ライフサイエンスコーパス: debilitate

1 ion, powerlessness and guilt were common and debilitating.

2 h usually self-limited, it can be severe and debilitating.

3 t of these strokes, which are often fatal or debilitating.

4 postoperative pain is uncommon, but at times debilitating.

5 ders being neurodevelopmental, lifelong, and debilitating.

6 age to the PNS by disease or injury is often debilitating.

7 IKV) is a re-emerging alphavirus that causes debilitating acute and chronic arthritis.

8 ding, mosquito-transmitted virus that causes debilitating acute and chronic musculoskeletal disease i

9 herpesviruses are responsible for a range of debilitating acute and recurrent diseases, including a n

10 metastatic bone disease often present with a debilitating acute phase response as a result of Vgamma9

11 Parkinson's disease is a debilitating, age-associated movement disorder.

12 MCS recipients are debilitated and have some immunological dysfunction.

13 In debilitated and immunocompromised individuals, C. albica

14 with which to prevent or treat these highly debilitating and currently incurable conditions.

15 a patients, working memory deficit is highly debilitating and currently without any efficacious treat

16 Sepsis remains one of the most debilitating and expensive illnesses, and its prevalence

17 atic dysfunction results in some of the most debilitating and fatal diseases, including pancreatic ca

18 ted and are associated with a broad range of debilitating and fatal diseases.

19 Bluetongue (BT) is a debilitating and in many cases lethal disease that affec

20 ) promise a therapeutic alternative for many debilitating and incurable diseases.

21 Parkinson disease is a debilitating and incurable neurodegenerative disorder af

22 cerebral palsy often exhibit crouch gait, a debilitating and inefficient walking pattern marked by e

23 athic pulmonary fibrosis (IPF), it remains a debilitating and lethal condition.

24 -inducing herpetic stromal keratitis, highly debilitating and lethal herpes simplex encephalitis, and

25 apies and, in some cases, may develop into a debilitating and life-threatening chronic illness.

26 AD and HF are both debilitating and life-threatening conditions, affecting

27 hemorrhagic telangiectasia (HHT) is a highly debilitating and life-threatening genetic vascular disor

28 letion of its namesake protein, triggering a debilitating and often fatal form of infantile Parkinson

29 motor neurons, skeletal muscle atrophy, and debilitating and often fatal motor dysfunction.

30 mas comprise a heterogeneous group of highly debilitating and painful disorders characterized by thic

31 The debilitating and persistent effects of ICU-acquired deli

32 inum neurotoxin serotype A (BoNT/A) causes a debilitating and potentially fatal illness known as botu

33 asma marginale causes bovine anaplasmosis, a debilitating and potentially fatal tick-borne infection

34 of striatal neurons and the midlife onset of debilitating and progressive chorea, dementia, and psych

35 , DMD, SMA, and infantile AMD are inexorably debilitating and require lifetime multidisciplinary clin

36 Met30 mutations are associated with the most debilitating and severe FAP ever described, with rapid o

37 Apathy is a debilitating and under-recognized condition that has a s

38 Major depressive disorder (MDD) is a debilitating and widespread illness that exerts signific

39 Mood disorders can be debilitating, and are often correlated with poor general

40 Depression is a common, debilitating, and costly disorder.

41 fibropapillomatosis, a globally distributed, debilitating, and fatal tumor disease of endangered mari

42 ic pulmonary hypertension (CTEPH) is a rare, debilitating, and life-threatening disease.

43 al manifestations range from none to severe, debilitating, and life-threatening disorders.

44 e delivery of care to patients who have this debilitating arrhythmia.

45 uch as severe back and small joint pain, and debilitating arthritis associated with crippling pains t

46 Such symptoms can be as debilitating as the disease itself.

47 A debilitating aspect of anxiety is its impact on decision

48 hizophrenia is one of the most pervasive and debilitating aspects of the disorder.

49 Multiple sclerosis (MS) is a debilitating autoimmune neuroinflammatory disease influe

50 lead to Marinesco-Sjogren syndrome (MSS), a debilitating autosomal recessive disease characterized b

51 ges in their shape and orientation can cause debilitating behavioral defects.

52 Osteoporosis is a common and debilitating bone disease that is characterised by low b

53 DDR is, however, to prevent the fixation of debilitating changes to DNA by activation of various DNA

54 wever, variable survival rates of 60-80% and debilitating chemotherapy sequelae argue for more inform

55 Rheumatoid arthritis (RA) is a severely debilitating chronic autoimmune disease that leads to lo

56 Depression is a debilitating chronic illness that affects around 350 mil

57 Eumycetoma is a debilitating, chronic, fungal infection that is endemic

58 Neuropathic pain is a debilitating clinical problem and difficult to treat.

59 tomatous lesions, which leads to diverse and debilitating clinical symptoms.

60 fatal degenerative disorder that results in debilitating cognitive and motor dysfunction.

61 e control of CNS malignancy, progressive and debilitating cognitive dysfunction remains a pressing un

62 d potential intervention strategies for this debilitating comorbid syndrome.

63 Sarcopenia, or skeletal muscle atrophy, is a debilitating comorbidity of many physiological and patho

64 erotinia sclerotiorum endornavirus 1 and was debilitated compared to cultures of the same isolate tha

65 Diabetic foot ulcers (DFUs) are a debilitating complication of diabetes in which bacterial

66 Cognitive decline is a debilitating condition associated with not only neurodeg

67 rapy promotes the development of cachexia, a debilitating condition characterized by muscle and fat l

68 Chronic itch is a prevalent and debilitating condition for which few effective therapies

69 Neuropathic pain is a debilitating condition for which the development of effe

70 Major depressive disorder (MDD) is a debilitating condition that affects over 14 million Amer

71 Endometriosis is a debilitating condition that is categorized by the abnorm

72 Lymphedema is a debilitating condition that often results secondary to t

73 wound healing, excessive scar formation is a debilitating condition that results in pain, loss of tis

74 Low back pain (LBP) is a common debilitating condition which aetiology and pathogenesis

75 Autism spectrum disorder is a debilitating condition with possible neurodevelopmental

76 ttraumatic stress disorder (PTSD)-a chronic, debilitating condition, broadly characterized by emotion

77 Borderline personality disorder (BPD) is a debilitating condition, but several psychotherapies are

78 offer opportunities to prevent or treat this debilitating condition.

79 most completely eradicated new cases of this debilitating condition.

80 ial candidate therapy for patients with this debilitating condition.

81 itus; for seven million people, it creates a debilitating condition.

82 d to improve or even prevent this common and debilitating condition.

83 improve the treatment of patients with this debilitating condition.

84 Cognitive dysfunction occurs in many debilitating conditions including Alzheimer's disease, D

85 tochondrial disorders are a diverse group of debilitating conditions resulting from nuclear and mitoc

86 Long-term infection can result in debilitating conditions such as pelvic inflammatory dise

87 ible patients as a result of age, underlying debilitating conditions, or immunosuppression.

88 l needs for life threatening or irreversibly debilitating conditions.

89 persistent fear and worries that are highly debilitating, conferring risk for lifelong psychopatholo

90 intractable neuropathic pain is a common and debilitating consequence of neuromyelitis optica spectru

91 Limiting the debilitating consequences of ageing is a major medical c

92 uce the risk of osteoporosis and potentially debilitating consequences of fractures in older individu

93 and transplant patients, can have severe and debilitating consequences.

94 abetes is a chronic disease with potentially debilitating consequences.

95 plasm characterized by anemia, splenomegaly, debilitating constitutional symptoms, and shortened surv

96 vinculin suffer from chronic, progressively debilitating DCM that ultimately leads to cardiac failur

97 Mucolipidosis IV is a debilitating developmental lysosomal storage disorder ch

98 Chronic spontaneous urticaria (CSU) can be debilitating, difficult to treat, and frustrating for pa

99 ain.SIGNIFICANCE STATEMENT Chronic pain is a debilitating disease affecting approximately one in thre

100 ntravascular, parasitic flatworms that cause debilitating disease afflicting >200 million people.

101 ns of the central nervous system can lead to debilitating disease and death.

102 ular necrosis of the femur head (AVNFH) is a debilitating disease caused due to the use of alcohol, s

103 egypti and Ae. albopictus mosquitoes, causes debilitating disease characterized by an acute febrile p

104 Osteoarthritis (OA) is a common, painful and debilitating disease of articulating joints resulting fr

105 Pancreatitis is a debilitating disease of the exocrine pancreas that, unde

106 unexplained nausea and vomiting (CUNV) is a debilitating disease of unknown cause.

107 ve multifocal leukoencephalopathy (PML) is a debilitating disease resulting from infection of oligode

108 r bacteria that cause brucellosis, a chronic debilitating disease significantly impacting global heal

109 Atopic dermatitis (AD) is a debilitating disease that significantly alters the quali

110 ) is the most common inherited neuropathy, a debilitating disease without known cure.

111 ebrate hosts, in which EEEV induces a highly debilitating disease, and the outcomes are frequently le

112 Buruli ulcer, a debilitating disease, is caused by Mycobacterium ulceran

113 (5-FU) is the first line of therapy for this debilitating disease, treatment effectiveness is often h

114 eatment, and follow-up in patients with this debilitating disease.

115 ) provides a potential gene therapy for this debilitating disease.

116 n, which causes periodic outbreaks of highly debilitating disease.

117 ogical levels, trigger the onset of multiple debilitating diseases and lead to a loss of function, an

118 eutic strategies for the treatment of severe debilitating diseases associated with type I IFNs due to

119 wel diseases (IBDs) are a set of complex and debilitating diseases for which there is no satisfactory

120 al Need for Life Threatening or Irreversibly Debilitating Diseases or Conditions document was issued

121 Psychiatric disorders are debilitating diseases, affecting >80 million people worl

122 yloid aggregates are associated with several debilitating diseases, and there are numerous efforts to

123 are being developed to ameliorate otherwise debilitating diseases.

124 ADAM17 is implicated in several debilitating diseases.

125 ens which cause periodic outbreaks of highly debilitating diseases.

126 are being developed to ameliorate otherwise debilitating diseases.

127 approach for treating otherwise terminal or debilitating diseases.

128 Cancer pain is a debilitating disorder and a primary determinant of the p

129 provide new insight into understanding this debilitating disorder and may lead to novel avenues for

130 (Hcrt) has been implicated in narcolepsy, a debilitating disorder characterized by excessive daytime

131 Low back pain (LBP) is a widespread debilitating disorder of significant socio-economic impo

132 Familial dysautonomia (FD) is a debilitating disorder that affects derivatives of the ne

133 Posttraumatic stress disorder (PTSD) is a debilitating disorder that has been associated with brai

134 s/chronic fatigue syndrome is an unexplained debilitating disorder that is frequently associated with

135 markers and therapeutic strategies for this debilitating disorder.

136 stems that mediate the inborn risk for these debilitating disorders remain unknown.

137 tations in mtDNA can cause fatal or severely debilitating disorders with limited treatment options.

138 s a therapeutic approach to the treatment of debilitating dyskinesias.

139 hly malignant childhood brain tumour, impose debilitating effects on the developing child, and highli

140 brain regions and thereby gives rise to the debilitating emotional and cognitive symptoms of stress-

141 squito-transmitted flavivirus that can cause debilitating encephalitis.

142 Cushing's disease is a rare debilitating endocrine disorder for which few prospectiv

143 parathyroidism is a frequent and potentially debilitating endocrine disorder for which surgery is the

144 Endometriosis is a debilitating, estrogen-dependent, progesterone-resistant

145 Schizophrenia is a debilitating familial neuropsychiatric disorder which af

146 rom repeated exposure to allergen that are a debilitating feature of severe chronic asthma.

147 Glomerulonephritis is a common and debilitating feature of systemic lupus erythematosus (SL

148 nyavirus that causes episodic outbreaks of a debilitating febrile illness in humans in countries of S

149 distress syndrome, lung adenocarcinoma, and debilitating fibrotic diseases, but the critical transcr

150 pathogen that causes human Q fever, an acute debilitating flu-like illness that can also present as c

151 l nerve sheath tumors that cause progressive debilitating focal extremity weakness.

152 te a cascade of chronic injuries that can be debilitating for both casual and high-performance athlet

153 ongenital hypoparathyroidism can be severely debilitating for patients, leading to renal failure at y

154 ating errors across repeated blinks would be debilitating for visual performance.

155 sely to both the understanding of frequently debilitating forms of anemia and the ability to treat af

156 r Hailey-Hailey disease (HHD), is a rare and debilitating genetic dermatosis characterized by chronic

157 addressed, particularly for those with more debilitating grief symptoms and for minorities.

158 The main cause of death globally remains debilitating heart conditions, such as dilated cardiomyo

159 ons in S1P are involved in the prevalent and debilitating hemolytic disorder sickle cell disease (SCD

160 yVs are established etiologic agents of many debilitating human diseases, especially in immunocomprom

161 ids, a family of protozoan parasites causing debilitating human diseases, possess multiply fragmented

162 regation into amyloid is linked with several debilitating human diseases.

163 PyVs are known to cause debilitating human diseases.

164 ing unprecedented opportunities for treating debilitating human diseases.

165 in organization is typically associated with debilitating human neuropathies and is seldom observed i

166 ive colitis (UC) is a chronic, relapsing and debilitating idiopathic inflammation, with variable and

167 cise correlates to the chronic phase of this debilitating illness and/or this remarkable heterogeneit

168 isease is a prevalent, neglected and serious debilitating illness caused by the kinetoplastid protozo

169 of schizophrenia is a pivotal phase of this debilitating illness.

170 affect millions of people worldwide, causing debilitating illnesses and death.

171 Amyloid disorders cause debilitating illnesses through the formation of toxic pr

172 The mutant virus was debilitated in primary T cells and macrophages--cellular

173 o viable treatment options for patients with debilitating inherited retinal degeneration.

174 psychiatric intervention that could prevent debilitating intrusive memories following trauma.

175 Spasms after spinal cord injury (SCI) are debilitating involuntary muscle contractions that have b

176 lity of methylidene complexes is a generally debilitating issue with all types of catalyst systems.

177 steoarthritis (OA) is the most prevalent and debilitating joint disease, and there are currently no e

178 tbreaks worldwide in the past decade, causes debilitating joint inflammation and severe pain.

179 die of the disease, and survivors have many debilitating late effects.

180 Importance: Fatigue is a common and debilitating late-term effect of breast cancer that is a

181 Palmoplantar keratoderma (PPK) are debilitating lesions that arise in individuals with pach

182 in membrane, and mutations in FA2H result in debilitating leukodystrophies and spastic paraparesis.

183 rious solid tumors, and in patients with the debilitating lung disease idiopathic pulmonary fibrosis

184 Cognitive decline is a debilitating manifestation of disease progression in Par

185 ociated ophthalmopathy (TAO) is a common and debilitating manifestation of Graves disease (GD).

186 s in patients with Krabbe disease is a major debilitating manifestation that worsens their quality of

187 more labile and suggest a strategy to modify debilitating memories.

188 sensitivity footpad-swelling reaction and in debilitating meningitis in mice of both the C57BL/6 and

189 raumatic stress disorder (PTSD) is a common, debilitating mental disorder that has been associated wi

190 Major depressive disorder (MDD) is a debilitating mental illness and a major cause of lost pr

191 Bipolar disorder (BD) is a debilitating mental illness associated with high costs t

192 et cognitive impairments in this chronic and debilitating mental illness.

193 ty are complex neurodevelopmental disorders, debilitating millions of people.

194 ifestations of Cushing's syndrome, including debilitating morbidities and increased mortality.

195 eripheral nerve sheath tumors that can cause debilitating morbidities.

196 This debilitating morbidity is attributed to axon demyelinati

197 ratory syncytial virus and those chronic and debilitating (mostly parasitic) infections known as negl

198 provide a promising new avenue to lessen the debilitating motor symptoms of HD.

199 s and tremor that is observed in dystonia, a debilitating movement disease.

200 DYT1 is a debilitating movement disorder caused by loss-of-functio

201 Isolated focal dystonia is a debilitating movement disorder of unknown pathophysiolog

202 ve fungal pathogen of humans, can cause both debilitating mucosal infections and fatal invasive infec

203 tis (ME)/chronic fatigue syndrome (CFS) is a debilitating multisystem condition affecting more than 1

204 on or its regenerative properties results in debilitating musculoskeletal disorders.

205 mosquito-transmitted alphavirus that causes debilitating musculoskeletal pain and inflammation and c

206 zeta induces Ca(2+) oscillations in eggs and debilitating mutations in the PLCZ1 gene are associated

207 tus and a mutation in human STAC3 causes the debilitating Native American myopathy (NAM), but the nat

208 Prism adaptation (PA) can reduce diverse debilitating neglect symptoms and it has been hypothesiz

209 Schistosomiasis is a debilitating neglected tropical disease, caused by flatw

210 Parkinson's disease is a highly debilitating neurodegenerative condition whose pathologi

211 Spinocerebellar ataxia type 7 (SCA7) is a debilitating neurodegenerative disease caused by expansi

212 Amyotrophic lateral sclerosis (ALS) is debilitating neurodegenerative disease characterized by

213 hic lateral sclerosis (ALS) is a progressive debilitating neurodegenerative disease, with a life expe

214 rials in humans afflicted with this chronic, debilitating neurodegenerative disease.

215 Expanded CAG repeats lead to debilitating neurodegenerative disorders characterized b

216 Angelman syndrome (AS) is a debilitating neurodevelopmental disorder caused by loss

217 Rett syndrome (RTT) is a debilitating neurodevelopmental disorder caused by mutat

218 an T-lymphotropic virus type 1) is a chronic debilitating neuroinflammatory disease with a predilecti

219 nergic inhibitory transmission underlies the debilitating neurological condition, hyperekplexia, whic

220 Migraine is among the most common and debilitating neurological conditions.

221 Migraine is a debilitating neurological disorder affecting around one

222 Rett syndrome (RS) is a debilitating neurological disorder affecting mostly girl

223 Rett syndrome (RTT) is a debilitating neurological disorder caused by mutations i

224 al cord injury (SCI) remains one of the most debilitating neurological disorders and the majority of

225 His clinical course was complicated by debilitating neurological symptoms and multiple hospital

226 age into mitochondria, a condition linked to debilitating neuromuscular disorders in humans.

227 opment or maintenance in adulthood result in debilitating neuromuscular disorders.

228 ns by anticancer pharmacotherapy, leading to debilitating neuropathic pain.

229 profile was suboptimal, including 5 cases of debilitating neuropathy and an unusually high angioedema

230 Many debilitating neuropsychiatric and neurodegenerative diso

231 resistant seizures; are often accompanied by debilitating neuropsychiatric and systemic comorbidities

232 Cocaine addiction is a debilitating neuropsychiatric disorder characterized by

233 Schizophrenia is a debilitating neuropsychiatric disorder typically diagnos

234 ering the root causes of a broad spectrum of debilitating neuropsychiatric disorders, including anxie

235 e that confers increased risk for a range of debilitating neuropsychiatric disorders.

236 Stroke is a highly debilitating, often fatal disorder for which current the

237 rtance as a largely unrecognized pathogen of debilitated older people is increasingly evident.

238 ity and could therefore be clinically lesser debilitating on long-term GC therapy.

239 older age groups, and patients have suffered debilitating or, in some cases, fatal long-term side eff

240 able gynecological disorder characterized by debilitating pain and the establishment of innervated en

241 nd effective final alternative to ameliorate debilitating pain and to help prevent the development of

242 Neuropathic pain is one of the most debilitating pain conditions, yet no therapeutic strateg

243 t metastasize to bone frequently suffer from debilitating pain, and effective therapies for treating

244 petite during sickness is a common and often debilitating phenomenon.

245 ngunya virus, and related alphaviruses cause debilitating polyarthralgia and myalgia.

246 ATA: HO in burns is an uncommon but severely debilitating problem with a poorly understood mechanism

247 in aggregates are a hallmark feature of many debilitating protein deposition diseases such as Alzheim

248 Posttraumatic stress disorder (PTSD) is a debilitating psychiatric disorder with a lifetime preval

249 me individuals succumb to stress and develop debilitating psychiatric disorders, whereas others adapt

250 Anxiety disorders are debilitating psychiatric illnesses with detrimental effe

251 immune signaling on the development of this debilitating psychological disorder is not known.

252 particularly susceptible with many suffering debilitating recurrent (r) infections.

253 treatments for diabetic nephropathy (DN), a debilitating renal complication.

254 ntrol and inevitability, personal relevance, debilitating repercussions, gaining awareness of risks,

255 igue in cancer patients, the most common and debilitating sequela associated with malignancy.

256 and neurodegeneration constitute clinically debilitating sequelae in demyelinating diseases such as

257 py-induced peripheral neuropathy (CIPN) is a debilitating side effect of many cancer treatments.

258 uropathic pain (CIPN) is a common and severe debilitating side effect of many widely used cytostatics

259 ation-induced pulmonary fibrosis (RIPF) is a debilitating side effect of radiation therapy (RT) of se

260 ation-induced pulmonary fibrosis (RIPF) is a debilitating side effect that occurs in up to 30% of tho

261 d available therapeutics are known to induce debilitating side effects.

262 ever, the treatment leads to a wide range of debilitating side effects.

263 anine (L-Dopa)-induced dyskinesia (LID), the debilitating side-effects of chronic dopamine replacemen

264 ne lesions, where bone is destroyed, lead to debilitating skeletal complications and increased patien

265 b1 gene expression; the former loss caused a debilitating skeletal phenotype, whereas the latter conf

266 l basis for the future understanding of this debilitating skin disease.

267 dysfunction of REM sleep mechanisms underlie debilitating sleep disorders such as REM sleep behaviour

268 The cachexia syndrome is a debilitating state of cancer that is, at least in part,

269 n (10%), gastrointestinal bleeding (8%), and debilitating stroke (modified Rankin Score > 3) (8%).

270 Hot flashes are a common and debilitating symptom among survivors of breast cancer.

271 Poststroke fatigue is a debilitating symptom and is poorly understood.

272 Mechanical hypersensitivity is a debilitating symptom for millions of chronic pain patien

273 Working memory dysfunction is an especially debilitating symptom in schizophrenia.

274 Cough can be a debilitating symptom of idiopathic pulmonary fibrosis (I

275 Anxiety is a debilitating symptom of most psychiatric disorders, incl

276 ase, chronic liver disease) commonly develop debilitating symptoms (i.e., sickness behaviors) that ar

277 incidents can lead to persistent, long-term debilitating symptoms and in some cases a progressive ne

278 iated with antitumour activity and relief of debilitating symptoms in patients with advanced colorect

279 egaly, cytopenias, bone marrow fibrosis, and debilitating symptoms including fatigue, weight loss, an

280 Serious and debilitating symptoms of anxiety are the most common men

281 inflammatory liver disease commonly develop debilitating symptoms, called sickness behaviors, which

282 PFC), but there are few treatments for these debilitating symptoms.

283 effective treatment in controlling otherwise debilitating symptoms.

284 Heart failure is a common, costly, and debilitating syndrome that is associated with a highly c

285 mt)DNA mutations can cause fatal or severely debilitating syndromes in children, with disease severit

286 linical symptom for many of the world's most debilitating syndromes.

287 Staphylococcus aureus enterotoxins cause debilitating systemic inflammatory responses, but how th

288 disorders, including psoriasis, a common and debilitating T-cell-driven disorder characterized by thi

289 Thirty-two patients with debilitating tinnitus were prospectively enrolled, and q

290 (OM) is among the most common, painful, and debilitating toxicities of cancer regimen-related treatm

291 Neuropathy is a debilitating toxicity associated with various chemothera

292 ed a screen for genes whose loss-of-function debilitated TP53 signaling and enabled oncogenic transfo

293 ress disorder (PTSD) is both a prevalent and debilitating trauma-related disorder associated with dys

294 tic stress disorder (PTSD), characterized by debilitating trauma-related intrusive thoughts, avoidanc

295 rtion of women with schizophrenia experience debilitating treatment-refractory symptoms.

296 Schistosomiasis is a debilitating tropical disease caused by infection with p

297 r the treatment of many life-threatening and debilitating vascular disorders.

298 he brain and spinal cord, leading to fatally debilitating weakness.

299 ut termination of opiate therapy can cause a debilitating withdrawal syndrome in chronic users.

300 Duchenne muscular dystrophy (DMD) is a debilitating X-linked disorder that is fatal.