ライフサイエンスコーパス: decarboxylate

1 and 3-indolepyruvate, respectively) and then decarboxylated.

2 nd subsite to the first subsite, where it is decarboxylated.

3 ydroxybenzoate, which is then prenylated and decarboxylated.

4 xide via an intermediate that is oxidatively decarboxylated.

5 ted that the clavulanic acid intermediate is decarboxylated.

6 ce, the ability of the D37A mutant enzyme to decarboxylate 2'-deoxyOMP was measured.

7 The enzyme did not decarboxylate 2-hydroxybenzoate, 3-hydroxybenzoate, 4-hy

8 t the parental NTera-2 teratocarcinoma line, decarboxylate [2-(15)N]glutamine to form gamma-[15N]amin

9 reby T. pseudonana produces and subsequently decarboxylates a C4 acid via PEPC2 and PYC, respectively

10 RG1 protein and identified its cis-aconitate decarboxylating activity in an enzymatic assay.

11 We show that the NAD(+)-dependent decarboxylating activity is contained in the 360 amino a

12 sely proportional to intracellular levels of decarboxylated AdoMet (dcAdoMet).

13 ng to reduction of a Schiff base adduct with decarboxylated AdoMet.

14 vity, whole cells of the mutant were able to decarboxylate alpha-[U-(14)C]ketoglutarate and [U-(14)C]

15 nent of mammalian multienzyme complexes that decarboxylate alpha-ketoacids and catabolize glycine.

16 A DisA-dependent decarboxylated amino acid may inhibit the formation of a

17 lar to amino acid decarboxylases, a panel of decarboxylated amino acids was tested for effects simila

18 anthraquinone carboxylic acid (DMAC) and its decarboxylated analog, aloesaponarin.

19 hydroindolizine-8-carboxylate as well as its decarboxylated analogue, 6-(2-bromophenylamino)-2,3-dihy

20 opylamine (3MTP) and isoamylamine (IAA), the decarboxylated analogues of methionine and leucine, usin

21 also employed this high-energy ionization to decarboxylate and analyze PFCAs by MS/MS (for the first

22 However, because pro-OCN is not efficiently decarboxylated and activated during bone resorption, ina

23 previously shown that several thyronamines, decarboxylated and deiodinated metabolites of the thyroi

24 Blue102 is cleaved out from the chromophore, decarboxylated and remains attached to the preceding Phe

25 phosphorylation, this precursor is oxidized, decarboxylated and then reductively thiolated to form Co

26 rial type III polyketide synthase (PKS) that decarboxylates and condenses four malonyl-CoA molecules

27 influenced by a tumor's capacity to take up, decarboxylate, and store amine precursors.

28 xanoyl-CoA and glutaramyl-CoA, which are not decarboxylated, are modestly affected by the mutations.

29 orporating d isomers at the P8 position or a decarboxylated arginine mimetic, we obtained analogues w

30 Like L-arginine, agmatine (decarboxylated arginine) also activated NO synthesis, ho

31 ne ureohydrolase enzyme to convert agmatine (decarboxylated arginine) into putrescine.

32 enzymes catalyze the conversion of agmatine (decarboxylated arginine) to N-carbamoyl putrescine and a

33 The distribution of agmatine (decarboxylated arginine) was mapped in the central nervo

34 lished that agmatine, an endogenously formed decarboxylated arginine, is a weak competitive inhibitor

35 nce response of Escherichia coli operates by decarboxylating arginine.

36 n to its principal functions, BAL can slowly decarboxylate aromatic amino acids such as benzoylformic

37 n, although uncharged 1-methylorotic acid is decarboxylated at a similar rate.

38 four of the substrate acetate groups can be decarboxylated at the same catalytic center.

39 , and report that, in vitro, AAO oxidatively decarboxylates auxin, suggesting a mechanism for regulat

40 generation of red fluorescent proteins and 6-decarboxylated betaxanthin pigments.

41 e tumor models via LAT1 transport but is not decarboxylated by AADC.

42 This compound is decarboxylated by ClaH to yield emodin, which is then co

43 The 10-carboxyl group was readily decarboxylated by heating in DMSO at temperatures of 110

44 so obtained were saponified and then readily decarboxylated by heating in Me2SO solution to provide t

45 Thialysine is, in turn, decarboxylated by lysine decarboxylase, releasing CO2 th

46 acid side-chains attached to C12 and C18 are decarboxylated by sirohaem decarboxylase, a heterodimeri

47 chain of Tyr(147) stabilizes the enolate of decarboxylated C(4) keto species ((2)H(1) half-chair) th

48 make Fe-coproporphyrin (coproheme), and then decarboxylate coproheme to generate protoheme.

49 hyl-1,4-dihydro-2,4,6-trimethyl-3,5-pyridine decarboxylate (DDC) for 10 weeks followed by 1 month of

50 The enzymes of the beta-decarboxylating dehydrogenase superfamily catalyze the o

51 ) is a member of a family of metal-dependent decarboxylating dehydrogenases.

52 building block of the pigment instead of the decarboxylated derivative (DHI)?

53 recarboxylates with ease; in contrast, OXA-1 decarboxylates easily but recarboxylates with difficulty

54 that PQQ forms stable hydrated carbonyls and decarboxylates easily.

55 ne moiety as a pyridoxal phosphate-dependent decarboxylating enzyme that uses branched-chain amino ac

56 ure methods have been used for assaying many decarboxylating enzymes including hydroxylation-coupled

57 Decarboxylated factor X in which the Gla residues were c

58 r factor Xa and approximately 1.5 microM for decarboxylated factor Xa.

59 Each variant was screened for its ability to decarboxylate five different substrates, i.e., benzoylfo

60 extracellular region with its intracellular decarboxylated form, agmatine (Agm(2+)).

61 man spectra obtained from nonilluminated and decarboxylated forms of wild-type GFP has provided furth

62 n process, which ionizes the chromophore and decarboxylates Glu-222, mimics the electrostatic and str

63 However, this mutant dehydrogenase decarboxylates glutaconyl-CoA to crotonyl-CoA without ox

64 central metabolism via beta-oxidation, a non-decarboxylating glutaryl-CoA dehydrogenase and a subsequ

65 gene, GLDPA, encodes the P-subunit of GDC, a decarboxylating Gly dehydrogenase.

66 GLDC) acts in the glycine cleavage system to decarboxylate glycine and transfer a one-carbon unit int

67 It remains to be determined where PS is decarboxylated in mitochondria and whether decarboxylati

68 inones are ring-opened by lithium iodide and decarboxylated in the presence of a mild proton source.

69 t increases, the ability of the NHC-CO(2) to decarboxylate increases.

70 resulting from incorrect protonation of the decarboxylated intermediate at the C4' position.

71 initial substrates and the various partially decarboxylated intermediates to be bound with equivalent

72 Isocitrate dehydrogenases, IDH1 and IDH2, decarboxylate isocitrate to alpha-ketoglutarate (alpha-K

73 thesize (3)H-PtdSer and, after a 20-min lag, decarboxylate it to form [(3)H]PtdEtn.

74 CobD was shown to decarboxylate L-threonine O-3-phosphate to yield (R)-1-a

75 was previously demonstrated to be capable of decarboxylating l-ornithine.

76 decarboxylase (TgPSD1), which preferentially decarboxylates liposomal PtdSer with an apparent K(m) of

77 EAEC strain 101-1 was unable to decarboxylate lysine in vitro due to deletions in cadA a

78 t was suspected of producing the cadaverine (decarboxylated lysine) backbone.

79 This enzyme decarboxylates lysine, an essential amino acid for denta

80 bon fixation, an NADP-malic enzyme (NADP-ME) decarboxylates malate in the chloroplasts of bundle shea

81 The E. histolytica malic enzyme, which decarboxylates malate to pyruvate, closely resembles tha

82 f NADP-malic enzyme (ME), the primary enzyme decarboxylating malate in bundle sheath cells to supply

83 enzymes required are described; oxaloacetate decarboxylating malic dehydrogenase is also suitable for

84 ert fumarate to malate and uses oxaloacetate decarboxylating malic dehydrogenase to convert malate to

85 oA decarboxylase (AdCMV-MCD), an enzyme that decarboxylates malonyl-CoA to acetyl-CoA.

86 g that catalyzes cleavage of the oxidatively decarboxylated MftA peptide to liberate its final two re

87 ecursor pathway is initiated by a remarkable decarboxylating monooxygenase with high specificity for

88 vered in the slr0721 gene, which encodes the decarboxylating NADP(+)-dependent malic enzyme in the cy

89 boxysome coat protein homologue, and me, the decarboxylating NADP(+)-dependent malic enzyme.

90 n support of photosynthesis) is either fully decarboxylated or inserted as (13)C-labeled glycyl resid

91 fatty acid oxidation, cannot be explained by decarboxylated osteocalcin changes, suggesting existence

92 atic assays led to the discovery that PA4872 decarboxylates oxaloacetate (kcat = 7500 s(-1) and Km =

93 -oxo-4(pyridin-3-yl)-3-butenoic acid and its decarboxylated product ( E)-3-(pyridine-3-yl)acrylaldehy

94 llular proton ending up in a C-H bond of the decarboxylated product agmatine (Agm(2+)).

95 , which ends up as a "virtual" proton in the decarboxylated product gamma-aminobutyric acid (GABA) an

96 hich it appears to encode a permease for the decarboxylated product of GadB.

97 difference between 2-thioisoorotate and its decarboxylated product, 2-thiouracil.

98 e resorption occurs at a pH acidic enough to decarboxylate proteins, osteoclasts determine the carbox

99 Second, Psd1 decarboxylates PS in the outer membrane in trans, indepe

100 of 1, and salinosporamide C (4), which is a decarboxylated pyrrole analogue.

101 ccus gordonii, use pyruvate dehydrogenase to decarboxylate pyruvate.

102 ur thiamin diphosphate enzymes, all of which decarboxylate pyruvate: the E1 component of human pyruva

103 uvate:ferredoxin oxidoreductase (PFO), which decarboxylates pyruvate and forms acetyl-coenzyme A with

104 family of bacterial pyruvate oxidases which decarboxylates pyruvate to acetyl phosphate plus H2O2 an

105 tosines, presumably via the ODC/ polyamines/ decarboxylated S-adenosylmethionine (dc-AdoMet) pathways

106 tions in tumours affecting the production of decarboxylated S-adenosylmethionine (dcSAM) and polyamin

107 The characterized pathway uses decarboxylated S-adenosylmethionine as the aminopropyl g

108 onine from methylthioadenosine, a product of decarboxylated S-adenosylmethionine from the polyamine s

109 ruvoyl cofactor to catalyze the formation of decarboxylated S-adenosylmethionine, which then donates

110 Here we show that plants can decarboxylate serine directly.

111 The 1.3S-CO2- intermediate decarboxylates spontaneously over a period of hours, and

112 This side reaction arises when the decarboxylated substrate intermediate is protonated at C

113 -CoAs as well as a modest preference for the decarboxylated substrate mimics acetyl-CoA and propionyl

114 traps the Schiff base between the enzyme and decarboxylated substrate, while little Schiff base speci

115 Namely, halogenases and hydroxylases alike decarboxylate the alphaKG co-substrate, facilitating for

116 oys a mononuclear transition metal center to decarboxylate the substrate in an oxidant-independent fa

117 uPFCAs by imposing high-energy ionization to decarboxylate the uPFCAs then focused on the fluorinated

118 The ketosynthase (KS) domain of EpoC decarboxylates the methylmalonyl-S-EpoC acyl enzyme to g

119 ng uroporphyrinogen to coproporphyrinogen by decarboxylating the four acetate side chains of the subs

120 anidinium carboxylate 9 was shown to readily decarboxylate to form crambescidin 359 (8).

121 l acyl carrier protein (ACP) may prematurely decarboxylate to generate the corresponding acyl-ACP, wh

122 nhydrides produce intermediates that readily decarboxylate to provide delta-lactams with high diaster

123 The resulting products were then decarboxylated to afford the highly valuable C-2-CF2H-su

124 In this response, l-arginine is decarboxylated to agmatine, thereby consuming one proton

125 ydroxybutyrate (DMSHB), which is oxidatively decarboxylated to DMSP.

126 he mitochondria by unknown gene products and decarboxylated to form phosphatidylethanolamine at the i

127 rboxylase 2 (Psd2p) in the Golgi/vacuole and decarboxylated to form phosphatidylethanolamine.

128 The closed form of 5 was further decarboxylated to generate 6, which was not photochromic

129 fatty acid biosynthesis) were hydrolyzed and decarboxylated to give C11, C13, and C15 methylketones,

130 new variation of the MVA pathway where PM is decarboxylated to give isopentenyl phosphate (IP), which

131 3,4-dihydroxyphenylserine (L-DOPS), which is decarboxylated to NE by the enzyme L-aromatic amino acid

132 independently of Psd1p, Ups1p, and Ups2p and decarboxylated to PE by Psd1p in the inner membrane.

133 ting of sugars to pyruvate, which in turn is decarboxylated to produce acetyl-coenzyme A (CoA) for va

134 The resulting 18-methyl-Z12-nonadecenoate is decarboxylated to the hydrocarbon, 2-methyl-Z7-octadecen

135 P oxidizes 1 to a cation radical, which then decarboxylates to an alpha-amino radical having carbanio

136 releases carboxybiuret, which spontaneously decarboxylates to biuret.

137 This intermediate subsequently decarboxylates to CO(2) and inorganic phosphate, and the

138 he Mn-enzyme gives an oxalate radical, which decarboxylates to yield a formate radical anion.

139 t enzymes found in the human microbiome that decarboxylate tryptophan to form the beta-arylamine neur

140 richia coli, the products of each gene could decarboxylate tryptophan, but were inactive against tyro

141 final two residues, including the C-terminal decarboxylated Tyr (VY*).

142 by MJ0050, the same enzyme that was found to decarboxylate tyrosine for methanofuran biosynthesis.

143 Because cell extracts from B. japonicum decarboxylated [U-(14)C]glutamate very slowly, the gamma

144 One activity is to decarboxylate UDP-glucuronic acid to UDP-beta-l-threo-pe

145 an be trapped as methyl esters or allowed to decarboxylate under mild conditions.

146 r either l-ornithine or l-lysine, which were decarboxylated with similar efficiency.

147 We conclude that OXA-24 not only decarboxylates with difficulty but also recarboxylates w