ライフサイエンスコーパス: deacetylase

1 s and chromatin localization of Sir2 histone deacetylase.

2 t physiological function of the CobB protein deacetylase.

3 ion by targeting the Sirtuin1 (Sirt1) lysine deacetylase.

4 were similar to those controlled by histone deacetylase.

5 ression via recruitment of the Set3C histone deacetylase.

6 that leads to cytoplasmic degradation of the deacetylase.

7 fines a previously unknown family of protein deacetylases.

8 in thioesterases and the described family of deacetylases.

9 nuclear targets, including class IIa histone deacetylases.

10 ating transcriptional repression via histone deacetylases.

11 nuclear targets, including class IIa histone deacetylases.

12 nd nuclear accumulation of class IIa histone deacetylases.

13 FTY720-P) is an inhibitor of class I histone deacetylases.

14 The induced heterochromatin required histone deacetylase 1 (HDA-1), with an intact catalytic domain,

15 FBP1 correlated with high levels of histone deacetylase 1 (HDAC1) and HDAC2 proteins in HCC patient

16 ible for the neurotoxic potential of histone deacetylase 1 (HDAC1) and its subcellular localization a

17 relate with a widespread increase of histone-deacetylase 1 (Hdac1) expression that is linked to alter

18 c-Myc target promoters and increased histone deacetylase 1 (HDAC1) recruitment, thereby decreasing tr

19 mplex comprised of MRG15, Sin3B, and histone deacetylase 1 (HDAC1) that functions as a transcriptiona

20 Calcium-dependent nuclear export of histone deacetylase 1 (HDAC1) was shown previously to precede ax

21 Histone deacetylase 1 activates PU.1 gene transcription through

22 d that 2-aminoacetophenone regulates histone deacetylase 1 expression and activity, resulting in hypo

23 DNA methyltransferase1/3 (DNMT1/3)-, histone deacetylase 1/2/4 (HDAC1/2/4)-, Setdb1/Suv39h1-, and Ezh

24 e nucleus, SK2 binds to and inhibits histone deacetylases 1 and 2 (HDAC1/2).

25 Here we report that histone deacetylase 10 (HDAC10) is a robust polyamine deacetylas

26 trate a previously undefined role of histone deacetylase 11 (HDAC11) in regulating T-cell effector fu

27 Histone Deacetylase 11 (HDAC11) is highly expressed in the centr

28 A reduction in histone deacetylase 2 (HDAC2) activity and expression has been r

29 e glucocorticoid response element of histone deacetylase 2 (HDAC2) promoter, resulting in the upregul

30 sor CoREST (also known as RCOR1) and histone deacetylase 2 in these early dividing cells; and (3) is

31 Histone deacetylase-2 (HDAC2), an epigenetic regulator, is criti

32 Histone deacetylase 3 (HDAC3) and linker histone H1 are involved

33 t SCI resulted in an upregulation of histone deacetylase 3 (HDAC3) in the innate immune cells at the

34 Here we show that histone deacetylase 3 (HDAC3) is required to activate brown adip

35 Histone deacetylase 3 (HDAC3) is the catalytic component of NCoR

36 opment, the histone-modifying enzyme histone deacetylase 3 (Hdac3) regulates the formation of both ly

37 Here we show that histone deacetylase 3 (HDAC3) regulates WAT metabolism and funct

38 depletion of the epigenome modifier histone deacetylase 3 (HDAC3) specifically in skeletal muscle ca

39 one receptors (SMRT) corepressors or histone deacetylase 3 (HDAC3), Dex-induced tethered transrepress

40 Histone deacetylase 3 and its cofactor NCOR1 regulate hepcidin;

41 ts cofactor NCOR1 regulate hepcidin; histone deacetylase 3 binds chromatin at the hepcidin locus, and

42 In iron deficient mice, the histone deacetylase 3 inhibitor RGFP966 increases hepcidin, and

43 chromatin at the hepcidin locus, and histone deacetylase 3 knockdown counteracts hepcidin suppression

44 on involves epigenetic regulation by histone deacetylase 3.Hepcidin controls systemic iron levels by

45 ed AAV9 transduction, while reducing histone deacetylase 4 (HDAC4) expression enhanced AAV transducti

46 ne for the transcriptional repressor histone deacetylase 4 (HDAC4) is associated with the risk of dev

47 Because histone deacetylase 4 (HDAC4) is highly expressed in liver cance

48 ) to dephosphorylate and translocate histone deacetylase 4 (HDAC4) to the nucleus for repression of 1

49 adian nucleocytoplasmic shuttling of Histone deacetylase 4 (HDAC4), a SIK3 phosphorylation target, in

50 was governed by liver kinase b1 and histone deacetylase 4 in white adipocytes.

51 tes in the HDAC4 gene, which encodes histone deacetylase 4, and is involved in long-term memory forma

52 Deletion of histone deacetylase-4 (HDAC4) partially recapitulates the PPR de

53 and a considerable up-regulation of histone deacetylase-4.

54 found that dephosphorylated, nuclear histone deacetylase 5 (HDAC5) in the nucleus accumbens (NAc) red

55 Mutating HISTONE DEACETYLASE 6 (HDA6), or the cytosine methyltransferase

56 we have observed that the levels of histone deacetylase 6 (HDAC6) and the related family member HDAC

57 Histone deacetylase 6 (HDAC6) catalyzes the removal of an acetyl

58 Ablation of histone deacetylase 6 (HDAC6) expression and its activity in HNS

59 Here, we studied the role of histone deacetylase 6 (HDAC6) in regulating cyst growth to test

60 tion as well as genetic silencing of histone deacetylase 6 (HDAC6) increase alpha-tubulin acetylation

61 At the same time, the abundance of histone deacetylase 6 (HDAC6) was diminished.

62 Histone deacetylase 6 (HDAC6), a class IIb HDAC, plays an import

63 ns that tau is a direct substrate of histone deacetylase 6 (HDAC6), we sought to map all HDAC6-respon

64 the nucleus, by which MIIP prevents histone deacetylase 6 (HDAC6)-mediated RelA deacetylation, and t

65 as rescued by inhibition of ROCK and histone deacetylase 6 but not by a GAP-mutant form of ARHGAP18.

66 that is correctable by inhibition of histone deacetylase-6 (HDAC6).

67 e structurally characterized isozyme histone deacetylase 8 (HDAC8).

68 nt inhibitors of Schistosoma mansoni histone deacetylase 8 (smHDAC8).

69 odds ratio (OR) = 1.22] and confirm histone deacetylase 9 (HDAC9) as a major risk gene for LAS with

70 hypoxia-inducible factor by using a histone deacetylase abexinostat in combination with pazopanib to

71 ortantly, manipulating histone acetylase and deacetylase activities established that histone acetylat

72 lytic domain of the protein, decreases SIRT6 deacetylase activity and promotes glycolysis.

73 nd SIRT3 acetylation at Lys(57) inhibits its deacetylase activity and promotes protein degradation.

74 R targeting strategy demonstrated that HDAC3 deacetylase activity and the formation of a functional c

75 The inhibition of the SIRT2 deacetylase activity by TPPP/p25 is evolved by the assem

76 Chemical inhibition of histone deacetylase activity by trichostatin A suppressed AFP ef

77 pment, whereas an Hdac3 point mutant lacking deacetylase activity failed to complement this defect.

78 5), we found that selectively blocking HDAC3 deacetylase activity in either the dorsal hippocampus or

79 Thus, the deacetylase activity of HDAC3 is a powerful negative reg

80 Thus, the deacetylase activity of Hdac3 is required for the genera

81 between PelA and PelB is direct and that the deacetylase activity of PelA increases and its hydrolase

82 leotid (NADH) ratio and the NAD(+)-dependent deacetylase activity of sirtuin 3 to inhibit superoxide

83 bute to genomic instability by impairing its deacetylase activity or diminishing its protein levels i

84 ripheral heterochromatin, and independent of deacetylase activity, Hdac3 tethers peripheral heterochr

85 nthesis linked to a loss of NAD(+)-dependent deacetylase activity, increased protein acetylation, and

86 s the active site and enhances significantly deacetylase activity, probably by creating a more favora

87 clear localization and modestly affected its deacetylase activity.

88 icates epigenetic mechanisms such as histone deacetylase activity.

89 s (Sirt1-Sirt7) are NAD(+)-dependent protein deacetylases/ADP ribosyltransferases, which play decisiv

90 functional characterization of a 237 residue deacetylase (AnCDA) from Aspergillus nidulans FGSC A4.

91 ivities of Sir2 and Top1 proteins, a histone deacetylase and a DNA topoisomerase, respectively, we in

92 ified peptide sequence from the Clr3 histone deacetylase and a previously identified sequence from th

93 ive up to 100 muM against Sirt1, -3, and -5 (deacetylase and desuccinylase activities).

94 r-expression of Sirtuin 1 (SIRT1), a histone deacetylase and gene silencer, in the eutopic endometriu

95 PelB interacts with PelA, an enzyme with PEL deacetylase and hydrolase activities.

96 dent proteins with the enzymatic activity of deacetylases and ADP ribosyltransferases.

97 acetylated chromatin from attack by histone deacetylases and allows acetylation to spread along the

98 In PV, inhibitors of histone deacetylases and human double minute 2 have activity, bu

99 Arabidopsis thaliana) interacts with histone deacetylases and quantitatively determines histone acety

100 esponse, including interactions with histone deacetylases and the co-repressor TOPLESS.

101 esponse, including interactions with histone deacetylases and the co-repressor TOPLESS.

102 Our lab has previously shown histone deacetylases are modulated in cells derived from alcohol

103 hila and identify HDAC6, a cytosolic histone deacetylase, as a suppressor of EFA.

104 e activity of plant-encoded enzymes (histone deacetylases) can be modulated to alter acetylation of n

105 and the genes encoding components of histone deacetylase Clr6 complex II suppress the defects in grow

106 The NAD+-dependent protein deacetylase CobB can reverse both enzymatic and non-enzy

107 The Escherichia coli deacetylase CobB could deacetylate acetylated MDH, while

108 rolled by the acetyltransferase Pka, and the deacetylase CobB, affects binding of the substrate and t

109 interacts with the nucleosome remodeling and deacetylase complex (NuRD) to inhibit premature differen

110 otein recruits the nucleosome remodeling and deacetylase complex (NuRD) to methylated DNA to modify c

111 We have previously shown that the Histone Deacetylase Complex 1 (HDC1) protein from Arabidopsis (A

112 ition of recombinant CHD4 to this nucleosome deacetylase complex reconstitutes a NuRD complex with nu

113 ngers of Rco1, a member of the Rpd3S histone deacetylase complex recruited to transcribing genes, ope

114 cytoplasmic SAP130 (a subunit of the histone deacetylase complex) was expressed in PDA in a RIP1/RIP3

115 uit the endogenous nucleosome remodeling and deacetylase complex, were both successful in targeted de

116 ion, and relies on Set2 and the Set3 histone deacetylase complex.

117 Here, we show that MSI1 is part of a histone deacetylase complex.

118 , coincided with NuRD (nucleosome-remodeling-deacetylase) complex recruitment to the promoters of the

119 These lysine deacetylases contribute to DNA repair by base excision r

120 tial component of the mammalian Sin3-histone deacetylase corepressor complex, severely impairs the co

121 xidase catalytic domain, represent the major deacetylase/deacetyliminase activity.

122 Using a dominant-negative, deacetylase-dead point mutant virus (AAV-HDAC3(Y298H)-v5

123 Sirtuin1 (SIRT1) deacetylase delays and improves many obesity-related dis

124 gainst DNA methyltransferases (DAC), histone deacetylases (Depsi), histone demethylases (KDM1A inhibi

125 y impairing the CTD's ability to bind to the deacetylase domain as well as its ability to function as

126 in histone acetylation and class IIa histone deacetylases expression, following pulmonary inflammatio

127 The histone deacetylase family comprises 18 enzymes that catalyze de

128 be a member of the PIG-LN-acetylglucosamine deacetylase family; GalB is structurally distinct from t

129 tone acetyl transferase GCN5 and the histone deacetylase HDA19 are required for H3K36ac homeostasis.

130 ole network is directly dependent on histone deacetylase HDA6.

131 Histone deacetylase (HDAC) 6 exists exclusively in cytoplasm and

132 In mammalian cells, histone deacetylase (HDAC) and Sirtuin (SIRT) are two families r

133 Here we describe a Cas9-based histone deacetylase (HDAC) and the design principles required to

134 How remodeler and histone deacetylase (HDAC) cooperate within NuRD complexes remai

135 We show that the histone deacetylase (HDAC) enzyme inhibitor trichostatin A block

136 Even though histone deacetylase (HDAC) inhibition has shown remarkable antit

137 ism and that both effects are due to histone deacetylase (HDAC) inhibition possibly linked to autopha

138 n/deacetylation balance, in part via histone deacetylase (HDAC) inhibition.

139 The oral histone deacetylase (HDAC) inhibitor (vorinostat) is safe and re

140 ulticomponent synthesis of a focused histone deacetylase (HDAC) inhibitor library with peptoid-based

141 aled that pretreating cells with the histone deacetylase (HDAC) inhibitor SAHA led to detectable clus

142 In this study, we found that histone deacetylase (HDAC) inhibitor suberoylanilide hydroxamic

143 sion in NK cells is inhibited by the histone deacetylase (HDAC) inhibitor valproic acid (VPA) and enh

144 The histone deacetylase (HDAC) inhibitor vorinostat (VOR) can increa

145 )-depudecin, a unique and unexplored histone deacetylase (HDAC) inhibitor, is reported.

146 Treatment with 109, a class I histone deacetylase (HDAC) inhibitor, resulted in increased leve

147 a first-in-class selective class IIa histone deacetylase (HDAC) inhibitor, TMP195, influenced human m

148 lax, alone and in combination with a histone deacetylase (HDAC) inhibitor, vorinostat or romidepsin.

149 Histone deacetylase (HDAC) inhibitors and DNA-damaging agents we

150 ncy reversing agents (LRAs), such as histone deacetylase (HDAC) inhibitors and protein kinase C (PKC)

151 nt, but not parental, CRC cells with histone deacetylase (HDAC) inhibitors can effectively overcome r

152 Previous studies showed that either histone deacetylase (HDAC) inhibitors or tumor necrosis factor-r

153 rototypical hydroxyamic acid-derived histone deacetylase (HDAC) inhibitors Panobinostat and Vorinosta

154 reasing speculation about the use of histone deacetylase (HDAC) inhibitors to treat skin diseases led

155 d by treatment with three additional histone deacetylase (HDAC) inhibitors, but not other antipsychot

156 class of broad-acting drugs known as histone deacetylase (HDAC) inhibitors.

157 ollows: increased stability, reduced histone deacetylase (HDAC) interaction, and increased DNA bindin

158 ance include activation of the mTOR, histone deacetylase (HDAC), MAPK, and ERBB4 pathways.

159 ion regulator 1 (SIRT1), a class-III histone deacetylase (HDAC), resulting in epigenetic transactivat

160 telomerase-negative human cells in a histone deacetylase (HDAC)-dependent manner, replicating the exp

161 ass of anticancer agents that target histone deacetylase (HDAC).

162 I3K) activity, and decreased nuclear histone deacetylase (HDAC)2 levels.

163 Histone deacetylases (HDAC) contain eighteen isoforms that can b

164 Here we demonstrate that the histone deacetylase Hdac1/Rpd3 functions together with self-rene

165 ed state in neural stem cells by the histone deacetylase Hdac1/Rpd3.

166 Here, we show that the class I histone deacetylases HDAC1 and HDAC2 contribute to maintain the

167 ogated ISL1-dependent recruitment of histone deacetylases HDAC1/5, inhibiting Nkx2.5 expression.

168 of ZRS activity, interacts with the histone deacetylase HDAC2 and ensures that the poised ZRS remain

169 The histone deacetylase HDAC3 is a critical mediator of hepatic lipi

170 plex together with the highly active class I deacetylase HDAC3.

171 We demonstrate that a histone deacetylase (Hdac3) organizes heterochromatin at the nuc

172 revious studies suggest that nuclear histone deacetylase HDAC5 has a dynamic relationship with drug-i

173 We observed that expression of histone deacetylases (HDACs) 1 and 9, and Silent information reg

174 ers/erasers and chromatin-binding of histone deacetylases (HDACs) and Polycomb-group (PcG) proteins.

175 Histone acetyltransferases and histone deacetylases (HDACs) are important epigenetic coregulato

176 Histone deacetylases (HDACs) are important modulators of epigene

177 Histone deacetylases (HDACs) catalyze deacetylation of acetyl-ly

178 istone acetyltransferases (HATs) and histone deacetylases (HDACs) compete to modulate histone acetyla

179 ne-specific demethylase 1 (LSD1) and histone deacetylases (HDACs) facilitates breast cancer prolifera

180 Class I histone deacetylases (HDACs) Hdac1 and Hdac2 can associate toget

181 To investigate the specific roles of histone deacetylases (HDACs) in rod differentiation in neonatal

182 Histone deacetylases (HDACs) modulate acetylation of lysine resi

183 stone deacetylation as inhibition of histone deacetylases (HDACs) not only induced acetylation of his

184 e, we present evidence that specific histone deacetylases (HDACs) play essential roles in the CSC phe

185 Histone deacetylases (HDACs) regulate myriad cellular processes

186 Histone deacetylases (HDACs) remove acetyl groups from lysine re

187 One approach, the inhibition of histone deacetylases (HDACs), has been reported to suppress panc

188 istone acetyltransferases (HATs) and histone deacetylases (HDACs), is a major epigenetic regulatory m

189 on of histone acetyltransferases and histone deacetylases (HDACs).

190 ana paralogs encoding plant-specific histone deacetylases, HDT1 and HDT2, regulate a second switch fr

191 nds to the nucleosome remodeling and histone deacetylase histone remodeling complex subunits LSD1, HD

192 homolog (MRE11) is downregulated by histone deacetylase inhibition (HDACi), resulting in reduced lev

193 In vitro, pan-histone deacetylase inhibition elevates hepcidin expression, and

194 a method for resetting via transient histone deacetylase inhibition.

195 that promotes chromatin opening, the histone deacetylase inhibitor (HDACi) AR-42, ameliorates the def

196 We show that the small-molecule histone deacetylase inhibitor M344 reduces beta-amyloid (Abeta),

197 effector molecule HC-toxin (HCT), a histone deacetylase inhibitor produced by the fungal pathogen Co

198 uencing (ATAC-seq), we show that the histone deacetylase inhibitor promotes accessibility at key gene

199 In particular, the histone deacetylase inhibitor sodium butyrate (SB) may indirectl

200 M(-/-) hearts, but trichostatin A, a histone deacetylase inhibitor that improves cardiac remodeling,

201 sments of response and resistance to histone deacetylase inhibitor therapy.

202 Deacetylase inhibitor treatment increased IQGAP1 acetyla

203 expression of Ascl1, together with a histone deacetylase inhibitor, enables adult mice to generate ne

204 When treated with the histone deacetylase inhibitor, Trichostatin A, genes nearby this

205 by the formal synthesis of a potent histone deacetylase inhibitor.

206 ion of the human Sin3 network with a histone deacetylase inhibitor.

207 nobinostat (pano) is an FDA-approved histone deacetylase inhibitor.

208 IMiDs), proteasome inhibitors (PIs), histone deacetylase inhibitors (DACIs), and monoclonal antibodie

209 oposed for DNA methyltransferase and histone deacetylase inhibitors (DNMTi and HDACi), primarily base

210 t doses of DNA methyltransferase and histone deacetylase inhibitors (DNMTi and HDACi, respectively) r

211 Controversially, histone deacetylase inhibitors (HDACi) are in clinical trial for

212 Clinical response to histone deacetylase inhibitors (HDACi) is strongly associated wi

213 ation of Treg function using histone/protein deacetylase inhibitors (HDACi) may allow more titratable

214 using a "drug repurposing" strategy, histone deacetylase inhibitors (HDACi), which are presently clin

215 + T cell phenotype and function: the histone deacetylase inhibitors (HDACis) and protein kinase C mod

216 ransferase inhibitors [DNMTis]) with histone deacetylase inhibitors (HDACis) holds promise for enhanc

217 We showed previously that the histone deacetylase inhibitors (HDACIs) trichostatin A and sodiu

218 dies and confirmed with nonselective histone deacetylase inhibitors (HDACis).

219 Indeed, treatment with novel histone deacetylase inhibitors abolished hypoxia-induced DUSP2 d

220 dependent antiretroviral activity of histone deacetylase inhibitors acting via p53 activation.

221 ther observed strong synergy between histone deacetylase inhibitors and EZH2 inhibitors.

222 d its analogues are isoform-targeted histone deacetylase inhibitors and potent LRAs.

223 Histone deacetylase inhibitors are currently approved to treat c

224 as several advantages over available histone deacetylase inhibitors now in clinical trials, our work

225 PCs are resistant to reactivation by histone deacetylase inhibitors or P-TEFb activation but are susc

226 PP-46 and shikonin or treatment with histone deacetylase inhibitors produced similar results.

227 Treatment of mammalian cells with histone deacetylase inhibitors to increase euchromatin or histon

228 tment of cells with phorbol ester or histone deacetylase inhibitors triggered the expression of many

229 vels of hTdp1 were more sensitive to histone deacetylase inhibitors valproic acid (VPA) and trichosta

230 As a class, histone deacetylase inhibitors were greatly overrepresented amon

231 Histone deacetylase inhibitors were used to treat cells.

232 sed sensitivity of leukemia cells to histone deacetylase inhibitors.

233 the highest level of sensitivity to histone deacetylase inhibitors.

234 wth of Salmonella in the presence of histone deacetylases inhibitors reduced expression of SPI1 by af

235 ulator 1 (SIRT1), a NAD(+)-dependent histone deacetylase, is an important regulator of various cellul

236 conserved mammalian NAD(+)-dependent protein deacetylase, is critically involved in modulating methio

237 AnCDA, providing insight into how the chitin deacetylase may interact with its substrates.

238 histone methyltransferase (PRC2) and histone deacetylase (NuRD and SIN3A) complexes through their com

239 he repressive Mbd3/nucleosome remodeling and deacetylase (NuRD) complex at the neurogenesis-associate

240 zation and nucleosome remodeling and histone deacetylase (NuRD) complex binding are required for the

241 vation by recruiting a nucleosome remodeling deacetylase (NuRD) complex to Pdcd1 regulatory regions.

242 itment of the Mi-2 nucleosome remodeling and deacetylase (NuRD) complex, a chromatin-modifying repres

243 sociates with the Nucleosome Remodelling and Deacetylase (NuRD) complex, Sall4 neither recruits NuRD

244 s or components of the nucleosome remodeling deacetylase (NuRD) complex, which associate with ZNF281,

245 interact with the Nucleosome Remodeling and Deacetylase (NuRD) complex.

246 ing the associated nucleosome remodeling and deacetylase (NuRD) complex.

247 ing Sin3B, nucleosome remodeling and histone deacetylase (NuRD), and corepressor of RE1 silencing tra

248 uripotency factor and nucleosome remodelling deacetylase (NuRD), we illustrate how the determination

249 followed by slow decrease, in Rpd3L histone deacetylase occupancy.

250 Importantly, SIRT6, a chromatin-bound deacetylase of the same class, does not influence NADH n

251 port that phosphorylation of the human SIRT1 deacetylase on Threonine 530 (T530-pSIRT1) modulates DNA

252 wo Bdellovibrio N-acetylglucosamine (GlcNAc) deacetylases, one of which we show to have a unique two

253 ich occurs in active sites of polysaccharide deacetylases (PDAs) from bacterial pathogens, modifying

254 lycan modifying enzymes: The peptidoglycan N-deacetylase PgdA and the peptidoglycan O-acetyltransfera

255 Histone/protein deacetylases play multiple roles in regulating gene expr

256 conserved mammalian NAD(+)-dependent protein deacetylase, plays a vital role in the regulation of met

257 Previous studies have found that SIRT2, a deacetylase, plays an important role in deacetylating PE

258 ional effects manifesting themselves by this deacetylase proteome could lead to the fine-tuning of th

259 HDAC6 is a cytoplasmic histone deacetylase regulating multiple pro-survival mechanisms

260 ylation through association with the histone deacetylase RPD3.

261 conserved mammalian NAD(+)-dependent protein deacetylase, senses environmental stress to alter intest

262 ine kinase known to recognize AC, and of the deacetylase silent information regulator T1, which had n

263 The NAD-dependent histone deacetylase Sir2 controls ribosomal DNA (rDNA) silencing

264 The SIR complex comprises the NAD-dependent deacetylase Sir2, the scaffolding protein Sir4, and the

265 nicotinamide adenine dinucleotide)-dependent deacetylase Sir2.

266 inamide adenine dinucleotide (NAD)-dependent deacetylase SIRT1 acts as an energy sensor and negativel

267 Here we identify the histone deacetylase Sirt1 as a Cdk2 regulator in OPC proliferati

268 signaling cascade involving AMPK and histone deacetylase SIRT1 displaces chromatin-bound BRD4, instig

269 wnregulation of methyltransferase DNMT3b and deacetylase SIRT1 may explain the observed p66(Shc)-rela

270 d expression of the NAD(+)-dependent protein deacetylase SIRT1.

271 by OGT is dependent on the NAD(+)-dependent deacetylase SIRT1.

272 NA replication is regulated by the class III deacetylase SIRT1; activation of the DNA damage response

273 Here we show that sirtuin 1 deacetylase (Sirt1) deacetylates Nav1.5 at lysine 1479 (

274 hc is a direct target of the Sirtuin1 lysine deacetylase (Sirt1), and Sirt1-regulated acetylation of

275 hat under calorie restriction, mitochondrial deacetylase Sirt3 deacetylates and activates IDH2, there

276 Here, we show that histone deacetylase Sirt6 protects against podocyte injury throu

277 ranscription factor 1 (HES1) and the protein deacetylase sirtuin 1 (SIRT1) at the Isl1 gene.

278 We found that higher abundance of the deacetylase sirtuin 1 (SIRT1) correlated with lower acet

279 ram mediated by the NAD(+)-dependent histone deacetylase Sirtuin 6 (SIRT6) that is critical for suppr

280 (TPPP/p25) and the NAD(+)-dependent tubulin deacetylase sirtuin-2 (SIRT2) play key roles in oligoden

281 ored the role of the NAD(+)-dependent lysine deacetylase, sirtuin 1 (SIRT1) in fibrogenesis in the ce

282 liorated by the allosteric modifier of Sirt1 deacetylase, SRT3025, in association with a reduction in

283 s presenting a general strategy for unbiased deacetylase substrate discovery.

284 l interactions between some AFPs and histone deacetylase subunits were observed in yeast two-hybrid a

285 tty acid metabolism and WAT browning.Histone deacetylases, such as HDAC3, have been shown to alter ce

286 Sirtuin-3 (Sirt3) is a mitochondrial deacetylase that could mediate this connection.

287 died its interaction with HDAC7, a class IIa deacetylase that interacts with the corepressor complex

288 Sirtuin1 (Sirt1) is a class III histone deacetylase that regulates a variety of physiological pr

289 Sirt1 is an NAD(+)-dependent protein deacetylase that regulates many physiological functions,

290 Here we report that inhibition of Sirt1 deacetylase through small interfering RNA or selective i

291 g SPL is intracellular inhibition of histone deacetylases, thus linking our observations in sphingoli

292 SIN3B targets histone deacetylases to chromatin to repress transcription.

293 We show that nuclear NAC1 binds to histone deacetylase type 4 (HDAC4), hindering phosphorylation of

294 eacetylase 10 (HDAC10) is a robust polyamine deacetylase, using recombinant enzymes from Homo sapiens

295 The binding site of class IIa deacetylases was previously mapped to an approximate 500

296 inhibitors of nuclear and cytosolic histone deacetylases was substantially lower than that of SAHA i

297 evity and is dependent on the conserved Sir2 deacetylase, whereas either sustained silencing or susta

298 Sirtuin 2 (SIRT2) is a sirtuin family deacetylase, which maintains genome integrity and preven

299 Sirtuins are NAD(+) dependent protein deacetylases, which are involved in many biological proc

300 SIRT2 is a protein deacetylase with tumor suppressor activity in breast and