ライフサイエンスコーパス: deaminase

1 lved in dNTP biosynthesis (e.g., RNR or dCMP deaminase).

2 s are damaged by activation-induced cytidine deaminase.

3 activity of the activation-induced cytidine deaminase.

4 se complexing protein 2 (CD26) and adenosine deaminase.

5 umor stroma, and down-regulation of cytidine deaminase.

6 anosine resistant to degradation by cytidine deaminase.

7 t dehydroxylamination catalyzed by adenosine deaminase.

8 quired in the reaction catalyzed by cytidine deaminase.

9 to interact with activation-induced cytidine deaminase.

10 ctive BLM and the downregulation of cytidine deaminase.

11 host antiviral factors, the APOBEC3 cytidine deaminases.

12 ivity of members of the AID/APOBEC family of deaminases.

13 r regulating the activity of A3F and related deaminases.

14 member of the AID/APOBEC family of cytidine deaminases.

15 ource of mutation in cancer, APOBEC cytidine deaminases.

16 nd that this is largely due to host cytidine deaminases.

17 that possesses high density of Mycobacterium deaminases.

18 with lineage-specific expression of cytidine deaminases.

19 Deficiency of adenosine deaminase 2 (DADA2) is caused by biallelic deleterious m

20 ation of anaplerotic reactions driven by AMP deaminase 3 (Ampd3) and catabolism of branched-chain ami

21 kinase/ganciclovir (TK/GCV), yeast cytosine deaminase/5-fluorocytosine (yCD/5-FC) and nitroreductase

22 Expression of cytidine deaminase, a dC-catabolizing enzyme, in leukemia cells b

23 Although APOBEC3 cytidine deaminases A3G, A3F, A3D and A3H are packaged into virio

24 R-loops limit activation-induced (cytosine) deaminase access to the transcribed DNA strand.

25 ure and the temporal expression of adenosine deaminase acting on RNA (ADAR) contribute to cis- and tr

26 and filamentous fungi do not have adenosine deaminase acting on RNA (ADAR) orthologs and are believe

27 double-stranded RNA that undergoes adenosine deaminase acting on RNA (ADAR)-dependent adenosine-to-in

28 nflammation-responsive RNA editase adenosine deaminase acting on RNA (ADAR)1 gene, occurs in 30-50% o

29 The human RNA-editing enzyme adenosine deaminase acting on RNA (ADAR1) carries a unique nuclear

30 we exploit the catalytic domain of Adenosine Deaminase Acting on RNA (ADAR2) that deaminates A to ino

31 nsing of viral RNA is regulated by adenosine deaminase acting on RNA 1 (ADAR1).

32 the Zalpha-binding domain of human adenosine deaminase acting on RNA 1 (ADAR1, hZalphaADAR1), as conf

33 inhibits editing, we do show that adenosine deaminase acting on RNA 1 and 2 and fibrillarin negative

34 kdown demonstrated that editing is adenosine deaminase acting on RNA 1 and 2 dependent.

35 Adenosine deaminase acting on RNA 2 (ADAR2) is a nuclear enzyme th

36 osine deaminase activity by ADAR2 (adenosine deaminase acting on RNA type 2) to transcripts in mammal

37 fication of RNA, mediated by ADAR (adenosine deaminase acting on RNA) enzymes.

38 characteristic of those favored by adenosine deaminase acting on RNA-1 (ADAR1), which catalyzes in do

39 motifs favoring recognition by the adenosine deaminase acting on RNA-1 (ADAR1).

40 to-inosine RNA editing mediated by adenosine deaminase acting on RNA1 (ADAR1) promotes cancer progres

41 Adenosine deaminases acting on double-stranded RNA (ADARs) catalyz

42 (A-to-I) RNA editing, catalyzed by Adenosine DeAminases acting on double-stranded RNA(dsRNA) (ADAR),

43 tases-like (OASL)(rs1169279CT) and adenosine deaminases acting on RNA (ADAR)(rs1127309TC) genes were

44 Adenosine deaminases acting on RNA (ADARs) catalyze the editing of

45 Adenosine deaminases acting on RNA (ADARs) hydrolytically deaminat

46 anticodon loop of tRNA targeted by adenosine deaminases acting on tRNA (ADATs).

47 tains residues conserved with known cytidine deaminase active sites; however, some PPR editing factor

48 deaminase activity and what are the relative deaminase activities for each APOBEC member remain uncle

49 that Vif binds and inhibits the non-cytosine deaminase activities of intact A3G and intact A3F, allow

50 Here, we performed a family-wide analysis of deaminase activities on C and mC by using purified recom

51 A3A and A3H showed distinctively high deaminase activities on C and mC with relatively high se

52 in vitro characterization of DNA binding and deaminase activities using purified wild-type and variou

53 Bacteria that express ACC deaminase activity also decrease the rate of flower wilt

54 ein, the interplay between sequence specific deaminase activity and A3G binding to ssDNA remains cont

55 x other APOBEC members showed relatively low deaminase activity and selectivity for mC.

56 nalyses revealed that each APOBEC has unique deaminase activity and selectivity for mC.

57 at loop-1 of A3A is responsible for its high deaminase activity and selectivity for mC.

58 ether the rest of APOBEC members have any mC deaminase activity and what are the relative deaminase a

59 as13 (dCas13) to direct adenosine-to-inosine deaminase activity by ADAR2 (adenosine deaminase acting

60 of CD1 on the N-terminus of CD2 enhances the deaminase activity by over an order of magnitude.

61 ngs, the Y315A mutant exhibited little to no deaminase activity in an Escherichia coli DNA mutator re

62 causing elevated A3B expression and cytosine deaminase activity in cancer cells.

63 e dissociation from DNA is reduced and their deaminase activity inhibited.

64 or the different haplotypes, suggesting that deaminase activity may be an important factor in determi

65 enome sequencing has implicated the cytosine deaminase activity of apolipoprotein B mRNA editing enzy

66 r each individual domain, as well as for the deaminase activity of CD2 domain in the full-length A3F.

67 We also queried the data for cytidine deaminase activity on the viral genome, which causes an

68 t growth-promoting bacteria that express ACC deaminase activity protect plants from growth inhibition

69 APOBEC3G (A3G) DNA deaminase activity requires a holoenzyme complex whose a

70 te a simple method for assaying DNA cytosine deaminase activity that eliminates potential polymerase

71 ng through DYW2, which probably provides the deaminase activity to E(+) editosomes.

72 c increases in CD26 expression and adenosine deaminase activity were observed in PTMs during chronic

73 c deaminase APOBEC3A leads to elevated ssDNA deaminase activity, likely by facilitating opening of th

74 057c/UK114 protein family have imine/enamine deaminase activity, notably on 2-aminoacrylate (2AA).

75 he seven haplotypes showed high cytosine (C) deaminase activity, with hap V displaying extremely high

76 in, and RNase A treatment enables strong DNA deaminase activity.

77 icant, but not sole, factor in resistance to deaminase activity.

78 , despite the bound RNA, has potent cytidine deaminase activity.

79 Little is known about the role of adenosine deaminase (ADA) 2 in regulation of immune responses, alt

80 Adenosine deaminase (ADA) deficiency is a rare, autosomal-recessiv

81 vide in vivo genetic evidence that adenosine deaminase (ADA) deficiency leads to excess plasma adenos

82 Adenosine deaminase (ADA) deficiency results in the accumulation o

83 Staufen1 exhibit dynamic sliding whereas two deaminases ADAR1 and ADAD2 mostly remain immobile when b

84 ng is caused by down-regulation of adenosine deaminase ADAR2 and that editing of at least one other A

85 rucei m(3)C methyltransferase TRM140 and the deaminase ADAT2/3.

86 y evolutionary precursors, the antibody gene deaminase AID and the RNA/DNA editing enzyme APOBEC1 (A1

87 actors and Aicda (which encodes the cytidine deaminase AID) and thus silenced B cell-specific gene ex

88 rn suggestive of activation-induced cytidine deaminase (AID) activity.

89 Igh locus in an activation-induced cytidine deaminase (AID) and H2AX-dependent fashion.

90 is initiated by activation-induced cytidine deaminase (AID) and requires base excision repair (BER)

91 ve reported that activation-induced cytidine deaminase (AID) and ten-eleven-translocation (TET) famil

92 Activation-induced deaminase (AID) can drive lymphomagenesis by generating

93 Activation-induced cytidine deaminase (AID) converts cytosine into uracil to initiat

94 Activation-induced deaminase (AID) converts DNA cytosines to uracils in imm

95 ed that E proteins induce activation-induced deaminase (AID) expression in activated B cells.

96 Activation-induced deaminase (AID) functions by deaminating cytosines and c

97 Activation-induced deoxycytidine deaminase (AID) generates antibody diversity in B cells

98 Activation-induced deaminase (AID) initiates antibody gene diversification

99 Activation-induced cytidine deaminase (AID) initiates both class switch recombinatio

100 Activation-induced cytidine deaminase (AID) initiates CSR by promoting deamination l

101 Activation-induced deaminase (AID) initiates mutagenic pathways to diversif

102 1, and paradoxically also activation-induced deaminase (AID) involved in somatic hypermutations/class

103 Activation-induced cytidine deaminase (AID) is a B-cell-specific enzyme that targets

104 Activation-induced cytidine deaminase (AID) is a genome-mutating enzyme that initiat

105 Activation-induced cytidine deaminase (AID) is a key regulator of class switch recom

106 Activation-induced cytidine deaminase (AID) is a mutator enzyme that targets immunog

107 Activation-induced cytidine deaminase (AID) mediates cytosine deamination and underl

108 Activation-induced deaminase (AID) mediates the somatic hypermutation (SHM)

109 s, we used human activation-induced cytidine deaminase (AID) to identify genes preventing R loops.

110 d recruitment of activation-induced cytidine deaminase (AID) to Ig switch regions (S regions).

111 , recruitment of activation-induced cytidine deaminase (AID) to S regions is critical for CSR; howeve

112 ess targeting of activation-induced cytidine deaminase (AID) to the Igh locus.

113 active dCas9 to recruit variants of cytidine deaminase (AID) with MS2-modified sgRNAs, we can specifi

114 rt the fusion of activation-induced cytidine deaminase (AID) with nuclease-inactive clustered regular

115 sion and express activation-induced cytidine deaminase (AID), a DNA mutator.

116 ession levels of activation-induced cytidine deaminase (AID), a key player in B-cell responses to ant

117 A, which encodes activation-induced cytidine deaminase (AID), display an impaired peripheral B cell t

118 is initiated by activation-induced cytidine deaminase (AID), the activity of which leads to DNA doub

119 e biomarkers are activation-induced cytidine deaminase (AID), the enzyme of class switch recombinatio

120 Activation-induced cytidine deaminase (AID), the enzyme responsible for induction of

121 Activation-induced cytidine deaminase (AID), the enzyme-mediating class-switch recom

122 ersification is driven by activation-induced deaminase (AID), which converts cytidine to uracil withi

123 permutation (SHM) enzyme, Activation Induced Deaminase (AID), which overlaps the CpG methylation site

124 introduction of activation-induced cytidine deaminase (AID)-instigated DNA double-strand breaks into

125 he expression of activation-induced cytosine deaminase (AID).

126 expressed enzyme Activation-induced cytidine Deaminase (AID).

127 ntroduced by the activation-induced cytidine deaminase (AID).

128 ine to uracil by activation-induced cytidine deaminase (AID).

129 witch region targeting by activation-induced deaminase (AID).

130 mutator protein activation-induced cytidine deaminase (AID).

131 ivity of the DNA activation-induced cytidine deaminase (AID).

132 ve proposed that activation-induced cytidine deaminase (AID, encoded by AICDA) links chronic inflamma

133 zymes in the biosynthetic network: threonine deaminase (also named l-O-methylthreonine resistant 1 [O

134 in of function in adenosine 5'-monophosphate deaminase (AMPD3).

135 libration curves, of 0.163 mM for creatinine deaminase and 0.139 mM for urease, respectively.

136 -editing enzyme complex 1 (APOBEC1) cytidine deaminase and Deadend-1, which are involved in C-to-U RN

137 ynthetic lethal interaction between cytidine deaminase and microtubule-associated protein Tau deficie

138 ivity, expresses activation-induced cytidine deaminase and T-bet, and exhibits evidence of somatic hy

139 In this work, a combination of creatinine deaminase and urease has been chosen as a model system t

140 activating the activities of the enzymes AMP deaminase and xanthine oxidase.

141 activation of DNA editing by APOBEC cytidine deaminases and of an endogenous clocklike mutational pro

142 Here we engineered programmable cytidine deaminases and test if we could introduce site-specific

143 he nematode Caenorhabditis elegans (cytidine deaminases) and its food (Escherichia coli); when fed fo

144 tive Streptococcus pyogenes Cas9, a cytidine deaminase, and an inhibitor of base excision repair.

145 of inhibitors of adenosine kinase, adenosine deaminase, and the equilibrative nucleoside transporter:

146 lytic, polypeptide-like 3 (APOBEC3) cytidine deaminases, and SAMHD1 (a cell cycle-regulated dNTP trip

147 mutation signature associated with cytidine deaminase APOBEC, which correlates with the upregulation

148 loop 1 to mimic the more potent cytoplasmic deaminase APOBEC3A leads to elevated ssDNA deaminase act

149 The catalytic activity of human cytidine deaminase APOBEC3B (A3B) has been correlated with kataeg

150 A likely cause is the DNA cytosine deaminase APOBEC3B (A3B).

151 Overexpression of the antiviral DNA cytosine deaminase APOBEC3B has been linked to somatic mutagenesi

152 cally induces the innate immune DNA cytosine deaminase APOBEC3B.

153 The single-stranded DNA (ssDNA) cytidine deaminase APOBEC3F (A3F) deaminates cytosine (C) to urac

154 Functional analyses identified the cytidine deaminase APOBEC3G as a barrier for chimpanzee-to-gorill

155 The enzymatic reaction of cytidine deaminase appears to be a distinct example.

156 ls introduced by activation-induced cytidine deaminase are processed by uracil-DNA glycosylase (UNG)

157 and homologous single-stranded DNA cytosine deaminases are unique to mammals.

158 Previous studies identified APOBEC deaminases as enzymes targeting hepatitis B virus (HBV)

159 ccDNA required activation of nuclear APOBEC3 deaminases by the cytokines.

160 olypeptide-like 3 (APOBEC3; A3) DNA cytosine deaminases can be incorporated into progeny virions and

161 The APOBEC3 family of cytidine deaminases cause lethal hypermutation of retroviruses vi

162 quires the activity of two enzymes: cytosine deaminase (CD) and UPRT.

163 ntified that L306 in the C-terminal cytidine deaminase (CD) domain contributed to its core localizati

164 with two Zn-coordinated homologous cytosine deaminase (CD) domains, with the others being A3G, A3D,

165 CYTIDINE DEAMINASE (CDA) catalyzes the deamination of cytidine to

166 ibilities for anti-cancer treatment.Cytidine deaminase (CDA) deficiency leads to genome instability.

167 tetrahydrouridine (THU) to inhibit cytidine deaminase (CDA), the enzyme that otherwise rapidly deami

168 susceptible cell lines overexpress cytidine deaminase (CDA).

169 to the AID/APOBEC protein family of cytidine deaminases (CDA) that bind to nucleic acids.

170 ong isoform of the bacterial enzyme cytidine deaminase (CDDL), seen primarily in Gammaproteobacteria.

171 rs, possibly due to an early increase of ADO deaminase complexing protein 2 (CD26) and adenosine deam

172 A focus on the mechanisms by which ACC deaminase-containing bacteria facilitate plant growth.Ba

173 asimonoclonal, activation-induced [cytidine] deaminase-Cre-tamoxifen-dependent estrogen receptor 2 [E

174 ease, asthma, cystic fibrosis, and adenosine deaminase deficiency (ADA(-/-)).

175 hat has shown clinical benefit for adenosine deaminase-deficient (ADA-deficient) SCID when combined w

176 genes enabling BLM-deficient and/or cytidine deaminase-deficient cells to tolerate constitutive DNA d

177 Tau is overexpressed in cytidine deaminase-deficient cells, and its depletion worsens gen

178 unctions in maintaining survival of cytidine deaminase-deficient cells, and ribosomal DNA transcripti

179 In dramatic contrast, 39 adenosine deaminase-deficient severe combined immunodeficiency (AD

180 be sufficient to competitively inhibit ssDNA deaminase-dependent antiviral activity.

181 h frequencies of activation-induced cytidine deaminase-dependent IgH locus chromosomal breaks and tra

182 pidly deaminated by the isolated human ADAR2 deaminase domain (hADAR2-D) to probe these interactions.

183 ating ssDNA interaction with or entry to the deaminase domain and hypothesize that RNA bound to Tyr-3

184 ported crystal structures of the human ADAR2 deaminase domain bound to duplex RNA revealing a protein

185 These results suggest that the deaminase domain of OTP84 is required for editing two of

186 his work, we examine the activity of the DYW deaminase domain through truncation or mutagenesis of th

187 , many PPR proteins include a C-terminal DYW deaminase domain with characteristic zinc binding motifs

188 catalytically inactive and CD2 is the active deaminase domain, presence of CD1 on the N-terminus of C

189 ent with full length ADAR2 than its isolated deaminase domain.

190 onserved catalytic residues in both cytidine deaminase domains are required for RNA editing.

191 ubstrates are deaminated efficiently by ADAR deaminase domains at dA-C mismatches and with E to Q mut

192 These results indicate that the DYW deaminase domains of PPR proteins are involved in editin

193 red base editors containing mutated cytidine deaminase domains that narrow the width of the editing w

194 es are the seven human APOBEC3 deoxycytidine deaminases, each with unique target sequence specificity

195 '-methylthioadenosine/S-adenosylhomocysteine deaminase (EC 3.5.4.31/3.5.4.28).

196 Our programmable deaminases effectively convert specific cytidines to thy

197 a single enzyme, activation-induced cytidine deaminase (encoded by Aicda), initiates both reactions.

198 neered fusions of CRISPR/Cas9 and a cytidine deaminase enzyme that retain the ability to be programme

199 Several adenosine or cytidine deaminase enzymes deaminate transcript sequences in a ce

200 or PTEN inversely affects activation-induced deaminase expression via modulating AKT activity.

201 d with increased activation-induced cytidine deaminase expression, and correlate with increased risk

202 a significant decline in activation-induced deaminase expression, resulting in decreased switch regi

203 vivo by altering activation-induced cytidine deaminase expression.

204 Here, the mechanisms behind bacterial ACC deaminase facilitation of plant growth and development a

205 is unique within the zinc-dependent cytidine deaminase family as being allosterically regulated, acti

206 indings to the wider zinc-dependent cytidine deaminase family is also discussed.

207 Deletion of yeast cytosine deaminase Fcy1 significantly decreased the rate of CAG r

208 ty and the intrinsic DNA binding affinity of deaminases for safer therapeutic applications.

209 l-Amino acid deaminase from Proteus myxofaciens (PmaLAAD) is a membra

210 as constructed by expressing an L-amino acid deaminase from Proteus vulgaris.

211 al structure of a dTTP-bound deoxycytidylate deaminase from the bacteriophage S-TIM5, confirming that

212 Using cytidine deaminase fused to Cas9 nickase, up to 28% of site-speci

213 ablation of the activation-induced cytidine deaminase gene required for class switch recombination/s

214 o upregulate the activation-induced cytidine deaminase gene through in vitro T-dependent and T-indepe

215 equent deletion polymorphism in the cytidine deaminases gene cluster APOBEC3 resulting in increased e

216 din was substituted with the human adenosine deaminase (hADA1)-streptavidin complex and adenosine as

217 B (A3B) single-stranded DNA (ssDNA) cytosine deaminase has important roles in innate immunity but is

218 The APOBEC3 family of DNA cytosine deaminases has important roles in innate immunity and ca

219 These deaminases have also been proposed to function in DNA de

220 was dependent on activation-induced cytidine deaminase, hematopoietic MyD88 expression, and an intact

221 cations for the control of another mutagenic deaminase, human AID, and provides a rationale for its r

222 ng with overexpression of activation-induced deaminase in their fimbrial epithelium.

223 genomes have implicated the APOBEC3 cytosine deaminases in oncogenesis, possibly offering a therapeut

224 55 target Aicda (activation-induced cytidine deaminase) in this process and, in combination with a ga

225 ty, providing new insights into how cytidine deaminase-induced mutagenesis might be activated in tumo

226 e: (1) dT+dC and (2) coadministration of the deaminase inhibitor, tetrahydrouridine (THU), with dTMP+

227 ated elevated global cytidine deamination at deaminase intrinsic binding sites.

228 e (APOBEC) proteins are a family of cytidine deaminases involved in various important biological proc

229 ed for editing two of the sites, but another deaminase is able to supply the deamination activity for

230 Deoxycytidylate deaminase is unique within the zinc-dependent cytidine d

231 The APOBEC3 family of DNA cytosine deaminases is capable of restricting the replication of

232 tein SLO2, which lacks a C-terminal cytidine deaminase-like DYW domain, interacts in vivo with the DY

233 The designed photocontrolled cytosine deaminases may also aid in improving chemotherapy approa

234 ansporters, and it was resistant to cytidine deaminase-mediated degradation.

235 BEC3G binds single-stranded DNA as an active deaminase monomer, subsequently forming catalytic-inacti

236 APOBEC cytidine deaminases mutate cancer genomes by converting cytidines

237 The APOBEC3 family of cytidine deaminases mutate the cancer genome in a range of cancer

238 PfkB, but not PfkA), glucosamine-6-phosphate deaminase (NagB), and adenylate kinase (Adk).

239 Several antiviral cytidine deaminases of the human APOBEC3 (hA3) family have been i

240 and CD73) and breakdown (CD26 and adenosine deaminase) on T cells from blood, lymph nodes, and intes

241 Activation-induced cytidine deaminase, one of the APOBEC members, was reported to de

242 -l-methionine (SAM) enzyme that can act as a deaminase or a dehydrogenase depending on the nature of

243 t of wild-type mice with pegylated adenosine deaminase or CD73 antibodies also significantly reduced

244 e, we report the discovery of a new class of deaminases, predominantly found in mycobacterial species

245 The activation-induced cytidine deaminase protein induces genome-wide DNA breaks that, i

246 Proteus vulgaris L-amino acid deaminase (pvLAAD) belongs to a class of bacterial membr

247 tensive computer simulations of the cytidine deaminase reaction and its temperature dependence.

248 rent base-editing platforms, including their deaminase recruitment strategies and editing outcomes, a

249 Therefore programmable deaminases represent a promising genome editing tool in

250 fic residues critical for editing, conserved deaminase residues in each PPR protein were mutagenized.

251 refore, the DYW motif, and specifically, the deaminase residues, of QED1 and RARE1 are required for e

252 oding nucleoside diphosphate kinase and dCTP deaminase, respectively, had a strongly suppressive effe

253 The reactive intermediate deaminase, RidA, is shown to prevent 2AA damage caused b

254 nscriptomes demonstrate that ADAR (adenosine deaminase, RNA-specific)-mediated RNA editing dynamicall

255 Single-strand DNA-specific APOBEC cytidine deaminase(s) are major source(s) of mutation in several

256 model used is not informative for adenosine deaminase-SCID, whereas hypomorphic mutations lead to le

257 associated) and lysosome function (adenosine deaminase) showed differential alternative splicing even

258 with altered CpGs and APOBEC-family cytosine deaminases similar to mutation signatures derived from s

259 some single strand-specific APOBEC cytidine deaminases, similar to the mutations that can typify the

260 acterize the interaction of A3G protein with deaminase specific and nonspecific ssDNA substrates.

261 onstrated that A3G has elevated affinity for deaminase specific ssDNA than for nonspecific ssDNA.

262 d by stronger and more stable complexes with deaminase specific ssDNA than with nonspecific ssDNA.

263 ublished APOBEC and phylogenetically related deaminase structures, as it is the first without zinc in

264 In this study, we identify adenosine deaminase that acts on RNA 3 (ADAR3) as an important reg

265 APOBEC3H is a deoxycytidine deaminase that can restrict the replication of HIV-1 in

266 APOBEC3B is a single-stranded DNA cytosine deaminase that functions normally as a nuclear-localized

267 Human APOBEC3H (A3H) is a cytidine deaminase that inhibits HIV-1 replication.

268 am effector APOBEC3, an IFN-induced cytidine deaminase that introduces lethal mutations during retrov

269 APOBEC3G (A3G) is a cellular cytidine deaminase that restricts HIV-1 replication by inducing G

270 Hyperediting by adenosine deaminases that act on RNA (ADAR) enzymes was quantified

271 Adenosine deaminases that act on RNA (ADARs) carry out adenosine (

272 ic subunit 3 (APOBEC-3) enzymes are cytidine deaminases that are broadly and constitutively expressed

273 LOXs) are a family of copper-dependent oxido-deaminases that can modify the side chain of lysyl resid

274 ADAR1 isoforms are adenosine deaminases that edit and destabilize double-stranded RNA

275 t-diverged AID orthologs are active cytidine deaminases that exhibit unique substrate specificities a

276 AID / APOBEC genes are a family of cytidine deaminases that have evolved in vertebrates, and particu

277 diting complex 3 family members are cytidine deaminases that play important roles in intrinsic respon

278 BEC3s (A3s) are single-stranded DNA cytosine deaminases that provide innate immune defences against r

279 a hybrid of a cytosine as well as a guanine deaminase, thereby conferring Msd the ability to expand

280 is likely conserved among all polynucleotide deaminases, thereby opening the door for the design of m

281 , as illustrated by the ability of adenosine deaminase to deaminate (tz)A as effectively as adenosine

282 s) are required to direct activation-induced deaminase to initiate class switching in B cells.

283 We evolved a transfer RNA adenosine deaminase to operate on DNA when fused to a catalyticall

284 e RNA allowing activation-induced (cytosine) deaminase to promote somatic hypermutation on both DNA s

285 ty used and then applied the enzyme D-serine deaminase to remove significant levels of D-serine.

286 al for targeting activation-induced cytidine deaminase to S regions, as was suggested.

287 se editing relies on recruitment of cytidine deaminases to introduce changes (rather than double-stra

288 ncer tissues presenting concomitant cytidine deaminase underexpression and Tau upregulation open up n

289 gle bifunctional yeast fusion gene, cytosine deaminase/uracil phosphoribosyltransferase (FCU).

290 (TK007 and TK(SR39) mutants), yeast cytosine deaminase:uracil phosphoribosyltransferase (yCD:UPRT) an

291 Members of the APOBEC3 family of cytidine deaminases vary in their proportions of a virion-incorpo

292 OBEC3G (A3G-CTD), an ssDNA-specific cytosine deaminase, was expressed in an Escherichia coli strain d

293 therapeutically useful enzyme yeast cytosine deaminase, we obtained a approximately 3-fold change in

294 zyme 1-aminocyclopropane-1-carboxylate (ACC) deaminase, when present either on the surface of plant r

295 ed APOBEC3B as the more likely major mutator deaminase, whereas the role of APOBEC3A is not establish

296 R) is induced by activation-induced cytidine deaminase, which initiates a cascade of events leading t

297 in the race by expressing activation-induced deaminase, which unleashes a tsunami of mutations in the

298 crystal structure of a complex of a cytidine deaminase with ssDNA bound in the active site at 2.2 A.

299 APOBEC3G is a cytidine deaminase with two homologous domains and restricts retr

300 l remodeling and down-regulation of cytidine deaminase without depletion of tumor stromal content.