ライフサイエンスコーパス: dauer

1 a stress-resistant, quiescent stage called 'dauer'.

2 the developmentally arrested stage known as dauer.

3 alternative developmental phenotype known as dauer.

4 ce response to environmental stress known as dauer.

5 enter a migratory diapause stage, called the dauer.

6 nimal cue) in nondauers to CO2 attraction in dauers.

7 or pathogens correlate with nonproliferating dauers.

8 actor DAF-16/FOXO to induce development into dauer, a diapause that withstands harsh conditions.

9 ng and stowing onto carrier animals, but how dauers acquire these behaviors, despite having a physica

10 age (Larva 1, Larva 2, Larva 3, Larva 4, and Dauer and adult) appears to be unique.

11 milar, except for the transition between non-dauer and dauer stages.

12 s much more pronounced in quiescent daf-2(-) dauer and dauer-like adult animals than in nondauaer ani

13 quired to promote VPC fate plasticity during dauer and for normal vulval patterning after passage thr

14 g lipid extracts of C. elegans larvae at the dauer and L3 stages that represent alternative developme

15 result the chemical characterization of the dauer and male attracting pheromones remained incomplete

16 8,042 genes differentially expressed during dauer and reproductive development and observed striking

17 We compared dauer and reproductive development using whole-animal RN

18 er-1 regulatory sequences, and is induced in dauers and at high temperatures.

19 We suggest that dauers and dauer-like quiescent adults may have underlyi

20 in many organisms, can stimulate movement in dauers and dauer-like quiescent adults.

21 ogenization of every larval stage, including dauers, and show that the Balch homogenizer can be used

22 end of number and abundance of glycans being Dauer approximately = L1 > adult approximately = L4 > L3

23 ike signaling functions in larvae to inhibit dauer arrest and acts during adulthood to regulate lifes

24 ompensation protein DPY-21 in the control of dauer arrest and DAF-2 ILS.

25 in the cytochrome P450 gene daf-9 also cause dauer arrest and defects in cell migration.

26 ulin-like protein, which when mutated causes dauer arrest and down-regulation of DAF-2/IR signaling.

27 tive insulin-like genes proposed to regulate dauer arrest and senescence.

28 Thus, dosage compensation enhances dauer arrest by repressing X-linked genes that promote r

29 lso influences dosage compensation, promotes dauer arrest in part by repressing the X-linked ins-9 ge

30 ession of daf-9 in the hypodermis suppresses dauer arrest of daf-7 mutant animals and inhibits dauer

31 The dauer arrest phenotype of eak-3 mutants is fully suppres

32 The influence of dosage compensation on dauer arrest, a larval developmental fate governed by th

33 f asm-3 extends animal lifespan and promotes dauer arrest, an alternative developmental process.

34 e, the long-lived growth arrest state called dauer arrest, in Caenorhabditis elegans.

35 In contrast to the well-studied dauer arrest, L1 arrest occurs without morphological mod

36 nto the intestinal lumen and degraded during dauer arrest, only to be secreted into the body cavity a

37 nsporters function redundantly in preventing dauer arrest, presumably by regulating the availability

38 ike XXX cells that are crucial in preventing dauer arrest, suggesting that it is involved in biosynth

39 I and ASJ, two sensory neurons that regulate dauer arrest.

40 1 null mutant displays defects in inhibiting dauer arrest: it forms dauers in the deletion mutant bac

41 C. elegans is strongly induced to form dauers at temperatures above 26 degrees, near the upper

42 nditions induce a state of diapause known as dauer by inhibiting the conserved DAF-2 insulin-like sig

43 ssion of several X-linked genes that promote dauer bypass is elevated, including four genes encoding

44 ed ASI sensory neurons that are required for dauer bypass.

45 as overexpression of LIN-42 can suppress the dauer constitutive phenotype of a ligand-insensitive daf

46 ins-9 repression in dauer-constitutive mutants requires DPY-21, SET-4 and th

47 e pathways were defined by mutants that form dauers constitutively (Daf-c) at 25 degrees.

48 sembly of the alae and the morphology of the dauer cuticle; because of its similarity to the other cu

49 we show that, independent of its role in the dauer decision, TGF-beta regulates the balance of prolif

50 ractive for the parasitic IJs and C. elegans dauers despite being repulsive for C. elegans adults, an

51 s to control adult phenotypic plasticity and dauer development and provide examples of modular genera

52 The RNA interference, dauer development, and programmed cell death pathways ar

53 rite arborization and axon remodeling during dauer development.

54 f the molecular mechanisms of the C. elegans dauer developmental decision has defined evolutionarily

55 regulated by DAF-2, including entry into the dauer developmental stage and aging.

56 enes, body size and entry into the alternate dauer developmental stage.

57 ife history traits, including entry into the dauer diapause and longevity.

58 -dafachronic acid (DA) promote bypass of the dauer diapause and proper gonadal migration during larva

59 plays a crucial role in the decision between dauer diapause and reproductive growth.

60 otein response (UPR) in promoting entry into dauer diapause and suggest that, in addition to cell-aut

61 -13 mutant exits L1 arrest and IIS-dependent dauer diapause faster than control worms, but is not inv

62 a key regulator of longevity, metabolism and dauer diapause in Caenorhabditis elegans.

63 ARD differs from the C. elegans dauer diapause in that it enables sexually mature adults

64 adverse environments, animals arrest at the dauer diapause, a long-lived stress resistant stage.

65 s orphan nuclear receptor, DAF-12, regulates dauer diapause, reproductive development, fat metabolism

66 n to regulate longevity, stress response and dauer diapause.

67 larval arrest, implying that CeTOR regulates dauer diapause.

68 n the ASI neuron pair, to promote entry into dauer diapause.

69 af-28(sa191), causes constitutive entry into dauer diapause.

70 choose between reproductive development and dauer diapause.

71 dentities of pheromone signals that modulate dauer entry have been characterized.

72 hat drive either reproductive development or dauer entry.

73 om its well-characterized role in preventing dauer entry.

74 g up-regulation of neuropeptide genes during dauer entry.

75 cts as a component of a switch that mediates dauer entry.

76 aviors dependent on the ASJ neurons, such as dauer exit and pathogen avoidance.

77 t uncover evidence of a robust conserved L3i/dauer 'expression signature.' Strikingly, in comparisons

78 Both dauer formation (a stage of developmental arrest) and ad

79 identify bacterial components that influence dauer formation and aging in C. elegans, we utilized the

80 Consistent with its role in dauer formation and aging, we show that insulin/insulin-

81 Intracellular receptor DAF-12 regulates dauer formation and developmental age and affects Caenor

82 IGF-1 signaling (IIS) pathway regulates both dauer formation and longevity.

83 nd biochemical pathways, including those for dauer formation and RNAi, are conserved.

84 s identify a new sensory pathway controlling dauer formation and shed light on ALK signaling, integra

85 Thus, male mating and dauer formation are linked through a common set of small

86 pak-1, nck-1, and ced-10 cause constitutive dauer formation at 27 degrees C, a phenotype also observ

87 on, we find that hbl-1 can also modulate the dauer formation decision in a complex manner.

88 through amphid neurons and actively inhibits dauer formation during reproductive developmental growth

89 Multigenic resistance to dauer formation has also arisen in high-density cultures

90 A molecular and genetic analysis of dauer formation has revealed key insights into how senso

91 architecture of natural genetic variation in dauer formation has, however, not been thoroughly invest

92 iverse E. coli deletion mutants that enhance dauer formation in an insulin-like receptor mutant (daf-

93 basis of these results, male attraction and dauer formation in C. elegans appear as alternative beha

94 that OGT modulates macronutrient storage and dauer formation in C. elegans, providing a unique geneti

95 Dauer formation in Caenorhabditis elegans is a temperatu

96 e abundantly produced by one genotype induce dauer formation in other genotypes, but not necessarily

97 tein)-coupled receptors (GPCRs) that mediate dauer formation in response to a subset of dauer pheromo

98 controlling nutrient storage, longevity, and dauer formation in the C. elegans O-GlcNAc cycling mutan

99 To begin to investigate the evolution of dauer formation in the genus Caenorhabditis at the molec

100 nd that the oga-1(ok1207) knockout augmented dauer formation induced by a temperature sensitive insul

101 Dauer formation is associated with increased autophagy a

102 e diapause of Drosophila melanogaster and in dauer formation of Caenorhabditis elegans suggests a con

103 r genes function in a hormonal branch of the dauer formation pathway upstream of daf-9 and daf-12, wh

104 t-2 specifically enhanced the daf-2-mediated dauer formation phenotype.

105 es named dafachronic acids (DAs) control the dauer formation program in Caenorhabditis elegans throug

106 cell fate decisions and those that regulate dauer formation promote the robustness of developmental

107 as at the higher concentrations required for dauer formation the compounds no longer attract males an

108 lic AMP, which extends lifespan and enhances dauer formation through the modulation of TGF-beta (daf-

109 2 function renders animals hypersensitive to dauer formation under stressful conditions, whereas mise

110 XX cells, which are implicated in regulating dauer formation via the daf-9 pathway.

111 gar ascarylose for developmental regulation (dauer formation), male sex attraction, aggregation, and

112 Dauer formation, a major nematode survival strategy, rep

113 Molecular pathways involved in dauer formation, an alternate larval stage that allows C

114 elegans, did not show any notable effect on dauer formation, DAF-16 localization, or DAF-16 downstre

115 on of lin-42 in the pre-dauer stage inhibits dauer formation, indicating that lin-42 acts as a negati

116 lin-like signaling pathway, is involved with dauer formation, longevity, and stress resistance.

117 ures associating them with processes such as dauer formation, male identity, sperm formation, and int

118 Here we show that by suppressing dauer formation, Rhabditis sp. SB347 develops into femal

119 elegans, the IGF-1R ortholog DAF-2 regulates dauer formation, stress resistance, metabolism, and life

120 pcm-1 mutation may inhibit autophagy during dauer formation, suggesting that the absence of protein

121 is responsible solely for the regulation of dauer formation, with no role in longevity regulation, w

122 ncluding fertility, reproductive timing, and dauer formation, yet each of these differed in their thr

123 e find that the type II BMP receptor, DAF-4 (dauer formation-defective-4), is retromer-independent an

124 d multigenic resistance to pheromone-induced dauer formation.

125 ns, which are required for pheromone-induced dauer formation.

126 lightly more potent than ascr#3 in promoting dauer formation.

127 inct from that which regulates longevity and dauer formation.

128 for activated STAT proteins in repression of dauer formation.

129 s, or stress response pathways that regulate dauer formation.

130 ns in which the ogt-1(ok430)-null diminished dauer formation.

131 hree of which are amphid neurons involved in dauer formation.

132 ctions, including life span, fat storage and dauer formation.

133 ulates macronutrient storage, longevity, and dauer formation.

134 s of C. elegans reproductive development and dauer formation.

135 del of intraspecific competition in nematode dauer formation.

136 10 quantitative trait loci (QTLs) affecting dauer formation.

137 habditis at the molecular level, we isolated dauer-formation mutations in C. briggsae, a species clos

138 142.2 to the periphery of the alae of L1 and dauers, forming two longitudinal ribbons over the hypode

139 nsidered "nonaging" because larvae that exit dauer have a normal life span.

140 elegans furin homolog KPC-1 is required for dauer IL2 dendritic arborization and dauer-specific nict

141 defects in inhibiting dauer arrest: it forms dauers in the deletion mutant backgrounds of ncr-1 or da

142 s an alternative developmental state, called dauer, in which glia and neurons of the amphid sensory o

143 By genetically delineating a dauer-independent rIIS ageing pathway, our results show

144 Long-term daf-22 and dhs-28 cultures develop dauer-inducing activity by accumulating less active, lon

145 o endogenously produced small molecules, the dauer-inducing ascarosides ascr#2 and ascr#3, regulate l

146 responses to ascr#2, one of the most potent dauer-inducing ascarosides, although this mutant respond

147 nal consists of a synergistic blend of three dauer-inducing ascarosides, which we call ascr#2, ascr#3

148 ssion in ASI and ASJ is down-regulated under dauer-inducing conditions and in mutants of DAF-11/guany

149 d hermaphroditic development if submitted to dauer-inducing conditions.

150 determine the chemical composition of their dauer-inducing metabolomes and responses to individual p

151 Free-living nematodes excrete dauer-inducing pheromones that have been assumed to targ

152 of whether an animal undergoes continuous or dauer-interrupted development.

153 diates the choice between the continuous vs. dauer-interrupted life history.

154 utcrossing and the obligatory development of dauers into self-propagating adults.

155 The dauer is a developmental stage in C. elegans that exhibi

156 The dauer is a dispersal stage with dauer-specific behaviors

157 The dauer is specialized for survival under harsh environmen

158 f developmental time by forming a long-lived dauer larva at the end of the second larval stage.

159 This would resemble dauer larva formation in Caenorhabditis elegans where Ak

160 of hbl-1 and of genes encoding regulators of dauer larva formation, we find that hbl-1 can also modul

161 IGF-like pathway essential for longevity and dauer larva formation.

162 developmentally quiescent, stress-resistant dauer larva stage, enabling them to survive for prolonge

163 an obligatory nonfeeding juvenile stage, the dauer larva.

164 ners in controlling the decision to become a dauer larva.

165 sient bottlenecks and ongoing dispersal as a dauer larva.

166 ethod, we profiled muscle gene expression in dauer larvae and aging worms, revealing gene expression

167 defects of pcm-1 mutants previously seen in dauer larvae and here in L1 larvae suggest a defect in t

168 To survive, C. elegans dauer larvae and stationary phase S. cerevisiae require

169 We found that dauer larvae and stationary phase yeast switched into a

170 Dauer larvae are characterized by the arrest of all prog

171 When dauer larvae are returned to favorable environmental con

172 an ncr-2; ncr-1 double deletion mutant forms dauer larvae constitutively (Daf-c).

173 Dauer larvae contained complex N-glycans with higher mol

174 o understand how the control of variation in dauer larvae development has evolved.

175 opeptide Y receptor homolog npr-1 can affect dauer larvae development in growing populations.

176 eport extensive natural genetic variation in dauer larvae development within growing populations acro

177 bditis elegans, the appropriate induction of dauer larvae development within growing populations is l

178 If dauer larvae encounter conditions favorable for resumpti

179 -1 was also required for temperature-induced dauer larvae formation in an ILS mutant.

180 complex genetic architecture of variation in dauer larvae formation in C. elegans and may help to und

181 The OGT knockout suppresses dauer larvae formation induced by a temperature-sensitiv

182 bditis elegans arrest development by forming dauer larvae in response to multiple unfavorable environ

183 2 target genes and initiate development from dauer larvae into adults.

184 Dauer larvae of the nematode Caenorhabditis elegans exhi

185 e development normally, indicating that post-dauer larvae possess mechanisms to accommodate an indefi

186 The formation of dauer larvae, a developmental state promoted by daf-16,

187 osyl Pc-glycan (Pc1dHex2Hex5HexNAc6) seen in Dauer larvae, have not been observed in any organism.

188 In dauer larvae, the steady-state level of the 2.0 kb mRNA

189 appendicularian mucous houses, and nematode dauer larvae, to serving as mechanotransducers in flies

190 Pc2Hex4HexNAc3, from Dauer larvae, when subjected to PSD MS analyses, showed

191 ites undergo a prolonged quiescent period as dauer larvae, which can endure for several months with p

192 ize, and egg laying and an inability to form dauer larvae.

193 storage, and a decreased propensity to form dauer larvae.

194 In addition, IFT can be observed in dauer larvae.

195 ively regulate formation of stress-resistant dauer larvae.

196 f lyso-maradolipids specifically enriched in dauer larvae.

197 nt, paralyzes J2 larva, and inhibits exit of dauer larvae.

198 legans larvae to arrest as stress-resistant "dauer" larvae after the second larval stage (L2), thereb

199 one) that regulates entry into the alternate dauer larval stage and also modulates adult behavior via

200 o induce development of the stress-resistant dauer larval stage and to coordinate various behaviors.

201 ransiently pass through the stress-resistant dauer larval stage exhibit distinct gene expression prof

202 ditis elegans enters into a stress-resistant dauer larval stage in response to an adverse environment

203 d to trigger entry into the stress-resistant dauer larval stage, Caenorhabditis elegans uses the daue

204 ates the decision to enter into the enduring dauer larval stage.

205 for entry into the developmentally arrested, dauer larval stage.

206 evelopment and entering the stress-resistant dauer larval stage.

207 Here, we identify several consequences of dauer life history for VPC specification.

208 e pronounced in quiescent daf-2(-) dauer and dauer-like adult animals than in nondauaer animals.

209 inally, the number of BxPrx homologs in both dauer-like and fungi-feeding B. xylophilus were comparab

210 ke dafachronic acids induced recovery of the dauer-like iL3 in parasitic nematodes by activating orth

211 imilar up-regulation of neuropeptides in the dauer-like infective juveniles of diverse parasitic nema

212 ved in parasitic nematodes to regulate their dauer-like infective larval stage, and as such, the DAF-

213 he genes encoding CeTOR and raptor result in dauer-like larval arrest, implying that CeTOR regulates

214 We suggest that dauers and dauer-like quiescent adults may have underlying changes

215 anisms, can stimulate movement in dauers and dauer-like quiescent adults.

216 A similar dauer-like quiescent state is produced in adults by rela

217 bust lifespan extension unaccompanied by any dauer-like traits.

218 lays a central role in regulating life span, dauer, metabolism, and stress.

219 R orthologs during the continuous growth and dauer molts.

220 We also demonstrate that during dauer neuropeptides modulate the dauer-specific nictatio

221 se of Drosophila melanogaster and the larval dauer of Caenorhabditis elegans.

222 Prenol was attractive to dauers of some free-living nematodes and insect larvae.

223 ascarosides, control developmental diapause (dauer), olfactory learning, and social behaviors of the

224 ifficult under certain conditions, e.g. from dauer or aging worms.

225 n to C. elegans homologs expressed in either dauer or nondauer stages, matches between S. stercoralis

226 dence suggested that the C. elegans TGF-beta Dauer pathway is responsible solely for the regulation o

227 ongevity-regulating activity by the TGF-beta Dauer pathway that is masked by an egg-laying (Egl) phen

228 The TGF-beta Dauer pathway's regulation of longevity appears to be me

229 rogram that is genetically distinct from the dauer pathway, and requires the Nrf (NF-E2-related facto

230 s appear to act in the insulin branch of the dauer pathway, including pdk-1, akt-1, aex-6, and hid-1.

231 posite behavioral responses in the adult and dauer pharynx.

232 Moreover, sta-1 mutants showed a synthetic dauer phenotype with selected TGF-beta mutations.

233 -chain fatty acid-derived side chains of the dauer pheromone and link dauer pheromone production to m

234 cellular pathways responsible for detecting dauer pheromone and temperature have been defined in par

235 rains, the desert strain fails to respond to dauer pheromone at 25 degrees C, but it does respond at

236 We found that these isolates produce dauer pheromone blends of different composition and resp

237 Furthermore, we show that the active dauer pheromone components that are produced by C. elega

238 e dauer formation in response to a subset of dauer pheromone components.

239 ut additional unidentified components of the dauer pheromone contribute to its activity.

240 Although the dauer pheromone has been studied for 25 years, its biosy

241 Several components of the dauer pheromone have been identified as derivatives of t

242 C. elegans constitutively secretes the dauer pheromone into its environment, enabling it to sen

243 e model organism Caenorhabditis elegans, the dauer pheromone is the primary cue for entry into the de

244 in Pristionchus pacificus revealed that the dauer pheromone of some strains affects conspecifics of

245 side chains of the dauer pheromone and link dauer pheromone production to metabolic state.

246 mutant is the only known mutant defective in dauer pheromone production.

247 Identification of dauer pheromone receptors will allow a better understand

248 de chain is a highly potent component of the dauer pheromone that acts synergistically with previousl

249 ture of small molecules (collectively termed dauer pheromone) that regulates entry into the alternate

250 based on sensing of environmental inputs and dauer pheromone, a small molecule signal that serves to

251 ta signaling, which mediates the response to dauer pheromone, but SCD-2 might mediate a nonpheromone

252 environmental stimuli, including exposure to dauer pheromone, food deprivation, and high temperature,

253 Identifying the active components of the dauer pheromone, the conditions under which they are pro

254 arval stage, Caenorhabditis elegans uses the dauer pheromone, which consists of ascaroside derivative

255 mponents of the density-dependent C. elegans dauer pheromone.

256 as a single mutant, it is hypersensitive to dauer pheromone.

257 anylyl cyclase, a predicted component of the dauer-pheromone-sensing pathway.

258 increases the production of the most potent dauer pheromones, those with the shortest side chains, u

259 sting that it is involved in biosynthesis of dauer-preventing steroid hormones.

260 ide signaling promotes the decision to enter dauer rather than reproductive development.

261 neurons and signaling pathways that control dauer recovery in Caenorhabditis elegans also control IJ

262 In a screen for dauer regulatory genes that control the activity of the

263 lays C. elegans ageing through activation of dauer-related processes during adulthood, but some rIIS

264 lifespan extension by even mild activity of dauer-related processes.

265 sory receptive endings of the AWC neurons in dauers remodel in the confines of a compartment defined

266 arrest of daf-7 mutant animals and inhibits dauer remodelling of some tissues in daf-2 mutant animal

267 We map this defect in dauer response to a mutation in the scd-2 gene, which, w

268 is no correlation between production of and dauer response to a specific compound in individual stra

269 The dauer is a dispersal stage with dauer-specific behaviors for finding and stowing onto ca

270 cell autonomously in IL2 neurons to regulate dauer-specific dendritic arborization and nictation.

271 that during dauer neuropeptides modulate the dauer-specific nictation behavior (carrier animal-hitchh

272 red for dauer IL2 dendritic arborization and dauer-specific nictation behavior.

273 L1 genes have homologs among the C. elegans dauer-specific transcripts, we did not uncover evidence

274 hway that regulates life span extension, the dauer-specifying insulin/IGF-1-like pathway.

275 , whereas misexpression of lin-42 in the pre-dauer stage inhibits dauer formation, indicating that li

276 e, can induce C. elegans larvae to enter the dauer stage, a developmentally arrested diapause state.

277 ntrations induce developmental arrest at the dauer stage, an alternative, nonaging larval stage.

278 to enter the long-lived but non-reproductive dauer stage.

279 ve development over entry into the diapausal dauer stage.

280 stage, the non-feeding and highly persistent dauer stage.

281 itis elegans, a species that has an L3i-like dauer stage.

282 es cause worms developmentally arrest at the Dauer stage.

283 rrest at the stress resistant and long-lived dauer stage.

284 ept for the transition between non-dauer and dauer stages.

285 The Caenorhabditis elegans dauer state is a hibernation-like state of diapause that

286 ould regulate the entry to and exit from the dauer state, and genes that encode components of metabol

287 In contrast, hypoxia, the dauer state, and high salt reduce touch sensitivity by p

288 Tail tap of dauers stimulates pumping through a mechanism involving

289 y-associated phenotypes including life span, dauer, stress resistance, and fat storage.

290 rmal vulval patterning after passage through dauer, suggesting that DAF-16/FoxO coordinates environme

291 phrodite and male animals indicates that the dauer suppression phenotype of dpy-21 mutants is due to

292 mponents of metabolic pathways important for dauer survival and longevity.

293 ecreased under conditions that do not induce dauer traits, SKN-1 most prominently increases expressio

294 delayed by interventions that do not involve dauer traits.

295 In wild-type dauers, VPCs undergo a phenomenon reminiscent of natural

296 s at various developmental stages (including dauer) were measured and different positions along the w

297 verexpression, we show that DAF-37 regulates dauer when expressed in ASI neurons and adult behavior w

298 itis elegans enters a diapause state, termed dauer, which is accompanied by remodeling of sensory neu

299 an alternative developmental stage known as dauer, which is characterized by adaptive changes in str

300 les (IJs) to those of Caenorhabditis elegans dauers, which are analogous life stages.