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1 pontaneous dephosphonylation and slow aging (dealkylation).
2 on, 2500-6000-fold, in the rate constant for dealkylation.
3  through an opening of piperazine ring via N-dealkylation.
4  alkyl adducts from nucleobases by oxidative dealkylation.
5 on which ALKBH3 preferentially functions for dealkylation.
6  EA via its canonical mechanism of oxidative dealkylation.
7 h higher temperature (380-530 degrees C) for dealkylation.
8 um and eliminate the three-carbon unit via N-dealkylation.
9 450 enzymes which catalyze their oxidative N-dealkylation.
10 ine O-dealkylase, showed novel and efficient dealkylation activities, including regio- and substrate-
11  peptide hydroxylation and the carbinolamide dealkylation activities.
12 no ether-based substrates to determine the O-dealkylation activity of human, mouse, and rat liver mic
13 developed a fluorescence-based assay for the dealkylation activity of this family of enzymes.
14  and Mn(II) partially restores carbinolamide dealkylation activity to the EDTA-treated enzyme.
15                               CYP2B35 had no dealkylation activity with 7-MFC or 7-EFC.
16  Co(II) produces the greatest restoration of dealkylation activity, 32% relative to a control not tre
17 ition results in the smallest restoration of dealkylation activity, only 3% relative to an untreated
18 al (S)-N-dansyl-Tyr-Val-alpha-hydroxyglycine dealkylation activity.
19                         The pH dependence of dealkylation (aging) in r mouse (Mo) acetylcholinesteras
20                                 The set of O-dealkylation and acetol formation results for wild-type
21  key role of biological dithiols in both the dealkylation and binding of organotin compounds.
22 ment resulted in significant increases in BQ dealkylation and CYP3A6-mediated [3H]testosterone metabo
23 ortance of the studied residues in substrate dealkylation and explained the formation of novel 7-buto
24 varied in terms of catalytic efficiency of O-dealkylation and in their selectivity as substrates for
25 ms and isotope effects associated with the N-dealkylation and N-atom oxidation of substituted N-methy
26 modifications did not significantly affect N-dealkylation and the formation of the piperidine 3.
27 o linuron, a compound detoxified by a single dealkylation, and a 10-fold increase in tolerance to iso
28 mediates, which could lead to the observed N-dealkylation, and to the identified formamide and aldehy
29 mpounds that could undergo N-dealkylation, O-dealkylation, benzylic hydroxylation, and aromatic hydro
30 isplay lower protein stability and decreased dealkylation but not decyanation activity, suggesting th
31 esized and characterized as substrates for O-dealkylation by recombinant cytochrome P450 2D6, a major
32 so electrophilic that they underwent in situ dealkylation by the triflate anion (see scheme; Tf = tri
33                This work reports oxidative N-dealkylation/carbonylation of tertiary amines to tertiar
34  highly effective Pd/C-catalyzed oxidative N-dealkylation/carbonylation of various aliphatic as well
35 most actinide-mediated bond activations, the dealkylation event mediated by 1 is remarkably general a
36 itterions, and these undergo amine catalyzed dealkylation forming N,N-disubstituted amides.
37 hese OP adducts acquire a negative charge by dealkylation in a process called aging.
38 pH-dependence and solvent isotope effects of dealkylation in diastereomeric adducts of Electric eel (
39 no)benzene were synthesized by the reductive dealkylation in Na/NH(3) of 1,3,5-tris(tert-butylseleno)
40                          Product analysis of dealkylation in P(S)C(S)-soman-inhibited electric eel ac
41                                          The dealkylation in soman-inhibited AChE at pH 5.0 +/- 0.2 a
42                                              Dealkylation in soman-inhibited AChEs is estimated to oc
43                                              Dealkylation in soman-inhibited BChE is consistent with
44 w results support the push-pull mechanism of dealkylation in soman-inhibited cholinesterases proposed
45      The reduction in the rate constants for dealkylation in the E197 mutants is highly pH dependent.
46                                  Oxidative N-dealkylation, in contrast, was subject to large normal (
47 significant proportion of atrazine (63%) via dealkylation, in which deethylation significantly domina
48                                              Dealkylation is found to be the most prevalent reaction
49                   Maximal rate constants for dealkylation (kmax) are 1-6 min-1 for AChE and 2 min-1 f
50 bitor specificity, support a structure-based dealkylation mechanism and suggest a molecular basis for
51 RNA base lesions by using a direct oxidative dealkylation mechanism.
52 th the highest relevance were N-oxidation, N-dealkylation, N-acetylation, and N-succinylation.
53 ibrary of QCA compounds that could undergo N-dealkylation, O-dealkylation, benzylic hydroxylation, an
54 giospecificities of the hydroxylations and O-dealkylations occurring in these two substrates which ar
55 d in Ar at 500 degrees C, demonstrating that dealkylation occurs at this temperature.
56 cetaldehyde, the product expected from the N-dealkylation of 18F-FECNT, or its oxidation product, 18F
57 ines 2a and 2b, and argue strongly for the N-dealkylation of 2a via a carbinolamine intermediate form
58  seen with a slower P450 3A4 reaction, the O-dealkylation of 7-benzyloxyquinoline.
59 hile the V363A mutant mainly catalyzed the O-dealkylation of 7-butoxycoumarin.
60  V363L mutant preferentially catalyzed the O-dealkylation of 7-methoxy- and 7-ethoxycoumarin, and a f
61 ase gene, the product of which catalyses the dealkylation of a sulfonylurea compound, R7402, into its
62 34(327) or E450(443), and H447(440)H+ in the dealkylation of AChE.
63 n of cyanocobalamin (vitamin B(12)), and the dealkylation of alkylcobalamins (e.g. methylcobalamin; M
64 It catalyzes the glutathione (GSH)-dependent dealkylation of alkylcobalamins and the reductive decyan
65  glyoxylate generation, the base-catalyzed N-dealkylation of alpha-hydroxyhippurate to benzamide and
66                                    In situ N-dealkylation of an intermediate gives the product that f
67 /(14)N versus (13)C/(12)C) isotope plots for dealkylation of atrazine agree with indirect photodegrad
68                PHM catalyzes the O-oxidative dealkylation of BIAA to benzaldoxime and glyoxylate with
69 n of a SET mechanism in the P450-catalyzed N-dealkylation of cyclopropylamines 2a and 2b, and argue s
70                                        The N-dealkylation of DMN had a high intrinsic kinetic deuteri
71       These compounds are active towards the dealkylation of many phosphates.
72       The catalytic turnover numbers for the dealkylation of methylcobalamin and 5'-deoxyadenosylcoba
73 ng C-P lyase (phnJL, an important enzyme for dealkylation of MPn), were only amplifiable from PMEZ DN
74 is protein functions in DNA repair by direct dealkylation of mutagenic O6-alkylguanine.
75     The early proposal that P450-catalyzed N-dealkylation of N,N-dialkylamines proceeds through a sin
76                                     In the N-dealkylation of N-ethyl,N-methylaniline by P450 2B1 (NAD
77 evirdine and delavirdine, is via oxidative N-dealkylation of the 3-ethyl- or 3-isopropylamino substit
78                                   Subsequent dealkylation of the alpha-hydroxyglycine by another enzy
79  the ascorbate-, O2-, and copper-independent dealkylation of the carbinolamide intermediate.
80 ecule and (b) decrease the rate of oxidative dealkylation of the target compounds.
81 e generated in vitro by hepatic microsomal O-dealkylation of the two methoxy substituents on the benz
82         Metabolic transformation including N-dealkylation of these compounds is also evaluated.
83 37, and the related CYP2B36, we tested the O-dealkylation of three series of related substrates-namel
84 ome P450, CYP76B1, catalyzes rapid oxidative dealkylation of various phenylurea herbicides to yield n
85                      Many enzymes catalyze N-dealkylations of alkylamines, including cytochrome P450
86 Cu(II)-OOH species that performs oxidative N-dealkylation on a dibenzylamino group that is appended t
87 used to examine whether the P450-catalyzed N-dealkylations proceed through a C(alpha)-H abstraction a
88  dramatic inhibition of 7-pentoxyresorufin-O-dealkylation (PROD) was observed when compared to simple
89 ation products were observed by GC-MS, the N-dealkylation product C3F7C(O)NH2 and two carbonyl produc
90   The production of 7-hydroxycoumarin, the O-dealkylation product, by the wild-type enzyme exhibited
91 in is oxidized to an acetol as well as the O-dealkylation product.
92 ne intermediates and thereby to "ordinary" N-dealkylation products including cyclopropanone hydrate.
93                  Furthermore, differences in dealkylation rates did not correlate with AGT protein af
94             Also, they were catalytic in the dealkylation reaction between trimethyl phosphate and ad
95 u(picoloyl)2], formed through an oxidative N-dealkylation reaction followed by further oxidation of t
96 fer at the enzymic transition states for the dealkylation reaction.
97 aturated alkyl chain from quaternary N via N-dealkylation reaction.
98  to determine the mechanistic details of the dealkylation reaction.
99                                 The reported dealkylation reactions are finely controlled by the anne
100 tails of the reaction pathways, showing that dealkylation reactions are surface-assisted and very dif
101 otope effects of 2-3 were measured for all O-dealkylation reactions examined with wild-type P450 1A2
102  electron transfer (SET) in P450-catalyzed N-dealkylation reactions has been studied using the probe
103 The difference in reactivity, as well as the dealkylation reactions that occur when the reaction of t
104 ilic Lewis acid in electrophilic cyclization/dealkylation reactions.
105 ivating agent capable of cyclization but not dealkylation, resulted in the isolation of a postcycliza
106 d an alternate synthesis involving a novel N-dealkylation route.
107  can improve yields and reduce the undesired dealkylation side reaction.
108 ated CYP1 catalytic activity for substrate O-dealkylation suggesting uncoupling.
109 ffects ( approximately 7) were seen in the N-dealkylations supported by the oxygen surrogate iodosylb
110 etermine which species could yield product O-dealkylation that matched our experimental data.
111 rophenyl phosphate (paraoxon) and subsequent dealkylation, the broad 16.1 ppm resonance increased in
112  possible operation of two hydrolytic, two N-dealkylation, three N-glucuronidation, one N-methylation
113 hloropicrin at high yields, likely by facile dealkylation to release the primary nitro compound.
114                                 For example, dealkylation trends and the overall loss of HMW species
115  (HRP), are generally accepted to catalyze N-dealkylations via 1-electron transfer processes.
116 bably possible for P450s to catalyze amine N-dealkylations via hydrogen atom abstraction when such a
117 nated dibenzyl ether loses formaldehyde upon dealkylation, via an ion-neutral complex of the benzylox
118                                         MeHg dealkylation was also observed in a lesser extent in blo
119 uctase concentration on 7-pentoxyresorufin-O-dealkylation was examined with 2B4-reductase and 1A2-red
120  with F206L and G478S mutants, the rate of O-dealkylation was low with all the compounds.
121                                           BQ dealkylation was measured in the naive rabbit lacrimal g
122 lly protonated at the oxygen, deacylation or dealkylation was observed in the collision-induced disso
123 he fate of the cyclopropyl group lost upon N-dealkylation, we have investigated the oxidation of N-cy
124                                  Enzymatic O-dealkylation yields 7-hydroxycoumarins, which have usefu

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