ライフサイエンスコーパス: de novo pathway

1 nine different organisms to form a ten-step de novo pathway.

2 s PGC1alpha deficiency or AKI attenuates the de novo pathway.

3 ucleotide triphosphate pools produced by the de novo pathway.

4 trioles have an activity that suppresses the de novo pathway.

5 o regulate the expression or activity of the de novo pathway.

6 ge pathway of ceramide formation and not the de novo pathway.

7 to occur primarily due to activation of the de novo pathway.

8 eramide in LNCaP cells is independent of the de novo pathway.

9 f DHFR and/or other enzymes along the purine de novo pathway.

10 the gene that encodes the third step in the de novo pathway, 3-dehydroquinate dehydratase (DHQ), was

11 80% of GDP-mannose synthesis comes from the de novo pathway and 20% from the salvage pathway.

12 eaction sits at the branch point between the de novo pathway and the salvage pathway, and has been sh

13 ays in hemopoietic and other cells that lack de novo pathways and are the route of cellular uptake fo

14 on of AT2 receptor induces the activation of de novo pathway, and a metabolite of this pathway, possi

15 ition of intracellular PA generation through de novo pathways attenuates sepsis-induced acute lung in

16 However, the regulation of the de novo pathway compared with the salvage pathway is not

17 Mutants in the de novo pathway died upon removal of exogenous nicotinam

18 phosphate (dCTP) can be produced both by the de novo pathway (DNP) and by the nucleoside salvage path

19 es mediating ceramide generation through the de novo pathway (e.g. serine palmitoyltransferase) and v

20 y of modular pathway screening to facilitate de novo pathway engineering.

21 ased activity of PDX3 as well as of the B(6) de novo pathway enzyme PDX1, correlating with increased

22 ite complementation." First, the trypanosome de novo pathway enzymes GDP-mannose dehydratase (GMD) an

23 the FX locus, which encodes an enzyme in the de novo pathway for GDP-fucose synthesis, exhibit a virt

24 ho1Delta/Delta) eliminates PS and blocks the de novo pathway for PE biosynthesis.

25 phenolate mofetil (MMF), an inhibitor of the de novo pathway for purine biosynthesis, decreases rejec

26 n of glycinamide ribonucleotide (GAR) in the de novo pathway for purine biosynthesis.

27 The first acylation step in the de novo pathway for TAG synthesis is catalyzed by glycer

28 athway, which provides an alternative to the de novo pathway for the biosynthesis of purine nucleotid

29 Biochemical assays of the de novo pathway for the synthesis of GDP-L-fucose indica

30 NAD biosynthesis, remarkably, they have one de novo pathway gene, nadC, encoding quinolinate phospho

31 reased expression of salvage and some of the de novo pathway genes was observed in both the pdx3 and

32 ittle change in expression of the vitamin B6 de novo pathway genes, but significant increases in expr

33 oxylase enzymes that convert PS to PE in the de novo pathway, has diminished PE levels like those of

34 While PLP can be synthesized by a de novo pathway in bacteria and plants, most higher orga

35 reduction in fatty acids synthesized by the de novo pathway in L2 MECs of bitransgenic versus contro

36 1) and endogenous ceramide generated via the de novo pathway in regulating this mechanism.

37 an evolutionary conserved activation of the de novo pathway in response to heat shock.

38 pids and specifically those generated in the de novo pathway in the cell cycle arrest response to hea

39 oss-talk between phospholipid remodeling and de novo pathways involves ubiquitin-lysosomal processing

40 hosphates generated from receptor-linked and de novo pathways is crucial to the maintenance of approp

41 This de novo pathway leads to the formation of a random numbe

42 cidal effect as sudden NAD starvation of the de novo pathway mutant in both actively growing and nonr

43 roceramide desaturase as a key enzyme in the de novo pathway of ceramide generation was investigated

44 IPS) catalyzes the first step of the unique, de novo pathway of inositol biosynthesis.

45 of ceramide was blocked by inhibitors of the de novo pathway of SL synthesis, beta-chloro-L-alanine a

46 The de novo pathway of sphingolipid synthesis has been ident

47 rine nucleotide biosynthesis, mutants in the de novo pathway that disable the feedback inhibition of

48 dicating that most GDP-fucose is formed by a de novo pathway that involves the bioconversion of GDP-m

49 ose isomerase occupies a key position on the de novo pathway to GDP-mannose from glucose, just before

50 deoxyribonucleotides, and represent the only de novo pathway to provide DNA building blocks.

51 ne (d3-PtdCho)--a metabolite produced in the de novo pathway via choline-derived methyl groups.

52 The GDP-Fuc de novo pathway, which requires the action of GDP-mannos

53 modifying natural pathways and establishing de novo pathways with enzymes from a variety of organism

54 osynthesized in this autotroph either by the de novo pathway, with chorismate as an intermediate, or