ライフサイエンスコーパス: daunting

1 racterization of cAMP signaling compartments daunting.

2 correlate structure and function have become daunting.

3 th very little programming experience can be daunting.

4 the less-defined course of an MD/MBA can be daunting.

5 xperimental and computational methods can be daunting.

6 nctional relationships has been particularly daunting.

7 , although the logistical considerations are daunting.

8 esource overhead made the scheme practically daunting.

9 challenging and make PIT program development daunting.

10 -throughput experimental design is even more daunting.

11 e the occurrence of this problem have proved daunting.

12 the development of this brain region rather daunting.

13 y under in vivo conditions, has proved to be daunting.

14 community engagement infrastructure, can be daunting.

15 ma that suggest the study of HERV RNA can be daunting.

16 acterium tuberculosis transmission, is quite daunting.

17 But the complexity of the challenge remains daunting.

18 gnosing, and treating periorbital edema less daunting.

19 ively cumbersome experimental procedures and daunting analytical frameworks.

20 Eliciting information on the exposome is daunting and not feasible at present; the undertaking ma

21 aid, and getting accustomed to its use is a daunting and often frustrating process.

22 atterns at successive levels of processing-a daunting and seemingly intractable task.

23 eresting genes generated by these studies is daunting, and biological and clinical relevance of these

24 implest of molecules, is both remarkable and daunting, and presents intriguing new possibilities for

25 of serious suicidal behavior, explaining the daunting array of suicide-related facts from the molecul

26 rategies to accomplish this task would prove daunting as it is both time-consuming and costly.

27 nderstood and the selection of immunogens is daunting as there are dozens of surface proteins and two

28 China's health-equity challenges are truly daunting because of a vicious cycle of three synergistic

29 tralizing antibodies (NAbs) against HIV-1 is daunting because of the extensive genetic and antigenic

30 rge-scale efforts to tackle some of the most daunting but important neuroscience questions.

31 the knottier it appears to be, suggesting a daunting (but stimulating) path ahead for neuroscience m

32 gets' that predict adverse drug reactions is daunting by empirical methods alone.

33 g domestic safety from terrorist attack is a daunting challenge because of the wide array of chemical

34 ributable to a specific electrical load is a daunting challenge but essential for many environmental

35 th analysis of the plasma proteome remains a daunting challenge due to its high complexity and the ex

36 lonal antibody (mAb) in tissues represents a daunting challenge due to the extremely low tissue level

37 nitoring of tumor drug delivery in vivo is a daunting challenge due to the heterogeneity and complexi

38 hrough the void spaces in porous metals is a daunting challenge for a variety of emerging interface t

39 g heat to and from conversion materials is a daunting challenge for a variety of innovative energy te

40 iant frontotemporal dementia (bvFTD) poses a daunting challenge for clinicians but will be critical f

41 onic cough is a common symptom that can be a daunting challenge for clinicians since treatment of the

42 Schizophrenia remains a daunting challenge for efforts aimed at identifying fund

43 nked peptides by mass spectrometry remains a daunting challenge for protein-protein cross-linking app

44 ate species at a single crystal surface is a daunting challenge for spectroscopic techniques.

45 of these associated complications, and is a daunting challenge given the high percentage of patients

46 Lentiviruses such as HIV have a daunting challenge in gaining access to a new host predo

47 ated by this profiling technology presents a daunting challenge in terms of effectively visualizing a

48 regenerative biology presents a particularly daunting challenge in this regard.

49 he importance of in silico approaches to the daunting challenge of assigning and predicting the funct

50 , I present suggestions on how to tackle the daunting challenge of building truly national HIV/AIDS p

51 py for the muscular dystrophies represents a daunting challenge requiring significant advances in our

52 the cardiovascular system; thus, it seems a daunting challenge to build predictive models that accou

53 Bioterrorism poses a daunting challenge to global security and public health

54 It remains a daunting challenge to reconcile data as diverse as synap

55 supply of corrected progeny remains the most daunting challenge to the success of human gene therapy.

56 ing protein 2 (MeCP2) overexpression poses a daunting challenge to traditional biochemical-pathway-ba

57 comprehensive microbial probe sets remains a daunting challenge, particularly in virology where rapid

58 the 1alpha,25-dihydroxy-VitD(3) constitute a daunting challenge.

59 organization in artificial systems remains a daunting challenge.

60 gement of septic patients has proven to be a daunting challenge.

61 sitivity of the tumors to therapy) remains a daunting challenge.

62 s, measuring lymphocyte diversity has been a daunting challenge.

63 and maintenance of allograft tolerance is a daunting challenge.

64 ing the neuronal basis of individuality is a daunting challenge.

65 fatty acid substrate site of InhA remains a daunting challenge.

66 zed precious metal-based catalysts remains a daunting challenge.

67 sensors for in vivo chemical monitoring is a daunting challenge.

68 chiral selection of molecules presents both daunting challenges and significant opportunities in mat

69 uced by several mechanisms and highlight the daunting challenges associated with preventing or overco

70 st in a series on primary care--outlines the daunting challenges facing primary care today.

71 Integral membrane proteins often present daunting challenges for biophysical characterization, a

72 kilometers per year, raising the prospect of daunting challenges for ecosystems, especially in the co

73 ast 5 years offer exciting opportunities and daunting challenges for the development of new therapeut

74 tes emerging from such in vitro studies face daunting challenges in the design of proof-of-concept st

75 One of the most daunting challenges is in creating large-area, perfectly

76 elopments in historical context, discuss the daunting challenges that have been overcome, and apprais

77 ing the multiple co-occurring events present daunting challenges to our scientific community.

78 The perception of color poses daunting challenges, because the light spectrum reaching

79 1 infection, the immune system already faces daunting challenges.

80 nsin B is an indole diterpenoid that bears a daunting chemical structure featuring a disubstituted ca

81 Although the daunting complexity of biological networks affects the d

82 The daunting complexity of ecosystems has led ecologists to

83 When considering the daunting complexity of eukaryotic genomes, some comfort

84 are discovering the unexpected necessity and daunting complexity of our microbial partners.

85 li translate into perception is a problem of daunting complexity.

86 This circumstance tends to generate daunting computational burdens, and often gives rise to

87 pedigrees with loops, which continue to pose daunting computational challenges.

88 and families, but such analysis represents a daunting computational task.

89 Envisioning the future of stroke appears daunting considering the milestones already achieved in

90 sease, measuring drug effectiveness, and the daunting cost of clinical trials hampers the development

91 d with endodontic lesions are among the most daunting diagnostic and therapeutic challenges faced by

92 tantial progress has already been made, many daunting difficulties remain.

93 But the challenge is daunting due to heterogeneity, feedbacks, and water's sp

94 a multitude of these individual measures is daunting due to the combinatorial explosion of possible

95 This task is daunting due to the complex nature of cellular processes

96 In the light of daunting global sustainability challenges such as climat

97 ently and with high efficiencies, has been a daunting goal for synthetic chemists for many years.

98 zing antibody response against HIV remains a daunting goal, data from both natural infection and vacc

99 This problem is particularly daunting in children with chronic GVHD, whereby the effe

100 The challenge of managing change is daunting in the coastal zone where diverse human pressur

101 bered can be not only tedious but also quite daunting, in the case of very large pedigrees.

102 h pericentrin-mediated disorders is somewhat daunting, insights into the cellular basis of disease ar

103 mate choice will lead an organisation facing daunting internal and external challenges, from its own

104 Equally daunting is that clouds themselves are complex, turbulen

105 Even more daunting is that many of these metastatic deposits silen

106 , mining of the UHPLC-HRAM-MS data is a very daunting, labor-intensive, and expertise-dependent proce

107 ve and post-preparative chemistry that poses daunting limitations in the context of delivery to any o

108 tant cousin Plasmodium vivax, resulting in a daunting morbidity and economic burden for countries acr

109 its apparently simple relay function and its daunting multinuclear structure--have been customarily v

110 iation studies (GWAS) has been hampered by a daunting multiple testing problem.

111 undertake a metabolomics oriented study is a daunting obstacle to investigators new to the field.

112 Daunting obstacles to the development of careers in acad

113 the inconvenience of two spacecraft, but the daunting optics challenges are replaced with a simple de

114 ith plasmonic nanoparticles to satisfy these daunting photocatalytic requirements.

115 The natural product possesses a daunting polycyclic skeleton that contains a furanoindol

116 ntal scientific challenge, but it also faces daunting practical and political challenges.

117 t T cell epitope diversity may not be such a daunting problem for the development of an HIV vaccine.

118 the presence or development of obesity is a daunting problem, it should not be ignored by mental hea

119 ession of cancer is a complex and clinically daunting process.

120 , along with the array of choices, present a daunting prospect for biologists, and other researchers

121 One approach for tackling such a daunting scientific endeavour for complex behaviour-base

122 lopmental intellectual disability (DID) is a daunting societal problem.

123 of increasingly complex polymers has created daunting, sometimes insurmountable problems for their ch

124 evelop chronic rejection within 10 years - a daunting statistic, particularly for young patients expe

125 Owing to their daunting structural framework and potential as pharmaceu

126 me editing in hPSCs has evolved from being a daunting task a few years ago to a routine procedure in

127 ciation in complex, real-world matrixes is a daunting task because of the low concentration of metals

128 allenges for all of these residents can be a daunting task but can be accomplished with proper curric

129 s' that predict adverse drug reactions, is a daunting task by experimental approaches alone.

130 n patterned multi-neuronal spiking remains a daunting task due to the high dimensionality of the acti

131 Understanding genes and their functions is a daunting task due to the level of complexity in biologic

132 ducing procedures is a necessary but often a daunting task for emergency medicine providers.

133 es displayed by each transcription factor, a daunting task given the current methodologies for measur

134 onal modification (PTM) signatures remains a daunting task in the epigenetics field.

135 This daunting task is executed by thousands of replication fo

136 advances reveal the cancer gene landscape, a daunting task is to understand how these genes contribut

137 Animals face the daunting task of controlling their limbs using a small s

138 DNA recombinases face the daunting task of locating and pairing up specific sequen

139 Notably, DCs in the gut have the daunting task of orchestrating the balance between immun

140 epartment of Defense (DoD) is faced with the daunting task of possible remediation of numerous soil-C

141 Researchers are then faced with the daunting task of prioritizing these candidate genes for

142 organisms, from bacteria to humans, face the daunting task of replicating, packaging and segregating

143 ntigen processing machinery accomplishes the daunting task of sampling these proteins and cleaving th

144 to the market, clinicians are faced with the daunting task of sifting through the published literatur

145 l reaction rates in the subsurface remains a daunting task partly because a key parameter for macrosc

146 y which complex nervous systems perform this daunting task remain largely unknown.

147 ith pooled genetic data, in particular, is a daunting task that raises important statistical issues.

148 However, it is still a daunting task to comprehensively identify and profile se

149 t involved in developing such models it is a daunting task to decide which, if any, coarse-grained mo

150 lly transmitted diseases (STDs) represents a daunting task, and there have been very few examples of

151 in practice will often find implementation a daunting task, as it tends to require special statistica

152 of most individual amacrine cell types is a daunting task, because few molecular or morphological ma

153 er, analyzing such data is a challenging and daunting task, both because of its sheer volume and beca

154 eavors, the imaging of such "potential" is a daunting task, but one that only molecular imaging--rath

155 lloys out of a vast compositional space is a daunting task, especially for bulk metallic glasses comp

156 h there are six copies of every gene seems a daunting task, however this has recently been reported.

157 entification of such conductive regions is a daunting task, particularly for metal-oxides capable of

158 Although it is a daunting task, there has never been a better opportunity

159 elective synthesis of furanosides is still a daunting task, unlike the pyranosides, for which several

160 molecular mechanisms is required and poses a daunting task.

161 tumor to identify its cellular origins is a daunting task.

162 ll proteins that recognize histone PTMs is a daunting task.

163 olecules with a high degree of ordering is a daunting task.

164 nning approaches, is still a challenging and daunting task.

165 mong highly divergent protein sequences is a daunting task.

166 tation of digital radiologic images can be a daunting task.

167 ing large lists of iTerm and gene pairs is a daunting task.

168 are removed in eukaryotic cells has proved a daunting task.

169 apid growth, makes access and assimilation a daunting task.

170 onnectivity in the neocortex may seem like a daunting task.

171 rvous system in higher vertebrates this is a daunting task.

172 d with common, complex diseases has become a daunting task.

173 ocesses utilizing molecular oxygen remains a daunting task.

174 system of human subject protections, faces a daunting task.

175 s essential for precision medicine remains a daunting task.

176 wide studies, quality control becomes a more daunting task.

177 ul information from large data sets can be a daunting task.

178 n function and dysfunction, yet it remains a daunting task.

179 articles that are published each month is a daunting task.

180 into testable hypotheses, however, remains a daunting task.

181 cells from inanimate components seem like a daunting task.

182 cades of research have proven that this is a daunting task.

183 es from high-throughput data still remains a daunting task.

184 e models of characterizing joint events is a daunting task.

185 the human naive T cell repertoire remains a daunting task; however, emerging data suggest that homeo

186 range in solubility or ionization, imposing daunting tasks in areas as different as lipidomics and p

187 ple imputation via chained equations, can be daunting tasks with large numbers of categorical and con

188 Paediatric EMG, while a daunting technical challenge to some practitioners, rema

189 y of episodic memory in nonhumans seems less daunting than it did five years ago.

190 Overcoming acquired resistance is a daunting therapeutic challenge, and little is known abou

191 ) type 1 within resting CD4+ T cells poses a daunting therapeutic challenge.

192 f sequence identifiers across databases is a daunting, time-consuming and computationally expensive p

193 are packages that are now available may seem daunting to an experimental biologist.

194 anyone new to this area, however, it can be daunting to decide which techniques or equipment to try.

195 methods for functional neural imaging can be daunting to the nonexpert to navigate.

196 ing and applying genomic knowledge remains a daunting undertaking.

197 Juxtaposition of Red, Ox, and Rel produces a daunting variety of metal electronic excitations, but on

198 The rapid and accurate processing of such daunting volumes of continuously changing data relies on

199 these often lethal biliary tract cancers are daunting, with conventional treatment options being limi