ライフサイエンスコーパス: deafferentation

1 e associated with dendrite and synapse loss (deafferentation).

2 y to the hypertension caused by baroreceptor deafferentation.

3 vagal complex were increased following vagal deafferentation.

4 CN neurons to either death or survival after deafferentation.

5 uring swimming and jumping, before and after deafferentation.

6 l neurons leaves the terminals in a state of deafferentation.

7 loss of iGluR4 immunoreactivity by 24 h post-deafferentation.

8 ain was further investigated after olfactory deafferentation.

9 ion of Purkinje cells to episodic functional deafferentation.

10 with previous subdiaphragmatic vagal sensory deafferentation.

11 s which can be observed within 1 h following deafferentation.

12 y : fibre ratio at 7 days) was unaffected by deafferentation.

13 any kinds of injuries, including axotomy and deafferentation.

14 r remodeling and synaptogenesis initiated by deafferentation.

15 omplexity of responses to different forms of deafferentation.

16 n, and is balanced in the setting of chronic deafferentation.

17 cortex are quickly reduced within minutes of deafferentation.

18 reduction of amyloid plaques on the side of deafferentation.

19 s in Alzheimer's disease, namely hippocampal deafferentation.

20 ceptors, within 4 h of unilateral vestibular deafferentation.

21 g differences between central and peripheral deafferentation.

22 This facilitation was blocked by vagal deafferentation.

23 the IPSC equilibrium potential within 1 d of deafferentation.

24 ng animals are also more affected by sensory deafferentation.

25 mice during and after recovery from chemical deafferentation.

26 the mitotic behavior of astrocytes following deafferentation.

27 n the OB can be reconstituted after chemical deafferentation.

28 inished at 1 week and absent by 3 weeks post-deafferentation.

29 lse facilitation was nearly eliminated after deafferentation.

30 was examined in zebrafish, using peripheral deafferentation.

31 e its target, the olfactory bulb (OB), after deafferentation.

32 urons following lesions, target loss, and/or deafferentation.

33 zation that immediately follows a peripheral deafferentation.

34 ssentially the same regardless of the age of deafferentation.

35 ion resulting from the reversible peripheral deafferentation.

36 his disease may be the result of cholinergic deafferentation.

37 ells exhibit markedly different responses to deafferentation.

38 recovery that follows unilateral vestibular deafferentation.

39 -NA) following neonatal unilateral vibrissae deafferentation.

40 ge from piston impact, brain displacement or deafferentation.

41 ular changes in response to brain injury and deafferentation.

42 otion of topographic plasticity after visual deafferentation.

43 strength was not observed following partial deafferentation.

44 l hippocampus indicating relatively complete deafferentation.

45 ceps brachii muscle proximal to the level of deafferentation.

46 or rats that received subdiaphragmatic vagal deafferentation.

47 l cuneate nucleus within three months of the deafferentation.

48 ease of central gain attributable to sensory deafferentation.

49 ton are responsible for cell death following deafferentation.

50 a-actin mRNAs were not noticeably altered by deafferentation.

51 atory response to nigrostriatal dopaminergic deafferentation.

52 tional protein synthesis apparatus following deafferentation.

53 in the human following peripheral or central deafferentation.

54 memory deficits associated with hippocampal deafferentation.

55 d transient hypersensitivity consistent with deafferentation.

56 s that had earlier received a surgical vagal deafferentation.

57 vasion by ectopic visual inputs and not from deafferentation.

58 llowing lithium administration and following deafferentation.

59 determinant of Bcl-2 upregulation following deafferentation.

60 pregulated in 20-30% of NM neurons following deafferentation.

61 -2 and increases neuronal survival following deafferentation.

62 e over an approximately 14-week period after deafferentation.

63 mulation, in contrast, were unaffected after deafferentation.

64 s in normally innervated cells but not after deafferentation.

65 be produced by the brain related to auditory deafferentation.

66 ntial parameters were observed after chronic deafferentation.

67 ainstem circuitry selectively in response to deafferentation.

68 on of somatosensory cortex that follows such deafferentations.

69 imals injected with PHA-L after intracranial deafferentations.

70 nsory input was reduced by either a complete deafferentation, a genetic impairment of neurotransmitte

71 For deafferentation above this threshold, however, a slow pe

72 A comparison of the extents of deafferentation across the monkeys shows that even if th

73 sent a compensatory mechanism in response to deafferentation after callosotomy.

74 One week of deafferentation altered the pattern of cell genesis, wit

75 Peripheral deafferentation alters cortical function and such altera

76 amputees during the first 12 weeks following deafferentation and at 26 and 30 weeks post-amputation.

77 N-gamma blocking antibody prevented neuronal deafferentation and clinical disease without reducing CT

78 electrophysiologically mapped to define hand deafferentation and cortical reactivation further.

79 with NFT densities respectively suggest that deafferentation and intrinsic neurofibrillary degenerati

80 ecovery are dependent both on the vestibular deafferentation and on the activation of glucocorticoid

81 We developed an in vitro model of deafferentation and reactive hyperexcitability using org

82 ct persisted throughout the entire period of deafferentation and returned to baseline values afterwar

83 lfactory system during development and after deafferentation and suggest that the expression of Na be

84 dorsal mPFC was enhanced after noradrenergic deafferentation and was negatively correlated with stres

85 the morphology found in mental retardation, deafferentation, and prionoses.

86 inhibition of the ipsi-lesional cells after deafferentation, and thus promote the recovery of restin

87 g that these responses of the MVN neurons to deafferentation are discrete, parallel processes.

88 l maps in primate somatosensory cortex after deafferentation are poorly understood.

89 rse and nature of development are altered by deafferentation at birth; 2) reorganization of terminals

90 vation but, surprisingly, did increase after deafferentation at P21, when all neurons ultimately surv

91 Furthermore, cholinergic deafferentation attenuated the frequency and amplitude o

92 lar topology and broadcast the presence of a deafferentation-based bottom-up prediction error as a re

93 , beneficial effects on cortical cholinergic deafferentation-based impairments in attention may remai

94 m limbs-whether resulting from amputation or deafferentation-became illustrated, and some reasons for

95 ytoskeleton is altered or degraded following deafferentation but that this process is not regulated a

96 stantially larger GFAP inductions than after deafferentation, but fewer effects of age.

97 tions correlates well with the extent of MGN deafferentation, but not with extent of removal of norma

98 it in recognition of target loss and partial deafferentation by aged granule cells and/or an impaired

99 Deafferentation by optic nerve section resulted in incre

100 Functional vagal deafferentation by perineural capsaicin or CCK A recepto

101 These results indicate that acute hand deafferentation can elicit a focal increase in excitabil

102 ing rule to show that loss of input (partial deafferentation) can trigger network reorganization that

103 he degradation of the cytoskeleton following deafferentation could potentially lead to either atrophy

104 For deafferentation degrees below this value, homeostatic up

105 In the long term, slow, deafferentation-dependent transneuronal atrophy at brain

106 , and that inhibition of axonal transport or deafferentation depletes BDNF.

107 Deafferentation did not immediately affect the dividing

108 to prevent microglial activation, olfactory deafferentation did not reduce adult neurogenesis, showi

109 bers) in response to target loss and partial deafferentation diminishes with age.

110 r volume of HG, which suggests that auditory deafferentation does not lead to cell loss within primar

111 nt and form of reorganization resulting from deafferentation early in life vs. adulthood are not the

112 s in the olfactory bulb, suggesting that the deafferentation effect is specific.

113 duced redox imbalance in the cochlea and the deafferentation effects upstream the acoustic pathway.

114 After selective vagal deafferentation, EGLU was without effect, suggesting tha

115 However, after deafferentation, EphA4-null mice had a significant, thre

116 d cells), but there was a critical degree of deafferentation for pathological network reorganization.

117 etwork target firing rate for all degrees of deafferentation (fraction of deafferented cells), but th

118 in the control situation and after selective deafferentation from cats with unilateral transection of

119 Three days after peripheral deafferentation, functional synapses become silent, lack

120 Deafferentation had no detectable effects on Na alpha I

121 Finally, retinal deafferentation had no significant effect on the number

122 SGN death following deafferentation has an early phase in which apoptosis is

123 Cortical cholinergic deafferentation has been considered to be a major neurop

124 rmine if NPY-containing neurons that survive deafferentation have any distinguishing morphological an

125 Deafferentation, however, did not alter Gsk-3beta or NFk

126 Cholinergic deafferentation, however, resulted in a decrease in the

127 , nucleus magnocellularis (NM) die following deafferentation (i.e., deafness produced by cochlea remo

128 Bergmann gliosis, and signs of Purkinje cell deafferentation; (iii) selective striatal cholinergic in

129 the capacity of this map to reorganize after deafferentation in adults and animals late in developmen

130 After chronic deafferentation in amputees, MEP amplitudes and motor ou

131 Septo-hippocampal deafferentation in both groups of lesioned animals faile

132 radation of responses to surgical vestibular deafferentation in humans, skew deviation only occurring

133 perceptual and cortical reorganization after deafferentation in humans.

134 n this study we delayed the onset of retinal deafferentation in rats and mice in order to determine t

135 tal cortical plasticity induced by vibrissae deafferentation in the rat.

136 of the inhibitory synaptic conductance after deafferentation, indicating that driving force was not s

137 -based transfer to new cell populations, and deafferentation induced degeneration are part of a proce

138 Our study also suggests that the deafferentation-induced alterations of the sleep slow os

139 Inhibition of NFAT significantly attenuates deafferentation-induced apoptosis of AVCN neurons and ab

140 FAT-mediated gene expression plays a role in deafferentation-induced apoptosis of cochlear nucleus ne

141 functional auditory-limbic connectivity, and deafferentation-induced atrophy in frontal brain regions

142 d whether the chloramphenicol enhancement of deafferentation-induced cell death reveals the same ultr

143 hibitor, results in a pronounced increase in deafferentation-induced cell death.

144 served, however, at times that coincide with deafferentation-induced cell loss (3 and 7 days).

145 that underlie AVCN neuron susceptibility to deafferentation-induced death remain unknown.

146 against subsequent programmed cell death or deafferentation-induced death.

147 We conclude that in CN neurons, the deafferentation-induced increase in calcium activates at

148 in regulating programmed neuronal death and deafferentation-induced neuronal death in the brainstem

149 The deafferentation-induced plastic changes can be up-regula

150 teral vs. contralateral target choice during deafferentation-induced plasticity.

151 al dendrites is a significant contributor to deafferentation-induced reactive hyperexcitability.

152 whether it is possible to purposely modulate deafferentation-induced reorganization.

153 of MMP inhibition during the early phases of deafferentation-induced sprouting, characterizing compon

154 To more precisely quantify deafferentation-induced structural plasticity of excitat

155 l elements accounts for at least part of the deafferentation-induced volume decrease in the zebrafish

156 Deafferentation induces rapid plastic changes in the cer

157 Long-term peripheral deafferentation induces representational map changes in

158 The present model suggests that deafferentation injury in sensory systems can cause apop

159 Although the process can be triggered by deafferentation, intense activation of glutamate recepto

160 n of Bcl-2 gene expression by lithium and by deafferentation involves different molecular pathways.

161 Ipsilaterally, both deafferentation (IoN transection) and deprivation (whisk

162 in a phantom limb after partial or complete deafferentation is an important problem.

163 that is seen immediately after a peripheral deafferentation is dependent upon both descending cortic

164 he adult somatosensory system as a result of deafferentation is elusive.

165 ccupancy of the vacant synaptic space due to deafferentation is the base for the mechanism of compens

166 Deafferentation leads to cortical reorganization that ma

167 Deafferentation led to a 24 mV depolarizing shift in the

168 We wished to test the hypothesis that deafferentation lesions cause changes in the regulation

169 pothesis that broad functional (or anatomic) deafferentation may combine to reduce central thalamus a

170 (SDA), the most complete and selective vagal deafferentation method existing to date, to study the co

171 One day after sensory deafferentation, microglial cells proliferate in the olf

172 l experiments revealed that, following vagal deafferentation, mu-opioid receptors were colocalized on

173 ted pathological features of neuronal system deafferentation, NFT progression and propagation, and ne

174 ter 2 weeks in all animals, neither striatal deafferentation nor in vitro induction of differentiatio

175 s in neuronal latency induced by the sensory deafferentation occurred as often in the thalamus as in

176 This suggests that if deafferentation occurs, synapses other than recurrent ex

177 us studies have indicated that amputation or deafferentation of a limb induces functional changes in

178 Acute deafferentation of a limb results in bilateral cortical

179 citatory perforant path results in the acute deafferentation of a segregated zone on the distal dendr

180 n area CA1 of hippocampus, septo-hippocampal deafferentation of adult gerbils was performed.

181 In a control group of animals with neonatal deafferentation of auditory thalamus but without redirec

182 ux was determined in rats sustaining partial deafferentation of cortical cholinergic inputs.

183 S lesions derive from the resulting combined deafferentation of dorsal and ventral hippocampal region

184 viously been suggested to indicate a partial deafferentation of epileptic neurons, but this interpret

185 We also found that, after extensive deafferentation of MGN, other axonal systems in addition

186 Deafferentation of motor neurons is an early event in SM

187 e show that only during this critical period deafferentation of mouse AVCN neurons by in vivo cochlea

188 Deafferentation of neural tissue can result in cell deat

189 ZnSO(4) produced a near complete deafferentation of OB within 3 days following intranasal

190 Deafferentation of OBs did not eliminate nicotine-stimul

191 ytochrome oxidase (CO) histochemistry, after deafferentation of one eye or even by leaving afferent i

192 tion', the behavioural recovery that follows deafferentation of one inner ear, are largely unknown.

193 The current data suggest that cholinergic deafferentation of prefrontal cortex alters top-down and

194 The effects of restricted cholinergic deafferentation of prefrontal cortex in rats on sustaine

195 he presence of primary cortical pathology or deafferentation of striato-cortical projections.

196 injury to the CNS results in chronic partial deafferentation of subsets of surviving neurons.

197 erent models of chronic synaptic inhibition: deafferentation of the barrel cortex and administration

198 The degree of deafferentation of the bulb by treatment with 3-MI was a

199 not appear to enter the cell cycle following deafferentation of the chicken auditory brainstem.

200 se phenotype in HD mice, we examined whether deafferentation of the corticostriatal and nigrostriatal

201 f mice, suggesting that the ensuing state of deafferentation of the DA terminals may contribute to th

202 The extent of deafferentation of the dorsal hippocampus was determined

203 in these nuclei during development and after deafferentation of the excitatory auditory nerve (nVIII)

204 otoxin, which leads to selective cholinergic deafferentation of the infused cortex, yielded recogniti

205 ptor loss and often result in remodeling and deafferentation of the inner retina.

206 ects of CL-316,243 in mice with the chemical deafferentation of the intra-scapular BAT pads.

207 activity was still observed even after total deafferentation of the laryngeal and pharyngeal areas in

208 e essential for odor discrimination and that deafferentation of the majority of bulbar glomeruli may

209 To this end, the effects of either surgical deafferentation of the mediobasal hypothalamus or admini

210 in DOPAC in the nucleus accumbens; surgical deafferentation of the mediobasal hypothalamus prevented

211 duction of normal retinal targets along with deafferentation of the MGN are two concurrent factors re

212 Cholinergic deafferentation of the mPFC, but not motor cortex, impai

213 Deafferentation of the olfactory bulb resulted in a tran

214 ed in ankle flexors of rats with and without deafferentation of the stimulated side.

215 Additional deafferentation of the transected animals did not alter

216 the cerebellar hemispheres reorganizes after deafferentation of the upper lip in neonatal rats (postn

217 g in older persons with vision impairment or deafferentation of the visual cortex.

218 Furthermore, deafferentation of the wiping limb did not significantly

219 tween brain and body and the effects of this deafferentation on body representation are poorly unders

220 e interactive effects of age and cholinergic deafferentation on synaptic connectivity in frontal cort

221 For most synergies, effects of deafferentation on the activation coefficients were not

222 amined both normal growth and the effects of deafferentation on the bulb from hatching to adulthood.

223 investigate the effects of very early visual deafferentation on the functional organization of the br

224 study evaluated the effects of total cardiac deafferentation on the reflex control of efferent renal

225 in cortical topography in primates following deafferentation or amputation, and this review will atte

226 e expression induced by peripheral olfactory deafferentation or naris blockade confirms that function

227 Here we report that either deafferentation or reduction of sensory input by nares o

228 Deafferentation or sensory deprivation decreases TH expr

229 enervation of the bladder, selective C-fiber deafferentation, or bladder sympathectomy prevented cyst

230 electroporation, live cell imaging, in vitro deafferentation, pharmacology, and electrophysiological

231 After partial deafferentation postsynaptic sites are reinnervated by l

232 Deafferentation produced a 298% increase in the metaboli

233 Vibrissae deafferentation produced a small but not statistically s

234 ted that less extensive cortical cholinergic deafferentation, produced by intracortical infusions of

235 To determine whether cortical deafferentation produces similar effects, we examined th

236 Contralaterally, deafferentation reduced more complex dendritic trees, an

237 Deafferentation remains the best available pathophysiolo

238 on is comparable with that induced by direct deafferentation resulting from transection of NM axons.

239 To test whether or not early deafferentation results in changes in calretinin immunos

240 ohistochemistry of the mouse CN to show that deafferentation results in strikingly different sets of

241 arlier study suggest that septal cholinergic deafferentation results in: (a) the loss of a distinct s

242 e used a rat model of subdiaphragmatic vagal deafferentation (SDA), the most complete and selective v

243 sh a role for MMP-dependent processes in the deafferentation/sprouting cycle.

244 t shared synergies, however, were altered by deafferentation, suggesting that sensory inflow modulate

245 pression of these glial factors in fields of deafferentation suggests the possibility of additive or

246 ress normally associated with the vestibular deafferentation syndrome.

247 rd section (approximately T8) and unilateral deafferentation (T12-S2) to answer the following questio

248 al studies suggest that temporary functional deafferentation (TFD) of parts of the stroke-affected up

249 Following chronic vagal deafferentation, the opioid agonist methionine-enkephali

250 Sixty minutes after deafferentation, the surviving neurons show increased ph

251 clearly demonstrate that peripheral sensory deafferentation triggers a system-wide reorganization, a

252 vity before and after unilateral cholinergic deafferentation using intracortical infusion of the immu

253 r the expression of GATs changes after nerve deafferentation using the rat superior colliculus (SC) a

254 subjects and six with unilateral vestibular deafferentation (UVD) underwent binocular eye and head m

255 on of these factors in unilateral vestibular deafferentation (UVD) was examined.

256 Rats undergoing PMV deafferentation via capsaicin, celiac-superior mesenteri

257 ase in average firing rate in the network by deafferentation was compensated by homeostatic synaptic

258 Transient forearm deafferentation was induced by ischemic nerve block (INB

259 in [3H]CP55,940 binding contralateral to the deafferentation were largely absent at all post-lesion d

260 changes in the motor cortex contralateral to deafferentation were probed with TMS, measuring motor th

261 ical cholinergic and/or caudate dopaminergic deafferentation were produced by bilateral infusions of

262 However, bilateral deafferentation, when performed in a single-stage proced

263 he somatosensory hand area of primates after deafferentation where cortex can become activated by a m

264 amina ganglion mother cells ceased following deafferentation, whereas cell death in the lamina cortex

265 tic spines may be a compensatory response to deafferentation, which is lost with advancing age.

266 After deafferentation, which was induced by dissection of the

267 phenotype was produced by chronic "chemical deafferentation" with glutamate receptor antagonists.

268 Both are also more affected by deafferentation, with at least a 35% reduction in lamina

269 In spite of this deafferentation, ZK 93,426 produced a transient potentia