ライフサイエンスコーパス: deconjugation

1 limination reactions, preventing nonspecific deconjugation.

2 that contribute to CSN activation and Nedd8 deconjugation.

3 ptide bond and study its Usp1/UAF1-dependent deconjugation.

4 dynamics of SUMO chains in vivo by constant deconjugation.

5 ving maturation, activation, conjugation and deconjugation.

6 ure form, and negatively, by catalyzing SUMO deconjugation.

7 minants of SUMO recognition, processing, and deconjugation.

8 resulted primarily from a deficit of SUMO2/3-deconjugation activity.

9 physiological dose did not affect bile acid deconjugation and had little effect on other intestinal

10 gases through RUB (for Related to Ubiquitin) deconjugation and highlight the unequal role that CSN(CS

11 erum samples were also analyzed by enzymatic deconjugation and liquid-liquid extraction (LLE) for the

12 Nedd8 deconjugation and re-engagement of the active site zinc

13 m Athens, Greece, were analyzed by enzymatic deconjugation and SPE.

14 The dynamics of conjugation and deconjugation and the role of SUMO during the cell cycle

15 in vivo, we highlight the importance of SUMO deconjugation, and we demonstrate the highly dynamic nat

16 uitin-related modifier (SUMO) processing and deconjugation are mediated by sentrin-specific proteases

17 The method is based on enzymatic deconjugation, automated liquid-liquid extraction, and g

18 that limits Smt3-protein ligation when Smt3 deconjugation by both Ulp1 and Ulp2 is compromised, allo

19 e modification is determined at the level of deconjugation by isopeptidases.

20 Early deconjugation by memory CD4 T cells is dependent on CD4-

21 lar basis for ubiquitin (Ub) recognition and deconjugation by MERS-CoV PL(pro), we determined its cry

22 more, we present the mechanism of SUMO chain deconjugation by SENPs, which occurs via a stochastic me

23 Although deconjugation can potentially occur in vivo to produce a

24 The enzymatic deconjugation efficiency, verified by deconjugation of u

25 as a conjugated internal standard to monitor deconjugation efficiency.

26 Deregulation of ubiquitin conjugation or deconjugation has been implicated in the pathogenesis of

27 th N-aryl maleimides exhibited less than 20% deconjugation in both thiol-containing buffer and serum

28 exogenous expression of either wild-type or deconjugation-inactive Usp18, and superimposition of an

29 Deconjugation is achieved by the SUMO protease ULP-4 and

30 rum of SUMO conjugates, indicating that SUMO deconjugation is substrate-specific and plays a critical

31 hese results suggest that regulation of SUMO deconjugation may be a major facet of B23/nucleophosmin

32 s product release, with SUMO conjugation and deconjugation needed for each catalytic cycle, but this

33 in the analytical procedure indicted that no deconjugation occurred during the SPE procedure.

34 Deconjugation of ABA-GE by the endoplasmic reticulum and

35 ulfatases/glucuronidases results in complete deconjugation of conjugated CEHC.

36 soflavonoid absorption from the gut requires deconjugation of glucosides to aglycones.

37 several factors involved in conjugation and deconjugation of Met1-linked polyubiquitin have been imp

38 led kinetic characterization of CSN-mediated deconjugation of Nedd8 from SCF.

39 he cleavage of NEDD8 from CRLs, and blocking deconjugation of NEDD8 traps the CRLs in a hyperactive s

40 ations in bile because of partial intestinal deconjugation of orally administered GCA.

41 that contribute to protease function during deconjugation of poly-SUMO chains.

42 ases (Ulp/SENPs) mediate both processing and deconjugation of small ubiquitin-like modifier proteins

43 full-length SUMO to its mature form and (2) deconjugation of SUMO from targeted proteins.

44 c process that requires both conjugation and deconjugation of SUMO moieties.

45 s, respectively, mediate the conjugation and deconjugation of SUMO molecules to/from target proteins.

46 roteases are required for the maturation and deconjugation of SUMO proteins, thereby either promoting

47 A family of proteases catalyzes deconjugation of SUMO-1-containing species.

48 It remained unknown, however, whether deconjugation of SUMO-1/Smt3 from proteins is also essen

49 Inhibition of viral DNA replication blocks deconjugation of SUMO-2 from Mre11 and Nbs1, indicating

50 ily of SUMO-specific proteases catalyzes the deconjugation of SUMO-modified proteins.

51 In the presence of inulin, more bacterial deconjugation of taurine from primary bile acids was obs

52 The inhibitor selectivity for deconjugation of the 26 and 17 kDa conjugates was simila

53 urine samples were processed using enzymatic deconjugation of the glucuronides followed by solid-phas

54 COP9 signalosome (CSN) mediates deconjugation of the ubiquitin-like protein Nedd8 from t

55 from substrates in a manner analogous to the deconjugation of Ub from eukaryotic proteins.

56 d as selective inhibitors of conjugation and deconjugation of ubiquitin catalyzed by reticulocyte fra

57 Deconjugation of ubiquitin from cellular proteins is cat

58 Specific deconjugation of ubiquitinated substrates has been descr

59 ymatic deconjugation efficiency, verified by deconjugation of urine samples spiked with alpha-naphthy

60 Microbial deconjugation of xenobiotics and release of aromatic moi

61 ction studies suggest that Velo acts in SUMO deconjugation rather than in maturation.

62 hat SENP6 and SENP7 prefer SUMO2 or SUMO3 in deconjugation reactions with rates comparable with those

63 served, yet the dynamics of SUMO conjugation/deconjugation remain poorly understood.

64 Here, we developed a deconjugation-resistant form of NEDD8 to stabilize the n

65 Together, the IRF8 SUMO conjugation/deconjugation switch is part of a larger transition in S

66 BA synthesis and catabolism, conjugation and deconjugation to glucose, and ABA transport all are invo

67 l ubiquitin-like modifier (SUMO) conjugation/deconjugation to heat shock transcription factors regula

68 epared with N-alkyl maleimides showed 35-67% deconjugation under the same conditions.

69 Thus, an enzymatic deconjugation with beta-glucuronidase was optimized.

70 Selective enzymatic deconjugation with glucuronidase and mixed glucuronidase

71 gase activity, and it is presumed that Nedd8 deconjugation would reverse these effects.