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2 xyinosine as its major product but will also deaminate 5'-methylthioadenosine, S-adenosylhomocysteine
3 the cytidine deaminases AID and APOBEC1 can deaminate 5-methylcytosine in vitro and in Escherichia c
6 echanism of 5-meC demethylation, whereby AID deaminates 5-meC, followed by thymine base excision by M
8 e gene expression epigenetically by directly deaminating 5-methylcytosine in concert with base-excisi
10 and other results suggest that the human AID deaminates 5mC's only weakly because the 5-methyl group
11 y and was at least 10-fold less efficient at deaminating 5mC compared to C in biochemical assays.
17 enosine Deaminase Acting on RNA (ADAR2) that deaminates A to inosine (I) residues that are subsequent
18 hADAT1 protein efficiently and specifically deaminates A(37) in the anticodon loop of tRNA(Ala) from
19 Ig receptor, although an additional role in deaminating a regulatory mRNA transcript has not been ru
21 c protein for which we find no evidence of a deaminating activity on cytidine whether as a free nucle
24 uman ADAR protein, hADAT1, that specifically deaminates adenosine 37 to inosine in eukaryotic tRNA(Al
25 minases acting on RNA (ADARs) hydrolytically deaminate adenosines (A) in a wide variety of duplex RNA
27 on RNA (ADARs) are RNA-editing enzymes that deaminate adenosines to create inosines in double-strand
28 Adenosine deaminases that act on RNA (ADARs) deaminate adenosines to produce inosines within RNAs tha
30 the LGST is accessible to cellular cytosine deaminating agents, explains the well-known GC skew in m
31 els of glucose through gluconeogenesis using deaminated amino acids with dicarboxylate products of pe
36 DNA by removing a wide variety of alkylated, deaminated, and lipid peroxidation-induced purine adduct
37 DNA by removing a wide variety of alkylated, deaminated, and lipid peroxidation-induced purine adduct
47 a copied DNA strand could be inhibited by a deaminated base in the alternate strand of a replication
51 mode switch by endonuclease V for removal of deaminated base lesions during endonuclease V-mediated r
55 mismatched primer-templates, even though the deaminated base-containing primer-templates are correctl
56 eal family-B DNA polymerases bind tightly to deaminated bases and stall replication on encountering u
59 and shape fit in determining selectivity for deaminated bases has been examined using nonpolar isoste
62 eal family B polymerases bind tightly to the deaminated bases uracil and hypoxanthine in single-stran
63 so cleaved DNA substrates that contained the deaminated bases uracil, hypoxanthine, or xanthine in a
64 , if the polymerase approaches closer to the deaminated bases, locating it at +3, +2, +1 or even 0 (p
67 e show that human APOBEC3A (A3A) efficiently deaminates both MeC to thymine (T) and normal C to uraci
69 o called Pou2af1), H2afx, Rhoh and Ebf1, are deaminated by AID but escape acquisition of most mutatio
71 ependent on transcriptional orientation, was deaminated by AID in vitro with the same transcriptional
72 tosine and 5-hydroxymethylcytosine are first deaminated by AID to thymine and 5-hydroxymethyluracil,
73 lymerase beta (Polbeta) would replace the dC deaminated by AID, leading to correct repair of the sing
76 aminoacrylate, and then the aminoacrylate is deaminated by nonenzymatic hydrolysis to produce pyruvat
77 tly discovered RNA substrate that is rapidly deaminated by the isolated human ADAR2 deaminase domain
79 on-induced cytosine deaminase preferentially deaminates C in DNA on the nontranscribed strand in vitr
80 It has been shown that in vitro, AID protein deaminates C in single-stranded DNA or the coding-strand
82 vation-induced deoxycytidine deaminase (AID) deaminates C to U on single-stranded DNA to initiate imm
85 triggers viral inactivation by processively deaminating C-->U, with 3'-->5' polarity, on nascent min
86 oB) mRNA assembled functional editosomes and deaminated C6666 to U in a mooring sequence-dependent fa
87 tic component of an RNA-editing complex that deaminates C6666 --> U in apolipoprotein B RNA in gastro
90 eveloped two methods to specifically measure deaminated CPDs in UV-irradiated human cells or DNA.
93 NA, the question remains whether it can also deaminate cytidine in mRNA, as originally proposed based
95 ced cytidine deaminase (AID), an enzyme that deaminates cytidine residues in single-stranded DNA.
97 ns: a catalytic C-terminal domain (CTD) that deaminates cytidine, and a N-terminal domain (NTD) that
98 AID is thought to make lesions in DNA by deaminating cytidine residues in single-stranded DNA exp
104 atic hypermutation (SHM) in B lymphocytes by deaminating cytidines on template and nontemplate strand
105 in newly infected cells, at least in part by deaminating cytidines on the negative strand DNA interme
106 SHM) and class switch recombination (CSR) by deaminating cytidines to uridines at V region (V) genes
107 (CSR) and Ig somatic hypermutation (SHM) by deaminating cytidines within, respectively, IgH switch (
108 de-like (APOBEC) family of proteins that can deaminate cytosine (C) to uracil (U) on nucleic acids.
109 Apobec/AID family of cytosine deaminases can deaminate cytosine and thereby contribute to adaptive an
114 ted base excision repair system, repair of a deaminated cytosine (i.e., uracil) opposite the adducted
115 , oxidative damage [fpg nei nth strain], and deaminated cytosine [ung strain]) showed essentially wil
118 as influenced by the sequence context of the deaminated cytosine, with individual hotspots exhibiting
119 NA (ssDNA) cytidine deaminase APOBEC3F (A3F) deaminates cytosine (C) to uracil (U) and is a known res
120 In the context of hypermutating B cells, AID deaminates cytosine in the DNA of immunoglobulin genes,
125 us infectivity factor (vif), A3F selectively deaminates cytosine within 5'-TTCA-3' motifs in single s
126 te their biological functions mostly through deaminating cytosine (C) to uracil on single-stranded DN
127 AID/APOBEC family enzymes are best known for deaminating cytosine bases to uracil in single-stranded
129 HIV/SIV replication to differing degrees by deaminating cytosine in viral (-)DNA, which forms promut
131 ion (CSR) and somatic hypermutation (SHM) by deaminating cytosine residues in immunoglobulin genes (I
132 deaminase (AID) initiates both processes by deaminating cytosine residues in immunoglobulin genes.
133 nd APOBEC3G restrict retroviral infection by deaminating cytosine residues in the first cDNA strand o
139 replication stress compromises the repair of deaminated cytosines and other damaged bases, leading to
140 response, activation-induced deaminase (AID) deaminates cytosines at immunoglobulin (Ig) loci, initia
141 tion-induced cytidine deaminase (AID), which deaminates cytosines in both the donor and acceptor S re
147 ivation-induced deaminase (AID) functions by deaminating cytosines and causing U:G mismatches, a rate
148 nd in vivo that AID initiates SHM and CSR by deaminating cytosines in DNA in a transcription-dependen
149 nt model, AID is proposed to initiate CSR by deaminating cytosines in the unpaired nontemplate strand
150 APOBEC3DE was encapsidated and capable of deaminating cytosines to uracils on viral minus-strand D
151 e potential cleavage sites for the enzyme by deaminating dAMP and dCMP in DNA to dIMP and dUMP, respe
152 ata in Escherichia coli suggest that AID may deaminate dC on DNA, but its putative biochemical activi
155 retroviral replication in infected cells by deaminating dC to dU in the first (minus)-strand cDNA re
157 -induced deaminase (AID), an enzyme that can deaminate deoxycytidine in DNA in vitro, where its activ
159 o be packaged into retroviral virions and to deaminate deoxycytidine to deoxyuridine in newly synthes
160 virion infectivity factor (Vif), where they deaminate deoxycytidine to deoxyuridine on the minus str
163 tion-induced cytidine deaminase (AID), which deaminates deoxycytidine to deoxyuridine in single-stran
165 an immunodeficiency virus type 1 virions and deaminates deoxycytidine to deoxyuridine on nascent minu
166 e of evidence suggests that AID functions by deaminating deoxycytidine in DNA, the question remains w
167 tidine deaminase (AID), which preferentially deaminates deoxycytidines at WRC (W = A/T, R = A/G) moti
169 ine deaminase (AID) initiates CSR and SHM by deaminating deoxycytidines (dCs) in switch (S) and V(D)J
173 he enzyme endonuclease V initiates repair of deaminated DNA bases by making an endonucleolytic incisi
178 inase (AID), the B-cell-specific factor that deaminates DNA to initiate immunoglobulin gene diversifi
181 further assessed APOBEC3A for the ability to deaminate dsDNA undergoing transcription, which could al
184 A new study shows that UV-damaged DNA is deaminated during transcription, which is a probable mec
188 uring that period, then half of the cytosine-deaminating events per unit biomass would have taken pla
189 The enzyme is ubiquitously expressed and deaminates exclusively guanosine and 2'-deoxyguanosine b
191 ng for AID's functional role posits that AID deaminates genomic deoxycytosine bases within the immuno
192 , we demonstrate that APOBEC3G is capable of deaminating genomic cytosines in Saccharomyces cerevisia
193 required to phosphorylate, deacetylate, and deaminate GlcNAc to convert it to fructose-6-PO(4) (HXK1
194 liver antigen, tissue transglutaminase, and deaminated gliadin peptides; the most frequently detecte
195 ied by Moth1224 from Moorella thermoacetica, deaminates guanine to xanthine, and another subgroup, ex
196 hia coli bound to the cleaved authentic hemi-deaminated/hemi-methylated dcm sequence 5'-C-OH-3' 5'-p-
198 POBEC3s act as host restriction factors that deaminate human immunodeficiency virus type 1 replicatio
199 nces, we analyzed the fraction of adenosines deaminated in a given RNA at complete reaction, or the e
201 ase (CDA), the enzyme that otherwise rapidly deaminates/inactivates decitabine, severely limiting its
204 eveal that AAG is most adept at excising the deaminated lesion hypoxanthine (k(st)/k(non) = 10(8)), s
207 sted by enzymology experiments, and Arad3529 deaminated many pterin metabolites (substrate, k(cat)/K(
208 r, APOBEC3A (A3A), has been shown to readily deaminate mC, raising the prospect of broader activity o
211 in brain norepinephrine (p < 0.001) and its deaminated metabolite, dihydroxyphenylglycol (p < 0.05).
212 no acids (BCAs) leucine/isoleucine and their deaminated metabolites, and lowered free fatty acids and
214 , one of the APOBEC members, was reported to deaminate methylated cytosine (mC) on DNA, and this mC d
216 a virion-encapsidated cellular protein that deaminates minus-strand reverse transcript cytosines to
218 OBEC3H haplotype II was able to processively deaminate multiple cytosines in a single enzyme-substrat
219 inhibits the replication of retroviruses by deaminating nascent retroviral cDNA cytosines to uracils
220 ts the replication of Vif-deficient HIV-1 by deaminating nascent viral cDNA cytosines to uracils, lea
222 otinamidase 1), which encodes an enzyme that deaminates nicotinamide, is both necessary and sufficien
224 hisms could increase the burden of mutagenic deaminated nucleobases in DNA and interfere with gene ex
225 tion with analytical methods for quantifying deaminated nucleobases in DNA and RNA, we observed large
228 Furthermore, we show that AID will bind and deaminate only single-stranded DNA, which implies a dire
229 an cell extracts and discovered that several deaminated or alkylated nucleotides are efficiently remo
231 mulative amount of dietary amino acids (AAs) deaminated over this 8-h period was 18.1 +/- 3.5%, 17.5%
232 ited roles in translesion DNA synthesis past deaminated, oxidized base lesions and/or UV-induced dama
233 ckbone and the action of DNA glycosylases on deaminated, oxidized, and alkylated bases are critical t
235 ch is known to hydroxylate position C5, also deaminates position C4 in a reaction implicating molecul
236 The isolated conjugate was converted to the deaminated product 2-hydroxy-3,8-dimethylimidazo[4,5-f]q
237 followed by oxidative decarboxylation of the deaminated product branched-chain alpha-keto acids, cata
238 l-2'-deoxycytidine glycol in the form of its deaminated product, namely, thymidine glycol (Tg), in me
242 eering to generate Escherichia coli that can deaminate protein hydrolysates, enabling the cells to co
245 DNA glycosylases that remove alkylated and deaminated purine nucleobases are essential DNA repair e
249 s of the human BER pathway for the repair of deaminated purines, alkyladenine DNA glycosylase (AAG) a
250 ety of base lesions, including alkylated and deaminated purines, and initiating their repair via the
252 presence of a Hoogsteen base pair within the deaminated recognition sequence and the substantial dist
256 l total syntheses of the naturally occurring deaminated sialic acids KDN (2), a potential oncofetal a
259 -to-inosine (I) RNA deaminases, enzymes that deaminate specific A residues in specific pre-mRNAs to p
261 different assays to demonstrate that AID can deaminate specifically cytidines on single-stranded (ss)
265 OBEC3G, exhibits low or no processivity when deaminating synthetic ssDNA substrates with two cytosine
266 Thus, it was shown that CPDs of TCG sites deaminate the fastest in vivo and that nucleosomes can m
267 1 virions and in the next round of infection deaminate the newly synthesized reverse transcripts.
268 ly, we observed that Xenopus and human ADAR1 deaminate the same adenosines on all RNAs tested, emphas
269 tosine within specific sequences (C5 Mtases) deaminate the target cytosine to uracil if the methyl do
272 C) is difficult as the reaction products can deaminate to the corresponding thymine derivatives, maki
273 C and 5-methyl-C in CPDs are not stable and deaminate to U and T, respectively, which leads to the i
274 e C or 5-methyl-C in CPDs are not stable and deaminate to U and T, respectively, which leads to the i
275 hylcytosine ((m)C) are not and spontaneously deaminate to U or T at pH 7 and 37 degrees C over a peri
276 mC of a CPD is not mutagenic and must first deaminate to U or T, respectively, for A to be inserted
278 e in the naturally occurring A.C mismatch is deaminated to approximately the same extent and only 4 t
279 nditions of excess enzyme, C/mC bases can be deaminated to completion in long DNA segments, regardles
280 ing is A-to-I editing, in which adenosine is deaminated to inosine, which is read as guanosine during
282 mical instability of cytosine, which readily deaminates to uracil, a primitive genetic system compose
284 eral adenosine or cytidine deaminase enzymes deaminate transcript sequences in a cell type or environ
285 hat A3A can inhibit L1 retrotransposition by deaminating transiently exposed single-strand DNA that a
286 Cell, Herranz et al. demonstrate that LOXL2 deaminates trimethylated histone 3 lysine 4 (H3K4me3), w
287 fied by Avi5431 from Agrobacterium vitis S4, deaminates two oxidatively damaged forms of adenine: 2-o
288 ed by a single biotransformation reaction to deaminate tyrosine to pHCA through immobilized E. coli c
289 ted by the ability of adenosine deaminase to deaminate (tz)A as effectively as adenosine, the native
291 orthern" (3'-endo, N) sugar ring pucker were deaminated up to 65-fold faster and bound more tightly t
292 ed subgroups of enzymes with the capacity to deaminate various combinations of the adenosine analogue
294 e A3G molecules packaged in the virion first deaminate viral DNA as monomers before dimerizing to for
295 ons, where it exerts its antiviral effect by deaminating viral cDNA cytosines during reverse transcri
300 has previously been shown to preferentially deaminate WRC (W = A/T, R = A/G) motif hot spots in in v
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