コーパス検索結果 (1語後でソート)
通し番号をクリックするとPubMedの該当ページを表示します
1 rease in SIRT1-MTORC2 interaction and RICTOR deacetylation.
2 methylation, histone methylation, or histone deacetylation.
3 d repressed transcription of Il6 via histone deacetylation.
4 regulation of alternative splicing via Sam68 deacetylation.
5 ular redox potential via HDAC3-mediated PGK1 deacetylation.
6 romotes HDAC3-PGK1 interaction and PGK1 K220 deacetylation.
7 gulation of BA homeostasis by persistent FXR deacetylation.
8 o lysozyme leads to additional peptidoglycan deacetylation.
9 esis, and bile acid (BA) homeostasis through deacetylation.
10 Sin3b decreases Myc protein levels upon Myc deacetylation.
11 ion of p53 by decreasing SIRT2-dependent p53 deacetylation.
12 tial regulation of epigenetic acetylation or deacetylation.
13 itors both induced BRM as well as caused BRM deacetylation.
14 and without splitomicin inhibition of lysine deacetylation.
15 y in part by regulating PDH function through deacetylation.
16 pigenetic modifications that include histone deacetylation.
17 lower molecular weight and higher degree of deacetylation.
18 e p53 protein and modulates p53 activity via deacetylation.
19 ivating AMPK through mechanisms that include deacetylation.
20 ck protein 70 family proteins, causing their deacetylation.
21 rectly interacts with STAT3 and promotes its deacetylation.
22 ondria and unexpectedly is a target of SIRT1 deacetylation.
23 ed and that HDAC6 promotes ERK1 activity via deacetylation.
24 nism for SIRT3 regulation via SIRT1-mediated deacetylation.
25 s required to achieve locus-specific histone deacetylation.
26 f non-coding RNA silencing and histone H4K16 deacetylation.
27 s resulted from successive deiodinations and deacetylations.
29 her posttranslational modifications, such as deacetylation/acetylation, methylation, and ubiquitinati
35 a new mechanism by which dynamic acetylation/deacetylation acts as a rheostat to fine-tune Aurora B a
36 -modifying enzymes with activities in lysine deacetylation, adenosinediphospho(ADP)-ribosylation, and
37 logical SIRT1 activators that promoted HDAC1 deacetylation also reduced DNA damage in two mouse model
39 demonstrate that SIRT1 induction causes the deacetylation and activation of FOXO3a in NAc, which lea
41 of SIRT1 on gene expression are mediated by deacetylation and activation of peroxisome proliferator
42 AMPK and SIRT1 in skeletal muscle leading to deacetylation and activation of PGC-1alpha, increased mi
43 imal structural elements required for lysine deacetylation and catalytic activation by small molecule
44 eate a hitherto-unknown mechanism of protein deacetylation and deacetylimination catalyzed by lysyl o
45 actions that contribute to podocyte protein deacetylation and degradation as well as renal dysfuncti
47 triggered by Lsd1-Mi2/NuRD-mediated histone deacetylation and demethylation at these pluripotency ge
48 genetic regulators necessary for (i) histone deacetylation and demethylation, (ii) binding to methyla
49 ce of conserved active site residues in PNAG deacetylation and demonstrate that the C-terminal domain
50 fication of FoxO3, including early (6 hours) deacetylation and dephosphorylation that coincide with l
52 and NAD(+) supplementation restored protein deacetylation and enhanced oxygen consumption in circadi
53 h the induction of SIRT2, leading to ALDH1A1 deacetylation and enzymatic activation to promote breast
54 last differentiation in part through histone deacetylation and epigenetic suppression of an alternati
55 nucleation region in vivo, promoting histone deacetylation and FLC transcriptional silencing, and int
56 tion repression activity of Tet2 via histone deacetylation and for the prevention of constant transcr
57 ment suppressed the effects of PH on histone deacetylation and hepatocellular bromodeoxyuridine (BrdU
58 activity is largely responsible for histone deacetylation and inflammatory responses of primary micr
59 X receptor (FXR) activity due to persistent deacetylation and lower protein expression that led to d
62 cystic epithelial cell proliferation through deacetylation and phosphorylation of Rb and regulated cy
63 o SIRT1-mediated p53 and histone 3 lysate 56 deacetylation and results in reduced EC senescence in vi
65 functional link between SIRT7-mediated H3K18 deacetylation and the maintenance of genome integrity.
66 1 gene transcription through regulating TAF9 deacetylation and transcription factor IID assembly.
67 ression screenings demonstrates that histone deacetylation and transcriptional dysregulation are two
68 dentified a subset of genes in which H3K9,14 deacetylation and transcriptional dysregulation concur.
69 haride composition analysis indicated that N-deacetylation and/or N-desulfation may have taken place.
70 d probes for chitosan (the product of chitin deacetylation) and for demethylesterified homogalacturon
71 ons, acetylated histone 3 on lysine 9 and 14 deacetylation, and acetylated histone 3 on lysine 9 meth
72 cetylases (HDA6 and HDA19), promotes histone deacetylation, and attenuates derepression of genes unde
73 ates a subset of neuronal genes through FOXO deacetylation, and disruption of HDAC3 contributes to co
76 sed carboxypeptidase activities, increased N-deacetylation, and increased O-acetylation in VRE when g
79 ivity can be modulated by lysine acetylation-deacetylation, and prevention of TopA inactivation from
80 histone deacetylase 6 (HDAC6)-mediated RelA deacetylation, and thus enhances transcriptional activit
81 n activity or affected for histone H4 Lys-16 deacetylation are impaired, at least in part, for telome
82 ing of the HLA class-I APM is due to histone deacetylation as inhibition of histone deacetylases (HDA
83 data reveal that loss of FBP1 due to histone deacetylation associates with poor prognosis of HCC and
84 ha-PLZF recruits HDAC1 and causes histone H3 deacetylation at C/EBPalpha target loci, thereby decreas
87 ranscriptional activity via reciprocal STAT3 deacetylation at Lys685 and phosphorylation at Tyr705.
89 ures, in which it binds and triggers histone deacetylation at the promoter of the calbindin gene (Cal
90 etic mechanisms, such as histone acetylation/deacetylation balance, in part via histone deacetylase (
91 On the other hand, inhibition of histone deacetylation by an inhibitor specific to HDACs 1-3, CI-
92 s, and particularly BMAL1-Lys537 acetylation/deacetylation by CLOCK/SIRT1, were shown to be critical
94 ohesin association with chromosomes, and its deacetylation by Hos1 in anaphase allows re-use of Smc3
95 on between Hst3 synthesis, genome-wide H3K56 deacetylation by Hst3, and cell cycle-regulated degradat
97 4 and SAGA as well as stimulating nucleosome deacetylation by multiple HDACs to maintain the proper l
101 xO1-dependent and furthermore required FoxO1 deacetylation by the NAD(+)-dependent deacetylase, SirT1
103 re, pharmacologically induced SIRT1-mediated deacetylation can attenuate aberrant NEDD4-mediated HSF1
105 oumarin enhances the catalytic efficiency of deacetylation catalyzed by cobalt(II)-bound histone deac
106 ation and the deacetylase sirtuin-1-mediated deacetylation coexist to maintain CREBH acetylation stat
107 the Dleu2 promoter via inhibition of histone deacetylation combined with BSAP knockdown increased miR
110 e data suggest that MSI1, HDA19, and HISTONE DEACETYLATION COMPLEX1 protein form a core complex that
111 in a subset of occluded genes, while histone deacetylation contributes to the implementation but not
112 ation, we tested the hypothesis that histone deacetylation contributes to the maintenance of chronic
113 neated a novel pathway through which histone deacetylation could contribute to CORT regulation of GR
119 s with different structural features, namely deacetylation degree (5-91%) and molecular weight (24-46
122 sed that FoxO proteins are activated through deacetylation-dependent nuclear translocation to foresta
124 e expression signature associated with FoxO1 deacetylation differs from wild type by only approximate
127 lterations including histone acetylation and deacetylation has been demonstrated to play an important
128 elbine with plasma revealed that vinorelbine deacetylation in Cyp3a and especially in P-gp/Cyp3a knoc
129 rts a central role of HDA-1-mediated histone deacetylation in heterochromatin spreading and gene sile
130 transcription through HDAC1-mediated histone deacetylation in LPS-induced macrophages, acting as a ne
131 IFICANCE STATEMENT The importance of histone deacetylation in normal brain functions and pathological
132 indicate an important role of SIRT1-mediated deacetylation in regulating the formation of DUBm subcom
133 of differentiation through continual histone deacetylation in stem cells enables self-renewal and rap
135 acts with TRbeta1 in vitro, promotes TRbeta1 deacetylation in the presence of T3 and enhances ubiquit
142 in mouse tumor models demonstrate that PKM2 deacetylation is integral to SIRT6-mediated tumor suppre
143 fied new targets of Sir2 and tested if their deacetylation is necessary for Clr4-mediated heterochrom
144 acological inhibition of SIRT2-dependent p53 deacetylation is of great therapeutic interest for the t
145 muscle revealed that a major target of Sirt3 deacetylation is the E1alpha subunit of PDH (PDH E1alpha
146 as a rate-limiting component of the histone deacetylation machinery and as an attractive tool for in
148 at local competition between acetylation and deacetylation may play a critical role in the resolution
150 genetic changes to active chromatin, such as deacetylation, may be mediated by HDAC3 in dying neurons
151 e 1479 (K1479) and stimulates INa via lysine-deacetylation-mediated trafficking of Nav1.5 to the plas
154 show that the Mbd3/nucleosome remodeling and deacetylation (NuRD) chromatin remodeling complex oppose
155 tions by forming a nucleosome remodeling and deacetylation (NuRD) complex that regulates transcriptio
160 ease, it was shown that AnCDA catalyses mono-deacetylation of (GlcNAc)2 and full deacetylation of (Gl
161 ses mono-deacetylation of (GlcNAc)2 and full deacetylation of (GlcNAc)3-6 in a non-processive manner.
162 ninvasive real-time progression assay, where deacetylation of a p53 based peptide was observed by nuc
163 summary, our results show that TH-dependent deacetylation of a second metabolically regulated transc
167 ic catalysis, and assays that measured SIRT2 deacetylation of acetylated alpha-tubulin revealed that
168 se family comprises 18 enzymes that catalyze deacetylation of acetylated lysine residues; however, th
174 s that respond to replication stress through deacetylation of CDK9, providing insight into how SIRT2
175 cell (mESC) differentiation in part through deacetylation of cellular retinoic acid binding protein
176 ates mitochondrial ceramide biosynthesis via deacetylation of ceramide synthase (CerS) 1, 2, and 6.
177 hypothesis that IR triggers SIRT3-dependent deacetylation of ceramide synthases and the elevation of
178 /reperfusion (IR) showed that SIRT3-mediated deacetylation of ceramide synthases increased enzyme act
179 e biotinyl-lysine method was used to compare deacetylation of chemically acetylated histones by the y
180 t evolutionarily conserved sites disrupt its deacetylation of DNA-damage response proteins by impairi
186 T2 regulates H4K20me1 deposition through the deacetylation of H4K16Ac (acetylation of H4K16) and dete
188 Specifically, these inhibitors limit the deacetylation of heat shock protein 90, resulting in les
191 enhancer-promoter communication and prompted deacetylation of histone H3 in the HNF4alpha P1 promoter
192 tion triggered by H3 S10 phosphorylation and deacetylation of histone H4 promote short-range compacti
194 alization of N-CoR/HDAC3, thereby inhibiting deacetylation of histones and HDAC4 client transcription
195 ges common in wild-type cells, including the deacetylation of histones, formation of heterochromatin,
197 anistic insights into the understanding that deacetylation of HSPA5 by HDAC6 facilitates GP78-mediate
199 d recruitment of SIRT1 activity promotes the deacetylation of individual SAGA complex components.
200 ts ability to promote cell migration through deacetylation of its cytoplasmic substrates such as alph
204 ns, we asked whether in vitro acetylation or deacetylation of lysine 40 (K40), a major posttranslatio
205 nspired by the posttranslational acetylation/deacetylation of lysine residues, in which a protein enc
206 g effects of Sirt1 evidently result from the deacetylation of many transcription factors and co-facto
209 nts but, rather, occurred via SIRT3-mediated deacetylation of mitochondrial SOD2, leading to SOD2 act
211 rtuins (SIRTs) catalyze the NAD(+)-dependent deacetylation of N(epsilon)-acetyl lysines on various pr
212 orms together with a close homolog HDAC2, is deacetylation of new histone H4 deposited at replication
214 ytes and that puerarin led to SIRT1-mediated deacetylation of NF-kappaB and suppression of NOX4 expre
216 interaction of HDAC1 and p53 resulted in the deacetylation of p53 and suppression of Bmf expression i
219 Collectively, these observations show that deacetylation of p53 suppresses Bmf expression and facil
221 iplasm and that this may allow for efficient deacetylation of PEL before its export from the cell.
222 The K m and k cat of AnCDA for the first deacetylation of penta-N-acetyl-chitopentaose are 72 mic
223 ore and potent activation of Sirt6-dependent deacetylation of peptide substrates and complete nucleos
224 of SIRT1, resulting in FGF21/SIRT1-dependent deacetylation of PGC-1alpha and induction of the brownin
225 DAC3 coactivation of ERRalpha is mediated by deacetylation of PGC-1alpha and is required for the tran
229 sensing activity and that the HDAC6-mediated deacetylation of RIG-I is critical for viral RNA detecti
230 rough histone deacetylase 6 (HDAC6)-mediated deacetylation of RNA-binding protein Sam68 (Src-associat
232 esents detailed kinetics for HDAC8-catalyzed deacetylation of singly-acetylated, full-length protein
233 ncreased SirT-1 protein levels and increased deacetylation of SirT-1 targets involved in DNA repair.
235 HDAC1 activates PU.1 gene transcription via deacetylation of TATA-binding protein-associated factor
236 HDAC9 promoter by DNMT3a, along with lysine deacetylation of TBK1 by HDAC9, are essential events dur
238 the reducing end sugar was much slower than deacetylation of the other sugars in chito-oligomers.
239 ne gene expression on IL-4-moDCs through the deacetylation of the promoters of these genes, leading t
242 may alter the preproPC2 gene directly or via deacetylation of the transcription factor Forkhead box p
243 d HDAC-3/5/7 with myocyte enhancer factor-2; deacetylation of these factors led to down-regulation of
244 6 (HDAC6) as the enzyme responsible for the deacetylation of these residues, and provide proof of co
245 on of the DNA damage response prevents SIRT1 deacetylation of TopBP1, resulting in a switch from DNA
247 ted step in the biosynthesis of lipid A, the deacetylation of uridyldiphospho-3-O-(R-hydroxydecanoyl)
248 ion of enzymes that regulate acetylation and deacetylation offers much potential for inhibiting cance
249 ffects of resveratrol, SIRT1, and PGC-1alpha deacetylation on mitochondrial biogenesis in muscle.
250 BpsB displays metal- and length-dependent deacetylation on poly-beta-1,6-N-acetyl-d-glucosamine (P
251 miR-193b-3p expression was caused by histone deacetylation on the miR-193b-3p promoter in the HepG2 c
252 Additionally, TH was unable to induce FoxO1 deacetylation or hepatic PCK1 gene expression in TH rece
253 ric DNA, but not by DNA methylation, histone deacetylation, or histone trimethylation at telomeres an
255 These results indicate that peptidoglycan deacetylation plays an important role in modulating host
256 lation at the promoter, H2Bubi initiates the deacetylation process, which decreases chromatin remodel
258 PP/p25 counteracts the SIRT2-derived tubulin deacetylation producing enhanced microtubule acetylation
259 ypothesis where the acetate byproduct of the deacetylation reaction escapes via the 14 A internal cav
260 ucture of an LpxC enzyme in complex with the deacetylation reaction product, UDP-(3-O-(R-3-hydroxymyr
261 specificity a conserved Pro, shares with the deacetylation reaction the same active site and one cata
266 n of H3K4 and consequent promoter nucleosome deacetylation repress ste11 induction and cell different
267 anscription via modulation of H3 acetylation/deacetylation, respectively, through competition for bin
269 that are involved in histone acetylation and deacetylation result in multiple congenital anomalies wi
271 tion by p300 overexpression or inhibition of deacetylation resulted in increases of Ser-294 phosphory
273 ylase, interacts with and keeps MORF4L1 in a deacetylation status at Lys(148) that triggers MORF4L1 s
276 in the range of 8-35 muM and increased H4K16 deacetylation, suggesting a possible role for SIRT1 acti
277 modulated in distinct fashion by acetylation/deacetylation, suggesting an integrated regulation mecha
281 tivity that is coordinated by an acetylation-deacetylation switch, p300/CBP-mediated Lys-53 acetylati
284 concert with enrichment of H4K16ac (itself a deacetylation target of SIRT1), which is associated with
285 -chain acyl-CoA dehydrogenase, a known SIRT3 deacetylation target; improved fatty acid beta-oxidation
287 beta-Chitin was more susceptible to alkali deacetylation than was alpha-chitin, and required a lowe
289 on/de-ubiquitination and histone acetylation/deacetylation, the repressive histone methyl transferase
290 on by inhibiting SIRT1-mediated beta-catenin deacetylation, thereby enhancing LEF1-beta-catenin compl
292 umerous transcription factors in response to deacetylation to promote mitochondrial biogenesis and ox
293 w that the RIG-I C-terminal region undergoes deacetylation to regulate its viral RNA-sensing activity
295 cohesion in early anaphase; subsequent Smc3 deacetylation, triggered by Scc1 cleavage, is also requi
299 sms, including histone modifications such as deacetylation, we tested the hypothesis that histone dea
WebLSDに未収録の専門用語(用法)は "新規対訳" から投稿できます。