3A4) crystal structure (Protein Data Bank entry 1W0E) to predict the sites of metabolism

121 was determined at 2.7 A resolution (Protein Data Bank entry 2PAJ ).

122 ive site for 8-oxoguanine deaminase (Protein Data Bank entry 2UZ9 ).

123 cl-XL protein and a Bax BH3 peptide (Protein Data Bank entry 3PL7).

124 cture of the archaeal NCX homologue (Protein Data Bank entry 3V5U ), we introduced cysteine residues

125 structure bound to PEP is reported (Protein Data Bank entry 4I4I ), and it exhibits a shifted struct

126 ucleotide Archive (ENA), UniProt and Protein Data Bank, Europe (PDBe), we demonstrate that text minin

127 sult holds for all structures in the Protein Data Bank, even when structural relationships between ev

128 e structure factors derived from the Protein Data Bank, explicit treatment of water molecules in the

129 Given an input Protein Data Bank file (PDB) for a protein or RNA molecule, Loca

130 Given a PDB file (a Protein Data Bank file format containing the 3D coordinates of t

131 web server that searches the entire Protein Data Bank for a given substructure defined by a set of a

132 claims reported to the National Practitioner Data Bank for events in the outpatient setting was simil

133 t, we successfully screen the entire Protein Data Bank for proteins that possess local surface simila

134 gands for hundreds of targets in the Protein Data Bank for which similar experimental information is

135 s, which are returned to the user in Protein Data Bank format via email.

136 ta, provided as a set of models in a Protein Data Bank format.

137 rotein, DNA or RNA structure in PDB (Protein Data Bank) format.

138 ns and show that no structure in the Protein Data Bank forms a link of this type.

139 on-capsid protein complexes from the Protein Data Bank found 418 generic protein-protein interfaces t

140 0 to 17 years old using the National Trauma Data Bank from January 1, 2007, to December 31, 2012.

141 e carried out a broad search of RIP sequence data banks from angiosperms in order to study their main

142 , we also present an instance of the Protein Data Bank fully integrated with BioLit data.

143 (varphi,psi) distributions from the Protein Data Bank further justifies the inclusion of many-body e

144 e of the valuable information in the Protein Data Bank generated by structural genomics projects but

145 non-redundant OMBB structures in the Protein Data Bank, half have been solved during the past 5 years

146 te of novel pockets deposited in the Protein Data Bank has been decreasing steadily over the recent y

147 t a quarter of all structures in the Protein Data Bank; however, available protein complexes cover le

148 he published IpaD crystal structure (Protein Data Bank ID 2j0o) how a multimer of IpaD would be incor

149 channel in the open state is known (Protein Data Bank ID code 2R9R).

150 reviously determined NTR1 structure (Protein Data Bank ID code 4GRV) in the ligand-binding pocket and

151 m formin binding protein 28 (FBP28) (Protein Data Bank ID: 1E0L) and its full-size, and singly- and d

152 The National Trauma Data Bank identified motorcycle crash patients from 2002

153 yielded two different crystal forms (Protein Data Bank identifiers [PDB ID], 3LQ6 and 3LQE).

154 is a close collaboration between the Protein Data Bank in Europe (PDBe) and UniProt.

155 The Protein Data Bank in Europe (PDBe) is actively working with its

156 MDataBank.org, a joint effort of the Protein Data Bank in Europe (PDBe), the Research Collaboratory f

157 The Protein Data Bank in Europe (pdbe.org) is a founding member of t

158 The Protein Data Bank in Europe (PDBe; pdbe.org) is a partner in the

159 The Protein Data Bank in Europe (PDBe; pdbe.org) is actively involve

160 The Protein Data Bank in Europe accepts and annotates depositions of

161 tatic structures of a protein in the Protein Data Bank in order to extract the progression of structu

162 f membrane protein structures in the Protein Data Bank is becoming significant and growing.

163 Each year, a data bank is developed by fermenting authentic apples ju

164 The data bank is maintained and updated automatically to inc

165 ssigned to the encoded protein in the genome data bank, is a CCBL2 (synonym KAT III).

166 rs participating in the 2010 National Trauma Data Bank (January 1 to December 31, 2010) were used to

167 tures are currently available in the Protein Data Bank, largely owing to inefficiencies in protein pr

168 Screening of the Protein Data Bank led to identification of a recurring structura

169 r one other protein structure in the Protein Data Bank, namely, YokD from Bacillus subtilis.

170 ,229 injured patients in the National Trauma Data Bank (NTDB 6.1) hospitalized between 2001 and 2005.

171 ents from 2003 to 2015), the National Trauma Data Bank (NTDB) (5755095 patients from 2003 to 2014), a

172 e from Lyon, France, and the National Trauma Data Bank (NTDB) of the United States.

173 ent years (2007-2009) in the National Trauma Data Bank (NTDB).

174 ta in 68 hospitals using the National Trauma Data Bank (NTDB, version 6.1).

175 crystal structures deposited in the Protein Data Bank of 32 different receptors from families scatte

176 uropean Nucleotide Archive (ENA) and the DNA Data Bank of Japan (DDBJ) ensures worldwide coverage.

177 uropean Nucleotide Archive (ENA) and the DNA Data Bank of Japan (DDBJ) ensures worldwide coverage.

178 uropean Nucleotide Archive (ENA) and the DNA Data Bank of Japan (DDBJ) ensures worldwide coverage.

179 uropean Nucleotide Archive (ENA) and the DNA Data Bank of Japan (DDBJ) ensures worldwide coverage.

180 uropean Nucleotide Archive (ENA) and the DNA Data Bank of Japan (DDBJ) ensures worldwide coverage.

181 Bioinformatics Institute (EBI), and the DNA Data Bank of Japan (DDBJ), have established the Sequence

182 n Bioinformatics Institute (EBI) and the DNA Data Bank of Japan (DDBJ).

183 the European Nucleotide Archive and the DNA Data Bank of Japan ensures worldwide coverage.

184 tide Sequence Database in Europe and the DNA Data Bank of Japan ensures worldwide coverage.

185 tide Sequence Database in Europe and the DNA Data Bank of Japan ensures worldwide coverage.

186 the European Nucleotide Archive and the DNA Data Bank of Japan ensures worldwide coverage.

187 And thanks in part to the large Protein Data Bank of known structures, predicting protein struct

188 An in vivo human tissue compliance data bank of the gastrointestinal tract was produced.

189 actively working with its Worldwide Protein Data Bank partners to enhance the quality and consistenc

190 he entries in the Protein Circular Dichroism Data Bank (PCDDB) for its comparison set, providing the

191 The Protein Circular Dichroism Data Bank (PCDDB) has been in operation for more than 5

192 The Protein Circular Dichroism Data Bank (PCDDB) is a public repository that archives a

193 obtained from the Protein Circular Dichroism Data Bank (PCDDB).

194 ere are few pMHC-I structures in the Protein Data Bank (PDB) (especially considering the total number

195 spatial information available in the Protein Data Bank (PDB) along with the mutational data in the Ca

196 However, with the steady growth of Protein Data Bank (PDB) and available PTM sites, it is now possi

197 cy set of RNA 3D structures from the Protein Data Bank (PDB) and calculate centroids (exemplars) for

198 and binding sites extracted from the Protein Data Bank (PDB) and small organic molecules from the Cam

199 xample, by combining the data in the Protein Data Bank (PDB) and the Catalogue of Somatic Mutations i

200 ating the spatial information in the Protein Data Bank (PDB) and the mutational data in the Catalogue

201 In ProtCID, protein chains in the protein data bank (PDB) are grouped based on their PFAM domain a

202 use the protein structures from the Protein Data Bank (PDB) as templates.

203 re of the crystal structure of ELIC [Protein Data Bank (PDB) code 2VL0], a bacterial member of the ni

204 d structural comparisons against the Protein Data Bank (PDB) combined with a rich and intuitive user

205 The Protein Data Bank (PDB) contains a wealth of data on nonbonded b

206 mparisons in seconds from a complete Protein Data Bank (PDB) database of 152,959 protein chains and t

207 complexes currently available in the Protein Data Bank (PDB) database, revealing a great diversity of

208 ation of interfaces across different Protein Data Bank (PDB) entries in a protein family reveals seve

209 ease of SCOPe, 2.03, contains 59 514 Protein Data Bank (PDB) entries, increasing the number of struct

210 d small molecule components found in Protein Data Bank (PDB) entries.

211 g loop (LL conformation), similar to Protein Data Bank (PDB) entry 1CMK , and a helix-turn-helix stru

212 developed to simplify the reading of Protein Data Bank (PDB) files containing glycans through the aut

213 reate the RNA CoSSMos database, 2156 Protein Data Bank (PDB) files were searched for internal, bulge

214 orresponding coordinate files in the Protein Data Bank (PDB) format.

215 sic use, requiring only two files in Protein Data Bank (PDB) format.

216 s in structured RNA molecules in the Protein Data Bank (PDB) hydrogen-bond with phosphates of other n

217 spatial structures maintained by the Protein Data Bank (PDB) into evolutionary groups of protein doma

218 Benchmark tests against the Protein Data Bank (PDB) N-linked glycan library and PDB homologo

219 The Protein Data Bank (PDB) now contains more than 120,000 three-dim

220 easy downloads of IBIS data for all Protein Data Bank (PDB) protein chains and the results for each

221 The Protein Data Bank (PDB) provided training data whilst the databa

222 available Apo EPK structures in the protein data bank (PDB) revealed four unique structural conforma

223 et al., using the limited number of protein data bank (PDB) structures available at that time, repor

224 can be used for databases other than Protein Data Bank (PDB) such as Protein families database or Clu

225 rization of 10,245 beta-turns in the protein data bank (PDB) suggested that trans-pyrrolidine-3,4-dic

226 n programming interface for the RCSB Protein Data Bank (PDB) that allows search and data retrieval fo

227 trieve structural fragments from the Protein Data Bank (PDB) that are very similar to the peptide's f

228 ANCHOR includes a Protein Data Bank (PDB) wide database of pre-computed anchor res

229 in crystal structures present in the Protein Data Bank (PDB) with a focus on PDE-ligand interactions.

230 central access to structures in the Protein Data Bank (PDB), along with functional annotations, asso

231 ctural data: EM Data Bank (EMDB) and Protein Data Bank (PDB), and facilitates use of EM structural da

232 crystal structures deposited in the Protein Data Bank (PDB), but only 50% of structures in the PDB a

233 Together with the Protein Data Bank (PDB), EMDB is becoming a fundamental resource

234 Ms that capture all structure in the Protein Data Bank (PDB), finding remarkable degeneracy.

235 multiple sequence alignments between Protein Data Bank (PDB), genomic and custom sequences.

236 tabase (MMDB), which is based on the Protein Data Bank (PDB), maintains a comprehensive and up-to-dat

237 100 000 structures available in the Protein Data Bank (PDB), of which approximately 30% are protein-

238 twork has at least two structures in Protein Data Bank (PDB), only 22% of them have alternative confo

239 th the continuous growth of the RCSB Protein Data Bank (PDB), providing an up-to-date systematic stru

240 ) and the spatial information in the Protein Data Bank (PDB), SpacePAC is able to identify novel muta

241 ctural knowledge, extracted from the Protein Data Bank (PDB), underlies numerous potential functions

242 ptimally modeled are abundant in the Protein Data Bank (PDB).

243 cocrystal structures present in the Protein Data Bank (PDB).

244 no structural analogues found in the Protein Data Bank (PDB).

245 ding "hot" and "warm" spots from the Protein Data Bank (PDB).

246 ed from the glycan structures in the Protein Data Bank (PDB).

247 and protein-protein complexes in the Protein Data Bank (PDB).

248 s to sequences and structures in the Protein Data Bank (PDB).

249 stal structures are available in the protein data bank (PDB).

250 aces extracted from complexes in the Protein Data Bank (PDB).

251 r MHC molecules are available in the Protein Data Bank (PDB).

252 ved in 3D structures archived in the Protein Data Bank (PDB).

253 o-macromolecular structure data, the Protein Data Bank (PDB).

254 ction information extracted from the Protein Data Bank (PDB).

255 H-bonds than regular proteins in the Protein Data Bank (PDB).

256 g(II) binding sites available in the protein data bank (PDB).

257 f congeneric ligand complexes in the Protein Data Bank (PDB).

258 e of RNA crystal structures from the Protein Data Bank (PDB).

259 s (ECOD) database] or 20,398 chains [Protein Data Bank (PDB)].

260 sting data based on crystallography (Protein Data Bank, PDB) can be used to discriminate between inte

261 f pre-calculated matches between all Protein Data Bank proteins and the library of catalytic sites.

262 r-specified catalytic site among all Protein Data Bank proteins rapidly (in less than a minute).

263 Mining of the Protein Data Bank provides an abundance of structures in which G

264 Extensive analysis of the Protein Data Bank provides strong support for a catalytic role o

265 3D structures that are found in the Protein Data Bank, providing interaction data at the molecular l

266 of domain-domain interactions in the Protein Data Bank, providing molecular details for such interact

267 NMR) techniques and deposited in the Protein Data Bank, rather than on ensembles specifically generat

268 ratory for Structural Bioinformatics Protein Data Bank (RCSB PDB) develops tools and resources that p

269 The RCSB Protein Data Bank (RCSB PDB) provides access to 3D structures of

270 ratory for Structural Bioinformatics Protein Data Bank (RCSB PDB) resource provides tools for query,

271 The RCSB Protein Data Bank (RCSB PDB) web site has been redesigned to inc

272 protein structures deposited in the Protein Data Bank resulted in 874 entries, consisting of 194 uni

273 he Cambridge Structural Database and Protein Data Bank reveal geometric preferences of some oxygen an

274 luding unpublished structures in the Protein Data Bank, revealed extensive variation in the relative

275 of a TEL fragment, deposited in the Protein Data Bank, revealed that the CID consists of two alpha-h

276 her examination of structures in the Protein Data Bank reveals that there is a great disparity betwee

277 A statistical analysis of the Protein Data Bank reveals that this mode of interaction is a com

278 einaceous tryptophans taken from the Protein Data Bank shows that sterically hindered ranges of dihed

279 grated computational approach of the Protein Data Bank structure analysis and atomistic molecular dyn

280 Starting from the native Protein Data Bank structure, nine (meta)stable states of the sys

281 ystematically maps human nsSNPs onto Protein Data Bank structures and annotates several biologically

282 s non-protein coding RNA, <2% of the protein data bank structures comprise RNA.

283 Analysis of the existing Protein Data Bank structures of Bcl-xL in both bound and unbound

284 UniProt identifiers and (optionally) Protein Data Bank structures.

285 alis alpha-actinin epitopes with proteins in data banks, such as Tritrichomonas suis, Candida albican

286 ogether molecular fragments from the Protein Data Bank that best fit experimental RDCs from samples w

287 ratory for Structural Bioinformatics Protein Data Bank, the US data center for the global PDB archive

288 f membrane protein structures in the Protein Data Bank, there are many transmembrane domains that app

289 uses similarity to sequences in the Protein Data Bank to infer annotations at the output level, and

290 of helical protein interfaces in the Protein Data Bank to obtain a snapshot of how helices that are c

291 cluding PubMed, UniProt and the RCSB Protein Data Bank, to provide multi-faceted views of polymerase

292 umber of unique binding sites in the Protein Data Bank was much slower than the growth rate of the nu

293 The National Trauma Data Bank was queried (version 6.2, 2001-2006) for infor

294 Using data from the National Practitioner Data Bank, we analyzed 66,426 claims paid against 54,099

295 n-DNA complexes now available in the Protein Data Bank, we argue that individual DNA-binding proteins

296 centers participating in the National Trauma Data Bank were identified using International Classifica

297 mination of protein complexes in the Protein Data Bank where alpha-helices or beta-strands form criti

298 ECTS: Trauma patients in the National Trauma Data Bank with a hospital length of stay greater than 2

299 one of the partners in the Worldwide Protein Data Bank (wwPDB; wwpdb.org).

300 crystal structures deposited in the Protein Data Bank (www.pdb.org) using the program O.