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1 a dominant-negative inhibitor of IGF1R (IGF1 decoy).
2 tream (eg, aurora-kinase inhibitors and STAT decoys).
3 han other incorrect glycopeptide candidates (decoys).
4 ze the ligand-mediated damage by acting as a decoy.
5 active when the chosen option dominated the decoy.
6 been shown to function as an APRIL-specific decoy.
7 the native state with respect to structural decoys.
8 ber of near-native poses found among the top decoys.
9 first MSMs out of all MetaCyc metabolites as decoys.
10 emains ligand enrichment against challenging decoys.
11 of competitor DNA duplexes, including Egr-1 decoys.
12 igands form more-resilient interactions than decoys.
13 nRNP L sequesters miR-574-3p, overcoming its decoy activity and seed sequence-dependent gene silencin
14 as been benchmarked widely on a large set of decoys, all models generated at the seventh worldwide ex
17 thasone, inhibition of miR-433 using a tough decoy altered the period and amplitude of Per2 gene expr
18 the role of CP(169-180) as an immunological decoy and illustrate the importance of the structural fo
19 ry rate of ~ 5% as estimated by naive target-decoy and MAYU approaches, signifying a 6-fold increase
20 nstrates the dependence of preference on the decoy and on the context in which the options are presen
21 ated neutralization by serving as an antigen decoy and to inhibit the antibody-mediated antiviral eff
22 targets available in the Directory of Useful Decoys and the performance was evaluated using the area
23 ormance of ROTAS was tested using 13 sets of decoys and was compared to those of existing atomic-leve
24 of dabigatran, the investigational factor Xa decoy andexanet alfa, and the synthetic small molecule c
25 eral HIV-protease inhibitors can function as decoy antigens to specifically inhibit the binding of an
26 ve flexibility, producing new small-molecule decoy antigens, which neutralize anti-dsDNA antibodies i
27 lenge is usually addressed by using a Target-Decoy Approach (TDA) to impose an empirical False Discov
31 n-native protein structure conformations (or decoys) are often used for designing protein folding sim
36 spatial information to inhibit selecting the decoy beacon, despite knowing the platform's actual spat
38 orithm, 3DRobot, to create protein structure decoys by free fragment assembly with enhanced hydrogen-
39 ; however, with the addition of an inferior "decoy" C, females reversed their preferences and chose A
40 effect": introducing an irrelevant option (a decoy) can influence choices among other (relevant) opti
43 t to conventional quantitative PCR assays or decoy cell counts, quantitative urinary PV-Haufen testin
45 erformance of quantitative viremia surpassed decoy cells (area under the curve of 0.95 and 0.79, resp
46 d the diagnostic test performance of urinary decoy cells and urinary SV40T immunochemistry of exfolia
51 phropathy, any urine cytology demonstrating "decoy" cells, and/or significant polyomavirus BK viremia
53 Recent studies have shown that non-signaling decoy chemokine receptors bind and modulate the expressi
54 sify models as correct/incorrect; discarding decoys classified as incorrect led to an enrichment in t
55 discriminate the near-native structures from decoy complexes and at the same time make conformational
56 he learning task further improves the target-decoy database analysis for identifying peptides, which
58 rget-decoy strategy in proteomics, employs a decoy database that is created based on the target prote
65 ent defense, and RPS4/RRS1 has integrated a "decoy" domain that enables detection of effectors that t
66 red plant immune receptors have incorporated decoy domains that structurally mimic pathogen virulence
67 advantage, of the combination of integrated decoy domains with additional independent effector-NLR i
70 results suggest that the neural basis of the decoy effect could be the context-dependent activation o
72 exhibit a violation of rationality known as "decoy effect": introducing an irrelevant option (a decoy
73 lausible neuronal model that can account for decoy effects based on the trial-by-trial adjustment of
75 the influence of the choice set size on the decoy effects, which are in contrast to previous models
77 coloration mechanism, the nano-bioreplicated decoys evoked the complete attraction and landing sequen
79 , in part, to the deployment/secretion of a "decoy flare," for example, anomalous cancer-associated a
80 MutY possesses an exo-site that serves as a decoy for C, and secondly, repulsive forces with a key a
81 I) into productive elongation by acting as a decoy for the negative elongation factor (NELF) complex
83 tion transgenic mice overexpressing microRNA decoys for either miR-23a or miR-27a, but not miR24-2, s
84 al penton-dodecahedral particles that act as decoys for HD5, thus preventing the inactivation of viru
85 t retrotransposon-derived transcripts act as decoys for miR171, triggering its degradation and thus r
86 mmatory signaling receptor, sRAGE acts as a "decoy" for RAGE ligands and prevents their interaction w
87 debranching activity and, hence, represent "decoys" for sequestering RNA binding proteins thought to
100 aria of transgenic mice expressing a miR-433 decoy in osteoblastic cells (Col3.6 promoter), the ampli
102 ere verified by shining a white laser on the decoys in a dark room and projecting the scattering patt
103 approach to discriminating native poses from decoys in difficult targets for which several scoring fu
105 y active immunoreceptors, ligands, and viral decoys, including challenging cell surface proteins that
106 bition of DLL1/4 with ligand-specific Notch1 decoys increased sprouting of sinusoidal endothelial cel
107 nown receptor-selective ligands from related decoys, indicating a high degree of precision in pocket
109 r functional analysis of microRNA (miRNA): a decoy library for inhibiting miRNA function and a sensor
110 MV genome encodes for MHC class I-homologous decoy ligands for inhibitory NK cell receptors to evade
115 teractions with influenza hemagglutinin, our decoy liposomes have potential as a new therapeutic agen
117 agglutinin binding pocket and the ability of decoy liposomes to form high avidity interactions with i
118 calculated accurately based on the number of decoy matches and the ratio of the number of targets to
122 using various techniques including receptor decoys, multiple co-operative binding sites, and sequent
123 lectively, our findings identify a molecular decoy naturally generated during apoptosis that inhibits
124 ch signaling, or its acute inhibition with a decoy Notch1 receptor, prevents hepatosteatosis by block
125 er, other hypotheses including virus-induced decoy of the immune system also warrant discussion in re
127 r mRNA splicing and translation by acting as decoys of RNA-binding proteins or microRNAs and can comp
129 eport the development of an engineered STAT3 decoy oligodeoxynucleotide (dODN) that is stable in seru
130 Moreover, pretreatment of the cells with a decoy oligonucleotide carrying wild-type p53-response el
131 ucleotide to restore SMN and a complementary decoy oligonucleotide to neutralize its effects in the C
132 hich AP-1 and IkappaB were down-regulated by decoy oligonucleotides and siRNA, suggest that the morph
133 ned the kinetic impact of DNA methylation of decoys on the search process of the Egr-1 zinc-finger pr
134 novel mechanism by which ROR may serve as a decoy oncoRNA that blocks binding surfaces, preventing t
135 t with the hypothesis that the presence of a decoy option influences the valuation of other options,
138 DNA binding (e.g., with oligodeoxynucleotide decoys or pyrrole-imidazole polyamides) has demonstrated
142 tion of HMVEC-Ls with a cell-permeable TRAF6 decoy peptide decreased both LPS-induced SFK activation
145 ts could be rescued by the treatment of this decoy peptide in both M17 cells overexpressing D620N or
146 we investigated the degree to which TLR TIR decoy peptide modified to include a TAT sequence (Trans-
149 define the binding site, we used a series of decoy peptides derived from the primary amino acid seque
151 FLNa interaction in neurons, with the use of decoy peptides that mimic the FLNa-binding domain of HCN
153 the native (or nativelike) binding pose from decoy poses that cannot be distinguished using scoring f
155 t) is a recombinant modified human factor Xa decoy protein that has been shown to reverse the inhibit
159 affinity bias of IL-1Ra for IL-1R1 over the decoy receptor (IL-1R2), and, surprisingly, is also more
162 binds to a secreted TNF family member called decoy receptor 3, which interferes with the interaction
163 operties required the engagement of the IL-1 decoy receptor 8 (IL-1R8) and the activation of AMP-acti
165 h neutralizing antibodies or the soluble IFN decoy receptor B18R nor by short hairpin RNA (shRNA) kno
168 e illustrate how GIF serves as a competitive decoy receptor by leveraging binding hotspots underlying
173 In contrast, soluble ST2 appears to act as a decoy receptor for IL-33, blocking myocardial and vascul
175 ernative to the widely used BAFF receptor-Fc decoy receptor for the specific depletion of BAFF in mic
176 pression of CyHV-3 ORF12, encoding a soluble decoy receptor for TNF-alpha, delayed the manifestation
177 ulated transcripts is TRAILR4 that encodes a decoy receptor for TRAIL-a pro-apoptotic cytokine that i
178 ring ischaemia, soluble CD163 functions as a decoy receptor for TWEAK, a secreted pro-inflammatory cy
179 loyed by poxviruses, encoding four viral TNF decoy receptor homologues (vTNFRs) named cytokine respon
184 a suggest that FGFRL1 does not function as a decoy receptor in beta-cells, but rather it enhances ERK
187 erleukin-1 receptor type 2 (IL1R2) acts as a decoy receptor of exogenous IL-1; however, its intracell
188 NF-kappaB, its ligand RANKL, and the soluble decoy receptor osteoprotegerin are the key regulators of
189 ing ligand, in conjunction with their shared decoy receptor osteoprotegerin, in the bone marrow of in
191 adial glia control this process via the Vegf decoy receptor sFlt1: sflt1 mutants exhibit the venous o
192 pha chain, or treatment with a soluble IL-33 decoy receptor significantly reduced release of inflamma
194 treatment of CD patients with etanercept, a decoy receptor that binds soluble TNF, fails to improve
195 ments, IFN-alphabeta was neutralized using a decoy receptor that blocks IFN signaling, whereas specif
197 1 (mVEGFR1) is an endothelial cell-intrinsic decoy receptor that negatively modulates blood vessel mo
198 ains, FGFRL1 has been postulated to act as a decoy receptor to inhibit canonical FGFR ligand-induced
200 ering a second-generation, high-affinity AXL decoy receptor with an apparent affinity of 93 femtomola
201 orm of IL23R mRNA (which then functions as a decoy receptor) and lowers the ability to develop a Th17
202 f WT mice with soluble IL-33 receptor (IL-33 decoy receptor) markedly reduced CCI-induced hyperalgesi
203 n primary ASMC migration and the role of the decoy receptor, Duffy AgR for chemokines (DARC), in this
207 mammalian CXCR7, the most recently described decoy receptor, results in postnatal lethality due to ab
209 encoding both the IL-33 receptor, ST2L, and decoy receptor, sST2, has been genetically associated wi
215 Our data indicate sCD48 as a SEB-induced 'decoy' receptor derived from eosinophil and therefore as
218 rming four signaling receptor complexes, two decoy receptors (IL-1R2, IL-18BP), and two negative regu
219 eveal a previously underappreciated role for decoy receptors as molecular rheostats in controlling th
220 R signaling and suggest that they can act as decoy receptors for self-antigens that are recognized by
221 Structural and mechanistic studies of these decoy receptors have provided a wealth of information, n
224 ion, and disruption of this interaction with decoy receptors or blocking Abs should mitigate disease
225 otein expression of TRAIL, DR5 and the TRAIL decoy receptors osteoprotegerin (OPG), mDcTRAILR1, and m
226 ection of cells, or alternatively can act as decoy receptors that bind virions and block virus infect
227 assembly, mimicking the biological effect of decoy receptors that lack the death domain to trigger ap
228 ulated that targeting the type I and type II decoy receptors used by poxvirus to subvert the host inn
229 ical 7-transmembrane receptors, often called decoy receptors, act promiscuously as molecular sinks to
230 xpression of soluble endogenous antagonists, decoy receptors, and posttranslational processing of bio
231 A tight regulation via receptor antagonists, decoy receptors, and signaling inhibitors ensures a bala
232 LR3 and TRAILR4 are generally referred to as decoy receptors, which have been shown to inhibit TRAIL-
235 results show that OPUS-DOSP has an increased decoy recognition capability comparing with those of oth
237 ry rate estimation method, based on a target-decoy search approach, is derived for assigning confiden
241 le to generate high-accuracy predictions and decoy sets enriched with near-native loop conformations,
242 ethod was benchmarked with three widely used decoy sets from ab initio folding and comparative modeli
246 SSOs bound to splicing regulatory motifs and decoy splice sites in primary transcripts revealed a mot
248 se train achieves a key rate comparable to a decoy-state QKD protocol, an often-used technique for la
249 ycopeptide analysis, adopted from the target-decoy strategy in proteomics, employs a decoy database t
252 imination of native protein-DNA complex from decoy structures, and most importantly in rigid TF-DNA d
254 ng domain (MBD), however, DNA methylation of decoys substantially ( approximately 10-30-fold) acceler
256 nhibition of RNA sensors, by providing viral decoy substrates for cellular kinase complexes, and thro
257 tationary phases (54 distinct systems and 16 decoy systems) in micellar electrokinetic chromatography
258 of adeno-associated virus expressing a Tough-Decoy targeting miR-26a prevents Smad down-regulation an
259 ng that such RNA transcripts may function as decoy targets or traps for NF-Y and thus inhibit the gro
262 s, such as antisense or Transcription Factor Decoys (TFDs), have the potential to circumvent current
263 erexpression of a 5' stem-loop RNA molecular decoy that sequesters LARP6, prevented the ability of IG
265 ogenic trickery using exogenously introduced decoys that present high-affinity mimics of cellular rec
266 ortant to fully characterize, as they may be decoys that promote nonneutralizing responses and may al
267 ions is an ability to act as scaffolds or as decoys that recruit or sequester effector proteins from
268 em by viruses is often mediated by molecular decoys that sequester host proteins pivotal to mounting
270 mycin-resistance by functioning as molecular decoys that titrate the antibiotic away from its intrace
274 graminicola coopts the plant BR pathway as a decoy to antagonize effectual SA- and GA-mediated defens
275 e herbivore exploits symbiotic bacteria as a decoy to deceive plants into incorrectly perceiving the
276 d with increasing distance from the predator decoy to examine how herbivorous fishes reconcile the co
277 , upregulated during regeneration, acts as a decoy to inhibit PDGF signalling and to prevent FAP over
280 mally degraded after splicing, likely act as decoys to sequester TDP-43 away from binding to and disr
281 ccumulate in the cytoplasm and likely act as decoys to sequester TDP-43, preventing it from interferi
282 e oligonucleotides, and transcription factor decoys to treat disease has prompted nearly 40 clinical
283 oduction of an irrelevant option (called the decoy) to a choice set does not change the preference be
285 h during peak mosquito abundance, this "host decoy" trap caught nearly ten times the number of Anophe
286 of mHtt exclude chromatin and form 'sticky' decoy traps that impede target search processes of key r
289 on of Notch, using a soluble receptor Notch1 decoy, unexpectedly caused a remarkable increase in live
291 y injected with adenoviral vector encoding a decoy VEGF receptor (Ad-Flk) or a control adenovirus (Ad
292 tor tyrosine kinase inhibitors and a soluble decoy VEGF receptor have demonstrated nominal benefit am
293 that fishes foraging closest to the predator decoy were 40% smaller than those that foraged at furthe
294 ory response and of soluble RAGE acting as a decoy were associated with up-regulation of the DAMP-rel
296 ed in a fragment assembly protocol to sample decoys, which are assessed by a composite scoring functi
297 hydrogen-bonding network and compactness of decoys, which eliminates the possibility of native struc
298 correct mutual orientation exist even in the decoys with a large overall root mean square deviation (
300 ales made brief flying approaches toward the decoys without nanostructured features, but diverted awa
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