ライフサイエンスコーパス: decapentaplegic

1 stabilizing Cubitus interruptus and inducing decapentaplegic.

2 ling by the bone morphogenetic protein (BMP) Decapentaplegic.

3 lium of a second signal, which we suggest is Decapentaplegic.

4 ted downstream of the action of Wingless and Decapentaplegic.

5 the positional cues encoded by wingless and decapentaplegic.

6 ownstream target genes including patched and decapentaplegic.

7 the vgQE acting in concert with Wingless and Decapentaplegic.

8 wo locally produced morphogens: Wingless and Decapentaplegic.

9 in the 3-4 intervein region independently of Decapentaplegic.

10 s in the GSTFs Suppressor of Mothers Against Decapentaplegic 2 (SMAD2) and SMAD4 are frequently assoc

11 sion and derepression of SMA mothers against decapentaplegic 2/3 signaling and was confirmed with qua

12 like kinase 1, endoglin, and mothers against decapentaplegic 9.

13 ave implicated glypicans in the signaling of decapentaplegic, a BMP homolog.

14 ous glycosaminoglycan/HSPG-binding morphogen Decapentaplegic-a transforming growth factor beta-like D

15 Decapentaplegic, acting through its receptor Thick veins

16 g) signaling protein and a subset of Wg- and Decapentaplegic-activated genes such as spalt-related, v

17 s that increase or reduce Notch, veinlet and decapentaplegic activities suggest that the maintenance

18 ile eyeless transcription does not depend on decapentaplegic activity, the expression of eyes absent,

19 ess-regulated genes nubbin, Distal-less, and decapentaplegic and a minimal enhancer from the Ultrabit

20 isc cells mutant for either gene can express decapentaplegic and atonal in response to Hedgehog signa

21 ates dorsal air sac development by producing decapentaplegic and fibroblast growth factor that travel

22 We also show that signaling by Decapentaplegic and Hedgehog normally blocks the posteri

23 ulated by the signalling molecules Wingless, Decapentaplegic and Hedgehog.

24 targets such as argos, ventral veinless and decapentaplegic and leads to formation of extra vein tis

25 The Decapentaplegic and Notch signaling pathways are thought

26 rstood regulatory network with the Hedgehog, Decapentaplegic and Notch signaling pathways to control

27 ts from three signalling pathways: wingless, decapentaplegic and Notch/Suppressor of Hairless.

28 , they are regulated by the secreted protein Decapentaplegic and participate in the positioning of th

29 hat initiation requires both the presence of decapentaplegic and the absence of wingless, which inhib

30 l-1 gene, a C. elegans homolog of Drosophila decapentaplegic and vertebrate BMP genes.

31 sed in complementary domains, while patched, decapentaplegic and wingless are expressed along the bor

32 while the quadrant enhancer responds to the Decapentaplegic and Wingless morphogen gradients emanati

33 d size modulates the interaction between the Decapentaplegic and Wingless pathways, thereby linking p

34 Signaling by the secreted hedgehog, decapentaplegic and wingless proteins organizes the patt

35 sophila endoderm is patterned by the signals Decapentaplegic and Wingless secreted from the visceral

36 that HS sulfation compensation rescues both Decapentaplegic and Wingless signaling, suggesting a uni

37 dedicated activator alleles fail to repress decapentaplegic and zerknullt in the syncytial blastoder

38 unctions as a dedicated repressor, silencing decapentaplegic and zerknullt while failing to activate

39 twist and snail and repressing genes such as decapentaplegic and zerknullt.

40 al role: to activate an effector, encoded by decapentaplegic, and an element of negative feedback reg

41 altered expression patterns of the wingless, decapentaplegic, and bric-a-brac genes.

42 molecules, including Hedgehog, Wingless, and Decapentaplegic, and how these define a proximodistal ax

43 nterruptus, branchless, breathless, sprouty, decapentaplegic, and mad are functionally conserved betw

44 e actions of factors downstream of wingless, decapentaplegic, and ras to generate the eve pattern.

45 However, here we show that wingless and decapentaplegic are not required throughout all of proxi

46 e Drosophila eye imaginal disc; hedgehog and decapentaplegic are required for differentiation to init

47 e secreted proteins, Hedgehog, Wingless, and Decapentaplegic, are expressed in the PM, yet they contr

48 rphogens Nodal, fibroblast growth factor and Decapentaplegic as case studies.

49 Here, we show that Decapentaplegic/bone morphogenetic protein (Dpp/BMP) sig

50 The role of Decapentaplegic/Bone morphogenetic protein (Dpp/BMP) sig

51 dependently regulated by hyperplastic discs; decapentaplegic can still be misexpressed in cells mutan

52 el of expression of genes responsive to Dpp (Decapentaplegic) caused by ectopic expression of the typ

53 Wnt and Decapentaplegic cell signaling pathways act synergistica

54 by which a general patterning signal such as Decapentaplegic cooperates reiteratively with tissue-spe

55 tic proteins (BMPs) composed of two ligands, decapentaplegic (Dpp) a BMP2/4 ortholog and screw (Scw)

56 ll-studied example is the Drosophila protein decapentaplegic (DPP) acting in the wing disc.

57 genetic evidence suggests that a gradient of Decapentaplegic (Dpp) activity determines distinct cell

58 A gradient of Decapentaplegic (Dpp) activity subdivides the dorsal ect

59 orming growth factor beta (TGF-beta) homolog Decapentaplegic (Dpp) acts as a morphogen that forms a l

60 orming Growth Factor-beta superfamily member decapentaplegic (dpp) acts as an extracellular morphogen

61 While Decapentaplegic (Dpp) acts downstream of Ras to maintain

62 ary for the maintenance of the expression of decapentaplegic (dpp) and becomes essential for vein dif

63 ade cytonemes that responded specifically to Decapentaplegic (Dpp) and cells in eye discs made cytone

64 interactions among the genes wingless (wg), decapentaplegic (dpp) and distalless (dll).

65 ied during the pupal stage by Wingless (Wg), Decapentaplegic (Dpp) and Drosophila EGF Receptor (DER)

66 ophila dorsal air sac development depends on Decapentaplegic (Dpp) and Fibroblast growth factor (FGF)

67 Two BMP-like molecules, Decapentaplegic (DPP) and Glass bottom boat, can mediate

68 We have analyzed the function of the Decapentaplegic (Dpp) and Hedgehog (Hh) signaling pathwa

69 is genetically dependent on the presence of Decapentaplegic (Dpp) and Hedgehog receptors.

70 etermination and morphogenesis of the CC are decapentaplegic (dpp) and its antagonist short gastrulat

71 g disc cells normally express high levels of decapentaplegic (dpp) and its downstream target, optomot

72 In this paper, we show that Decapentaplegic (DPP) and JNK form a coherent FFL that c

73 Hedgehog (Hh), Decapentaplegic (Dpp) and Notch (N) signaling all contri

74 sterior margin to maintain the expression of decapentaplegic (dpp) and of the proneural gene atonal.

75 uires transport of a heterodimer of the BMPs Decapentaplegic (Dpp) and Screw (Scw) in a protein shutt

76 the bone morphogenetic protein (BMP) family, Decapentaplegic (Dpp) and Screw (Scw), are broadly trans

77 of the Drosophila blastoderm embryo requires Decapentaplegic (Dpp) and Screw (Scw), two BMP family me

78 unction of Tld is to augment the activity of Decapentaplegic (Dpp) and Screw (Scw), two members of th

79 tic signaling between the BMP family members Decapentaplegic (DPP) and Screw (SCW).

80 dient of two TGF(&bgr;) signaling molecules, Decapentaplegic (Dpp) and Screw (Scw).

81 expression of Hh-responsive genes including decapentaplegic (dpp) and wg.

82 is induced in response to the Hedgehog (Hh), Decapentaplegic (Dpp) and Wingless (Wg) morphogens.

83 ved signaling molecules encoded by the genes decapentaplegic (dpp) and wingless (wg) play key roles.

84 cific enhancer elements which are targets of Decapentaplegic (Dpp) and Wingless (Wg) signaling, respe

85 and Wnt signalling from sources of ligands, Decapentaplegic (Dpp) and Wingless (Wg), in dorsal and v

86 res the cooperation of two secreted signals, Decapentaplegic (Dpp) and Wingless (Wg), to form the pro

87 elopment of the Drosophila leg requires both Decapentaplegic (Dpp) and Wingless (Wg), two signals tha

88 ol of the secreted morphogens Hedgehog (Hh), Decapentaplegic (Dpp) and Wingless (Wg).

89 targets such as the signaling molecule genes decapentaplegic (dpp) and wingless (wg).

90 ila is mediated by the extracellular signals Decapentaplegic (Dpp) and Wingless (Wg).

91 terior compartment to express the morphogens Decapentaplegic (Dpp) and Wingless (Wg).

92 liferation through secretion of the mitogens Decapentaplegic (Dpp) and Wingless (Wg).

93 merous studies have shown that it influences Decapentaplegic (Dpp) and Wingless signaling.

94 n the Drosophila leg disc, wingless (wg) and decapentaplegic (dpp) are expressed in a ventral-anterio

95 naling in the posterior crossvein depends on Decapentaplegic (Dpp) at a stage when it is being produc

96 We demonstrate that Wingless (Wg) and Decapentaplegic (Dpp) confer competence for receptor tyr

97 The Drosophila TGF-beta family member decapentaplegic (dpp) contributes to the development of

98 cell clones deprived of the BMP-like ligand Decapentaplegic (DPP) do not die as previously thought b

99 iation is to alleviate repression of eya and decapentaplegic (dpp) expression by the zinc-finger tran

100 nalysis shows that Lsd1 functions to repress decapentaplegic (dpp) expression in adult germaria.

101 During germ band elongation, widespread decapentaplegic (dpp) expression in the dorsal ectoderm

102 Activation of decapentaplegic (dpp) expression in the posterior eye di

103 The decapentaplegic (dpp) gene directs numerous developmenta

104 tion is dependent upon the activation of the decapentaplegic (dpp) gene in a stripe of cells just ant

105 The decapentaplegic (dpp) gene influences many developmental

106 The Drosophila decapentaplegic (dpp) gene, encoding a secreted protein

107 The decapentaplegic (dpp) gene, which encodes a transforming

108 ation of a natural Ubx molecular target, the decapentaplegic (dpp) gene, within the embryonic mesoder

109 The short gastrulation (sog) and decapentaplegic (dpp) genes function antagonistically in

110 tes the patched (ptc), gooseberry (gsb), and decapentaplegic (dpp) genes.

111 Although the Drosophila embryonic Decapentaplegic (Dpp) gradient has served as a model to

112 on has come from a variety of studies of the Decapentaplegic (Dpp) gradient of the Drosophila larval

113 The BMP-related ligand Decapentaplegic (Dpp) has a well-characterized role in p

114 The Drosophila TGFbeta family member Decapentaplegic (DPP) has been proposed to function as a

115 er, NS cleavage was required in vivo for Gbb-Decapentaplegic (Dpp) heterodimer-mediated wing vein pat

116 beta)-related signalling proteins, including Decapentaplegic (Dpp) in Drosophila-and bone morphogenic

117 The gradient of Decapentaplegic (Dpp) in the Drosophila wing has served

118 analyzing the role of the BMP family member decapentaplegic (dpp) in the process of head formation,

119 decapentaplegic (dpp) is a direct target of Ultrabithora

120 Decapentaplegic (Dpp) is a Drosophila member of the Tran

121 decapentaplegic (dpp) is a Transforming Growth Factor be

122 F-beta superfamily member and BMP orthologue Decapentaplegic (Dpp) is crucial for multiple developmen

123 In Drosophila, a BMP-related ligand Decapentaplegic (Dpp) is essential for cell fate specifi

124 and the transforming growth factor-beta gene decapentaplegic (dpp) is expressed in an asymmetric fash

125 rphogenetic protein 2/4 (BMP2/4)-like ligand Decapentaplegic (Dpp) is proposed to form a long-range s

126 Here we show that the BMP2/4 homolog decapentaplegic (dpp) is specifically required to mainta

127 hin the cis-regulatory heldout region of the decapentaplegic (dpp) locus in Drosophila melanogaster.

128 The product of the Drosophila decapentaplegic (dpp) locus is a well-characterized memb

129 The Decapentaplegic (DPP) morphogen controls growth in the D

130 Here, we present evidence that the decapentaplegic (Dpp) morphogen distribution in the deve

131 ial for proper interpretation of the zygotic Decapentaplegic (Dpp) morphogen gradient that patterns t

132 oll, and dorsal mutants, but is unaltered in decapentaplegic (dpp) or punt mutants, suggesting that t

133 polarise abdominal cells by utilising either Decapentaplegic (Dpp) or Wingless (Wg), the two morphoge

134 ignaling molecules such as Wingless (Wg) and Decapentaplegic (Dpp) organize positional information al

135 lio (pum) or for signaling components of the decapentaplegic (dpp) pathway also differentiate.

136 , the secreted signaling molecule encoded by decapentaplegic (dpp) prevents activation of salivary gl

137 to study the extracellular dispersal of the Decapentaplegic (Dpp) protein and show that the Dpp grad

138 sponse to the Drosophila BMP 2/4-like ligand Decapentaplegic (DPP) serves as one of the best-studied

139 rosophila gene zen, which is a target of the Decapentaplegic (Dpp) signaling pathway during cellular

140 tterning through regulation of the conserved Decapentaplegic (Dpp) signaling pathway.

141 rning, and members of both Hedgehog (Hh) and Decapentaplegic (Dpp) signaling pathways, which promote

142 MAD plays an important role in decapentaplegic (DPP) signaling throughout Drosophila de

143 Mothers against dpp (Mad) mediates Decapentaplegic (DPP) signaling throughout Drosophila de

144 mutations in sotv and ttv impair Hh, Wg and Decapentaplegic (Dpp) signaling.

145 to the domain in which the Wingless (WG) and Decapentaplegic (DPP) signals are active.

146 During germ-band extension, Decapentaplegic (Dpp) signals from the dorsal ectoderm t

147 The finding that Wingless (WG) and Decapentaplegic (DPP) suppress each others transcription

148 gurken (grk), oskar (osk), bicoid (bcd), and decapentaplegic (dpp) transcripts are normal, with a sli

149 transforming growth factor-beta-related gene decapentaplegic (dpp) was required for the synchronizati

150 Decapentaplegic (Dpp), a BMP2/4 homologue, has been post

151 We find that Decapentaplegic (Dpp), a Bone Morphogenetic Protein (BMP

152 Decapentaplegic (Dpp), a Drosophila homologue of bone mo

153 Signaling by decapentaplegic (Dpp), a Drosophila member of the transf

154 Decapentaplegic (Dpp), a Drosophila morphogen signaling

155 aster female germline stem cell (GSC) niche, Decapentaplegic (Dpp), a fly transforming growth factor

156 Decapentaplegic (Dpp), a homolog of vertebrate bone morp

157 ryos is specified by an activity gradient of Decapentaplegic (Dpp), a homologue of bone morphogenetic

158 Decapentaplegic (Dpp), a member of the transforming grow

159 of a number of downstream targets, including decapentaplegic (dpp), a TGFbeta homolog.

160 ng is required for the correct expression of decapentaplegic (dpp), a Transforming Growth Factor (bet

161 p vector and generated two unique alleles of decapentaplegic (dpp), a transforming growth factor-beta

162 The first signal, Decapentaplegic (Dpp), acts at long range on undifferent

163 Previous studies have shown that the Dorsal, Decapentaplegic (Dpp), and EGF receptor (Egfr) signaling

164 ing the signaling pathways Hedgehog (Hh) and Decapentaplegic (Dpp), and more recently downstream comp

165 la development, including the hedgehog (hh), decapentaplegic (dpp), and Toll pathways.

166 proteins (BMPs), including the fly homologue Decapentaplegic (DPP), are important regulators of early

167 y role in signaling by the Bmp2/Bmp4 homolog Decapentaplegic (Dpp), by forming a Shn/Smad repression

168 The Drosophila BMP, decapentaplegic (dpp), controls morphogenesis of the ven

169 , which are controlled by the convergence of Decapentaplegic (Dpp), fibroblast growth factor (FGF), W

170 two TGF-beta superfamily members, dawdle and decapentaplegic (dpp), in response to wounding and infec

171 signaling through a Drosophila BMP homolog, Decapentaplegic (Dpp), is disrupted.

172 axis formation, including wingless (wg) and decapentaplegic (dpp), is required for allocating and pa

173 gless (wg) expression at the margins induces decapentaplegic (dpp), optomotor blind (omb), and arista

174 regulates the transcription of target genes decapentaplegic (dpp), patched (ptc) and engrailed (en)

175 by bone morphogenetic protein 4 (BMP-4) and Decapentaplegic (Dpp), respectively.

176 rtebrate bone morphogenetic proteins (BMPs): Decapentaplegic (Dpp), Screw, and Glass bottom boat-60A.

177 Decapentaplegic (Dpp), secreted along the dorsal midline

178 rphogenetic Protein (BMP) signaling pathway, Decapentaplegic (Dpp), specifically in the Class IV mult

179 e Morphogenetic Protein (BMP) ligand family, Decapentaplegic (Dpp), sustains ovarian GSCs by suppress

180 In Drosophila, Decapentaplegic (Dpp), the BMP2/4 homolog, downregulates

181 decapentaplegic (dpp), the Drosophila homolog of human b

182 eins are intracellular signal transducers of decapentaplegic (dpp), the Drosophila transforming growt

183 74, a visceral mesoderm-specific enhancer of decapentaplegic (dpp), to investigate functional dominan

184 ationship with the Drosophila BMP2/4 homolog decapentaplegic (dpp), we have used clonal analysis to d

185 action of two morphogens, Hedgehog (Hh) and Decapentaplegic (Dpp), which act sequentially to organiz

186 umnar epithelia requires the secreted signal Decapentaplegic (DPP), which also acts as a gradient mor

187 o also require the Drosophila BMP2/4 homolog decapentaplegic (dpp), while others do not.

188 rning, we have analyzed a Hedgehog (Hh)- and Decapentaplegic (Dpp)-responsive enhancer of the h gene,

189 h overexpression of either unpaired (upd) or decapentaplegic (dpp).

190 nscription and the mobility of the morphogen Decapentaplegic (Dpp).

191 ates MAD and inhibits signal transduction of Decapentaplegic (DPP).

192 ress the secretory factors wingless (wg) and decapentaplegic (dpp).

193 s including Wingless (Wg), Hedgehog (Hh) and Decapentaplegic (Dpp).

194 NK-regulated expression of the BMP4 ortholog Decapentaplegic (Dpp).

195 ticularly those encoded by wingless (wg) and decapentaplegic (dpp).

196 he pattern formation genes wingless (wg) and decapentaplegic (dpp).

197 re embryos null for the TGF-beta-like ligand decapentaplegic (dpp).

198 , which in turn induces the transcription of decapentaplegic (dpp).

199 creted signaling molecules Wingless (Wg) and Decapentaplegic (Dpp).

200 d by morphogens such as the TGF-beta homolog Decapentaplegic (DPP).

201 f two secreted morphogens, Wingless (Wg) and Decapentaplegic (Dpp).

202 nctions as an antagonist of the signaling of decapentaplegic (Dpp)/bone morphogenetic protein (BMP) i

203 Here, we report that Decapentaplegic (Dpp; a Drosophila BMP family member) pl

204 y expressed signaling molecules Hedgehog and Decapentaplegic drive photoreceptor differentiation in t

205 the homolog of the gene for mothers against decapentaplegic, Drosophila, (MADH4, also known as SMAD4

206 ver-producing the BMP4-like stem cell signal Decapentaplegic efficiently convert into single stem-lik

207 y to operate through the conventional Notch, Decapentaplegic, EGF or FGF transduction pathways, or to

208 gless signaling is also required to activate decapentaplegic expression and to coordinate cell shape

209 yegone are required for normal activation of decapentaplegic expression at the posterior and lateral

210 rmation is indeed controlled at the level of Decapentaplegic expression but critical steps in regiona

211 motes dorsal closure, in part, by regulating decapentaplegic expression in the dorsal epidermis.

212 ial entry into host cells, ACP competes with Decapentaplegic for binding to glycosaminoglycans/HSPGs

213 noglycan-binding domain of ACP competed with Decapentaplegic for binding to the soluble glycosaminogl

214 ithelium or loss of the BMP signaling ligand decapentaplegic from visceral muscle resulted in phenoty

215 This signal depends upon decapentaplegic function.

216 sophila gene termed MAD (mothers against the decapentaplegic gene).

217 Decapentaplegic has long been thought to be a morphogen

218 e bone morphogenetic protein-mothers against decapentaplegic homolog (Bmp-Smad) pathway is upregulate

219 eptor-mediated activation of Mothers Against Decapentaplegic homolog (SMAD) proteins, although altern

220 amined for EMT and the small mothers against decapentaplegic homolog (Smad), phosphatidylinositol-3-k

221 , and upregulated Similar to Mothers Against Decapentaplegic homolog (Smad)2/3 phosphorylation in und

222 eukin-6 (IL-6) by effects on mothers against decapentaplegic homolog (Smad)4 or signal transducer and

223 Mothers against decapentaplegic homolog (Smad3) inhibited both CYP7A1 pr

224 hat protein levels of SMAD1 (mothers against decapentaplegic homolog 1) and BAG-4/SODD were strongly

225 nces nuclear accumulation of mothers against decapentaplegic homolog 2 (Smad2) in embryonic cells.

226 ferentiation and blocking of mothers against decapentaplegic homolog 2 (SMAD2) signaling in MDLC rest

227 F-beta by inducing the small mothers against decapentaplegic homolog 3 (SMAD3) nuclear translocation

228 nse elements), NFkappaB, and mothers against decapentaplegic homolog 3 (SMAD3) promoters were created

229 ROM1pos cells with activated Mothers Against Decapentaplegic Homolog 3 (SMAD3) signaling in associati

230 ein expression of CCN1 via a mothers against decapentaplegic homolog 3 (SMAD3)-dependent mechanism.

231 egulation of CD25 in a small mothers against decapentaplegic homolog 3 (Smad3)-dependent mechanism.

232 effects by deactivating the mothers against decapentaplegic homolog 3 (Smad3)/Smad4 transcription co

233 ing galectin-1 (Lgals1), and mothers against decapentaplegic homolog 3 or Smad3, both previously impl

234 LOXL2 transcription through mothers against decapentaplegic homolog 4 (Smad4), whereas two frequentl

235 homologs 2 and 3 and common mothers against decapentaplegic homolog 4, alpha-smooth muscle actin, CD

236 nd tensin homolog (PTEN) and mothers against decapentaplegic homolog 7 (SMAD7) were subsequently iden

237 in ligase SMURF2, and SMAD7 (mothers against decapentaplegic homolog 7) genes and proteins.

238 s approach identified Smads (mothers against decapentaplegic homolog), the key TGFbeta signaling mole

239 , which negatively regulates mothers against decapentaplegic homolog-3 (Smad3)-initiated production o

240 n deposition, phosphorylated mothers against decapentaplegic homologs 2 and 3 and common mothers agai

241 entified known genes, including hedgehog and decapentaplegic, implicated in these processes.

242 n of Wingless target genes Ultrabithorax and decapentaplegic in the mesoderm and labial in the endode

243 ns of Dally and Dally-like with Wingless and Decapentaplegic in the third-instar Drosophila wing disc

244 nvestigated the role of the TGF-beta homolog decapentaplegic in this pathway.

245 erm-line cells or the overexpression of Dpp (decapentaplegic) in ovarian somatic cells.

246 Ectopic expression of Decapentaplegic induces extra macrochaetes only in cells

247 It is shown that decapentaplegic is expressed in the pupal veins under th

248 tive TCF blocks them, and a known Wg target, decapentaplegic, is activated in double mutant clones, s

249 ation of the Drosophila Smad Mothers against Decapentaplegic (Mad) as the readout, we carried out a w

250 red for dephosphorylation of Mothers against Decapentaplegic (MAD), a Drosophila Smad.

251 stabilizes the SMAD protein Mothers against decapentaplegic (Mad), facilitates its phosphorylation,

252 role for Merlin and Expanded specifically in Decapentaplegic-mediated differentiation events.

253 gnaling molecules and Class III genes encode Decapentaplegic-mediated signaling molecules.

254 ription factor Cubitus interruptus can block decapentaplegic misexpression but not hedgehog misexpres

255 culis and dachshund are greatly reduced in a decapentaplegic mutant background.

256 argets co-regulated by Eyeless and Hedgehog, Decapentaplegic or Notch.

257 By contrast, perturbation of Decapentaplegic or Wingless signaling failed to affect R

258 sing a mutant, non-glycosaminoglycan-binding Decapentaplegic, or the other endogenous glycosaminoglyc

259 We show that Tsg binds both the vertebrate Decapentaplegic orthologue BMP4 and chordin, and that th

260 gnition proteins and antimicrobial peptides, Decapentaplegic overexpression suppressed transcription

261 sphatase that functions in Drosophila in the Decapentaplegic pathway and in mammalian cells in the BM

262 lays antagonistic interactions with the DPP (decapentaplegic) pathway, which regulates branching alon

263 this pathway, phosphorylated mothers against decapentaplegic (pMAD), was reduced.

264 e phosphorylated form of the mothers against decapentaplegic proteins (pSMAD1/5), and transcriptomic

265 sed phosphorylation of small mothers against decapentaplegic proteins.

266 ype II serine/threonine kinase TGF-beta/Dpp (Decapentaplegic) receptor.

267 hSmad (mothers against decapentaplegic)-related proteins are important messenge

268 Overlapping Mad sites predominate in decapentaplegic response elements, consistent with a hig

269 direct transcriptional targets of the early Decapentaplegic/Screw patterning gradient, to establish

270 in the regulation of tkv gene expression and Decapentaplegic signal transduction that are essential f

271 entiation downstream of the reception of the decapentaplegic signal.

272 gaster JUN N-terminal kinase (DJNK) and DPP (decapentaplegic) signal transduction pathways coordinate

273 We also show that decapentaplegic signaling acts synergistically with and

274 r Eyeless expression and in combination with Decapentaplegic signaling can promote its downregulation

275 wingless and decapentaplegic signaling establishes the proximal-dista

276 saminoglycan synthesis regulate Wingless and Decapentaplegic signaling in Drosophila, and body size i

277 We also provide evidence that decapentaplegic signaling may posttranslationally regula

278 genetic protein (BMP)-son of mothers against decapentaplegic signaling pathway and inhibited by ineff

279 ctions among these QTL with the Hedgehog and Decapentaplegic signaling pathways, which are important

280 rphogenetic protein /sons of mothers against decapentaplegic signaling with no evident adverse effect

281 e existence of redundant mechanisms to block Decapentaplegic signaling.

282 events are independent of hh, wingless, and decapentaplegic signaling.

283 l-family member Escargot and, in subdomains, Decapentaplegic signaling.

284 tkv), which encodes a type I receptor of the Decapentaplegic-signaling pathway.

285 signalling pathways, including Hedgehog and Decapentaplegic signalling.

286 che requiring adhesive stromal cap cells and Decapentaplegic signals.

287 nterior in a wave driven by the Hedgehog and Decapentaplegic signals.

288 ization of activated sons of mothers against decapentaplegic (Smad) and increased the nuclear pool of

289 rphogenetic protein 6 (BMP6)/mothers against decapentaplegic (SMAD) homolog signaling, the main pathw

290 enetic protein (BMP)/sons of mothers against decapentaplegic (SMAD) pathway target genes, a key pathw

291 Small mothers against decapentaplegic (SMAD) proteins are a family of signal t

292 phogenic protein (BMP)/small mothers against decapentaplegic (Smad) signaling cascade is central to t

293 Because activation of small mothers against decapentaplegic (Smads) 2/3 is critical for myofibroblas

294 us, organized by the morphogens Wingless and Decapentaplegic, suppress Warts by acting via the atypic

295 ion and its downstream targets, particularly decapentaplegic the Drosophila TGFbeta homolog, suggests

296 ervein cell development, including rhomboid, decapentaplegic, thick veins, and blistered, suggesting

297 headcase, plexus, kohtalo, crumbs, hedgehog, decapentaplegic, thickveins, saxophone, and Mothers agai

298 the bone morphogenetic protein 2/4 homolog, decapentaplegic, to allow progenitors to divide in an un

299 or, acts by activating SMAD (mothers against decapentaplegic) transcription factors, which bind to SM

300 known and novel components of the Hedgehog, Decapentaplegic, Wingless, Epidermal growth factor recep