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1 pontaneous dephosphonylation and slow aging (dealkylation).
2 on, 2500-6000-fold, in the rate constant for dealkylation.
3 through an opening of piperazine ring via N-dealkylation.
4 alkyl adducts from nucleobases by oxidative dealkylation.
5 on which ALKBH3 preferentially functions for dealkylation.
6 EA via its canonical mechanism of oxidative dealkylation.
7 h higher temperature (380-530 degrees C) for dealkylation.
8 um and eliminate the three-carbon unit via N-dealkylation.
9 450 enzymes which catalyze their oxidative N-dealkylation.
10 ine O-dealkylase, showed novel and efficient dealkylation activities, including regio- and substrate-
12 no ether-based substrates to determine the O-dealkylation activity of human, mouse, and rat liver mic
16 Co(II) produces the greatest restoration of dealkylation activity, 32% relative to a control not tre
17 ition results in the smallest restoration of dealkylation activity, only 3% relative to an untreated
22 ment resulted in significant increases in BQ dealkylation and CYP3A6-mediated [3H]testosterone metabo
23 ortance of the studied residues in substrate dealkylation and explained the formation of novel 7-buto
24 varied in terms of catalytic efficiency of O-dealkylation and in their selectivity as substrates for
25 ms and isotope effects associated with the N-dealkylation and N-atom oxidation of substituted N-methy
27 o linuron, a compound detoxified by a single dealkylation, and a 10-fold increase in tolerance to iso
28 mediates, which could lead to the observed N-dealkylation, and to the identified formamide and aldehy
29 mpounds that could undergo N-dealkylation, O-dealkylation, benzylic hydroxylation, and aromatic hydro
30 isplay lower protein stability and decreased dealkylation but not decyanation activity, suggesting th
31 esized and characterized as substrates for O-dealkylation by recombinant cytochrome P450 2D6, a major
32 so electrophilic that they underwent in situ dealkylation by the triflate anion (see scheme; Tf = tri
34 highly effective Pd/C-catalyzed oxidative N-dealkylation/carbonylation of various aliphatic as well
35 most actinide-mediated bond activations, the dealkylation event mediated by 1 is remarkably general a
38 pH-dependence and solvent isotope effects of dealkylation in diastereomeric adducts of Electric eel (
39 no)benzene were synthesized by the reductive dealkylation in Na/NH(3) of 1,3,5-tris(tert-butylseleno)
44 w results support the push-pull mechanism of dealkylation in soman-inhibited cholinesterases proposed
47 significant proportion of atrazine (63%) via dealkylation, in which deethylation significantly domina
50 bitor specificity, support a structure-based dealkylation mechanism and suggest a molecular basis for
53 ibrary of QCA compounds that could undergo N-dealkylation, O-dealkylation, benzylic hydroxylation, an
54 giospecificities of the hydroxylations and O-dealkylations occurring in these two substrates which ar
56 cetaldehyde, the product expected from the N-dealkylation of 18F-FECNT, or its oxidation product, 18F
57 ines 2a and 2b, and argue strongly for the N-dealkylation of 2a via a carbinolamine intermediate form
60 V363L mutant preferentially catalyzed the O-dealkylation of 7-methoxy- and 7-ethoxycoumarin, and a f
61 ase gene, the product of which catalyses the dealkylation of a sulfonylurea compound, R7402, into its
63 n of cyanocobalamin (vitamin B(12)), and the dealkylation of alkylcobalamins (e.g. methylcobalamin; M
64 It catalyzes the glutathione (GSH)-dependent dealkylation of alkylcobalamins and the reductive decyan
65 glyoxylate generation, the base-catalyzed N-dealkylation of alpha-hydroxyhippurate to benzamide and
67 /(14)N versus (13)C/(12)C) isotope plots for dealkylation of atrazine agree with indirect photodegrad
69 n of a SET mechanism in the P450-catalyzed N-dealkylation of cyclopropylamines 2a and 2b, and argue s
73 ng C-P lyase (phnJL, an important enzyme for dealkylation of MPn), were only amplifiable from PMEZ DN
75 The early proposal that P450-catalyzed N-dealkylation of N,N-dialkylamines proceeds through a sin
77 evirdine and delavirdine, is via oxidative N-dealkylation of the 3-ethyl- or 3-isopropylamino substit
81 e generated in vitro by hepatic microsomal O-dealkylation of the two methoxy substituents on the benz
83 37, and the related CYP2B36, we tested the O-dealkylation of three series of related substrates-namel
84 ome P450, CYP76B1, catalyzes rapid oxidative dealkylation of various phenylurea herbicides to yield n
86 Cu(II)-OOH species that performs oxidative N-dealkylation on a dibenzylamino group that is appended t
87 used to examine whether the P450-catalyzed N-dealkylations proceed through a C(alpha)-H abstraction a
88 dramatic inhibition of 7-pentoxyresorufin-O-dealkylation (PROD) was observed when compared to simple
89 ation products were observed by GC-MS, the N-dealkylation product C3F7C(O)NH2 and two carbonyl produc
90 The production of 7-hydroxycoumarin, the O-dealkylation product, by the wild-type enzyme exhibited
92 ne intermediates and thereby to "ordinary" N-dealkylation products including cyclopropanone hydrate.
95 u(picoloyl)2], formed through an oxidative N-dealkylation reaction followed by further oxidation of t
100 tails of the reaction pathways, showing that dealkylation reactions are surface-assisted and very dif
101 otope effects of 2-3 were measured for all O-dealkylation reactions examined with wild-type P450 1A2
102 electron transfer (SET) in P450-catalyzed N-dealkylation reactions has been studied using the probe
103 The difference in reactivity, as well as the dealkylation reactions that occur when the reaction of t
105 ivating agent capable of cyclization but not dealkylation, resulted in the isolation of a postcycliza
109 ffects ( approximately 7) were seen in the N-dealkylations supported by the oxygen surrogate iodosylb
111 rophenyl phosphate (paraoxon) and subsequent dealkylation, the broad 16.1 ppm resonance increased in
112 possible operation of two hydrolytic, two N-dealkylation, three N-glucuronidation, one N-methylation
113 hloropicrin at high yields, likely by facile dealkylation to release the primary nitro compound.
116 bably possible for P450s to catalyze amine N-dealkylations via hydrogen atom abstraction when such a
117 nated dibenzyl ether loses formaldehyde upon dealkylation, via an ion-neutral complex of the benzylox
119 uctase concentration on 7-pentoxyresorufin-O-dealkylation was examined with 2B4-reductase and 1A2-red
122 lly protonated at the oxygen, deacylation or dealkylation was observed in the collision-induced disso
123 he fate of the cyclopropyl group lost upon N-dealkylation, we have investigated the oxidation of N-cy
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