ライフサイエンスコーパス: deactivation

1 sor movement, which indirectly slows current deactivation.

2 13 catalyst cannot overcome owing to thermal deactivation.

3 fication of kinetics in ionic activation and deactivation.

4 catalysis to proceed without sulfur loss and deactivation.

5 results in a faster structural collapse and deactivation.

6 voltage dependence of channel activation and deactivation.

7 terised by slower desensitisation and faster deactivation.

8 -length F508del-CFTR and accelerated channel deactivation.

9 Au-CO bond and a change in the mechanism of deactivation.

10 terior as the driving forces behind catalyst deactivation.

11 urfaces controlling cobalamin reactivity and deactivation.

12 the structural changes that lead to catalyst deactivation.

13 an also develop via intracellular antibiotic deactivation.

14 formation prevail, leading to rapid catalyst deactivation.

15 rsible Re complex decomposition and catalyst deactivation.

16 ency, photon integration over time, and slow deactivation.

17 broadened through competitive and reversible deactivation.

18 forated-patch conditions and slowed receptor deactivation.

19 11) substitutions exhibited a faster current deactivation.

20 ct on NMDAR Glu EC50, and slowing of channel deactivation.

21 complex with its catalytic activity and its deactivation.

22 accounts instead for tertiary axial C-H bond deactivation.

23 were required to achieve maximal slowing of deactivation.

24 so reduced stationary gating and accelerated deactivation.

25 wer pressure and significantly less catalyst deactivation.

26 t and protect it, e.g., from degradation and deactivation.

27 imulation, consistent with the term monocyte deactivation.

28 ation, S140G and V141M, drastically slow IKs deactivation.

29 el activation voltage and an accelerated HCN deactivation.

30 s highly robust with no evidence of catalyst deactivation.

31 * and CO* intermediates, leading to catalyst deactivation.

32 Subsequent self-oxidation eventually causes deactivation.

33 that lead to catalytic activity and material deactivation.

34 the pore gate and the voltage sensor during deactivation.

35 e scales of activation, desensitization, and deactivation.

36 creasing competition of nonradiative surface deactivation.

37 ein kinase (MAPK), and nitric oxide synthase deactivation.

38 ensor-pore coupling, thereby slowing current deactivation.

39 tization activities and avoid rapid catalyst deactivation.

40 GTPase-activating proteins, potentiating Gq deactivation.

41 approximately 2H2O) transitions and SCO-deactivation (1)).

42 Our associated meta-analysis of functional deactivations-a scarcely addressed dynamic in fMRI fear-

43 uring sustained ATP application and receptor deactivation after ATP washout, and makes the receptor p

44 d chemical functionalities without catalytic deactivation after reactions over 8 h.

45 ed only by covalent attachment of amino acid deactivation agents to residual activated carboxy groups

46 physiology, including increased task-induced deactivation, altered limbic connectivity and increased

47 ighest activity and stability, whereas rapid deactivation and a low catalytic activity were observed

48 uced slowing of ERG1, ERG3, and ELK1 channel deactivation and accelerated the rate of EAG1 channel ac

49 in an hour of left ventricular assist device deactivation and all within 26 hours.

50 elated mortality is associated with monocyte deactivation and an antiinflammatory blood immune signat

51 l]-piperidine-3-carboxylic acid] (RPR) slows deactivation and attenuates inactivation of hERG1 channe

52 studied the relationship between activation/deactivation and C-type inactivation/recovery.

53 he spine-actin regulator RhoA, promoting its deactivation and degradation, respectively, and destabil

54 he spine-actin regulator RhoA, promoting its deactivation and degradation, respectively, and destabil

55 s remain an unsolved problem due to catalyst deactivation and deleterious side reactions.

56 GSG1L also speeds up AMPAR deactivation and desensitization in hippocampal CA1 neur

57 as there an association between reduced rACC deactivation and Gln/Glu, Glu, or Gln in the OCD group.

58 of coupling between drug binding and altered deactivation and inactivation.

59 rative umpolung annulation eliminates mutual deactivation and leads to a diverse set of benzazepine d

60 nels terminates because of voltage-dependent deactivation and not by Ca(2+)-dependent inactivation, a

61 and voltage sensor-pore coupling to slow IKs deactivation and provide a key step toward developing me

62 it provides a unique measure of immune cell deactivation and quiescence.

63 Here we demonstrate the reversible deactivation and reactivation of an iron-based non-preci

64 octreotide mediated Akt/mTOR/p70S6K pathway deactivation and reduction of kidney inflammation and ap

65 ive responses to infection, but their prompt deactivation and removal are essential for limiting tiss

66 species in the MOFs prevents intermolecular deactivation and stabilizes solution-inaccessible cataly

67 ntracellular end for fast channel activation/deactivation and the other at the selectivity filter for

68 synergize with inhibitors of endocannabinoid deactivation and/or an orthosteric cannabinoid agonist.

69 before sleep (anodal 'activation', cathodal 'deactivation', and sham stimulation).

70 sites reduced stationary gating, accelerated deactivation, and imparted sensitivity to aniracetam, an

71 ge dependence of activation, regulating slow deactivation, and modulating C-type inactivation of Kv11

72 eased IHVR, enhanced NO bioavailability, HSC deactivation, and reduced intrahepatic microthrombosis.

73 ly, in vivo studies validated our controlled deactivation approach in rodents and non-human primates.

74 o their poor activity, sulfur loss and rapid deactivation at elevated temperature.

75 have evolved to compensate for the faster HA deactivation at low pH, with a commensurate increase in

76 By measuring slow activation and deactivation at steady state we found the "true" mode-sh

77 hing in-flow as a function of excitation and deactivation beam fluence, flow speed, and protein conce

78 A two-color array of 20 excitation and deactivation beams generated with diffractive optics was

79 at ASICs show such steeply agonist-dependent deactivation because of strong cooperativity in proton b

80 Both antibodies increase the rate of deactivation but have different effects on channel activ

81 ) was shown to rescue p53 from mdm2-mediated deactivation, but the mechanism is unknown.

82 tic deceleration of current and fluorescence deactivation, but these effects are attenuated upon disr

83 es are populated within 50 fs during exciton deactivation, but they are short-lived ( approximately 1

84 enzymes require protection to prevent their deactivation by bleach.

85 d stabilizing Cu catalyst electrodes against deactivation by carbonaceous species accumulation in CO2

86 nhanced Maxwell-Wagner polarization.Catalyst deactivation by coke deposition is a major drawback in i

87 l current peak amplitude but altered current deactivation by decreasing or increasing single channel

88 block in glycolysis associated with monocyte deactivation by endotoxin, a process contributing to imm

89 d on triplet excited state ensembles against deactivation by molecular oxygen though quenching and ph

90 Tyr-545 contributes to the slow kinetics of deactivation by primarily stabilizing the transition sta

91 s formed upon photolysis, and prevents their deactivation by reaction with protons or oxygen.

92 TOR) signaling controls the dynamics of IRE1 deactivation by regulating ER-mitochondria physical cont

93 The slowing of deactivation by RPR was proportional to the number of wi

94 solvent Lewis basicity, indicating that C-H deactivation can be modulated by varying the nature of t

95 In pursuit of safer controlled-deactivation cannabinoids with high potency and short du

96 Conversely, pulvinar deactivation caused an increase in low-frequency cortica

97 aintenance of this, along with maintained DM deactivation, characterizes successful ageing and may ex

98 transient binding sites slows activation and deactivation, consistent with slower glutamate binding a

99 that persistent cycles of UPR activation and deactivation create an altered, quasi-stable setpoint fo

100 rigger a rapid, receptor-specific activation/deactivation cycle of beta-arrestins, which permits thei

101 l FPCN connectivity during WM, whereas vmPFC deactivation differences persisted regardless of WM perf

102 al order judgments while iCA1-->mPFC pathway deactivation disrupted spatial memory.

103 aminant of many fuels, and are vulnerable to deactivation due to carbon deposition when using carbon-

104 HT1A -IPSCs was primarily shaped by receptor deactivation due to clearance via serotonin reuptake tra

105 vide a new approach to investigate catalytic deactivation due to hydrocarbon coking or poisoning of z

106 nts' symptom provocation preceded subsequent deactivation during avoidance and relief events, indicat

107 , PEip, and somatosensory cortex also showed deactivations during saccades relative to fixation only.

108 etic capacity (i.e., activation energy, Ea ; deactivation energy, Hd ; entropy parameter, DeltaS) or

109 itions, while also reducing the frequency of deactivation events.

110 mplex behavior to the CoRA dependence of Env deactivation following FI binding.

111 nfirms stepwise electronic/inductive lactone deactivation for both BTF and BTP, the unusually fast an

112 glycol, an important reaction well known for deactivation from copper nanoparticle sintering, can sho

113 domains, plays a critical role in this slow deactivation gating.

114 Deactivation has been less studied, during which the two

115 m of ion-pairing, ring-opening, and catalyst deactivation have been studied in the condensed phase wi

116 response to extrinsic noises perturbing gene deactivation in a variety of settings where the network

117 of balance between G-protein activation and deactivation in cancers has been interrogated by studyin

118 e active sites within the composite.Catalyst deactivation in fluid catalytic cracking processes is un

119 during indirect O2 reduction and a source of deactivation in fuel cells.

120 modulation may play a critical role in mPFC deactivation in neuropathic pain and underlie the mPFC-s

121 h the patterns of Default Mode Network (DMN) deactivation in Obsessive Compulsive Disorder (OCD) in t

122 binant and native ASICs show extremely rapid deactivation in outside-out patches when jumping from a

123 shift in voltage sensitivity, and slowing of deactivation in response to a depolarizing prepulse.

124 ated before death, with all but 3 undergoing deactivation in the hospital.

125 eposits and are responsible for the critical deactivation in the methanol to olefin process.

126 (3) kinetics of Ca(2+) channel activation or deactivation in the photoreceptor terminal.

127 We investigated the mechanisms of mPFC deactivation in the rat spared nerve injury (SNI) model

128 C, when compared with OCD, had a significant deactivation in two anterior nodes of the DMN (medial fr

129 tal and cerebellar regions, and task-related deactivations in default mode network (DMN) areas.

130 4) and 2 experimental groups with surfactant deactivation induced by polysorbate lavage: the LTVV gro

131 ot of Panax ginseng, slows the rate of hERG1 deactivation, induces channels to open at more negative

132 We found that ASIC deactivation is extremely fast and, in contrast to most

133 the molecular basis of TRPV1 activation and deactivation is not fully understood.

134 example of a ligand-gated ion channel whose deactivation is sensitive to agonist concentrations that

135 rordinate, dichotomous pattern of activation/deactivation, is common across a variety of task demands

136 issociation or PLC-beta3-potentiated Galphaq deactivation, is not sufficient to explain the observed

137 were made with inhibitors of endocannabinoid deactivation (JZL184, URB597) or an orthosteric cannabin

138 diheteromeric GluN1/2B receptors with slower deactivation kinetics is decreased.

139 ectrochemical methods to study the real-time deactivation kinetics of a Pt/C electrocatalyst at singl

140 l firing patterns characteristic of the fast deactivation kinetics of the KCNH2-3.1 isoform were also

141 hERG1a and hERG1b RNA yielded channels with deactivation kinetics that reached a plateau and were di

142 NMDARs display slow deactivation kinetics, are highly Ca(2+) permeable, and

143 novel mIPSC patterns differing in activation/deactivation kinetics, charge transfer, and sensitivity

144 iheteromeric GluN1/2A/2B receptors with fast deactivation kinetics, whereas expression of diheteromer

145 IK,L also showed complex activation and deactivation kinetics, which we faithfully reproduced by

146 voltage dependence of activation, and slowed deactivation kinetics.

147 5 ms), whereas it only had a minor effect on deactivation kinetics.

148 activation, including altered activation and deactivation kinetics.

149 Structure (XANES) spectroscopy confirms that deactivation largely occurs through the migration of Ni

150 However, pulvinar deactivation led to a reduction of attentional effects o

151 s not extend on ring A, making excited-state deactivation less sensitive to ring A mobility.

152 small platinum clusters followed by a rapid deactivation likely due to hydrogen bubble formation.

153 recovery of the photoresponse, faster PDE6C deactivation may blunt the rise in background-induced st

154 talyst rapidly deactivates on-stream and the deactivation mechanism remains unclear.

155 role, thereby constituting a unique delayed deactivation mechanism.

156 zed pCB coatings is strongly influenced by a deactivation method affecting the ultra-low-fouling mole

157 alysts (i.e., loss of Mo species thus causes deactivation), Mo-SIM demonstrated no loss in the metal

158 n azametallacycle (4) suggests that catalyst deactivation occurs with a large excess of cyanamide ove

159 t, compared with OCD, HC had a significantly deactivation of a widespread brain network (superior fro

160 I3K-Akt targets, 75% could be explained by a deactivation of adenylate-uridylate-rich element (ARE)-b

161 Ca(ClO4)2, that promotes deactivation of amines and amides by Ca(2+) binding, off

162 the three-carbon bridge leads to the partial deactivation of anomeric effects.

163 Enzymatic deactivation of antibiotics, a common mechanism of antib

164 eport that the slow desensitization and fast deactivation of ASIC1a/2a heteromers enables them to sus

165 Surprisingly, the deactivation of ASICs was steeply dependent on the pH, s

166 NMDAR- and Ca(2+)-permeable AMPAR-dependent deactivation of BCR in hippocampal but not cortical neur

167 ed Tiam1 activation but has no effect on the deactivation of BCR.

168 demonstrated through optical activation and deactivation of both exogenous and endogenous gene funct

169 ted and Lewis acids determines a significant deactivation of C-H bonds alpha to the amide nitrogen of

170 slow opening/closing of stomata, activation/deactivation of C3 cycle enzymes, and up-regulation/down

171 al challenges, for example, those related to deactivation of cardiac devices, such as pacemakers, def

172 te pores during catalysis leads to temporary deactivation of catalyst, necessitating regeneration ste

173 NP provided information about the origins of deactivation of catalytic NPs and the effects of various

174 he placebo, butorphanol produced a bilateral deactivation of claustrum, insula, and putamen, areas ac

175 that OCD patients had difficulties with the deactivation of DMN even when the non-rest condition inc

176 xy-group-terminated OEG-SAMs, only a partial deactivation of EDC/NHS-activated zwitterionic carboxy g

177 While deactivation of either pathway impaired episodic memory,

178 their lifetime, probably due to nonradiative deactivation of excited states by N-H bonds.

179 SHP2 effects were mediated through deactivation of fibrosis-relevant tyrosine kinase and se

180 therefore uncover a cycle of activation and deactivation of Foxd3 required for exit from naive pluri

181 tein (GAP) activity, ultimately accelerating deactivation of G protein signaling.

182 ng NO3(-) addition, followed within hours by deactivation of genes encoding enzymes for chlorophyll b

183 n-coupled receptor signaling by accelerating deactivation of Gi/o alpha-subunits, several neurologica

184 Downregulation of CK2 and EGFR also caused deactivation of heat shock protein 90 (Hsp90) co-chapero

185 Slow deactivation of hERG channels is critical for preventing

186 ulators of G protein Signaling (RGS) promote deactivation of heterotrimeric G proteins thus controlli

187 ull-length F508del-CFTR and slightly delayed deactivation of individual F508del-CFTR Cl(-) channels.

188 minimize the background noise, that is, the deactivation of intracellular dehydrogenases, degradatio

189 h subsequent SAMHD1 T592 phosphorylation and deactivation of its antiviral activity.

190 Slow deactivation of Kv11.1 channels is critical for its func

191 Deactivation of LBPA using anti-LBPA antibody significan

192 an, TPO, and TEM analysis confirmed that the deactivation of monometallic Ni catalysts was in large d

193 Deactivation of mPFC output is causally correlated with

194 Subsequent deactivation of Myc in established adenocarcinomas trigg

195 In particular, it is ideal for the catalytic deactivation of nerve agents, and it shows great promise

196 n in the tumor cells in mice, which leads to deactivation of NF-kappaB pathway, and consequently inhi

197 ly slowed the activation but accelerated the deactivation of NsVBa, whereas the local anesthetic drug

198 ted protein kinase, which was accompanied by deactivation of oncogenic mechanistic target of rapamyci

199 cross-coupling generally requires a designed deactivation of one nucleophile towards transmetallation

200 cal properties for dentin bonding, including deactivation of oral pathogens, modification of surface

201 500 and not observed in muscles with genetic deactivation of P2Y1 receptors.

202 To overcome deactivation of Pd-based catalysts at high temperatures,

203 an increased spontaneous activity and faster deactivation of PDE6C compared with PDE6AB in darkness,

204 ROS elicited oxidation and deactivation of phosphatase and tensin homolog (PTEN), r

205 n important and long debated pathway for the deactivation of photoexcited base pairs, with possible i

206 and induced pre-BCR signaling, resulting in deactivation of PI3K/Akt signaling.

207 dephosphorylation of Tyr(P)(346) may include deactivation of receptor-activated Syk or suppression of

208 ation of carboxy groups, BRE attachment, and deactivation of residual activated groups on recently de

209 thermolability of Rca is responsible for the deactivation of Rubisco and reduction of photosynthesis

210 Coking leads to the deactivation of solid acid catalyst.

211 n, as well as for those that require minimal deactivation of the (3)MLCT state through low-lying meta

212 Deactivation of the 3DOM Co3O4-supported Au-Pd, Pd-CoO,

213 nsmitter glycine; this resulted from a rapid deactivation of the agonist current at mutant GlyRs.

214 ights they provide as to both activation and deactivation of the antibacterial.

215 tal evidence for S-glutathionylation induced deactivation of the Arabidopsis thaliana kinase BRASSINO

216 bonding can provide a convenient method for deactivation of the C-H bond of amides toward HAT.

217 rationalized on the basis of an acid-induced deactivation of the C-H bonds alpha to nitrogen toward H

218 spectroscopy, we observed the activation and deactivation of the catalyst at various stages.

219 before, during, and following recovery from deactivation of the contralateral IC by cryoloop cooling

220 lar enucleation (ME) results in an immediate deactivation of the contralateral medial monocular visua

221 pattern of mnemonic deficits was different: deactivation of the dCA1-->mPFC pathway selectively disr

222 Our findings demonstrate steady-state deactivation of the default network under acute hypoxia,

223 ment primarily by triggering the degradation/deactivation of the DELLA proteins.

224 lipase (MGL), a key actor in the hydrolytic deactivation of the endocannabinoid 2-arachidonoyl-sn-gl

225 Moreover, deactivation of the left inferior parietal cortex predic

226 s, as aberrant NOSTRIN expression leading to deactivation of the NFkappaB pathway, in turn triggering

227 of hydroxyl on the catalyst surface, whereas deactivation of the Pd-CoO/3DOM Co3O4 catalyst at high t

228 In contrast, controls demonstrated stronger deactivation of the ventromedial prefrontal cortex (vmPF

229 and the salience network) as well as reduced deactivation of the visual system and the dorsal attenti

230 A model for redox activation and deactivation of the yeast Yvc1p channel is presented.

231 own that the vast majority of the activation/deactivation of these drug targets is driven by phosphor

232 respect that potentiates the activation and deactivation of two different clusters of emotions.

233 p53 is an important tumor-suppressor protein deactivation of which by mdm2 results in cancers.

234 Here, the authors visualize the deactivation of zeolite catalysts by ptychography and ot

235 rus and the cuneus, as well as with extended deactivations of superior parietal and occipital regions

236 t the implications of cooperative antibiotic deactivation on the population and evolutionary dynamics

237 istics of AMPARs, including desensitization, deactivation or recovery.

238 (1) general emotional arousal (activation vs deactivation) or (2) specific emotion categories (fear v

239 motor cortex, children who stutter exhibited deactivation over these left hemisphere regions.

240 dditionally, solvent polarity influences the deactivation pathway, greatly affecting the strength of

241 nthesis rates and plagued by an unidentified deactivation pathway.

242 t a synthetic strategy that blocks the major deactivation pathway: excited-state trans-to-cis polyene

243 the Ln(3+) cation by minimizing nonradiative deactivation pathways due to the presence of -OH, -NH an

244 and potentially coupled excited states, the deactivation pathways in these systems are particularly

245 ; d) Characterization of multiple activation/deactivation pathways of MOR, and e) Suggestion from cal

246 s as well as the reaction energy profiles of deactivation pathways with different photoredox catalyst

247 resence of the B3N3 rings engages additional deactivation pathways, possibly involving excited states

248 on of others, producing a complex activation/deactivation pattern during the reach.

249 ations of the superordinate brain activation/deactivation pattern, each emphasizing different context

250 ciated with a superordinate brain activation/deactivation pattern, explained the majority of the vari

251 play critical but distinct roles in the slow deactivation phenotype, which is a hallmark of Kv11.1 ch

252 m temperature, and their rapid excited-state deactivation precludes their use as photosensitizers.

253 The developed deactivation procedure is further combined with ultra-lo

254 These findings suggest that the primary deactivation process consists of the loss of active site

255 likely active ruthenium species and the main deactivation process.

256 ct reverse of DET pathway) is favored in the deactivation process.

257 polymerization strategies such as reversible deactivation radical polymerization (RDRP) have paved th

258 The use of reversible deactivation radical polymerization (RDRP) methods has s

259 ive polymers, in particular using reversible deactivation radical polymerization (RDRP), formerly kno

260 s well as to effectively catalyze reversible deactivation radical polymerizations and living polymeri

261 the voltage dependence of activation and the deactivation rate of mutant channel currents were charac

262 compromised by mutations that increase this deactivation rate.

263 lated to myosin detachment and thin filament deactivation rates, decreased with gestation age.

264 a-F elimination is not an important catalyst deactivation reaction in this system.

265 h early mortality, characterized by monocyte deactivation (reduced HLA-DR expression and tumor necros

266 deactivated for all tasks, with the level of deactivation related to task difficulty.

267 During deactivation, responses were rescaled by divisive gain c

268 Mast cell deactivation resulted in reduced inflammation, consequen

269 In addition to the known ERK deactivation, retinoschisin treatment of retinoschisin-d

270 Evaluation of the kinetics of microbial deactivation showed that the nanoemulsion killed all the

271 voltage dependence of activation and slowing deactivation, similar to perfusion of isoproterenol.

272 fMRI neocortical activation and subcortical deactivation specifically after ripples [27].

273 Finally, the deactivation step is contingent upon the oxidation of th

274 all of them participated efficiently in the deactivation step.

275 To select high-threshold channels for deactivation, subjects' threshold profiles were processe

276 Here application of a pharmacogenetic deactivation technique enabled us to investigate the mne

277 ise Cu atoms from aggregation in accelerated deactivation tests.

278 )beta2gamma2 receptors also exhibited faster deactivation than their WT counterparts, revealing that

279 ponent hemispheric pattern of activation and deactivation that depends on the availability of interau

280 itability contributes to the functional mPFC deactivation that is causal for the pain phenotype and r

281 Removal of the nanobody leads to GPCR deactivation that is characterized by inward movement of

282 that drive leukemia regulomes, as well as TF deactivations that alter host T cells in CTCL patients.

283 its zymogenic form and the possible modes of deactivation (thrombin mediated secondary cleavage) of t

284 Moreover, this mutation prolongs the deactivation time course after glutamate removal, which

285 agonist application revealed faster glycine deactivation times for the N46K mutant compared with the

286 e inverse agonist increases the frequency of deactivation transitions.

287 be robust and recoverable catalysts with no deactivation under reaction conditions.

288 llapse and surface area reduction leading to deactivation under these conditions.

289 ome antihyperlipidemics may inhibit warfarin deactivation via the hepatic cytochrome P450 system.

290 No C-H deactivation was observed in DMSO after addition of Li(+

291 ly in the first 5 h when the highest rate of deactivation was observed.

292 To monitor kinetics of Galpha deactivation, we coupled this strategy with measuring ch

293 Concomitant relative deactivations were seen in the ventral striatum and orbi

294 l activation and reduced posterior cingulate deactivation, whereas OCD patients showed temporoparieta

295 aC helix is highly disordered, a hallmark of deactivation, whereas the BRI1 alphaC helix is moderatel

296 oplasmic region of melanopsin contributes to deactivation, which in turn determines response latency

297 d voltage dependence of ionic activation and deactivation with gating charge movement.

298 2Me, Cl, Br, and CN, indicative of alpha-CH2 deactivation with HAT that predominantly occurs from the

299 The combination of unusually fast deactivation with slow desensitzation enables recombinan

300 Reduced deactivation within the default mode network (DMN) is co