ライフサイエンスコーパス: decline in

1 levels on Line P and that they will begin to decline in 2017-2018.

2 Herein we identify predictors for viral decline in a cohort of HCV-infected postpartum women.

3 au were high and predicted subsequent memory decline in a larger sample of normal elderly.

4 may be a mechanism leading to lung function decline in a subset of children with asthma.

5 These results suggest that declines in a critical foundation species may have alrea

6 ot increase consistently with concentration, declined in abundance.

7 Declines in abundance after 2005 were more pronounced fo

8 At each site, declines in accretion rates and parrotfish abundance wer

9 When ELM is intact, there is a shallow decline in acuity with increasing subretinal fluid but a

10 lmark of the ageing process is a significant decline in adaptive homeostasis capacity.

11 ased incidence of myeloid malignancies and a decline in adaptive immunity.

12 Significant declines in adjusted means from the lowest to highest qu

13 While the utility of NFL declines in advanced glaucoma, GCC remains a sensitive p

14 The results demonstrated significant declines in age-adjusted all-cause and HIV-related morta

15 memories, are both hippocampus-dependent and decline in aging.

16 that a value-anticipation mechanism in vmPFC declines in aging, and that this mechanism is associated

17 ast to previous reports, we did not detect a decline in all-cause pneumonia in older adults in any co

18 -beta-induced loss of synapses and cognitive decline in Alzheimer's disease mice.

19 attention for these patients, the absence of declines in annual event rates calls for continuous surv

20 2%, 19% and 17% normal respectively; further decline in anticoagulants; thrombocytopenia; neutrophili

21 While there was no group decline in any neuropsychological assessment, a signific

22 Ironically, the decline in applications to ID programs is occurring at a

23 Recent massive decline in aspen-dominated forests and an increased aspe

24 ly suspected to underpin much of the ice age decline in atmospheric CO2 concentration, but the specif

25 was almost completely negated by a long-term decline in atmospheric CO2.

26 s not represent a single response to a rapid decline in atmospheric pCO2 at the EOT.

27 step with published data showing latitudinal declines in atmospheric mercury deposition in Canada, we

28 Over time, a greater decline in bilateral CA1 subfield volumes was found in t

29 world's forests and contribute to worldwide declines in biodiversity and ecosystem functions.

30 After adjustment for gestational length, the decline in birth weight was attenuated (0.37 grams/year)

31 This change was concurrent with declines in body condition of polar bears and observed c

32 Recent studies suggest drought is causing a decline in boreal spruce growth, leading to predictions

33 f systolic blood pressure and attenuation of decline in both grip strength and time to death.

34 Here, we evaluate decline in both perceptual performance and metacognitive

35 The decline in both progression and relapse of EAE occurred

36 Decline in both telomere length and physical fitness ove

37 otal tau levels were associated with greater decline in both visuospatial ability (regression coeffic

38 However, observed declines in calcification performance and survival proba

39 during a period of Pi starvation, there is a decline in cellular [ATP]; the unusually low affinity of

40 expression could contribute to a progressive decline in cellular function, understanding the mechanis

41 esterol levels, and respond rapidly to small declines in cellular cholesterol by activating SREBPs, i

42 mong absorptive roots, we observed a gradual decline in chemical defenses (phenolic compounds) with d

43 pt levels remained high in SM101 but rapidly declined in CN3718.

44 ne perfusion was associated with accelerated decline in cognition (global cognition: beta=-0.029, P=0

45 lso correlated significantly with subsequent decline in cognition (symbol-digit modality test r=-0.37

46 ed cortical connectivity in HD contribute to decline in cognitive abilities associated with heavy alc

47 INTERPRETATION: Decline in cognitive function was more frequent with WBR

48 s, including cardiovascular disease, cancer, decline in cognitive function, and mortality.We investig

49 An additional 80 men declined in cognitive function as assessed with the use

50 Alcohol-induced declines in cognitive performance were associated with c

51 These factors declined in concentration during some portions of the mo

52 None of the factors displayed consistent declines in concentration throughout the monitoring peri

53 determine whether increases in neuroticism, declines in conscientiousness, and changes in other pers

54 We argue that this decline in contempt, as reflected in cultural products,

55 Declines in coral abundance have been linked to increase

56 c females, production of Amh and Sox9, and a decline in Cyp19a1 and Foxl2.

57 a baseline DAT deficit experienced a 4-year decline in DAT binding of 20.23% (SD, 15.04%) compared w

58 The abrupt decline in delta(82/78)Se and Se/TOC values during the s

59 were independently associated with cognitive decline in different ways according to sex and relations

60 ed beta-cell function, evidenced by a faster decline in disposition index (DI) and a lower DI at age

61 Peanut-specific IgE levels significantly declined in E-OIT-treated children, who were 19 times mo

62 s revealed that responders showed a stronger decline in EEG-vigilance levels from baseline to T1 than

63 The predictor was the percentage decline in eGFR (<5%, 5% to <20%, or >/=20%) between ran

64 were associated with reduced risks of >/=30% decline in eGFR (hazard ratio [HR]: 0.77; 95% confidence

65 both found to be independent predictors of a decline in eGFR at 1-year follow-up (-7.57%, p = 0.014;

66 ut HF, and 22% of patients with HF had rapid decline in eGFR compared with 8.5% in patients without H

67 terval, 0.73 to 0.98] for >3 ml/min per year decline in eGFR), but not of incident CKD (incident rate

68 % confidence interval, 0.66 to 0.93] for 30% decline in eGFR, and 0.85 [95% confidence interval, 0.73

69 was 24.4%, 4.0%, 14.8%, and 1.7% for >/=30% decline in eGFR, doubling of serum creatinine, AKI, and

70 sCD40R was negatively associated with declines in eGFR.

71 iscussion was not associated with a temporal decline in either measure.

72 eep-disordered breathing (SDB) and cognitive decline in elderly persons.

73 A significant (p = 0.002) decline in EMG --> SBP causality was observed in the eld

74 ty specifically in EC leads to a paradoxical decline in endothelial function, mediated by increased t

75 First, if C difficile infection declines in England were driven by reductions in use of

76 Normal aging is associated with a decline in episodic memory and also with aggregation of

77 or their effects on 4 renal outcomes: >/=30% decline in estimated glomerular filtration rate (eGFR),

78 ted that sCD40L was directly associated with declines in estimated glomerular filtration rate (eGFR).

79 For men, 9.5% is the result of a decline in external injuries.

80 e pressures to breed early, such as seasonal declines in fecundity or competition for high-quality ma

81 esia, reduced ovulation rate, and a dramatic decline in fertility is observed in alpha-SNAP-mutant fe

82 duration was associated with 1.00 ml/yr less decline in FEV1 (P < 0.001) and 1.55 ml/yr less decline

83 A concentration of histamine inducing a 20% decline in FEV1 (PC20 ) </=16 mg/mL showed a sensitivity

84 The mean (SD) rate of decline in FEV1 was 39.0 (58.6) ml/yr.

85 h the risk of COPD exacerbations, mortality, decline in FEV1, and response to both inhaled and system

86 nts showed increase from baseline in PTH and decline in FGF23 by study week 4, with no differences in

87 Greater decline in fitness was associated with greater annual de

88 terior, and (iii) nest building caused a 62% decline in forest tree sapling density over the 24-year

89 ongly, with an early spring peak followed by decline in forests, and a more extended summer season in

90 caused by fluoroquinolone-resistant isolates declined in four distinct genotypes (p<0.01).

91 After adjusting for inflation, the decline in funding to dental institutions from the NIDCR

92 line in FEV1 (P < 0.001) and 1.55 ml/yr less decline in FVC (P < 0.001).

93 in population size can trigger corresponding declines in genetic variation.

94 LPAR inhibition also prevented the decline in GFR observed in vehicle-treated mice, such th

95 tween genotypes at baseline it significantly declined in GG-carriers after 6 weeks HF diet (p = 0.001

96 mazon forest (Jaru RJA) exhibited dry-season declines in GPP and Re consistent with most DGVMs simula

97 Models simulated consistent dry-season declines in GPP in the equatorial Amazon (Manaus K34, Sa

98 h as tectonics, sea-level fall and long-term decline in greenhouse gas concentrations during the late

99 aretta caretta-exhibited similar significant declines in growth rates starting in 1997 in the West At

100 rage and improve storm protection, but cause declines in habitat availability for fauna requiring ope

101 ore, synapse loss, the hallmark of cognitive decline in HAND, is reversible.

102 As well as contributing to a significant decline in health status in many patients, this conditio

103 One year later, she experienced a more rapid decline in her gait with parkinsonism, visual difficulti

104 rlier, and the patient noticed a progressive decline in his daily routine due to gait difficulties in

105 todendritic damage correlates with cognitive decline in HIV-associated neurocognitive disorder (HAND)

106 ers (up to 2.6% per year), mainly because of declines in HIV, cancer, and heart disease deaths, resul

107 Median of the maximum declines in HIV-1 RNA were similar for the 40-120 mg onc

108 .72, -1.37) and 2.77% (95% CI, -4.36, -1.77) decline in HOMA-IR and insulin respectively, and a 2.55%

109 g synthetic controls, we found a substantial decline in hospitalizations for all-cause pneumonia in i

110 quinolone prescribing appears to explain the decline in incidence of C difficile infections, above ot

111 logy of HF in Medicare beneficiaries, with a decline in incident HF and a decrease in 1-year HF morta

112 MCI or AD (p = 0.038) and against cognitive decline in individuals who develop dementia (p = 3.41 x

113 of the stable reversal of hyperglycemia, and decline in insulin autoantibody positivity was an immune

114 vage and oncosis was associated with a rapid decline in intracellular ATP levels, which was a consequ

115 cases were more likely to have a measurable decline in IP-10 at day 7 than clinically diagnosed case

116 tion between greater blood lead levels and a decline in IQ and socioeconomic status from childhood to

117 evel of klotho associated with lower odds of decline in kidney function (odds ratio, 0.78 [95% confid

118 sociations between soluble klotho levels and decline in kidney function (relative decline: eGFR decli

119 we show in two large, unrelated cohorts that decline in kidney function associated with APOL1 risk va

120 Postoperative decline in kidney function occurred mainly in the first

121 ndependently associated with a lower risk of decline in kidney function.

122 ns in circulating GDF-15 are associated with decline in kidney function.

123 ter AKI may lead to progressive fibrosis and decline in kidney function.

124 To determine whether the acute declines in kidney function in the intensive BP lowering

125 Despite important ART-related declines in KS incidence, men and women in South Africa

126 ; 3 with mild denervation developed interval decline in lateral and inferior segments (diff-SEP -82 t

127 Severe drought caused major declines in leaf water potential, elevated foliar ABA co

128 of 297 in the trastuzumab group had a > 10% decline in left ventricular ejection fraction from basel

129 onfidence interval, 1.09-2.07), but not with decline in left ventricular ejection fraction.

130 to the controller animals led to a specific decline in levels of CD8(+) T cells and the rapid reappe

131 d 47%, respectively, corresponding to a mean decline in linear extension of -29.56 cm yr(-1) (+/-7.08

132 AD reduces brain atrophy, prevents cognitive decline in LMCI and delays conversion to AD dementia for

133 nal airway fibrosis leads to an irreversible decline in lung function termed bronchiolitis obliterans

134 sual care, but this did not result in slower decline in lung function.

135 n fitness was associated with greater annual decline in lung function.

136 er baseline fitness was associated with less decline in lung function.

137 nical symptoms and may result in a sustained decline in lung function.

138 In secondary analyses, trastuzumab-mediated decline in LVEF was attenuated in bisoprolol-treated pat

139 d trastuzumab resulted in modest, persistent declines in LVEF at 3 years.

140 ervices in agricultural settings, and recent declines in managed populations have caused concern.

141 iddle East (14%), and central Asia (16%) and decline in many African savannas (e.g., -18% in sub-Saha

142 f Plasmodium falciparum malaria is gradually declining in many parts of Africa, it is characterized b

143 at might have contributed to the substantial decline in maternal mortality between 1997 and 2014.

144 opose that the hominin lineage experienced a decline in maximum dynamic force and power output during

145 ses of sunitinib were cytotoxic, triggered a decline in MCL-1 levels, and inhibited mTORC1 signaling.

146 To mitigate the decline in measles virus antibody titers in IVIGs and to

147 ly stressful, and many caregivers experience declines in mental health.

148 spectroscopy to explore the extent to which declines in microbial decay in a long-term (ca. 20 yrs.)

149 as determined by gas chromatography and the decline in moisture content.

150 Commensurate with this progress has been a decline in morbid and mortal events.

151 the first half of the 20th century, then the decline in mortality from coronary heart disease and str

152 rred, at least in the US Since 1978, a sharp decline in mortality rates from coronary heart disease a

153 not receive ANS showed that their estimated decline in mortality would be 26%.

154 en since the early 1980s, largely reflecting declines in mortality that have been disproportionately

155 frequency of cerebellar Purkinje cells and a decline in motor function.

156 2% (2.7% to 5.6%), attributable to an annual decline in MRSA of 10.9% (9.3% to 12.6%).

157 An ensuing decline in mTORC1 activity is crucial to allow myelinati

158 Falling 4C use predicted rapid declines in multidrug-resistant ribotypes R001 and R027.

159 in a mouse model of replicative senescence, decline in muscle satellite cell-mediated regeneration c

160 erentiated cell counts, but was related to a decline in naive T cells.

161 of three mangrove species further shows the decline in Ne to be strongly associated with the speed o

162 AKT1-silenced plants exhibited a significant decline in net uptake of K(+) and Na(+) , resulting in d

163 logical changes was a progressive, selective decline in neural connectivity, affecting hippocampal ef

164 In summary, although modest declines in neurocognitive performance were seen in sing

165 two patients, one with agranulocytosis), and decline in neurological functioning (one event, likely d

166 fuel availability as evidenced by the rapid decline in neuronal function during ischemic attacks and

167 , moderately lowered IIS rescues age-related decline in neurotransmission through the Drosophila gian

168 everely affected countries despite the sharp decline in new cases in recent years.

169 d Mo which are enriched in bitumen) has been declining in northern Alberta for decades.

170 Our analyses show that the decline in number and biomass of oaks started around the

171 se of multi-drug resistant pathogens and the decline in number of potential new antibiotics in develo

172 at entorhinal tau pathology underlies memory decline in old age even without Abeta.SIGNIFICANCE STATE

173 Because functional decline in older adults has similar features, current in

174 nment, which was associated with significant decline in oocyte cleavage and blastocyst development af

175 tion, a process contributing to fibrosis and decline in organ function.

176 tes, we show that at least two-thirds of the decline in organic aerosol can be explained by changes i

177 types, including newly detected clones and a decline in overall T-cell clonality.

178 tinib (20.3%), and bevacizumab (18.9%) and a decline in paclitaxel (38.7%), gemcitabine (17.0%), and

179 rrier is that HIV-1-specific ADCC antibodies decline in patients on long-term antiretroviral therapy

180 Serotype 6A declined in PCV10 and PCV13 counties, whereas serotype 1

181 In contrast, the decline in peripheral vascular resistance and the increa

182 tion of starch declined in proportion to the decline in photosynthesis if the decrease occurred <10 h

183 sian spatial regression) to test whether the decline in pneumonia hospitalizations associated with va

184 important ecosystem function and the global decline in pollinators attenuates the resistance of natu

185 regulation of bone marrow cells with a rapid decline in population at midlife and a concomitant incre

186 the cultivated lineage experienced a steady decline in population size (Ne ) thereafter.

187 m days per week, pinteraction=0.94), and the decline in postbronchodilator lung function was less at

188 B expression near term may contribute to the decline in PR function, leading to labor.

189 t this currently dominant prairie grass will decline in prevalence and stature.

190 Escherichia coli and Campylobacter spp. that declined in prevalence based on the TAC assay.

191 s study provides strong evidence that if the decline in primary production continues, knock-on effect

192 Rather than a gradual linear decline in productivity, there is some limited but nonco

193 ntensity, the rate of accumulation of starch declined in proportion to the decline in photosynthesis

194 The Kok effect - an abrupt decline in quantum yield (QY) of net CO2 assimilation at

195 le our elders showed the previously reported decline in rationality compared with younger subjects, c

196 flow behaviour causing the counter-intuitive decline in recovery of the defending fluid from weak imb

197 crease of 4.1% per year, consistent with the decline in regional atmospheric Hg emissions and water H

198 osis, portal hypertension, and a progressive decline in renal blood flow and renal function.

199 In two mouse models of CKD, the decline in renal function associated with the accumulati

200 cyst growth, interstitial fibrosis, and the decline in renal function in PKD mice.

201 The magnitude of decline in renal function that should be tolerated durin

202 ithin this fixed pool causes an irreversible decline in reproductive capacity, known as the ovarian r

203 Plant mortality rates and biomass declines in response to drought depend on stomatal and x

204 pe characterized by time- and dose-dependent declines in rod and cone photoreceptor functions as earl

205 tertiary care institutions in Boston, MA, a decline in S. aureus infections has been accompanied by

206 but it is unclear whether this represents a decline in S. aureus infections overall.

207 ARA), was partially oxidized, resulting in a decline in saturates and aromatics, but increases in res

208 f these species had projected end-of-century declines in scleractinian calcification of >50% relative

209 When left unchecked, algae can cause declines in seagrass productivity and persistence throug

210 re likely to report a clinically significant decline in self-reported cognitive function than were co

211 Post-PCV13 declines in serotype 19A IPD in persons aged <2 years (I

212 Two donors exceeded 10-point declines in SF-36 summary scores and increased their HAD

213 Most critically we report major declines in shallow fore-reef carbonate budgets, these s

214 NO2 and PM2.5 were associated with a faster decline in SI and a lower SI at age 18 years, independen

215 Moreover, declines in silicon occurred mainly in native species (-

216 in relation to socioeconomic status, and the decline in sizes of private gardens in newer urban devel

217 There was no evidence of faster cognitive decline in socioeconomically disadvantaged groups.

218 has stagnated among poor Americans and even declined in some demographic groups.

219 Routine childhood vaccination is declining in some regions of the United States due to va

220 These lags decline in species that have colonized more sites and th

221 is governed by a gradual, distance-dependent decline in spine size, which we visualized using serial

222 Significant declines in SSB sales, even in this relatively affluent

223 e reduction in mucosal damage occurs through decline in stem/clonogenic epithelial cell loss mediated

224 PrEP coverage could result in a significant decline in STI incidence among MSM.

225 t limitation provide insight into how global declines in structurally complex estuarine habitats may

226 Under-5 mortality has declined in sub-Saharan Africa over the last decades.

227 d that frequently burned plots experienced a decline in surface soil carbon and nitrogen that was non

228 cular interstitial collagen deposition and a decline in systolic and diastolic function were present

229 Cardiac function significantly declined in T-cell-specific CD4-Cre(+/)(-)CD73(flox/flox

230 All scenarios projected a flattening of the decline in TB incidence by 2025 without additional resou

231 presenting different explanations for recent declines in TB incidence.

232 Amazon Basin have contributed to short-term declines in terrestrial carbon dioxide uptake and storag

233 Even with the large decline in TFA concentrations, differences between demog

234 a remote coral reef ecosystem, we observe a decline in the (15)N/(14)N of coral skeleton-bound organ

235 o laser axotomy model, we show a progressive decline in the ability of cut CNS axons to form a new gr

236 allow the documentation of an age-dependent decline in the approximate sense of complexity.

237 Here we show that a decline in the autophagy-lysosome system contributes to

238 terial segments correlated with a log-linear decline in the bulk absorption rate-constant of (14)C-la

239 om forest to non-forest types, and suggest a decline in the contribution of Sierra Nevada forests to

240 urve with either mutation alone, and a sharp decline in the curve with coexisting mutations.

241 rvival curve with neither mutation, a modest decline in the curve with either mutation alone, and a s

242 In sum, the decline in the ecological role for cod that began with o

243 14 638 eyes did, and there was a significant decline in the endophthalmitis rate, from 0.07% (214/302

244 An observed decline in the Fe(II) oxidation rate in nonirradiated an

245 tients with concussive blast TBI (72%) had a decline in the GOS-E from the 1- to 5-year evaluations,

246 The precipitous decline in the host's clinical status and the lack of ta

247 es initiated under STEP led to a decade-long decline in the incidence levels.

248 ation after injury and reduced myofiber size decline in the muscular dystrophy model.

249 bjective was to determine whether there is a decline in the prevalence of AD in population-based coho

250 African continent has witnessed a long-term decline in the prevalence of Plasmodium falciparum from

251 Due to a very slow decline in the prevalence of stunting, the total number

252 played a significant role, in particular, a decline in the retirement rate of older scientists, indu

253 We observed a similar 59% decline in the risk of a district reaching the epidemic

254 Whether a reported decline in the risk of developing age-related macular de

255 VE tended to decline in the second year of life, particularly in medi

256 lion residents of central India because of a decline in the total rainfall and a concurrent rise in t

257 sociated with a stronger absolute or percent decline in the unfavorable season.

258 Compared with a <5% eGFR decline in the usual BP arm, a 5% to <20% eGFR decline d

259 trend of surface PM concentration in the SMA declined in the 2000s, but since 2012 its concentrations

260 udinally, mean platelet counts significantly declined in the CFLD group (from 310 to 230 U/L, P = 0.0

261 Declines in the abundance of long-lived and habitat-form

262 d CO2 and temperature will lead to long-term declines in the amount of carbon stored in agricultural

263 ination and development have led to dramatic declines in the global burden of measles, but the virus

264 stress-inducible protein, Sestrin2 (Sesn2), declines in the heart with aging.

265 Declines in the size of peripheral populations did not d

266 ient cycling and climate regulation, but are declining in the face of multiple threats.

267 zed in niches in the subependymal area and a decline in their number was observed with age.

268 se in frail nursing home residents without a decline in their well-being.

269 of the altered glucose metabolism and memory decline in these disorders.

270 ntrations of mercury, are driving short-term declines in THg concentrations in southern Beaufort Sea

271 a primary contributor to TDF-associated BMD decline in this age group.

272 3) from 1990 to 2015, the rates of mortality decline in this period substantially varied across the p

273 However, cognitive decline in this population was much lower than expected,

274 15.4 points at 3 months, as compared with a decline in this score in a historical cohort.

275 In contrast, the rate of decline in thymic epithelial cell numbers with age was r

276 Gracilaria and Ulva and yielded significant declines in tissue delta(13)C, suggesting that increased

277 8, IL-1beta, and TGF-beta, despite a gradual decline in TNF-alpha expression and macrophage infiltrat

278 anthropogenic factors often drive population declines in top predators, but how their influences may

279 increasing Tgrowth , linked to a concomitant decline in total leaf protein per unit leaf area and Rub

280 ibotypes and was associated with substantial declines in total C difficile infections in northeast Sc

281 However, substantial declines in total P may drive tropical plantations towar

282 ermogenesis occurred prior to any functional decline in transverse aortic constriction hearts.

283 ds increased by 22%-117%, corresponding with declines in tree species richness, regeneration, and sur

284 tuberculosis transmission and accelerate the decline in tuberculosis incidence and mortality.

285 nfidence interval: 5.8-7.0) percentage-point decline in uninsured and a 9.6 (95% confidence interval:

286 se who were not treated showed a significant decline in VA at 1 year (mean logMAR VA decline: 0.03 un

287 accounts for the effect of Tgrowth -mediated declines in Vcmax(25) on An , complementing current phot

288 alized to initial value showed a significant decline in ventilated-not paced but not in ventilated-pa

289 ical assessment, a significant postoperative decline in verbal memory and confrontational naming was

290 ty, and highlights the potential for ongoing declines in vertebrate seed dispersers to profoundly alt

291 onential growth results in a more pronounced decline in VieA specific activity compared to the classi

292 A mathematical model describing the decline in volatile compounds during heating of simple l

293 This decline in volume correlated with symptomatic worsening.

294 Climate change is predicted to cause a decline in warm-margin plant populations, but this hypot

295 weaning, genetic (co)variances had somewhat declined in weight and were not statistically significan

296 productivity in the US and Canada) and large declines in western Africa (-46% in sub-Saharan western

297 ocesses of dementia resulted in the greatest decline, in which the interaction contributed an additio

298 ct future increase in summer temperature and decline in winter snowfall.

299 n primary prevention, the rate of MI has not declined in young adults.

300 metamorphosis on insect chemistry were large declines in zinc concentrations coupled with increased d