ライフサイエンスコーパス: de novo synthesis

1 from the extracellular milieu as opposed to de novo synthesis.

2 1), the first and rate-limiting enzyme of FA de novo synthesis.

3 idine, due to suppression of both uptake and de novo synthesis.

4 small and that sustained secretion requires de novo synthesis.

5 protein expression through inhibition of its de novo synthesis.

6 amino acid addition, suggesting a completely de novo synthesis.

7 rous reports of elegant strategies for their de novo synthesis.

8 filaments, suggesting a mechanism involving de novo synthesis.

9 owed an approximately 50% increase in serine de novo synthesis.

10 embranes, is generated by its remodeling and de novo synthesis.

11 ion channels, has been made possible through de novo synthesis.

12 alpha(1)-AR mediated IL-6 secretion through de novo synthesis.

13 dentified niacin-responsive repressor of NAD de novo synthesis.

14 : bulk uptake from the cytoplasmic pool, and de novo synthesis.

15 ns, mobilization of intracellular lipid, and de novo synthesis.

16 erated either by salvage pathways or through de novo synthesis.

17 without significant enhancement of collagen de novo synthesis.

18 nzo-p-dioxins and dibenzofurans (PBDD/Fs) by de novo synthesis.

19 The nature of the de novo synthesis also enables the preparation of both e

20 are the only cell type that must balance the de novo synthesis and absorption of cholesterol, althoug

21 arum undergoes rapid proliferation fueled by de novo synthesis and acquisition of host cell lipids.

22 ation, we conclude that only one pathway for de novo synthesis and attachment of lipoic acid exists i

23 Here we report the first de novo synthesis and cell-free cloning of custom DNA li

24 that the rise in PC resulted from increased de novo synthesis and correlated with an induction of ch

25 we showed that SR141716 induced cholesterol de novo synthesis and high-density lipoprotein uptake, r

26 nes of serum-starved 3T3-L6 myoblasts due to de novo synthesis and increased lipid stability.

27 and elicited a NALP3 activation, leading to de novo synthesis and inflammasome priming.

28 Improvements in de novo synthesis and intestinal absorption increase glu

29 eded for steroidogenesis is provided by both de novo synthesis and isoprenylation-dependent mechanism

30 was no evidence of a difference in cysteine de novo synthesis and its total flux or erythrocyte glut

31 hould enable broad synthetic applications in de novo synthesis and late-stage functionalization chemi

32 ows for integrated, physiological studies of de novo synthesis and metabolism and transport of materi

33 Transcriptional analysis of the de novo synthesis and putative salvage pathway genes rev

34 The cysteine flux, its de novo synthesis and release from protein breakdown, an

35 African trypanosomes are capable of both de novo synthesis and salvage of pyrimidines.

36 iliary atresia through a unique mechanism of de novo synthesis and secretion of bile salts in intesti

37 of preformed inflammatory mediators and the de novo synthesis and secretion of cytokines and chemoki

38 ted in different domains as a result of both de novo synthesis and transport.

39 correspond to fatty acid uptake from media, de novo synthesis, and elongation.

40 mM through a combination of dietary uptake, de novo synthesis, and muscle protein catabolism.

41 possible CCR5 degradation with a subsequent de novo synthesis, and that re-expression of CCR5 on the

42 The last two steps in de novo synthesis are catalysed by UMP synthase (UMPS) -

43 Collagen breakdown and de novo synthesis are important processes during early w

44 nd in pharmaceutical substances; this leaves de novo synthesis as the principal strategy for preparat

45 role in all three routes of NAD biogenesis, de novo synthesis as well as the two salvage pathways.

46 ty by upregulation of B1R expression through de novo synthesis, as well as rapid translocation of pre

47 De novo synthesis at high NTP concentrations was shown t

48 c and genetic inhibition of PI3K/Akt reduced de novo synthesis by 75% in logarithmically growing cell

49 ogy-mediated end joining (SD-MMEJ), in which de novo synthesis by an accurate non-processive DNA poly

50 obalamin in the surface ocean is a result of de novo synthesis by heterotrophic bacteria or via modif

51 PI3K/Akt regulated early steps of de novo synthesis by modulating phosphoribosylpyrophosph

52 nd calculated indexes of FA desaturation and de novo synthesis by the mammary gland.

53 ion caused TRAIL secretion in the absence of de novo synthesis by triggering release of prefabricated

54 ut in the absence of preexisting centrioles, de novo synthesis can occur.

55 by Zn2+ is irreversible, and thus only their de novo synthesis can restore function, which may underl

56 In addition to de novo synthesis, cells recycle nucleotides from the DN

57 c In-vitro Cloning (MIC) and applied them to de novo synthesis, combinatorial assembly and cell-free

58 However, the current cost of de novo synthesis-driven largely by reagent and handling

59 ased ceramide levels reflected their reduced de novo synthesis, due to inhibition of the activity of

60 uptake because, unlike in plants, nucleotide de novo synthesis exclusively occurs in the cytosol.

61 e functionality of HCMV virions; rather, its de novo synthesis facilitates viral DNA synthesis, which

62 t the UVR8 dimer is not regenerated by rapid de novo synthesis following destruction of the monomer.

63 adrenal precursor steroids or possibly from de novo synthesis from cholesterol commonly requires enz

64 Intracellular myo-inositol is generated by de novo synthesis from glucose 6-phosphate or is provide

65 In the second phase, de novo synthesis generates ceramide that reduces the ce

66 ial RNA polymerases that perform the initial de novo synthesis, generating the first 8-10 nucleotides

67 t is recognized that the rapid adaptation of de novo synthesis has a key role in adjusting required B

68 A de novo synthesis has been employed to prepare bacterioc

69 hich increases protein concentration without de novo synthesis; (ii) reduced protein degradation rate

70 intestinal cholesterol absorption as well as de novo synthesis in gallstone patients stratified accor

71 Here, through reconstitution of de novo synthesis in human cells, we surprisingly found

72 y the energy demand of amino acid and enzyme de novo synthesis in photoautotrophic growth conditions.

73 Cells acquire cholesterol either by de novo synthesis in the endoplasmic reticulum or by int

74 e catalytic domain of ADAMTS-4, and required de novo synthesis in the presence of IL-1 for its genera

75 De novo synthesis in vivo requires an endogenous accepto

76 atic steatosis in alcohol-fed mice, but only de novo synthesis inhibition, not sphingomyelin hydrolys

77 De novo synthesis is a unique phase in the transcription

78 The rate-limiting step of 6BH(4) de novo synthesis is controlled by guanosine triphosphat

79 Nucleotide de novo synthesis is highly conserved among organisms an

80 vide insights into the many systems in which de novo synthesis is increased in the absence of elevate

81 urated acyl chains into phospholipids during de novo synthesis is primarily mediated by the 1-acyl-sn

82 t differences in obese mice lacking ceramide de novo synthesis machinery in macrophages.

83 itochondrial synthesis of acetyl-CoA, as the de novo synthesis of (13)C-labeled palmitate was increas

84 line required several hours, indicating that de novo synthesis of 18S was necessary.

85 ribution of energy resources only increasing de novo synthesis of a few key proteins.

86 s 25-hydroxyvitamin D 1alpha-hydroxylase for de novo synthesis of a focally high 1,25-dihydroxyvitami

87 in porous materials circumvents the need for de novo synthesis of a metal-organic framework, making i

88 capsid protein from 1 to 72 h and increasing de novo synthesis of a previously unidentified 17-kDa pr

89 d capillary dysfunction can be attributed to de novo synthesis of a specific ensemble of proteins tha

90 An enantioselective de novo synthesis of a thioglycoside derivative of the 6

91 of Phex in UMR106 cells and did not require de novo synthesis of a transrepressor.

92 malian codons (codon deoptimization) for the de novo synthesis of a viral NS RNA segment based on inf

93 in isolated functional nuclei decreased the de novo synthesis of acetyl-CoA and acetylation of core

94 Our data suggest that de novo synthesis of active GAs is necessary for stamen

95 ransferase (EC 3.1.3.73) and is required for de novo synthesis of AdoCbl (coenzyme B(12)).

96 (PMo) required activation of TLR4 to induce de novo synthesis of alphavbeta3 enabling WISP1 to stimu

97 e has been hypothesized to include increased de novo synthesis of amino acid neurotransmitters, espec

98 nction in one-carbon metabolism to allow the de novo synthesis of amino acids and nucleosides.

99 f carbon and energy, it is not known whether de novo synthesis of amino acids by intravacuolar L. pne

100 adenylosuccinate to AMP, which occurs in the de novo synthesis of AMP and also in the purine nucleoti

101 ADSL executes two nonsequential steps in the de novo synthesis of AMP: the conversion of phosphoribos

102 r exogenously introduced ganglioside induces de novo synthesis of an enzymatic machinery to modify it

103 De novo synthesis of an inhibitory transcription factor

104 provide strong genetic evidence implicating de novo synthesis of Ang II in the SFO as an integral pl

105 Glutamine is the ultimate source for de novo synthesis of arginine in humans via the intestin

106 establish the contribution of the kidneys to de novo synthesis of arginine in patients receiving intr

107 whole-body citrulline turnover was used for de novo synthesis of arginine.

108 tional integral membrane proteins during the de novo synthesis of biomimetic phospholipid bilayers is

109 ts recent impressive progress in the area of de novo synthesis of carbohydrates by using organocataly

110 or CD4(+) T cells and APCs are too short for de novo synthesis of CD40L.

111 nt interactions that are too brief to permit de novo synthesis of CD40L.

112 tirely elucidated, we have hypothesized that de novo synthesis of ceramide, through the rate-limiting

113 Here we report that doxorubicin stimulates de novo synthesis of ceramide, which in turn activates C

114 depletion induces the UPR by increasing the de novo synthesis of ceramide.

115 g DRMs by lowering cholesterol or inhibiting de novo synthesis of ceramides at the ER largely decreas

116 ansferase (SPT), the rate-limiting enzyme in de novo synthesis of ceramides, but both message and pro

117 se model (Dhcr7(-/-)), which is incapable of de novo synthesis of cholesterol, in utero treatment wit

118 terica is an l-threonine kinase used for the de novo synthesis of coenzyme B(12) and the assimilation

119 own to be an L-threonine kinase used for the de novo synthesis of coenzyme B(12) and the assimilation

120 owed that a pduX mutant was impaired for the de novo synthesis of coenzyme B(12) as expected.

121 Npr1-phosphorylated Orm1 and Orm2 stimulate de novo synthesis of complex sphingolipids downstream of

122 sses all steroidogenic enzymes necessary for de novo synthesis of corticosterone from cholesterol, fu

123 TPS) catalyzes the rate-limiting step in the de novo synthesis of CTP, and both the yeast and human e

124 miR-503 precursor (pre-miR-503) reduced the de novo synthesis of CUGBP1 protein, whereas inhibiting

125 The de novo synthesis of cysteinyl leukotrienes, TNFalpha, C

126 egulation of three of the LHCX genes and the de novo synthesis of Dd+Dt led to a pronounced rise of q

127 aled the participation of this enzyme in the de novo synthesis of defensive monoterpenoids in the bee

128 uctase (RR), the rate-limiting enzyme in the de novo synthesis of deoxyribonucleoside triphosphates,

129 eductase (RNR) is the only enzyme capable of de novo synthesis of deoxyribonucleotide triphosphates (

130 uctases (RNRs) catalyze the only pathway for de novo synthesis of deoxyribonucleotides needed for DNA

131 erol concentration was found to be caused by de novo synthesis of diacylglycerol from medium-chain ac

132 ntegral membrane protein responsible for the de novo synthesis of disulfide bonds in Escherichia coli

133 ly, lapatinib and palbociclib strictly block de novo synthesis of DNA, mostly through disruption of E

134 aring drugs in mouse tissues and visualizing de novo synthesis of DNA, RNA, proteins, phospholipids a

135 ere we summarize methods and caveats for the de novo synthesis of DNA, with particular emphasis on re

136 ibonucleotide reductase, responsible for the de novo synthesis of dNTPs, is a cytosolic enzyme maxima

137 Inhibition of de novo synthesis of Drosha and Dicer in the embryo led

138 c pathways, including those required for the de novo synthesis of dTMP and purine nucleotides and for

139 es present in the decidual tissue to support de novo synthesis of E.

140 p to 3 m NaCl in a minimal medium due to the de novo synthesis of ectoines.

141 in cargo concentration acts as a trigger for de novo synthesis of ERES.

142 revealed that, following embryo attachment, de novo synthesis of estrogen by the decidual cells is c

143 s served an essential role in supporting the de novo synthesis of fatty acids for the expansion of th

144 ciency leads to a decrease in glycolysis and de novo synthesis of fatty acids in hepatocytes.

145 The first and rate-limiting reaction in de novo synthesis of fatty acids is carboxylation of ace

146 nucleocytosolic acetyl-CoA is also used for de novo synthesis of fatty acids, histone acetylation an

147 nthase (FAS), the enzyme responsible for the de novo synthesis of fatty acids, is highly expressed in

148 ), the multifunctional enzyme catalyzing the de novo synthesis of fatty acids, was confirmed to be hi

149 the first and rate-limiting reaction in the de novo synthesis of fatty acids.

150 CoA, the first and rate-limiting reaction in de novo synthesis of fatty acids.

151 cell is dependent on both salvage as well as de novo synthesis of fatty acids.

152 t p120-catenin in LPP3-depleted ECs restored de novo synthesis of fibronectin, which mediated EC migr

153 hellem, but in E. romaleae those involved in de novo synthesis of folate are all pseudogenes.

154 synthase (FASN), the enzyme responsible for de novo synthesis of free fatty acids, is up-regulated i

155 A divergent, practical, and efficient de novo synthesis of fully functionalized L-colitose (3,

156 iological components has been facilitated by de novo synthesis of gene-length DNA.

157 order, and chromosome structure through the de novo synthesis of genetic information, much as synthe

158 ompounds require accurate and cost-effective de novo synthesis of genetic pathways.

159 trate that CPT1C is directly involved in the de novo synthesis of GluA1 and not in protein degradatio

160 ediated increases in GLUT1 transcription and de novo synthesis of GLUT1 and another part dependent on

161 he Krebs cycle, was shown to be required for de novo synthesis of glutamate and glutamine in Listeria

162 e/cysteine transporter EAAC1 is required for de novo synthesis of glutathione in neurons.

163 PEP) generated from pyruvate is required for de novo synthesis of glycerol and glycogen in skeletal m

164 tion and Western blotting analyses show that de novo synthesis of GSH is required for EGCG to regulat

165 rom its antioxidant capability by increasing de novo synthesis of GSH.

166 on of the catalytic subunit GCLc, leading to de novo synthesis of GSH.

167 nase (IMPDH), a rate-limiting enzyme for the de novo synthesis of guanine nucleotides, leading to dep

168 BACKGROUND & AIMS: De novo synthesis of guanosine diphosphate (GDP)-fucose,

169 De novo synthesis of guanosine diphosphate (GDP)-fucose,

170 e dehydrogenase (IMPDH), a key enzyme in the de novo synthesis of guanosine nucleotides, catalyzes th

171 Thus, de novo synthesis of IE1 is required for virus-induced a

172 onical NF-kappaB and involves the sequential de novo synthesis of IFN regulatory factor (IRF)1 and Vi

173 t TGF-beta led to enhanced transcription and de novo synthesis of IL-6 upon activation without affect

174 noimidazole carboxamide, which occurs in the de novo synthesis of IMP, and the conversion of adenylos

175 ost saturated fatty acids to be used for the de novo synthesis of its membrane constituents.

176 amines as efficient organocatalysts for the de novo synthesis of ketoses and deoxyketoses.

177 During subsequent dark or shade recovery, de novo synthesis of L and Z continued, followed by epox

178 The highly stereocontrolled de novo synthesis of l-NBDNJ (the unnatural enantiomer o

179 PDGFRalpha has been reported to induce de novo synthesis of LAMB1 protein in a Sjogren syndrome

180 ssed including the tantalizing vision of the de novo synthesis of life and the idea of self-synthesis

181 reactions can be harnessed to achieve facile de novo synthesis of lipid membranes, and spontaneous me

182 It has been proposed that de novo synthesis of long-chain acyl-CoA (LC-CoA) is a s

183 t on the level of phosphatidate used for the de novo synthesis of membrane phospholipids.

184 Solvent assisted linker exchange (SALE) and de novo synthesis of mixed-linker ZIFs have been demonst

185 Unfortunately, de novo synthesis of MOFs with desirable function-proper

186 Stearoyl-CoA desaturase-1 (SCD1) catalyzes de novo synthesis of monounsaturated fatty acids from sa

187 panosoma brucei use microsomal elongases for de novo synthesis of most of its fatty acids.

188 asting synaptic plasticity and memory is the de novo synthesis of mRNAs and proteins.

189 Because the de novo synthesis of multiple glutamine-derived anabolic

190 ; EC 3.1.3.25) activity is essential for the de novo synthesis of myo-Inositol (Ins), and for recycli

191 xpression of BNA2, which is required for the de novo synthesis of NAD(+).

192 -dependent type I PA phosphatase involved in de novo synthesis of neutral lipids and phospholipids.

193 notransferase pathways and redirected to the de novo synthesis of nitrogen assimilation machinery, si

194 ses had previously been shown to promote the de novo synthesis of nucleotide precursors, as well as t

195 irst members of the family in the 1990s, the de novo synthesis of only a single polycyclic furanobute

196 talyst constitute two parallel routes to the de novo synthesis of orthogonally protected biologically

197 tilization of trehalose as an energy source, de novo synthesis of other stress effectors, or the meta

198 Suppression of the de novo synthesis of PA resulted in G1 cell cycle arrest

199 to exogenously supplied fatty acids via the de novo synthesis of PA, a central metabolite for membra

200 s dependent upon the enzymes responsible for de novo synthesis of PA.

201 acid synthase (FASN) is responsible for the de novo synthesis of palmitate.

202 In plants, de novo synthesis of pCho relies on the phosphobase meth

203 Once at this new site, PBP2x catalyses the de novo synthesis of peptidoglycan, which is imaged by t

204 may be exocytosed by neurons during OGD and de novo synthesis of perlecan is increased during reperf

205 holine requirement can be met via endogenous de novo synthesis of phosphatidylcholine catalyzed by ph

206 The deletant lacking the de novo synthesis of phosphatidylcholine, opi3delta, is

207 ission, choline can also be derived from the de novo synthesis of phosphatidylcholine, which is up-re

208 We found that genetic inactivation of de novo synthesis of phosphatidylethanolamine (PE) mitig

209 osphatidic acid phosphatases involved in the de novo synthesis of phospholipids and triglycerides.

210 hosphatidic acid phosphatase involved in the de novo synthesis of phospholipids and triglycerides.

211 s on phytol derived from chlorophyll, not on de novo synthesis of phytyl-diphosphate from geranylgera

212 creased PKMzeta activity that maintains LTP: de novo synthesis of PKMzeta and phosphorylation of its

213 We conclude that de novo synthesis of polyamines during adipogenesis is r

214 Thus, de novo synthesis of precursors for the protein lipoylat

215 ept that glycerophosphoinositol inhibits the de novo synthesis of proinflammatory and prothrombotic c

216 n, the transcription factor Nrf1 facilitates de novo synthesis of proteasomes by inducing proteasome

217 e thought to be solidified (consolidated) by de novo synthesis of proteins in the period subsequent t

218 ion mechanism of PSII is associated with the de novo synthesis of proteins.

219 tion that can result in increased demand for de novo synthesis of purine and pyrimidine bases require

220 DE4 gene in wild-type cells, which increases de novo synthesis of purine nucleotides, also resulted i

221 ylori has lost several genes involved in the de novo synthesis of purine nucleotides, and without thi

222 The de novo synthesis of purine precursors is under tight ne

223 ed genome and lacks the enzymes required for de novo synthesis of purines for synthesis of RNA and DN

224 to carry and activate single carbons for the de novo synthesis of purines, thymidylate, and for the r

225 ed one-carbon metabolism is required for the de novo synthesis of purines, thymidylate, and S-adenosy

226 ivergently from pdxR and responsible for the de novo synthesis of pyridoxal 5'-phosphate (PLP), the m

227 In plants, the pathway for de novo synthesis of pyridoxal phosphate has been well c

228 sential vitamins and cofactors and decreased de novo synthesis of pyrimidines in cycle two.

229 on of dihydroorotate (DHO) to orotate in the de novo synthesis of pyrimidines.

230 i appears to lack the metabolic capacity for de novo synthesis of riboflavin and so likely relies on

231 reducing power from the Calvin cycle to the de novo synthesis of saturated fatty acids to replace po

232 Through de novo synthesis of sceptrin and massadine, we show tha

233 These vDNAs template de novo synthesis of secondary viral siRNAs (vsRNA), whi

234 arry out the specialized function of halting de novo synthesis of several abundant porins when envelo

235 We stimulated de novo synthesis of SNAT2 mRNA and increased SNAT2 mRNA

236 herosclerosis is reduced in mice by blocking de novo synthesis of sphingolipids catalyzed by serine p

237 The results showed that inhibition of de novo synthesis of sphingolipids, pharmacologically or

238 NKPD1 is predicted to be involved in the de novo synthesis of sphingolipids, which have been impl

239 Human chorionic gonadotropin (hCG) induces de novo synthesis of STAR, a process shown to parallel m

240 A de novo synthesis of substituted pyridines is described

241 such as histamine and proteases, and in the de novo synthesis of sulfidoleukotrienes.

242 We describe a one-pot de novo synthesis of sulfonimidamides from widely availa

243 Treatment with deguelin inhibited de novo synthesis of survivin protein and induced apopto

244 pids to TAG but being impaired in additional de novo synthesis of TAG during -N stress.

245 ained induction by NF-kappaB, which promoted de novo synthesis of Tat.

246 yeast, PLMT activities are required for the de novo synthesis of the choline headgroup found in PtdC

247 , which functions in the visual cycle and in de novo synthesis of the chromophore.

248 ZmPep1 activates de novo synthesis of the hormones jasmonic acid and ethy

249 Importantly, doxorubicin also increased de novo synthesis of the pro-apoptotic sphingolipid meta

250 diated via ceramide synthase (CS)-stimulated de novo synthesis of the proapoptotic sphingolipid ceram

251 t myosin heavy chain (MyHC) isoforms induced de novo synthesis of the slower, more oxidative type IIa

252 ellular dihydroceramides, sphingoid bases in de novo synthesis of the sphingolipid pathway.

253 De novo synthesis of the sphingolipid sphingomyelin requ

254 h subsequent translational control, enhanced de novo synthesis of the transcription factor ATF4.

255 tionally active and we demonstrate the novel de novo synthesis of the triamine spermidine from the di

256 fractions, respectively, indicating partial de novo synthesis of these amino acids by L. pneumophila

257 nate and that Histoplasma virulence requires de novo synthesis of these cofactor precursors.

258 r cyclin B1 destruction because of regulated de novo synthesis of this cyclin after prometaphase onse

259 o the microRNA 29a promoter, thus inducing a de novo synthesis of this miRNA.

260 se subunit 1 declined concomitantly with the de novo synthesis of this subunit whereas polyadenylatio

261 rconnected pathways that is required for the de novo synthesis of three of the four DNA bases and the

262 Here, we describe the de novo synthesis of three paralytic shellfish poisons,

263 De novo synthesis of threonine from aspartate occurs via

264 Neurons are considered incapable of de novo synthesis of tricarboxylic acid cycle intermedia

265 c pathway requires glucose and glutamine for de novo synthesis of UDP-GlcNAc, a sugar-nucleotide that

266 implications are discussed, suggesting that de novo synthesis of urease under anoxic conditions is n

267 promotes cellular adaptation, including the de novo synthesis of vacuolar hydrolases to boost the va

268 s, indicating that MDMs are able to initiate de novo synthesis of viral DNA and promote virus release

269 t the internalization of virus could lead to de novo synthesis of viral protein from incoming viral R

270 Rates of de novo synthesis of viral proteins in wild-type and SGM

271 ion of integrin alpha4beta7 was dependent on de novo synthesis of viral proteins, but neither cell de

272 e ability to eliminate infected cells before de novo synthesis of viral proteins, which was also obse

273 ) the increase of viral RNAs along time; (3) de novo synthesis of viral proteins; and (4) secretion o

274 While these events that occur prior to the de novo synthesis of viral RNA are required for the indu

275 olution, we describe a low-cost, easy-to-use de novo synthesis oligonucleotide microarray technology

276 rhGH increased glutamine de novo synthesis (P < 0.02) and plasma concentrations (

277 Recently, we characterized a new de novo synthesis pathway for the RelB NF-kappaB subunit

278 s two fatty acid synthesis pathways: a major de novo synthesis pathway in the ER and a mitochondrial

279 mutations in KDSR, encoding an enzyme in the de novo synthesis pathway of ceramides.

280 es from two sources: a salvage pathway and a de novo synthesis pathway that depends on two enzymes, t

281 phingomyelinase pathway rather than ceramide de novo synthesis pathway was important for inflammatory

282 e incorporation into RNA and DNA through the de novo synthesis pathway.

283 ssential enzyme common to both recycling and de novo synthesis pathways, displayed the same bacterici

284 ue to reduced production secondary to slower de novo synthesis plus decreased release from protein br

285 lts indicate that both choline transport and de novo synthesis provide choline for ACh synthesis in C

286 ive, and (iv) HIV-1 ligands are derived from de novo synthesis rather than endocytic sampling.

287 t at the plasma membrane was slow, requiring de novo synthesis, rather than recycling.

288 r in apoptosis signaling and is generated by de novo synthesis, sphingomyelin hydrolysis, or recyclin

289 cation is a complex process composed of many de novo synthesis steps catalyzed by a myriad of molecul

290 haride in the absence of exogenous acceptor (de novo synthesis) than PmHS1.

291 er derived from exogenous sources or through de novo synthesis, thiamin must be pyrophosphorylated fo

292 biosynthesis, demonstrating contribution of de novo synthesis to NAD(+) homeostasis.

293 fer that peroxisome biogenesis switches from de novo synthesis to primarily fission.

294 d import does not contribute to heat-induced de novo synthesis under normal conditions.

295 Surprisingly, inhibition of de novo synthesis using myriocin or fumonisin B1 resulte

296 Notably, inhibition of de novo synthesis was associated with potentiation of AD

297 In contrast, inhibition of de novo synthesis was linked to decreased expression of

298 es despite the absence of other genes of NAD de novo synthesis, was elucidated.

299 when produced by pathways other than that of de novo synthesis, we examined primary mouse hepatocytes

300 ve gene machinery for pyrimidine salvage and de novo synthesis, we inferred genealogies for each enzy