ライフサイエンスコーパス: deacetylate

1 is unknown if and how autoacetylated p300 is deacetylated.

2 only when the carbohydrate moiety was fully deacetylated.

3 rRNA) genes, whereas silenced rRNA genes are deacetylated.

4 D, superoxide dismutase, and PEPCK1 were not deacetylated.

5 Sirtuins are NAD (+)-dependent enzymes that deacetylate a variety of cellular proteins and in some c

6 In addition to histones, HDACs bind to and deacetylate a variety of other protein targets including

7 egatively regulates poly(A)RNA transport via deacetylating a poly(A)-binding protein, PABP1.

8 RT1 physically associates with DNMT1 and can deacetylate acetylated DNMT1 in vitro and in vivo.

9 The Escherichia coli deacetylase CobB could deacetylate acetylated MDH, while the E. coli acetyltran

10 A case in point is the N-deacetylated AF lesion [N-(2'-deoxyguanosin-8-yl)-2-amin

11 Although SIRT1 deacetylates Akt to promote phosphatidylinositol (3,4,5)

12 dependent deacetylases because cells fail to deacetylate alpha-tubulin-K40 and histone H3-K9.

13 is a class IIb deacetylase that specifically deacetylates alpha-tubulin, modulates microtubule dynami

14 ylase 6 (HDAC6), a cytosolic enzyme that, by deacetylating alpha-tubulin, can alter the stability of

15 zyme HDAC6 regulates microtubule function by deacetylating alpha-tubulin, which suppresses microtubul

16 keletal muscle, primarily via its ability to deacetylate and activate peroxisome proliferator-activat

17 xl3) associates with Stat3 in the nucleus to deacetylate and deacetyliminate Stat3 on multiple acetyl

18 ced to a reduced effect of Sirt1 to directly deacetylate and repress IRS-1 function.

19 SIRT3 deacetylated and activated GSK3beta and thereby blocked

20 In response to cAMP signaling, SIRT3 deacetylated and activated leucine-rich protein 130 (LRP

21 oactivator 1-alpha (PGC1alpha), which became deacetylated and hyperactive after oleic acid treatment.

22 edia, whereas lipids that pass the cycle are deacetylated and retained within the cell.

23 The latter was sequentially deacetylated and selectively benzylated to give 8-azido-

24 Nakagawa et al. show that the sirtuin SIRT5 deacetylates and activates a mitochondrial enzyme, carba

25 restriction, mitochondrial deacetylase Sirt3 deacetylates and activates IDH2, thereby regulating the

26 SIRT3 deacetylates and activates LKB1, thus augmenting the act

27 In response to CR, Sirt3 directly deacetylates and activates mitochondrial isocitrate dehy

28 transcriptional activity, whereas sirtuin 1 deacetylates and activates PGC-1alpha.

29 We show that under normal conditions, Sirt1 deacetylates and activates TORC1 by promoting its dephos

30 SIRT1 deacetylates and coactivates the retinoic acid receptor

31 y, the protein deacetylase sirtuin 2 (SIRT2) deacetylates and destabilizes ACLY.

32 SIRT4 deacetylates and inhibits malonyl CoA decarboxylase (MCD

33 tylation-defective mutants showed that SIRT1 deacetylates and inhibits SREBP-1c transactivation by de

34 Sirtuin 3 (SIRT3) deacetylates and regulates many mitochondrial proteins t

35 ual complex made up of SIRT1 and HDAC4 which deacetylates and thereby favors SUMOylation of HIC1 by a

36 t histone deacetylase 6 (HDAC6) sequentially deacetylates and ubiquitinates MSH2, leading to MSH2 deg

37 nd controls reactive oxygen species (ROS) by deacetylating and activating isocitrate dehydrogenase 2

38 ny proteins, but whether SIRT1 has a role in deacetylating and altering the function of SIRT3 is unkn

39 etic repressor and its associated HDAC1 from deacetylating and suppressing E2F1.

40 eleting the genes required to phosphorylate, deacetylate, and deaminate GlcNAc to convert it to fruct

41 Here we demonstrate that SIRT2 binds, deacetylates, and inhibits the peroxidase activity of th

42 benzothiazine compound (IX, originated from deacetylated APAP), through mass isotopomer analysis, ac

43 SIRT1 deacetylates APE1 in vitro and in vivo targeting lysines

44 cetylation while bound to chromosomes but is deacetylated as soon as it dissociates from chromosomes

45 HDAC3, by deacetylating aspirin-acetylated eNOS, antagonizes aspir

46 HDAC9 deacetylates ATDC, alters the ability of ATDC to associa

47 Nucleosomes must be deacetylated behind elongating RNA polymerase II to prev

48 HDAC6 deacetylates beta-catenin at lysine 49, a site frequentl

49 (HDAC6), which destabilizes microtubules by deacetylating beta-tubulin, protected both the microtubu

50 Moreover, MTA1 deacetylates BMAL1 at lysine 538 through regulating deac

51 Acetylated SacAcsA was deacetylated by a sirtuin-type NAD(+)-dependent consumin

52 Acetylated SlAacS was deacetylated by a sirtuin-type protein deacetylase.

53 Alternatively, NA-DCVC can be deacetylated by aminoacylase 3 (AA3), an enzyme that is

54 In addition, each Htz1 N-terminal lysine is deacetylated by Hda1 in response to benomyl and reacetyl

55 Cdt1 undergoes acetylation and is reversibly deacetylated by HDAC11.

56 regulated through lysine acetylation and was deacetylated by HDAC6.

57 Following anaphase, ac-SMC3 is deacetylated by HDAC8.

58 Under fasting conditions, USF-1 is deacetylated by HDAC9, causing promoter inactivation.

59 As pH(i) decreases, histones are globally deacetylated by histone deacetylases (HDACs), and the re

60 tylated under high glucose conditions and is deacetylated by Sirt1 on lysine 81.

61 elated nuclear, p53, and Hsp10 were robustly deacetylated by Sirt1-3.

62 nscription factor-1a and beta-catenin can be deacetylated by Sirt1.

63 nt to Lys-318/Lys-322, were also efficiently deacetylated by SIRT3 following chemical acetylation.

64 lysines 6 and 10 and that these residues are deacetylated by sirtuin 2.

65 ass spectrometry (MS) to identify substrates deacetylated by sirtuins.

66 L. monocytogenes peptidoglycan is deacetylated by the action of N-acetylglucosamine deacet

67 propagate across these loci as histones are deacetylated by the NAD(+)-dependent histone deacetylase

68 Lysine 9 of histone H3 (H3K9) is deacetylated by the NuRD complex, methylated by a histon

69 is acetylated during hypoxia but is rapidly deacetylated by the stress-responsive deacetylase Sirtui

70 ished.Furthermore, Sirt1 interacted with and deacetylated c-Jun, yielding an inactive AP-1 factor.

71 Furthermore, SIRT1 directly bound to and deacetylated c-MYC.

72 We further showed that SIRT1 deacetylates c-Jun and that the cAMP pathway participate

73 However, SIRT1 interacts with and deacetylates c-Myc, resulting in decreased c-Myc stabili

74 SIRT2 interacts with and deacetylates CDK9 at lysine 48 in response to replicatio

75 ely little is known about enzymes capable of deacetylating chitin.

76 ires all three Sir proteins, even with fully deacetylated chromatin, and involves the specific associ

77 ts and show that the SIR complex efficiently deacetylates chromatin templates and promotes the assemb

78 The current view is that they function by deacetylating chromatin, thereby limiting accessibility

79 Importantly, HDAC6 deacetylates CIDEC, leading to destabilization and reduc

80 This is due to Dyn2's interactions with deacetylated cortactin and downstream effectors, which c

81 We show that SIRT1 deacetylates cortactin in vivo and in vitro and that the

82 SIRT5 deacetylates CPS1 and upregulates its activity.

83 SIRT1 interacts with and deacetylates CRABPII, regulating its subcellular localiz

84 This is rescued by forced expression of a deacetylated CTTN mimetic.

85 tylase 3 (HDAC3) directly interacts with and deacetylates cyclin A.

86 (HDAC) 6 exists exclusively in cytoplasm and deacetylates cytoplasmic proteins such as alpha-tubulin.

87 SIRT1 was found to deacetylate Dcoh2, promoting its interaction with HNF-1a

88 unological properties of both chitin and its deacetylated derivative chitosan are of relevance becaus

89 Chitosan, the deacetylated derivative of chitin, can be found in the c

90 Assays with the 4-deacetylated diterpene substrates and acetyl CoA reveale

91 hock promoter Hsp70 by maintaining HSF1 in a deacetylated, DNA-binding competent state.

92 , correlating with active transcription, but deacetylated during EMT, reflecting the repressive state

93 2015) describe a nuclear pool of LC3 that is deacetylated during starvation, leading to redistributio

94 thetases identified by this work, and RpLdaA deacetylated eight of them.

95 oprecipitate in endothelial cells, and SIRT1 deacetylates eNOS, stimulating eNOS activity and increas

96 O and endothelium-dependent vascular tone by deacetylating eNOS.

97 naturally modified cATPase with the in vitro deacetylated enzyme revealed a major conformational chan

98 asticity mediated by histone acetylating and deacetylating enzymes may contribute to addiction-like b

99 or depletion of HDAC6, suggesting that HDAC6 deacetylates ERK1/2.

100 m ethanol-treated cells was able to bind and deacetylate exogenous tubulin to the same extent as cont

101 ity of SIRT1 was required and PGC-1alpha was deacetylated following addition of T(3).

102 YATL2, indicating that Lys-19 requires to be deacetylated for full activity.

103 mation regulation 2 homolog 1 (SIRT1), which deacetylates forkhead box o3 (FOXO3a), leading to repres

104 reserving renal Sirt1 expression, the latter deacetylating forkhead box O3a (FOXO3a), inducing Bnip 3

105 We produced MOF protein in the deacetylated form by using a nonspecific lysine deacetyl

106 Chitosan, a deacetylated form of chitin, is a dietary fibre known fo

107 uld be killed by rabbit IgG specific for the deacetylated form of the staphylococcal PNAG.

108 aled a 10-fold higher contamination with its deacetylated form, named NX-3, (up to 540 mg kg(-1) ) co

109 SIRT1 and SIRT2 deacetylate FOXO factors to regulate FOXO function.

110 However, how deacetylated FoxO exert their actions remains unclear.

111 ice homozygous for knock-in alleles encoding deacetylated FoxO1 (6KR).

112 knock-in of alleles encoding constitutively deacetylated FoxO1 in mice (Foxo1(KR/KR)) improves hepat

113 The data support the notion that deacetylated FoxO1 protects beta-cell function by limiti

114 SIRT1 deacetylates FoxO1 and enables activation of FoxO1 trans

115 nistically, SIRT2 suppresses adipogenesis by deacetylating FOXO1 to promote FOXO1's binding to PPARga

116 totranscription through interacting with and deacetylating FoxO1.

117 rtuins 1 and 7 (SIRT1 and SIRT7) are able to deacetylate FOXO3 in vitro and in vivo, and that lipopol

118 0 and K569) of FOXO3 into arginines to mimic deacetylated FOXO3 resulted in enhanced Skp2 binding but

119 ligase subunit Skp2 binds preferentially to deacetylated FOXO3.

120 We demonstrate that SIRT2 deacetylates Foxo3a, activates Bim, and induces apoptosi

121 We show here that SIRT2 deacetylates Foxo3a, increases RNA and protein levels of

122 Polyclonal animal antibody raised to deacetylated glycoforms of PNAG and a fully human IgG1 m

123 clonal antibody that both bind to native and deacetylated glycoforms of PNAG mediated complement-depe

124 , we propose that silencing occurs when Sir2 deacetylates H3 K56 to close the nucleosomal entry-exit

125 We suggest that Sir2 deacetylates H3K14 to target Clr4 to centromeres.

126 of a specific set of gene targets, where it deacetylates H3K18Ac and promotes transcriptional repres

127 as Drosophila Sir2 and human SIRT1 and SIRT2 deacetylate H3K56ac.

128 At telomeric chromatin, SIRT6 deacetylates H3K9 and is required for the stable associa

129 By binding to their promoters and deacetylating H3K9 at these sites, SIRT6 downregulates t

130 Sir2 also deacetylates H3K9Ac and H3K14Ac.

131 epistatic to sas2 deletion, indicating that deacetylated H4K16 mediates the delay caused by sas2 del

132 16 to arginine, which mimics constitutively deacetylated H4K16, delayed senescence and was epistatic

133 volves the specific association of Sir3 with deacetylated H4K16.

134 Sir2 preferentially deacetylates H4K16Ac and H3K4Ac, but mutation of these r

135 We found that SIRT1 deacetylated HDAC1 and stimulated its enzymatic activity

136 f Molecular Cell, Lim et al. show that SIRT1 deacetylates HIF-1alpha and regulates its ability to res

137 Histone deacetylases (HDACs) that deacetylate histone and nonhistone proteins play crucial

138 the E-cadherin proximal promoter by ZEB1 to deacetylate histone H3 and to reduce binding of RNA poly

139 Sir3 binds to nucleosomes containing deacetylated histone H4 lysine 16 (H4K16) and, with Sir4

140 lase activity and the affinity of Sir3/4 for deacetylated histone tails.

141 RT1) is a class III histone deacetylase that deacetylates histone and nonhistone proteins to regulate

142 occur when Sir2, an NAD(+)-dependent enzyme, deacetylates histone H3 and H4 N termini, in particular

143 oximal promoter region of the Pcsk9 gene and deacetylates histone H3 at lysines 9 and 56, thereby sup

144 Intriguingly, Sir2 preferentially deacetylates histone H3 lysine 79 as compared to Hst2.

145 nteracts with the NF-kappaB RELA subunit and deacetylates histone H3 lysine 9 (H3K9) at NF-kappaB tar

146 hanistically, SIRT6 interacts with c-JUN and deacetylates histone H3 lysine 9 (H3K9) at the promoter

147 hromatin remodeler SNF2H to DSBs and focally deacetylates histone H3K56.

148 Throughout the macrophage genome, HDAC3 deacetylates histone tails at regulatory regions, leadin

149 -related genes by interacting with c-Jun and deacetylating histone 3 at Lys9 (H3K9).

150 inhibits Notch1 and Notch4 transcription by deacetylating histone H3K9.

151 known as transcription corepressors through deacetylating histone tails.

152 in protein 1 (HP1)-containing complexes that deacetylate histones and methylate cytosine bases in DNA

153 er, localizing the Hos2 and Hst1 subunits to deacetylate histones in 5' transcribed regions.

154 Surprisingly, Hdac6 does not appear to deacetylate histones, but rather is required for Tip60-p

155 g mark and accordingly recruits enzymes that deacetylate histones.

156 t the latent proviruses carry high levels of deacetylated histones and trimethylated histones.

157 t to formation of condensed structures, with deacetylated histones giving rise to highly compacted ch

158 SirT1 (Sir2 in Drosophila melanogaster) deacetylates histones and other proteins including trans

159 acetylation, and the sirtuin Sir2/SIRT1 that deacetylates histones and transcription factors is essen

160 ession via its association with HDAC2, which deacetylates histones H2A and H3 on the miR-155 promoter

161 The SIN3A-HDAC complex deacetylates histones thereby repressing gene transcript

162 Silent Information Regulator 2 (Sir2) gene, deacetylates histones, p300, p53, and the androgen recep

163 duced with the treatment of apelin-13, which deacetylates histones.

164 to generate chromatin structures, with Sir2 deacetylating histones and Orc1 binding to these deacety

165 Some may alter cell cycle progression by deacetylating histones and repressing transcription of k

166 Hos2, and Hda1 have overlapping functions in deacetylating histones and suppressing cotranscriptional

167 HDAC10 regulates cyclin A2 expression by deacetylating histones near the let-7 promoter, thereby

168 HARP, recruiting SMRT, activating HDAC3, and deacetylating histones to exclude Pol II across the X ch

169 ates within the Sir pathway, spreading while deacetylating histones.

170 further demonstrate that Sirt1 interacts and deacetylates homologous recombination (HR) repair machin

171 We show that SIRT1 deacetylates HSF1 (heat shock factor 1) and increases HS

172 biquitin ligase GP78 preferentially binds to deacetylated HSPA5.

173 to levels similar to LPS, whereas partially deacetylated hyaluronan had no stimulatory effect, indic

174 ing of ischaemia-reperfusion injury, RIP1 is deacetylated in a SIRT2-dependent fashion.

175 histones at the Rgs10 proximal promoter are deacetylated in BV-2 microglia following LPS activation,

176 LCAD is deacetylated in wild-type mice under fasted conditions a

177 ed at low levels in the nucleus, albeit in a deacetylated, inactive state.

178 SIRT2 bound to LKB1 and deacetylated it at lysine 48, which promoted the phospho

179 SIRT3 physically binds to Ku70 and deacetylates it, and this promotes interaction of Ku70 w

180 as previously been shown to activate HSF1 by deacetylating it, leading to increased DNA binding abili

181 in vitro and in vivo data indicate that Sir2 deacetylates K56 directly in telomeric heterochromatin t

182 tylase sirtuin 2 (SIRT2) associated with and deacetylated K8.

183 The association of deacetylated LC3 with autophagic factors shifts LC3's di

184 s of nutrients were reversed by SIRT3, which deacetylates lys(101) acetylation.

185 ot deacetylation null Sirt3 into Sirt3/ MEFs deacetylated lysine and restored MnSOD activity.

186 zed to purify the substrate and identify the deacetylated lysine by MS.

187 epsilon-amino-acetylated lysine residues to deacetylated lysine, nicotinamide, and 2'-O-acetyl-ADP-r

188 namide, 2'-O-acetyl-ADP-ribose (OAADPr), and deacetylated lysine.

189 kdown of histone deacetylase (HDAC) 6, which deacetylates lysine residues in hsp90, induces reversibl

190 SIRT2 deacetylates lysine residues in the catalytic domain of

191 Although early studies showed that sirtuins deacetylated lysines in a reaction that consumes NAD(+),

192 ondrial reactive oxygen species, in part, by deacetylating manganese superoxide dismutase (MnSOD) and

193 racts aging- and obesity-related diseases by deacetylating many proteins, but whether SIRT1 has a rol

194 protein regulated by SIRT1, which binds and deacetylates Mcm10 both in vivo and in vitro, and modula

195 We show in this article that PAF and its 2-deacetylated metabolite (lysoPAF) promote degranulation

196 le only minimal amounts of the corresponding deacetylated metabolite of 10 were observed in hepatocyt

197 441C, Y1699C) preferentially associates with deacetylated microtubules, and inhibits axonal transport

198 1B-1 antibody recognizes both acetylated and deacetylated microtubules.

199 dative stress was dependent on IDH2, and the deacetylated mimic, IDH2(K413R) variant was able to prot

200 and the histone acetylation activity of the deacetylated MOF were found to be very close to that of

201 nd that the autoacetylation rates of MOF and deacetylated MOF were much slower than the cognate subst

202 t with MSH2, HDAC10 is the major enzyme that deacetylates MSH2 at Lys-73.

203 C terminus, and histone deacetylase (HDAC6) deacetylates MSH2.

204 Deacetylated MT accumulation resulted in Golgi fragmenta

205 A sirtuin-like enzyme can deacetylate multiple FadDs, thus completing the regulato

206 ially deacetylated, whereas several major PG-deacetylated muropeptides are absent or significantly re

207 the A band of sarcomeres and was capable of deacetylating myosin heavy chain (MHC) isoforms.

208 lized to A-band of sarcomeres and capable of deacetylating myosin heavy chain (MHC) isoforms.

209 The N-deacetylated N-(2'-deoxyguanosin-8-yl)-7-fluoro-2-aminof

210 e we show that sirtuin 1 deacetylase (Sirt1) deacetylates Nav1.5 at lysine 1479 (K1479) and stimulate

211 Thus, Sirt1, by deacetylating Nav1.5, plays an essential part in the reg

212 NF-kappaB, and the full capacity of AMPK to deacetylate NF-kappaB and inhibit its signaling requires

213 MPK activation mimics the effect of SIRT1 on deacetylating NF-kappaB, and the full capacity of AMPK t

214 , it is found associated with HDAC5, whereas deacetylated Nkx2.5 is in complex with p300.

215 le-associated deacetylase that predominantly deacetylates nonhistone proteins, including alpha-tubuli

216 Like most histone deacetylases, SIRT1 also deacetylates nonhistone proteins.

217 Here we report that SIRT6 binds to and deacetylates nuclear PKM2 (pyruvate kinase M2) at the ly

218 tains cellular iron levels by binding to and deacetylating nuclear factor erythroid-derived 2-related

219 etylating histones and Orc1 binding to these deacetylated nucleosomes through its BAH domain.

220 luding significant amounts of Sir3 and H4K16 deacetylated nucleosomes.

221 s, Rpd3L regulates the activation of RNR3 by deacetylating nucleosomes at the promoter, not at the op

222 ators FOG1 and the nucleosome remodeling and deacetylating (NuRD) complex.

223 he rate at which histones are acetylated and deacetylated on a residue-specific basis has not been qu

224 tochondrial deacetylase SIRT3 was capable of deacetylating OPA1 and elevating its GTPase activity.

225 between cryo-EM reconstructions of maximally deacetylated or acetylated microtubules.

226 romoter were determined using constitutively deacetylated or acetylated Sp3 mutants at lysine (K) 551

227 In contrast, sirt3(-/-) mice failed to deacetylate OTC in response to CR.

228 al analysis demonstrated that Sirt3 directly deacetylates OTC and stimulates its activity.

229 e NAD(+)-dependent histone deacetylase SIRT2 deacetylates p300 in vitro and in cells.

230 ifs, which selectively recruit an NcoR-Hdac3-deacetylated-p50 repressosome to inflammatory genes.

231 HDAC8 aberrantly deacetylates p53 and promotes LSC transformation and mai

232 y found that SIRT1 promotes cell survival by deacetylating p53.

233 energy starvation, SIRT1 interacts with and deacetylates PABP1 and deactivates its poly(A)RNA bindin

234 In SCs, we found that Sirt2 deacetylates Par-3, a master regulator of cell polarity.

235 SIRT1 physically binds to and deacetylates PARP1.

236 Furthermore, Sir2p deacetylated Pck1p both in vitro and in vivo.

237 2, a deacetylase, plays an important role in deacetylating PEPCK1 and little is known about the anti-

238 cancer-1 (Dbc1) promote "browning" of WAT by deacetylating peroxisome proliferator-activated receptor

239 Notably, ectopic overexpression of a deacetylated PKM2 mutant in Sirt2-deficient mammary tumo

240 nsis extracts by immunoblotting with an anti-deacetylated PNAG antibody or wheat germ agglutinin.

241 9GlcNH(2), in place of chemically partially deacetylated PNAG, three conjugate vaccines consisting o

242 Thus, the deacetylated polysaccharide chitosan potently activates

243 SirT2 binds and deacetylates PR-Set7 at K90, modulating its chromatin lo

244 tyl-lysine-containing peptide substrate from deacetylated product which bears an additional positive

245 o-arginine (KR) mutant of LRP130 that mimics deacetylated protein.

246 Sirtuins utilize NAD(+) to deacetylate proteins, yielding O-acetyl-ADP-ribose (OAAD

247 t regulator in CR adaptation by coordinately deacetylating proteins involved in diverse pathways of m

248 their moisture absorption ability (MAA) and deacetylating reaction were investigated and compared wi

249 During this initial process, SIRT1 deacetylated RelA/p65 lysine 310 and nucleosomal histone

250 The method permits labeling of deacetylated residues with amine-reactive biotin on the

251 Sirt1 deacetylates retinoblastoma (Rb) in the Rb/E2F1 complex,

252 Deacetylated Rtt109 was prepared by reacting with a sirt

253 SIRT1 deacetylates S6K1, thereby enhancing its phosphorylation

254 tuting the lysine at residue 633, one of the deacetylated sites of HDAC6, with a glutamine resulted i

255 beta2(TGF-beta2)-induced EMT of RPE cells by deacetylating SMAD4.

256 We provide direct evidence that Hos1 can deacetylate Smc3 and retains a soluble pool of deacetyla

257 acetylate Smc3 and retains a soluble pool of deacetylated Smc3.

258 yeast, the class I histone deacetylase Hos1 deacetylates SMC3 during anaphase.

259 are needed to maintain AcsA as active (i.e., deacetylated) so the cell can grow with low concentratio

260 Sp3 mutant (K551Q-Sp3) did not bind whereas deacetylated Sp3 (K551R-Sp3) mutant bound strongly to th

261 Expression of the deacetylated Sp3 mutant resulted in repression, whereas

262 endogenous ceramides and mechanisms by which deacetylated Sp3 regulates the hTERT promoter activity i

263 iated the association and recruitment of the deacetylated Sp3/HDAC1 complex to the hTERT promoter DNA

264 Our data reveal that SIRT1 can directly deacetylate SREBP, and modulation of SIRT1 activity resu

265 Conversely, mutations mimicking the deacetylated state (KR series) promote FoxO1 nuclear ret

266 indicate that Aurora B is more active in its deacetylated state and further suggest a new mechanism b

267 f SIRT2 to maintain lysine-668 of BubR1 in a deacetylated state, which is counteracted by the acetylt

268 ly, SMAR1 through HDAC6 maintains Sam68 in a deacetylated state.

269 to the c-fos gene promoter, which, in turn, deacetylates surrounding histones and attenuates gene ac

270 Together, these data imply that HDAC6 deacetylates survivin to regulate its nuclear export, a

271 cleus following CBP activation where it then deacetylates survivin.

272 SIRT1 interacts directly with, recruits and deacetylates SUV39H1, and these activities independently

273 t1 requires autodeacetylation to efficiently deacetylate targets such as p53, H3K9, and H4K16.

274 itro and that it functions during S phase to deacetylate the core domain of histone H3 at lysine 56 (

275 effects were due to the ability of SIRT1 to deacetylate the FOXO3 transcription factor, since Foxo3

276 s Dnmt3a via PHB2 and HDAC1 to methylate and deacetylate the miR-34a promoter simultaneously, hence e

277 3K36me on one nucleosome stimulates Rpd3S to deacetylate the neighboring nucleosomes when those two n

278 and recruiting histone deacetylase 1, which deacetylated the Il7ra promoter.

279 NAD(+)-dependent deacetylase, bound TUG and deacetylated the TUG peptide.

280 SIRT1 deacetylates the brain-specific helix-loop-helix transcr

281 ndria of SIRT3-null mice, and SIRT3 directly deacetylates the ceramide synthases in a NAD(+)-dependen

282 The intracellular enzyme that deacetylates the PAF (PAFAH1B) is composed of a tetramer

283 fers protection against polyQ-expanded AR by deacetylating the AR at lysines 630/632/633.

284 SIRT1 promotes catabolic gene expression by deacetylating the forkhead factor FOXO in response to st

285 SIRT2 promotes AMPK activation by deacetylating the kinase LKB1.

286 We found that either deacetylating the microtubules via overexpression of HDA

287 how that SIRT1 may mediate both processes by deacetylating the transcription factor retinoic acid rec

288 allowing histone HDAC2 and cofactor Sin3A to deacetylate these histones at the ASS1 promoter, thereby

289 eover, we identified SIRT1 that specifically deacetylates TIP60 and negatively regulates TIP60 activi

290 a-D-Glcp-O-iPr (23), which was selectively S-deacetylated to give 25.

291 glucose deprivation, SIRT1 is activated and deacetylates TopBP1, resulting in TopBP1-Treslin disasso

292 K36me targets the Rpd3S complex to deacetylate transcribed regions and suppress cryptic tra

293 Sirtuin research has focused on SirT1, which deacetylates transcription factors and cofactors in the

294 its was markedly improved in the presence of deacetylated tRNA, emphasizing the importance of tRNAs d

295 roach, we describe the ability of Sirt1-3 to deacetylate two adjacent acetylated lysine residues.

296 ld-type C. difficile is intrinsically highly deacetylated, we have found that exposure to lysozyme le

297 The parent strain PG is partially deacetylated, whereas several major PG-deacetylated muro

298 by acetyltransferase CBP/p300, and SIRT1 can deacetylate WRN both in vitro and in vivo.

299 SIRT1 deacetylates XPA both in vitro and in cells.

300 ing CBM reduced the capacity of esterases to deacetylate xylan in tobacco walls.